Pomegranate peel – anti-COVID19, may block ACE2 receptor access to the SARS-CoV-2 virus

Pomegranate peel extract has been found helpful at preventing access of the SARS-CoV-2 virus to ACE2 receptors in a cell based study (in vitro). The pomegranate peel extract would contain mixed plant phytonutrients that might include EGCG, ellagitannins and gallotannins. The extract also inhibited “the activity of the virus 3CL protease.” (1)

In this study, by using different in vitro approaches, we uncovered the role of a pomegranate peel extract in attenuating the interaction between the SARS-CoV-2 Spike glycoprotein and the human Angiotensin-Converting Enzyme 2 (ACE2) receptor, and in inhibiting the activity of the virus 3CL protease.” (1)

Ellagitannins and gallotannins are hydrolyzable tannins and have been found to have anti-viral effects against the herpes simplex virus. (search results ellagitannins antiviral)

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Reference List

  1. Annalisa Tito, Antonio Colantuono, Luciano Pirone, Emilia Pedone, Daniela Intartaglia, Giuliana Giamundo, Ivan Conte, Paola Vitaglione, Fabio Apone A pomegranate peel extract as inhibitor of SARS-CoV-2 Spike binding to human ACE2 (in vitro): a promising source of novel antiviral drugs. bioRxiv 2020.12.01.406116;  doi: https://doi.org/10.1101/2020.12.01.406116 This article is a preprint and has not been certified by peer review. https://www.biorxiv.org/content/10.1101/2020.12.01.406116v1