Adaptive Immunity, ADE, and Antibodies

ADE & Neutralizing Vs Non-Neutralizing Antibodies 

The CoV “vaccines” cause the person’s own cells to make spike protein and put it on the surface of the human cell – this would never happen in an actual viral infection. In viral replication the virus with spike are made within the host cell and then burst forth, killing the host cell and possibly also using part of the host cell membrane as part of the membrane of the many replicated virus. The cellular debris from the cell being killed by the exit of the virus leaves inflammatory chemicals in the extracellular fluid.

In the case of the gene therapy “vaccines” the human cell itself has spike proteins produced on the surface – which may be identified by immune cells as an actual foreign protein with viral origin and neutralizing antibodies would be made that attack as if it is a virus – neutralizing the virus from being infectious. Or since it is a human cell, non-neutralizing antibodies might be made that recognize it as a ‘self’ protein – it is on human cell after all.

When the injected person’s immune cells recognize the viral protein on the human cell surface, they make antibodies against the spike protein, and eventually, those antibodies, whether neutralizing type or non-neutralizing, would connect with the spike proteins located on the surface of the human cells – throughout the body, wherever spike is being produced. Depending on the type of antibodies that had been made, other immune cells will either attack the human cell as if it is viral or cause the human cell to die – they were neutralizing antibodies – but instead of neutralizing an infectious pathogen a human cell was killed instead. The immune cells will also be extra busy with all that work, recognizing and killing all human cells that have the spike protein on the surface, so any other random infection may be ignored simply because the immune system is too busy attacking the human cells that have spike – whether a cold, flu, or SARS-CoV2.

Or, if non-neutralizing antibodies had been made, the other immune cells would leave the human cells with spike protein alone. That might seem good, but it also means that a real coronavirus infection might also be ignored by the immune cells, primed with non-neutralizing antibodies that think spike protein is ‘self’ now. 

Neutralizing antibodies are the goal of a vaccine because they would help prevent infection or symptoms from the infectious pathogen – neutralizing it from doing harm. In the case of the CoV “vaccines” though, neutralizing antibodies are also causing the human cells with spike on their surface to be killed by immune cells – as if the human cells are a foreign virus. That is similar to autoimmune disease except for many different types of cells throughout the body may all be involved instead of more specific autoimmune antibodies against thyroid tissue and gluten for example (molecular mimicry – similar chemical shape). 

Non-neutralizing antibodies are not the goal of vaccines but animal research with mRNA vaccine found that it was a big problem. Eventually all the animals died once exposed to the wild type virus. This is referred to in medical research as Antibody-Dependent Enhancement, (ADE), and more recently has been called as Vaccine Enhanced Disease. 

If the non-neutralizing antibodies encounter a SARS-CoV2 virus, any variant with a closely matching spike protein, they will bind with the spike. However the non-neutralizing antibodies are labeling it as ‘self’ and immune cells will ignore the virus as if it was a human cell – not neutralizing the virus. The non-neutralizing antibodies also would not be causing the killing of any human cells that have spike protein being produced on their surface. 

People with minimal symptoms after the jabs may have been one of the lucky ones to get the ~30% saline solution batches, or they may be more at risk for ADE infections to any coronavirus that has somewhat similar spike proteins.

Vaccine Enhanced Disease is a descriptive name. The vaccine caused the formation of non-neutralizing antibodies which accept the pathogen as ‘self’, instead of neutralizing ones that would be protective. The infection is able to grow freely, unstopped by the immune cells – which means the disease process was ‘enhanced’ – the infection will be much worse than if there hadn’t been a vaccine inducing non-neutralizing antibodies.

ADE reactions generally lead to death of the research animal with mRNA gene therapy research, and there is limited information regarding the condition in humans as adverse vaccine reactions tend to be called other things rather than performing autopsies and finding out in more detail. A nasal infection leading to lung infection would show more damage in the upper area of the lungs. An ADE infection would likely have damage more throughout the lungs and body.

In the case of an RSV vaccine and later infection, the ADE reaction was “termed vaccine-associated enhanced respiratory disease.” (1)

Recent research is showing a disease enhancement effect occurring with the CoV gene treatments. Infection rate is higher in the injected than those who have not had the CoV injections:

“Earlier, I had published and announced in a public speech (Harrisburg) that the vaccine program had failed, in part based on my findings that the number of new cases was highest in countries with highest vaccine uptake (See article here). The Israeli and UK data showed more cases in the vaccinated than in the unvaccinated, and my analysis yesterday should silence the pedestrian response “that’s because there are more people who are vaccinated”. I’ve pointed out (as have others) that Fauci’s “go home until you are sick enough to need emergency care” makes people variant incubators.

Now a new study has found the specific mutations by which the SARS-CoV-2 lineages have escaped the vaccine. The study, which is behind a paywall (US$40), reports that these mutations lead to less infectivity compared to the original SARS-CoV-2, but, according to the authors, “can disrupt existing antibodies that neutralize the virus“.

That sounds like disease enhancement to me.” – James Lyons-Weiler (2)

People getting CoV injections are supposed to be informed of increased risk of infection being possible as a result, rather than protection. Research focused on whether they are being informed of the risk of ADE or Vaccine enhanced disease found that there was insufficient awareness. (3)

Variants with a spike modification that evades the antibodies, whether neutralizing or non-neutralizing may also be an increased risk of the leaky gene treatments, (4), called vaccines by the new definition of the word.

Adaptive immunity – ability to make new types of antibodies & more B or T immune cells.

Adaptive immunity means our ability to make new types of antibodies whenever we need, and allow the transformation of undifferentiated immune cells into the active B or T cell type that is ready to make antibodies (B), or fight infection (T). Without the DNA repair function the immune cell differentiation can not occur either. Lack of DNA repair also is a problem because DNA changes can lead to cancer or mitochondrial dysfunction conditions which can include Parkinson’s disease (PD). (5

The viral infection leads to inflammation, oxidative stress, and that leads to increased DNA damage, which might be random. Adequate nutrients can help correct the oxidative stress chemical imbalance before damage occurs. After DNA damage occurs, it may be too late to correct DNA changes that were replicated in a large enough number of defective mitochondria or cells to cause noticeable symptoms.

Consistent with our results, clinical observations also show that the risk of severe illness or death with COVID–19 increases with age, especially older adults who are at the highest risk [22]. This may be because SARS–CoV–2 spike proteins can weaken the DNA repair system of older people and consequently impede V(D)J recombination and adaptive immunity. 

In contrast, our data provide valuable details on the involvement of spike protein subunits in DNA damage repair, indicating that full–length spike–based vaccines may inhibit the recombination of V(D)J in B cells, which is also consistent with a recent study that a full–length spike–based vaccine induced lower antibody titers compared to the RBD–based vaccine [28]

This suggests that the use of antigenic epitopes of the spike as a SARS–CoV–2 vaccine might be safer and more efficacious than the full–length spike. Taken together, we identified one of the potentially important mechanisms of SARS–CoV–2 suppression of the host adaptive immune machinery. Furthermore, our findings also imply a potential side effect of the full–length spike–based vaccine.” (6)

DNA Damage can lead to cancer or mitochondrial conditions, like Parkinson’s Disease, PD.

DNA damage can be prevented more easily then it can be changed back to healthy – unless it is just an epigenetic change. Methyl groups are an atom of oxygen and hydrogen that can be added to the side of DNA sequences where they act kind of like a bottle cap to keep the DNA in a closed or off position.

Epigenetic changes where a gene is active when it should be inactive, can change back when adequate methyl donor vitamins are available (methyl or hydroxy B12, folate, and choline). Some people may need extra due to a genetic inability somewhere in the methylation steps, or because inflammation/infection caused an big increase in need for the nutrients.

Other phytonutrients may also help with DNA damage and protect against cancerous changes. 

Recently, we have shown that dietary phytochemicals such as quercetin, rutin, rosmarinic acid, luteolin, and others not only protect DNA damage but also stimulate DNA repair in liver and colon cell lines (Lima et al., 2006; Ramos et al., 2008; Ramos et al., 2010b; Ramos et al., 2010a). These effects may contribute to their anti-carcinogenic effects” (Ramos et al, 2011) (7)

See jenniferdepew.com page Phytonutrients for food sources and more information about quercetin, rutin, rosmarinic acid, luteolin and other phytonutrients.

The menu and beverage ideas for Nrf2 Promoting Foods (G10) on effectivecare.info would also be helpful for DNA repair, and Pomegranate (G13) or Citrus Peel (G14). Zinc is also important, food sources on (G15), or see reference (8).

Thiamine, vitamin B1, is also needed in larger amounts during severe inflammation or infection and possibly for a long time aferwards, a LongCovid personal story: (9). Riboflavin, B2, is important to take along with it, and niacin/nicotinic acid, B3, pantothenic acid, B5, and the other methyl donors, folate, methyl or hydroxy B12, and choline. Betaine, TMG, may also be beneficial to take and CoQ10 and alpha lipoic acid, both cofactors for mitochondrial use of the citric acid cycle (see post Niacin for preventing migraines) for converting glucose into usable energy or as heat, which can reduce inflammation. (see post Niacin & Early Treatment)

Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a [*functional] health professional for individual health care purposes.

Reference List

  1. Arvin, A.M., Fink, K., Schmid, M.A. et al. A perspective on potential antibody-dependent enhancement of SARS-CoV-2. Nature 584, 353–363 (2020). https://doi.org/10.1038/s41586-020-2538-8 https://www.nature.com/articles/s41586-020-2538-8
  2. James Lyons-Weiler. Spike-Only Vaccine a Colossal Blunder: Michigan State University Shows SARS-CoV-2 Vaccine Escape is Due to Vaccination. Dec. 8, 2021, https://popularrationalism.substack.com/p/spike-only-vaccine-a-colossal-blunder
  3. Timothy Cardozo, Ronald Veazey. Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease. Int J Clin Pract. 2021;75:e13795. DOI: 10.1111/ijcp.13795 https://onlinelibrary.wiley.com/doi/pdf/10.1111/ijcp.13795
  4. Wang R, Chen J, Wei G-W. Mechanisms of SARS-CoV-2 Evolution Revealing Vaccine-Resistant Mutations in Europe and America. J. Phys. Chem. Lett. 2021, 12, XXX, 11850–11857, December 7, 2021 https://doi.org/10.1021/acs.jpclett.1c03380
  5. Park JS, Davis RL, Sue CM. Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives. Curr Neurol Neurosci Rep. 2018;18(5):21. Published 2018 Apr 3. doi:10.1007/s11910-018-0829-3 https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5882770/
  6. Hui Jiang, Ya-Fang Mei. SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Viruses 2021, 13(10), 2056; DOI: 10.3390/v13102056 https://www.mdpi.com/1999-4915/13/10/2056/htm 
  7. Alice A. Ramos, Cristóvão F. Lima and Cristina Pereira-Wilson, Chapter: DNA Damage Protection and Induction of Repair by Dietary Phytochemicals and Cancer Prevention: What Do We Know? October 26th 2011, DOI: 10.5772/22125, From: Selected Topics in DNA Repair. Ed. Clark Chen, U of California, San Diego, USA, DOI: 10.5772/1749 https://www.intechopen.com/chapters/22717
  8. Song Y, Leonard SW, Traber MG, Ho E. Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats. J Nutr. 2009;139(9):1626-1631. doi:10.3945/jn.109.106369 https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3151020/
  9. Barb Check, Recovering from Long Covid with Thiamine. Sept. 1, 2021, https://www.hormonesmatter.com/recovering-from-long-covid-with-thiamine/
https://ijvtpr.com/index.php/IJVTPR/article/view/23

Individual Nutrition assessment – an example chart note

What is health care? What is included in an individualized health care appointment?

The answer varies with the type of specialist you are seeing – and what they are allowed to do within their facilities’, or the individual’s insurance plans protocols.

My nutrition counseling experience was in prenatal/early childhood, and residential (nursing home) facilities.

Chart notes would be written for high risk clients when working in either role. Occasionally the nutrition assessment and recommendations note would be sent to the physician directly if very high risk.

As a preventive health focused prenatal/early childhood counselor, or for residential facility chart review (nutrition assessments of all nursing home residents considered high risk nutritionally, occasionally would include an in person visit with the resident to visually observe and ask further questions about their health and diet symptoms.

Patients typically do not see a chart note. They might be given the ‘Problem’ and ‘Assessment’ sections as an action list of recommendations on a simpler handout. The medical chart has a Care Plan section where recommendations for a daily change in care might be added – such as adding a high protein snack in the evening.

I would typically spend a half hour to an hour per client and writing a good note might take an additional 15 minutes. Current insurance standards have been set which limit physicians to 15 minutes per patient appointment – and only scheduling/discussing one symptom per appointment. That would make a differential diagnosis fairly impossible.

  • The entirety of a person’s symptoms – and what makes the problems worse, and what seems to improve things – is what provides clues to the underlying issues that may have led to the increased inflammation and/or decreased function.
  • Health is a balance of not too much inflammatory response -> autoimmune or allergies – or too little -> rampant infection and catching every cold.
  • Health is also a balance of enough nutrients and not too many toxins to cope with, whether from air, water, food, or touch, or from internal production of stress chemicals caused by emotional or physical stress.

Autoimmune issues are particularly challenging because many odd symptoms can occur, and more than one type of autoimmune antibody may be involved – not just one ‘autoimmune disease’ – several. Low vitamin D makes autoimmune issues more likely to occur, and low magnesium can make low vitamin D more likely – even with supplements of vitamin D.

Low magnesium also increases inflammation symptoms, pain, and anxiety, depression or anger and irritability.

A physician might look at my example note (below) and think: ‘but this is not my field‘ — exactly — please refer to the specialist – a registered dietitian or clinically trained nutritionist. Caution, there are many ‘nutrition certification’ programs online which are not equivalent to a college education, internship, and the equivalent of a lawyer’s Board Exam.

The client gave permission to share the write-up for educational purposes or maybe to help someone. Patients know that pain hurts, and that health is better. Too often I hear from physicians something like ~ ‘we don’t know what is causing this, … so the patient will probably die‘ – but it is regarding symptoms that likely involve nutrient deficiency.

Even sick patients need to eat or be fed and their nutrient needs are likely increased, or decreased, due to the illness, for a few specific nutrients affecting or being used in excess by the underlying issue. Telling a patient there is no hope is providing a nocebo – a negative expectation. Saying “I don’t know,” – when that is the true situation – would at least not be setting up a roadblock for the patient to seek further information or a second opinion.

If in reading my example chart note*, as a physician, you think, ‘but this is not my field‘ — exactly — you are correct – but it is the patient’s whole health that matters, not just symptoms that may be temporarily controllable by medications.

SOAPE note

The SOAPE chart note* below, is an extended version compared to what would be likely to be written in a patient chart. SOAPE note: Subjective, what the client said; Objective, what the clinician observed; Assessment; what the clinician believes may be underlying issues; Problem/Plan, recommendations being made by the clinician; Evaluation – an opinion statement about the likelihood of positive change, based on the overall attitude or motivation the client is presenting and social factors that may impact the client positively or negatively.

I included extra information that might be in a report to the client, with the education they might need to understand the reasoning for the recommendation, or how to proceed. Complex strategies can take several weeks of a class like setting possibly with cooking and tasting demonstrations. My web pages and posts try to provide self care guidance so a motivated learner could just try things and see if they help.

I added some additional info links for the version in this post, to pages or posts that provide some next step guidance, Gluten Free diet? what is that? The products on the market are not ideal suppliers of nutrients in my personal and professional opinion and learning how to bake gluten free can be healthier and less expensive for the nutrient value. My websites are my file cabinet of patient handouts, some of it.

While working as a public health nutrition counselor I did occasionally write a very thorough note for someone with a complicated case, and send it to the client’s physician on their or their child’s behalf.

Nutrient deficiencies can lead to death (niacin/pellagra example) – and can turn around dramatically very shortly after the nutrients and any cofactors are provided (nutrients are a team – refeed gradually and in balance).

Sometimes nutrition care is a life or death situation. Continue the nutrient deficiencies and deterioration can be rapid, and death can be the result. Niacin deficiency, pellagra, has a nickname for symptoms – the four D’s: “Pellagra defines systemic disease as resulting from a marked cellular deficiency of niacin. It is characterized by 4 “D’s”: diarrhea, dermatitis, dementia, and death.” (1) If there is severe lower leg rash and edema – suspect a B vitamin deficiency.


Nutrition assessment

Subjective:

  1. CoV like symptoms, mild, ~ early outbreak mid 2020, left a new problem, 2. swollen throat, reflux like pain/not quite reflux though, flair up of CoV symptoms again later when family had it 2021, again not too bad. 
  2. Swollen throat symptoms – has had labs showing autoimmune thyroid condition.
  3. Thyroid symptoms had improved a year or so earlier after stopping use of wheat/gluten and dairy. Recently started using ginger tea for the throat problem and it sooths. Hasn’t used long term, recent addition. 
  4. Reading about eosinophilic esophagitis did not sound like the problem. 
  5. Reading about histamine/MCAS symptoms did sound like it might be a problem. Tomato/salsa particularly, chicken causes congestion. Likes to drink orange juice.

Objective:

  1. Pale complection, may suggest magnesium deficiency/low vitamin D, low level anemia of chronic inflammation possibly.
  2. Throat visibly enlarged in pattern of enlarged thyroid gland 

Assessment: 

  1. CoV, even with mild symptoms, may have increased autoimmune antibodies, or created new types. Pale complection may suggest magnesium deficiency/low vitamin D, low level anemia of chronic inflammation possibly.
  2. Enlarged thyroid gland would be likely to cause difficulty swallowing at times, particularly if a food flair of the underlying autoimmune antibody sensitivity. (The thyroid gland presses inwards also and can narrow the throat significantly – *personal experience from also being an autoimmune thyroid patient, swallowing a large supplement can be very painful, and may feel stuck even.)
    1. Eosinophilic esophagitis might also be adding to swallowing symptoms if early stages, wouldn’t be causing as severe reflux symptoms as a more advanced case which is more likely to be what is described in articles about the problem. Food sensitivities are the most frequent cause and include gluten, dairy, eggs, and other common food sensitivity foods.
  3. Autoimmune thyroiditis can be a gluten molecular mimicry problem – the thyroid hormone chemically is similar to the gluten molecule. 
  4. Autoimmune antibodies to other food chemicals might also flair up an underlying autoimmune overactive eosinophile problem, white blood cells. Ginger contains a chemical similar to albumin and an egg sensitivity might be triggered by a sudden increase in use of ginger – or chicken – or eggs, or any animal product containing albumin. *also learned from personal experience – this can be a significant problem – I developed sensitivity to eggs and gradually realized I needed to exclude all sources of albumin or my symptoms would flair up again (non healing rash, not quite eczema – more wounds, lack of skin regrowth).
    1. An apparent ‘wheat/gluten’ sensitivity might be an albumin sensitivity, see one of my early posts with the information about plant albumin in wheat and ginger: Wheat is rich in albumin – so are ginger and egg whites.
  5. Histamine sensitivity seems a problem worth working on by decreasing trigger foods. Orange juice could be an additive problem food. The total load is part of the problem but even small amounts can set off the allergy cells that increase inflammatory cytokines and pain/inflammation signals – swollen, itchy, sore throat, dry eyes, but it can also effect mood when a more severe problem – extreme anxiety and fear, or out of control, hyper-excitable.

Problem:

  1. Elevated iron and symptoms of anemia of chronic inflammation may be a lingering CoV effect or of autoimmune conditions – it can be common to have several types of autoimmune antibodies also, and there has been cases of LongCovid where autoimmune antibodies were found. The spike lodges in a receptor and antibodies are made against the receptor, instead of against spike.. 
    1. Iron chelators may help mitigate chronic inflammation damage, restore energy level if that is a problem. The quercetin is one, continue regularly, opposite the niacin protocol if following that., or eat more of the good plant sources of a few, EGCG, pomegranate peel, green tea, oregano, olive leaf extract, there are many see the Iron chelator section of this Resources & Iron Chelators list
    2. Epsom salt soaks for a topical source of magnesium, help immune function, energy level, fluid balance. Continue if already using or start 1-3 times a week.
    3. Sunshine or Full spectrum light 20-30 minutes per day and or a moderate dose vitamin D3 ~ 600-1000 IU. 
    4. Avoid glyphosate residue. Consider supplementing with DMG, dimethylglycine, bulk powder, 1/2 spoonful once or twice a day in water or with a little juice and water. (too much juice is not really good for us).
  2. Thyroid problems in the modern world are likely related to excess fluoride and bromide and too little iodine. Cautiously increasing iodine and 200 mcg selenium may be helpful. Higher dose for one month can help the body to dump fluoride, bromide and chloride. When there is a lack of iodine the body will build molecules with the other halides, but then the thyroid hormone or other chemical won’t work right. Lab tests may show ‘normal’ levels of thyroid hormone but symptoms of hypothyroidism may still be present.
    1. In autoimmune conditions, when possible, it is essential to identify the trigger foods and strictly avoid them. It can take 6 months for antibodies to fade away, at which point symptoms should improve, but memory B cells still exist so even little tastes of the problem foods can set off a new 6 month batch of autoimmune antibodies that will attack the thyroid gland, or esophagus, or wherever else the problem point is located. 
    2. In this case eggs/chicken/ animal products/ ginger/ albumin /*hemp kernels too then/, may be part of the problem foods – 
    3. Elimination type diets that start with the least risky foods and gradually reintroduce things one at a time can be the best way to individualize what is the problem for you the individual. 
  3. Gluten was definitely identified as a part of the thyroid problem by removing, it already had helped to stop that. Dairy has a variety of allergens, and also would have albumin. Removing food triggers strictly, can help a swollen thyroid gland reduce in size – versus get more swollen when trigger foods are eaten.
    1. Gluten free baking recipes and tips for converting recipes: effectivecare.info – G8. Cookies & Bean Soup. -> and it mentions that increasing corn or corn flour instead, is not ideal either. Corn or gluten can increase zonulin which also increases leaky membranes in the gut or blood brain barrier, and more open membranes can increase risk of allergens entering undigested from the diet. See: What is Zonulin? (2)
    2. A quick mix recipe that can be used for pancakes or muffins, a post: Pancakes in a Jiffy – Quick Bread Mix.
  4. Eosinophilic esophagitis may be related to food sensitivities, so as food elimination is attempted it would also be helpful to pay attention to the swallowing symptoms to see if change occurs other than the swollen pressure feeling of the enlarged thyroid gland.
    1. Research shows a strong connection between food allergies and eosinophilic esophagitis (EOE). These six foods are most commonly associated with this allergic response: dairy, wheat, soy, eggs, nuts, and seafood/shellfish. Unfortunately, there is no accurate test to identify food allergies* connected with EOE.” (3
    2. *The food sensitivity is not the same type as tested for people who get hives to peanut butter or eggs or are allergic to bee stings. It is food sensitivity that activates white blood cells though, called eosinophils. 
    3. During normal function eosinophils fight parasites for us. So …. Maybe they are doing something in ‘autoimmune disease’ that involves their normal function too fighting an unidentified parasite – or they are responding to chemicals of the six foods listed above in an allergy-like way. 
    4. Asthma and allergies involve increased eosinophil activity, which can lead to inflammation symptoms and tissue damage: “Eosinophils can consume foreign substances. For example, they fight substances related to parasitic infection that have been flagged for destruction by your immune system. Regulating inflammation. Eosinophils help promote inflammation, which plays a beneficial role in isolating and controlling a disease site.” […] “…eosinophils play a key role in the symptoms of asthma and allergies, such as hay fever. Other immune system disorders also can contribute to ongoing (chronic) inflammation.” (4
  5. Eliminating common histamine problem foods may help anxiety and inflammatory symptoms. Orange juice, tomatoes, fermented foods, or older leftovers, cranberries, others, it is a lengthy list but can make a huge difference *personal issue for me also.
    1. More info on page MCAS/Histamine, jenniferdepew.com: MCAS/HIstamine.
    2. Summary of foods to avoid, or a few helpful in an over-reaction: Histamine Food Lists. it is a document (6)

Evaluation:

Client seems motivated and capable of making positive changes for improving health, cheerful and confident amid a complex set of problems, and has support of family.


So does my disclaimer make more sense now?

  • Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

My professional and personal expectations of individualized health care guidance does not include a 15 minute appointment limited to discussing one symptom. In seeking a health care provider I recommend searching for ‘functional health’ or possibly holistic but that is less precisely used than ‘functional’. The orthomolecular approach is also whole body and restoring function oriented.

*am I taking clients? I am working in that direction but I am still in initial stages of having a system set up.


Change is easiest by just practicing the desired habit and the more often it is remembered, practiced, then the more that brain pathway will be strengthened and the old one is gradually deactivated, becomes harder for the nerve cells to fire instead of being an automatic habit like happens without even thinking consciously – to change that ingrained of a habit takes substituting a new pattern rather than trying to ‘attack’ with ‘will power’. Work with nature and it will work with you. Attack and it tends to have an undesired ripple effect.

Pain hurts, health is better.

We all die, the question is quality of life while living – and enjoying that life while living.

Namaste – the soul in me, sees the soul in you.

We are all children, under the care of Mother Nature and Father Sun.

Where there is light there is life, and there is hope.

Reference List

  1. Hegyi J, Schwartz RA, Hegyi V. Pellagra: dermatitis, dementia, and diarrhea. Int J Dermatol. 2004 Jan;43(1):1-5. doi: 10.1111/j.1365-4632.2004.01959.x. PMID: 14693013. https://pubmed.ncbi.nlm.nih.gov/14693013/
  2. What is Zonulin? https://www.creative-diagnostics.com/blog/index.php/what-is-zonulin/
  3. 6 Food Elimination Eosinophilic Esophagitis, oregonclinic.com, https://www.oregonclinic.com/6-Food-Elimination-Eosinophilic-Esophagitis-EOE 
  4. Eosinophilia, symptoms, mayoclinic.com, https://www.mayoclinic.org/symptoms/eosinophilia/basics/causes/sym-20050752

Documents, Posts & Pages

  1. Wheat is rich in albumin – so are ginger and egg whites, post transcendingsquare.com
  2. Resources & Iron Chelators list, document https://docs.google.com/document/d/1XiwJBPoFUnUTQKcRAW_8NMriQMt8b31zjeTY4zV0wJo/edit?usp=sharing
  3. effectivecare.info – G8. Cookies & Bean Soup, webpage
  4. Pancakes in a Jiffy – Quick Bread Mix. post transcendingsquare.com
  5. MCAS/Histamine. webpage, jenniferdepew.com
  6. Histamine Food Lists. document, https://docs.google.com/document/d/17iz9lsJyGqIUUjF0p-totXp4R2GhgRi2Na4gYueisTM/edit?usp=sharing

EPIGIRL 2

EpiGirl is a fictional character in the SPARS epidemic scenario that was published in 2017. EpiGirl collates the adverse reaction reports from VAERS and other patient forums and it seems worse. The scenario works through that issue by suggesting it was duplicated records.

2017 SPARS Report –

A database is needed, collecting data is needed – that is basic to experimental design – collect data, all the data. And in this case, all the data includes adverse reactions in the experimental group or in those with passive exposure reactions. That is even stated in the branded experimental design literature. In this case data is not being collected and definitions are being changed so the data that is being collected does not match the redefined label.

A whistleblower nurse shared what is happening with the data regarding who is in the hospitals with Covid currently – the experimental group (vac) or the control group (unvac)? The definition was changed to call anyone within 14 days of an injection unvaccinated, allegedly because their antibodies wouldn’t be expected to be elevated enough to be protective yet. That may be true but it doesn’t change the fact the person was in the experimental group – did receive an injection, or a second injection – they are no longer in the ‘unvaccinated’ control group immediately after getting the first injection.

The adverse reactions tend to occur early also, within the first few days after an injection, or second one, according to the nurse. See the full story here: twitter.com/AxelSavage4/status/1437624425281511429?s=20.

From the replies:

Benny Nomad@BennySeattle· Replying to @AxelSavage4 : “Have you considered that what you are describing is fraud? They are calling everyone who has had their first shot un-vaxxed, and if they have had the second shot, for the following 14 days they are still considered un-vaxxed. How is that not fraud?

LibertySavage@AxelSavage4·That’s exactly what it is”

The first injection or exposure can prime an allergy-like over response of the immune system to occur the next time the antigen is present in the body. People who were already sick with CoV may be at more risk of an over-reaction to an injection, because their immune system was primed by the earlier sickness.

Another medical professional shared concerns over underreporting of adverse reactions, to the US VAERS adverse reaction database. Doctors are being threatened to not report cases to the system. See: EXCLUSIVE: COVID Whistleblower Claims the VAERS Reporting Database Tracking Vaccine Complications is WRONG and Undercounting by a Factor of 100! (thegatewaypundit.com/2021/09)

170,000 comments about adverse reactions have been submitted to a news website:

News article about the ABC website postings: Unexpected and heartbreaking: Thousands flood ABC affiliate’s Facebook page with vaccination horror stories. (Sept 13, 2021, worldtribune.com) “39,000 responses (as of mid-day Sept. 13)

We need reliable data that has been double checked for identity, confidentially, in order to prevent duplication of record entries. We need reliable data that is contained in a cybersecure location on a hosting platform that is independent from technology that may be compromised regarding reliability, on Linux systems for example.

  • *Guidance is being provided on Telegram, if you are interested in learning about using Linux instead of Windows type systems. Sign up on Telegram first, and then search for and follow ‘Jeffrey Peterson,’ in his pinned posts look for the discussion Chat room link: @jptchat. People are helping each other get set up and Jeffrey also provides guidance and has tutorials.
  • Invite link: JP’s technology chat: https://t.me/jptchat

EPIGIRL 2 will need funding and a lot of volunteers around the world. These adverse reactions are happening around the world. The injection batches were not claimed to be or required to be, all the same product, so different locations may have been test cases for different experimental batches. Adverse reactions may cluster by batch/location, not just by ethnic/genetic or health differences. Without reliable data at an international level, those patterns will not be revealed. Giving us the need for EPIGIRL 2 – Epidemiologic Patterns in Genetics; Injection Reaction Log – an Extremely Professional, International, Giant, Injection Reaction Log. EPIGIRL squared – two names to represent the two strands of the double helix of a DNA molecule.

The recommendations made by the committee investigating adverse reactions should be included as the basis of EPIGIRL 2 (from the last post, Chimeric Spike, with Prion-like areas). If we are to follow the ‘science’ – that is what the science says:

Immunization Safety Review Committee

  • Surveillance of adverse events related to vaccines is important and should be strengthened in several ways:
  • The committee recommends that standardized case definitions for adverse events be adopted.
  • The committee recommends that formal guidelines or criteria be developed for using VAERS data to study adverse events.
  • The committee recommends the continued use of large-linked databases, active surveillance, and other tools to evaluate potential vaccine-related adverse events.
  • The committee supports the development of Clinical Immunization Safety Assessment (CISA) centers to improve understanding of adverse events at the individual level.
  • One area of complementary research that the committee continues to recommend is surveillance of ASD* as exposure to thimerosal declines. (*Autism Spectrum Disorder)
  • The committee recommends increased efforts to quantify the level of prenatal and postnatal exposure to thimerosal and other forms of mercury in infants, children, and pregnant women. 
  • 2. Excerpt : Immunization Safety Review: Vaccines & AutismBOX 2, Comm. Conclusions & Rec. Institute of Medicine (US) Immunization Safety Review Committee. Washington (DC): National Academies Press (US); 2004. https://www.ncbi.nlm.nih.gov/books/NBK25349/#a2000af8fddd00068

The SPARS report predicted an EpiGirl – we need her, badly, desperately – truthfully. This is dangerous, and is a genocide because some are more at risk than others.

Methylation: Anyone with methylation gene defects would be more at risk for epigenetic gene changes which can lead to conditions like POTS. See: Epigenetic changes may also be involved in Covid19 or LongCovid, Nov 18, 2020. They would be healthier by not taking standard B supplements which have unmethylated forms of B12 and folate. Instead seek out food sources that aren’t the supplement fortified types, and/or methylated forms of folate and B12 (not folic acid or cyanocobalamin – yes the standard form of B12 used in the US contains cyanide and taking too much of it for too long can lead to cyanide poisoning – does it make sense to use cyanide in a dietary supplement? NO, but that is off-topic.).

BHMT: People with a BHMT gene allele would also be more at risk for inflammatory membrane break-down. There is an ethnic difference in rate – people with Caucasian or African ancestry are more likely to have a defective BHMT gene allele than people of Asian ancestry. See: Cannabinoids are made with the BHMT gene (and others). Feb, 25, 2021.

Glyphosate: Glyphosate residue is also likely a factor in rate of severe reactions in CoV illness or injection reactions. See: Glyphosate and COVID-19, Oct 25, 2020, it has dietary tips for trying to reduce glyphosate intake and improve the negative effects. Glyphosate can increase the risk of misfolded proteins and may be adding to the out of control inflammation. It also likely is increasing the risk of low vitamin D and minerals such as manganese and the amino acid methionine. Manganese is really essential for mitochondria to function normally. Tracking patterns of severity of illness over geographic regions that produce or use more biofuel made with biomass from glyphosate crops is a need. Asking people with adverse reactions, and the control group, those without, to have a urine test for glyphosate residue, is a need. Reliable data requires collecting data in a method that is consistent and has quality control standards to assure the results are reliable. How a sample is taken, stored, and tested, all may affect quality of the results.

Citric Acid Cycle Nutrients & Cofactors: The spike protein is harming mitochondria, which then the debris from the mitochondria, harms our cells. We need to protect our mitochondria as cancer and other chronic degenerative disease is preceded by dysfunction of mitochondria. They switch from using oxygen and the Citric Acid Cycle. For mitochondria to be able to perform the chemical reactions of Citric Acid Cycle they require that we have nineteen different nutrients and cofactors available to them – and in balance and in adequate amounts – not just ‘one’ nutrient. One problem/one cure – is not how the body works or how nutrition works.)

Cytokine storm risk: Ten to fifteen percent of the population are estimated to be at great risk for a severe cytokine storm reaction to ANY severe immune challenge, whether a vaccine or an infection. (5) See: Cytokine Storm, SIDS, autism and Vitamin C, March 29, 2020. Their bodies do not react normally to infection. Genetic screening is needed to identify the genes involved and then screen for those at risk.

In the meantime, high dose intravenous vitamin C (Marik Protocol) therapy does work well to reduce the cytokine storm from escalating and prevent the damage that can be caused by it. See: Bitter taste receptors in the lungs & Hesperidin’s decongestant properties. April 7,2020 < the food and supplement recommendations are still valid.

You can lead a horse to water, but you can’t make it drink.” Self care – includes the word self, because oneself, is in charge of self care. It is not about spa treatments or getting disabling nail extensions applied with potentially toxic chemicals. That is not self care in any kind of health sense.

The only problem with that plan is that the FDA is preventing use of the treatment for Covid related care. It does not have risky side effects and has a large amount of supportive research for similar cytokine conditions. There is no sensible reason to not approve it for use during an alleged pandemic emergency – if we have an emergency, then we should be providing emergency care to those who need it – NOT WITH-HOLDING IT, or criminalizing the use of it by independent physicians who deem it in their patient’s best interest.

Vitamin C given in advance of a vaccine may also help reduce the risk of an over-reaction of the immune system – even for animals that can make some of their own vitamin C (we can’t make any). From the post: “Giving extra vitamin C before vaccines was found to be protective even in lab animals that genetically can make vitamin C. (4)

If health is the goal – then why hasn’t everyone been told that taking vitamin C in advance of a vaccine can help prevent an over-reaction of the immune system?

If health is the goal – then why don’t we screen for the 10-15% who will have a very severe reaction, which may result in a neurological condition that lasts the rest of their life, and EXCLUDE them from being given an immune challenge? They likely would never get exposed to tetanus or many of the other rare conditions that many vaccines are designed to protect against.

If health is the goal – then why did 170,000 people reply to a news-site about the death of someone they know that occurred after a CoV injection? If the VAERS system is only collecting 1% of adverse reactions, and currently shows a death count of ~14000 (check this, yes, almost 15,000 now, and over 19,000 people were left permanently disabled after CoV injections).

If health is the goal – then why are the CoV injections seeming to be used as a euthanasia device?

Adverse reaction entry to VAERS, shared by AMM MD on Telegram, invite link if you are on Telegram:

AMM, MD
Covid vaccine AEs and other hidden truths
https://t.me/AMM_MD

WHY VACCINATE PEOPLE IN THE LAST DAYS OF THEIR LIFE? 🤬” (- AMM MD)
71 yo F “In her end days of lung cancer was not eating and drinking very little for 3d before vaccination was given. She became very ill as she was told she might and was unresponsive and in the hospice 2d later. [Died 6d after vax.]. The adverse effects of this vaccine served no purpose to be administered to an imminent end to this dying woman. The vaccines effects would never have gotten in her body till after she had died and only made her more sick and weak then she needed to be.
Write-up: Suddenly more weak , exhausted, all around much worse then she had been feeling as she was in her last days of lung cancer. Within hours of the vaccine she was worse and in 2d unresponsive and in a hospice. 4d [later] she died
.” 1637303″ (quoted from VAERS, the US adverse reaction database).

Health doesn’t seem to be the goal to me.

15 Signs That You Might Be an Abusive Government (or Relationship).
– guidance about emotional manipulation- domestic violence often dies not include outright hitting, may just be threats or verbal abuse, or silent treatment to ‘punish’ the victims.

American Frontline Doctors is a group working towards making early treatment available to anyone who wants it. Their site has a proposed Vaccine Bill of Rights: https://americasfrontlinedoctors.org/take-action/the-vaccine-bill-of-rights/

EPIGIRL 2 is needed, with a giant team, for a giant project, because a giant massacre is happening, and being lied about – ask yourself “What would Viktor Fankl do?

Answer – take notes, really good notes.

More info: Viktor Frankl on the Human Search for Meaning, Maria Popova, (brainpickings.org).

I have begun a Protocol on a supplement dispensing site – people who enroll as clients could order at a discount from the items I’ve prescreened and added dosing details for, or browse the catalog. People who enroll as clients could be later added to an EPIGIRL 2 database. Starting is a place to start.

The Protocol: Health Aids for Special Times – it has a lot of food and general health info also. I maxed out the memory and need to copy it over to a pdf though, and probably break the supplements and protocol into smaller groups. Important point to add – to detox – don’t overeat regularly. The body needs to get a little hungry to have the time and need for white blood cells to go looking around for cellular debris to clear up and reuse for nutrients. When we overeat the body and blood cells are busy coping with storing all the excess nutrients as fat or cholesterol plaque or excreting some of it.

Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Spike summary spreadsheet; telomerase, Circadian cycle & Nrf2

The spike protein may be rapidly increasing aging by affecting the length of telomerase, a topic discussed in a previous post with potential dietary/phytonutrient aids. EGCG and other nutrients that promote the Nrf2 gene or protein have protective effects growth and repair and immune function. In the process of reorganizing the Spike protein Risks & Aids – Summary List into a spreadsheet,* a pattern emerged in the various phytonutrient and other aids – they promote Nrf2 and inhibit NFkB along with the rest of the circadian cycle promoting lifestyle factors.

  • *Spike protein Risks & Aids – Summary List into a spreadsheet, * To read each box of the table click on the box and a drop down window should appear with all the text whether brief or a long list of references.
  • The vitamins, minerals, and TMG & DMG, have dosing details listed now on a new page of my jenniferdepew.com/nutrients site with dosing ranges and links for food sources and more info if interested.
  • I will add another page for the phytonutrients, antioxidants, and cofactors, or maybe a few pages. goals
  • Various covid19 protocols are listed on this site: https://c19protocols.com/author/c19prot/

*Addition – 8/30/2021 article about the senescence effect of the spike protein: Le SARS-COV2 accélérerait l’âge biologiqueSARS-COV2 would accelerate biological age, (FranceSoir), translated from French, written by a group that includes Nobel Prize winning scientist Luc Montagnie, (2008 Nobel Prize in Medicine) and Walter Chesnut whose work is included in earlier posts on this site; Xavier Azalbert, Anne-Typhaine Bouthors, Michel Brack, Dominique Cerdan, Walter Chesnut, Gérard Guillaume, Jean-François Lesgards, Luc Montagnier, Jean-Claude Perez for FranceSoir.

~

Modern life seems to be the underlying theme of what is a risk factor and what might help – return to more ancient darkness for sleep, get full spectrum light with UV for 15-30 minutes per day, in the morning hours of your day may be ideal. Adequate iodine and magnesium is needed to help the body not have a calcified pineal gland and the pineal gland is needed to make melatonin. Melatonin is needed for immune function and has a role in energy production and inflammation removal involving niacin and the Citric Acid Cycle. Melatonin can be taken as a supplement however, then your body may be even less likely to make its own – working on improving pineal health and nighttime darkness (eye mask if need be, but covering the skin is needed too, we can sense light with photosensitive skin receptors).

Metabolic Syndrome involves magnesium deficiency, which increases hypertension and insulin resistance. The Citric Acid Cycle uses glucose to provide ATP for cellular energy or to be released as heat by a special type of adipose tissue called brown fat. People living in cold climates who spend time in the cold tend to have larger amounts of brown fat then people living in warm climates. The niacin receptor is involved in ‘uncoupling’ the Citric Acid Cycle from producing ATP as energy storage units and instead releasing it directly as warmth. The heat and reddening of the skin during a niacin flush is an example of the release of energy as heat.

There are many cofactors necessary for the Citric Acid Cycle, the chemical pathways used by mitochondria for the release of energy from glucose. The cofactors almost all also are promoters of the anti-inflammatory Nrf2 pathways, although the levels of a few minerals are regulated by Nrf2. Excess copper or iron can be inflammatory. So making sure the diet has plenty of the food sources or supplements of all the various cofactors is helping the body remove inflammation directly within mitochondria to be released as a little extra warmth, and also to produce energy for cellular use, and your thinking and daily activity.

It may also be protective during times of infection to have adequate Nrf2 and Citric Acid Cycle capacity, and also adequate uncoupling capacity: adequate niacin and/or butyrate to activate the GP109 receptors that are involved in the mitochondrial energy uncoupling, so the excess energy from oxidative stress chemicals or free iron, can be released as fairly harmless heat instead of transferred to ATP molecules. The heat during a fever is from a different cause than the temporary warmth experienced after taking a high dose of niacin – which gets milder after having been using it for a while, and is milder when there is adequate melatonin present.

About the spreadsheet & reading it – the organization style.

This is the very initial stage of writing, and many of the references are new additions. I am sharing it early because it may help people and: Pain hurts, health is better, and health is worth some effort, even a lot of effort.

The spreadsheet has categories of What? is the problem, symptom, negative effect of the spike protein, in rows. Each category often had more than one and sometimes many aids that might help or be a negative factor, so the spreadsheet is extended into many columns so each aid or lifestyle factor could have its own individual column. The columns have an ‘x‘ for the category if it is an aid and there may be a note if the item is otherwise affected by the category. Some aids may help many types of problems, inflammation and direct anti-viral for example, so there would be an ‘x‘ in the inflammation category and an anti-viral category. Each box in the columns has references about that aid and how it relates to the category. Eventually this will be useful for writing an organized reference list and document or app of some sort.

Yes this is complex, not just one or two supplements to take – breaking news – life is a miracle, it is amazing that any of us function at all. Given that, we do know a lot about what might help prevent illness or chronic degeneration, if we are allowed to put it into individual self care practice. Individualized care means – Pay attention to what seems to help and stick with that, possibly with breaks occasionally or rotating things over days, weeks or months, in season or what seems particularly good at that time.

Rotating favorites can be protective, or herbal supplements too maybe. Sensitivities to foods or substances are more likely to occur with something eaten every single day or very often. On average wheat and corn, eggs and dairy are in foods commonly eaten at every meal.

Other nutrient supplements are needed daily because they are water soluble. Some are found in many common foods and generally are rarely deficient – except during times of severe malnutrition or infection – thiamine, B1, is one of those. Vitamin C needs are also incredibly increased during severe infection or inflammation, in part because our own production of antioxidants is reduced, we normally make far more than we would ever get from a vitamin C food or capsule (equivalent to 300 orange’s worth of vitamin C, approximately per day for normal health, but glutathione and other antioxidants).

The B vitamins and C are water soluble and magnesium is readily lost in sweat and urine so we need that daily similarly to potassium and sodium, like an electrolyte – to help maintain good fluid balance. We also need calcium regularly but the bones are storage account for both magnesium and calcium so an acute or chronic deficiency is less obvious than for sodium and potassium. Very acute magnesium deficiency can occur during strenuous exercise on a hot day, and cause death from a stroke. Ischemic stroke led to death due to any reason more often in hospitalized patients with lower magnesium levels, than for those with higher levels. (ref)

Via @DGrouf Dr Grouf

Early or preventive treatment for viral infection, per Dr. Grouf.

via Dmitry Katz, PhD: Niacin, NA, within a cell, graphic. The green oval is an endolysosome, (hopefully removing spike protein), and it is complex… :-)

Niacin helps with endolysomes which are like grocery or garbage sacks for engulfing cellular debris or pathogens to be processed into usable nutrients or waste removal. (Reference needed) via https://twitter.com/SantaKlauSchwab/status/1376187499584704513?s=19

Protocol by Dmitry Katz, PhD focuses on melatonin and recommends a high dose of it. There may be a risk that a person starts making less of their own. Focu

Also using blackout curtains at night with no little lights or alarm clock, or using an eyemask during sleep can help us make our own melatonin. Supplements might be useful if there was a lack of sleep night. The melatonin helps the niacin flush reaction be milder. I have found high dose niacin helpful, see an earlier post https://transcendingsquare.com/2021/01/22/niacin-early-treatment-in-general-for-sars-cov-2-is-sensible-reduces-hospitalization-and-mortality-rate/ for more information, and some precautions.

Niatonin Protocol by Dmitry Katz, PhD, *His website: niacincurescovid.com.

How to get started on the niacin part of the protocol and cautions about potential side effects and medications that may increase risk of side effects is available in this post: Niacin, & early treatment in general for SARS-CoV-2 is sensible, reduces hospitalization and mortality rate. Jan 22, 2021.

Disclaimer: Information shared for educational purposes within the guidelines of Fair Use. It is not intended as individual health guidance, please see a health care professional for individualized guidance. ‘Functional medicine’ practitioners work to restore normal function, nutritional adequacy and modify other lifestyle factors that might be part of a health problem.

Reference List

  1. You S, Zhong C, Du H, Zhang Y, Zheng D, Wang X, Qiu C, Zhao H, Cao Y, Liu C, -F: Admission Low Magnesium Level Is Associated with In-Hospital Mortality in Acute Ischemic Stroke Patients. Cerebrovasc Dis 2017;44:35-42. doi: 10.1159/000471858 https://www.karger.com/Article/Abstract/471858