EpiGirl is a fictional character in the SPARS epidemic scenario that was published in 2017. EpiGirl collates the adverse reaction reports from VAERS and other patient forums and it seems worse. The scenario works through that issue by suggesting it was duplicated records.

2017 SPARS Report –

A database is needed, collecting data is needed – that is basic to experimental design – collect data, all the data. And in this case, all the data includes adverse reactions in the experimental group or in those with passive exposure reactions. That is even stated in the branded experimental design literature. In this case data is not being collected and definitions are being changed so the data that is being collected does not match the redefined label.

A whistleblower nurse shared what is happening with the data regarding who is in the hospitals with Covid currently – the experimental group (vac) or the control group (unvac)? The definition was changed to call anyone within 14 days of an injection unvaccinated, allegedly because their antibodies wouldn’t be expected to be elevated enough to be protective yet. That may be true but it doesn’t change the fact the person was in the experimental group – did receive an injection, or a second injection – they are no longer in the ‘unvaccinated’ control group immediately after getting the first injection.

The adverse reactions tend to occur early also, within the first few days after an injection, or second one, according to the nurse. See the full story here: twitter.com/AxelSavage4/status/1437624425281511429?s=20.

From the replies:

Benny Nomad@BennySeattle· Replying to @AxelSavage4 : “Have you considered that what you are describing is fraud? They are calling everyone who has had their first shot un-vaxxed, and if they have had the second shot, for the following 14 days they are still considered un-vaxxed. How is that not fraud?

LibertySavage@AxelSavage4·That’s exactly what it is”

The first injection or exposure can prime an allergy-like over response of the immune system to occur the next time the antigen is present in the body. People who were already sick with CoV may be at more risk of an over-reaction to an injection, because their immune system was primed by the earlier sickness.

Another medical professional shared concerns over underreporting of adverse reactions, to the US VAERS adverse reaction database. Doctors are being threatened to not report cases to the system. See: EXCLUSIVE: COVID Whistleblower Claims the VAERS Reporting Database Tracking Vaccine Complications is WRONG and Undercounting by a Factor of 100! (thegatewaypundit.com/2021/09)

170,000 comments about adverse reactions have been submitted to a news website:

News article about the ABC website postings: Unexpected and heartbreaking: Thousands flood ABC affiliate’s Facebook page with vaccination horror stories. (Sept 13, 2021, worldtribune.com) “39,000 responses (as of mid-day Sept. 13)

We need reliable data that has been double checked for identity, confidentially, in order to prevent duplication of record entries. We need reliable data that is contained in a cybersecure location on a hosting platform that is independent from technology that may be compromised regarding reliability, on Linux systems for example.

  • *Guidance is being provided on Telegram, if you are interested in learning about using Linux instead of Windows type systems. Sign up on Telegram first, and then search for and follow ‘Jeffrey Peterson,’ in his pinned posts look for the discussion Chat room link: @jptchat. People are helping each other get set up and Jeffrey also provides guidance and has tutorials.
  • Invite link: JP’s technology chat: https://t.me/jptchat

EPIGIRL 2 will need funding and a lot of volunteers around the world. These adverse reactions are happening around the world. The injection batches were not claimed to be or required to be, all the same product, so different locations may have been test cases for different experimental batches. Adverse reactions may cluster by batch/location, not just by ethnic/genetic or health differences. Without reliable data at an international level, those patterns will not be revealed. Giving us the need for EPIGIRL 2 – Epidemiologic Patterns in Genetics; Injection Reaction Log – an Extremely Professional, International, Giant, Injection Reaction Log. EPIGIRL squared – two names to represent the two strands of the double helix of a DNA molecule.

The recommendations made by the committee investigating adverse reactions should be included as the basis of EPIGIRL 2 (from the last post, Chimeric Spike, with Prion-like areas). If we are to follow the ‘science’ – that is what the science says:

Immunization Safety Review Committee

  • Surveillance of adverse events related to vaccines is important and should be strengthened in several ways:
  • The committee recommends that standardized case definitions for adverse events be adopted.
  • The committee recommends that formal guidelines or criteria be developed for using VAERS data to study adverse events.
  • The committee recommends the continued use of large-linked databases, active surveillance, and other tools to evaluate potential vaccine-related adverse events.
  • The committee supports the development of Clinical Immunization Safety Assessment (CISA) centers to improve understanding of adverse events at the individual level.
  • One area of complementary research that the committee continues to recommend is surveillance of ASD* as exposure to thimerosal declines. (*Autism Spectrum Disorder)
  • The committee recommends increased efforts to quantify the level of prenatal and postnatal exposure to thimerosal and other forms of mercury in infants, children, and pregnant women. 
  • 2. Excerpt : Immunization Safety Review: Vaccines & AutismBOX 2, Comm. Conclusions & Rec. Institute of Medicine (US) Immunization Safety Review Committee. Washington (DC): National Academies Press (US); 2004. https://www.ncbi.nlm.nih.gov/books/NBK25349/#a2000af8fddd00068

The SPARS report predicted an EpiGirl – we need her, badly, desperately – truthfully. This is dangerous, and is a genocide because some are more at risk than others.

Methylation: Anyone with methylation gene defects would be more at risk for epigenetic gene changes which can lead to conditions like POTS. See: Epigenetic changes may also be involved in Covid19 or LongCovid, Nov 18, 2020. They would be healthier by not taking standard B supplements which have unmethylated forms of B12 and folate. Instead seek out food sources that aren’t the supplement fortified types, and/or methylated forms of folate and B12 (not folic acid or cyanocobalamin – yes the standard form of B12 used in the US contains cyanide and taking too much of it for too long can lead to cyanide poisoning – does it make sense to use cyanide in a dietary supplement? NO, but that is off-topic.).

BHMT: People with a BHMT gene allele would also be more at risk for inflammatory membrane break-down. There is an ethnic difference in rate – people with Caucasian or African ancestry are more likely to have a defective BHMT gene allele than people of Asian ancestry. See: Cannabinoids are made with the BHMT gene (and others). Feb, 25, 2021.

Glyphosate: Glyphosate residue is also likely a factor in rate of severe reactions in CoV illness or injection reactions. See: Glyphosate and COVID-19, Oct 25, 2020, it has dietary tips for trying to reduce glyphosate intake and improve the negative effects. Glyphosate can increase the risk of misfolded proteins and may be adding to the out of control inflammation. It also likely is increasing the risk of low vitamin D and minerals such as manganese and the amino acid methionine. Manganese is really essential for mitochondria to function normally. Tracking patterns of severity of illness over geographic regions that produce or use more biofuel made with biomass from glyphosate crops is a need. Asking people with adverse reactions, and the control group, those without, to have a urine test for glyphosate residue, is a need. Reliable data requires collecting data in a method that is consistent and has quality control standards to assure the results are reliable. How a sample is taken, stored, and tested, all may affect quality of the results.

Citric Acid Cycle Nutrients & Cofactors: The spike protein is harming mitochondria, which then the debris from the mitochondria, harms our cells. We need to protect our mitochondria as cancer and other chronic degenerative disease is preceded by dysfunction of mitochondria. They switch from using oxygen and the Citric Acid Cycle. For mitochondria to be able to perform the chemical reactions of Citric Acid Cycle they require that we have nineteen different nutrients and cofactors available to them – and in balance and in adequate amounts – not just ‘one’ nutrient. One problem/one cure – is not how the body works or how nutrition works.)

Cytokine storm risk: Ten to fifteen percent of the population are estimated to be at great risk for a severe cytokine storm reaction to ANY severe immune challenge, whether a vaccine or an infection. (5) See: Cytokine Storm, SIDS, autism and Vitamin C, March 29, 2020. Their bodies do not react normally to infection. Genetic screening is needed to identify the genes involved and then screen for those at risk.

In the meantime, high dose intravenous vitamin C (Marik Protocol) therapy does work well to reduce the cytokine storm from escalating and prevent the damage that can be caused by it. See: Bitter taste receptors in the lungs & Hesperidin’s decongestant properties. April 7,2020 < the food and supplement recommendations are still valid.

You can lead a horse to water, but you can’t make it drink.” Self care – includes the word self, because oneself, is in charge of self care. It is not about spa treatments or getting disabling nail extensions applied with potentially toxic chemicals. That is not self care in any kind of health sense.

The only problem with that plan is that the FDA is preventing use of the treatment for Covid related care. It does not have risky side effects and has a large amount of supportive research for similar cytokine conditions. There is no sensible reason to not approve it for use during an alleged pandemic emergency – if we have an emergency, then we should be providing emergency care to those who need it – NOT WITH-HOLDING IT, or criminalizing the use of it by independent physicians who deem it in their patient’s best interest.

Vitamin C given in advance of a vaccine may also help reduce the risk of an over-reaction of the immune system – even for animals that can make some of their own vitamin C (we can’t make any). From the post: “Giving extra vitamin C before vaccines was found to be protective even in lab animals that genetically can make vitamin C. (4)

If health is the goal – then why hasn’t everyone been told that taking vitamin C in advance of a vaccine can help prevent an over-reaction of the immune system?

If health is the goal – then why don’t we screen for the 10-15% who will have a very severe reaction, which may result in a neurological condition that lasts the rest of their life, and EXCLUDE them from being given an immune challenge? They likely would never get exposed to tetanus or many of the other rare conditions that many vaccines are designed to protect against.

If health is the goal – then why did 170,000 people reply to a news-site about the death of someone they know that occurred after a CoV injection? If the VAERS system is only collecting 1% of adverse reactions, and currently shows a death count of ~14000 (check this, yes, almost 15,000 now, and over 19,000 people were left permanently disabled after CoV injections).

If health is the goal – then why are the CoV injections seeming to be used as a euthanasia device?

Adverse reaction entry to VAERS, shared by AMM MD on Telegram, invite link if you are on Telegram:

Covid vaccine AEs and other hidden truths

71 yo F “In her end days of lung cancer was not eating and drinking very little for 3d before vaccination was given. She became very ill as she was told she might and was unresponsive and in the hospice 2d later. [Died 6d after vax.]. The adverse effects of this vaccine served no purpose to be administered to an imminent end to this dying woman. The vaccines effects would never have gotten in her body till after she had died and only made her more sick and weak then she needed to be.
Write-up: Suddenly more weak , exhausted, all around much worse then she had been feeling as she was in her last days of lung cancer. Within hours of the vaccine she was worse and in 2d unresponsive and in a hospice. 4d [later] she died
.” 1637303″ (quoted from VAERS, the US adverse reaction database).

Health doesn’t seem to be the goal to me.

15 Signs That You Might Be an Abusive Government (or Relationship).
– guidance about emotional manipulation- domestic violence often dies not include outright hitting, may just be threats or verbal abuse, or silent treatment to ‘punish’ the victims.

American Frontline Doctors is a group working towards making early treatment available to anyone who wants it. Their site has a proposed Vaccine Bill of Rights: https://americasfrontlinedoctors.org/take-action/the-vaccine-bill-of-rights/

EPIGIRL 2 is needed, with a giant team, for a giant project, because a giant massacre is happening, and being lied about – ask yourself “What would Viktor Fankl do?

Answer – take notes, really good notes.

More info: Viktor Frankl on the Human Search for Meaning, Maria Popova, (brainpickings.org).

I have begun a Protocol on a supplement dispensing site – people who enroll as clients could order at a discount from the items I’ve prescreened and added dosing details for, or browse the catalog. People who enroll as clients could be later added to an EPIGIRL 2 database. Starting is a place to start.

The Protocol: Health Aids for Special Times – it has a lot of food and general health info also. I maxed out the memory and need to copy it over to a pdf though, and probably break the supplements and protocol into smaller groups. Important point to add – to detox – don’t overeat regularly. The body needs to get a little hungry to have the time and need for white blood cells to go looking around for cellular debris to clear up and reuse for nutrients. When we overeat the body and blood cells are busy coping with storing all the excess nutrients as fat or cholesterol plaque or excreting some of it.

Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Glycine – good for our extracellular matrix & for immune protection against viral infection.

The extracellular matrix is very important for our immune defense as white blood cells actively patrol the areas surrounding cells for pathogens to remove, such as virus. Deficiency of glycine may be involved for patients with more severe COVID-19. “Glycine intake as nutritional supplement was very effective against virus infections.” (1)

Glycine is an amino acid and is important in the structure of protein chains because it is small in size and can allow folding of the long chain into a three dimensional shape. (See post: Glyphosate & COVID19) It is important within proteins (such as collagen) that help stabilize the gooey gelatin like fluid that supports the areas within our cells and surrounding our cells. There can be a thicker layer immediately surrounding cells which is called a glycocalyx, a term also used to describe the gel coating that surrounds bacteria.

Biofilms formed by an alginate-overproducing strain of Pseudomonas aeruginosa have a complex structural architecture that allows them to more resist tobramycin than biofilms formed by an isogenic nonmucoid strain. This suggests that an altered structure of biofilms cause increased resistance of pathogens against antibiotics.182 ” (9)

It helps protect our cells from bacteria, virus and other pathogens. A stronger extracellular matrix, made possible with daily supplements of 10 grams of glycine, was found to help protect against viral infection. (1)

Glycine is used often in the assembly of collagen proteins. The small glycine molecules help stabilize the triple helix shape of the long column like folded protein. The long sturdy fiber like proteins help add stability and structure to the three dimensional woven mesh of the fluid gelatin like extracellular matrix or cytoplasm within cells.

Glycine is utilized to synthesize serine, sarcosine, purines, creatine, heme group, glutathione, and collagen. Glycine is a major quantitative component of collagen. In addition, the role of glycine maintaining collagen structure is critical, as glycine residues are required to stabilize the triple helix of the collagen molecule.

The collagen fibers can be chemically stained for viewing on microscope slides. In an image here (7, 8) the collagen fibers are greenish and surround the cells that each have a brownish-black nucleus in the middle.

Extracellular matrix – our glycocalyx – our jelly lining.

We need a healthy extracellular matrix that is not too sticky and dehydrated to prevent easy flow of fluid and cells and not too watery as some solid support is needed. We are almost 70% water but it doesn’t seem like it. Magnesium is also essential for the structure of the gelatin like matrix within and surrounding cells. Each atom of magnesium can hold 18 molecules of water in an electrically stabilized cloud of water surrounding the magnesium atom. Sulfates are also essential for the stability of the matrix structure. Monosaccharides, single molecules of sugars, are also an important part of the glycocalyx on cell surfaces. Different types of monosaccarides are combined into surface glycoproteins that tell the immune system information about the cell – whether friend or foe.

Many of the extracellular proteins, such as sialic acid, also carry a negative electrical charge so there is a slight magnetic like repelling against other cells. This is critically important for holding vessel walls open – the negative charge surrounding the interior repels the other wall from collapsing inward. Some food additive emulsifiers may be too effective and also may emulsify our intestinal lining and cause bowel troubles such as diarrhea and discomfort. Gumbo file is a very healthy emulsifier from nature -powdered sassafras leaves – used by indigenous Americans.

Cells encounter surrounding surfaces first through their glycocalyx and therefore it may substantially contribute to crucial physiological and pathophysiological processes. The glycocalyx is a carbohydrate-enriched sugar coating that covers the surface of many cells, including cancer cells, presumably greatly influencing cellular interactions with their environment at the molecular scale. Its components are glycolipids, glycoproteins and glycosaminoglycans (GAGs). Glycocalyx contains large amounts of chondroitin sulfate (CS), dermatan sulfate, heparan sulfate, sialic acid, and hyaluronic acid, all negatively charged at neutral pH21.” (4)

The amino acid Glycine – available in supplements as Dimethylglycine (DMG) and Trimethylglycine (TMG).

Glycine is available as a bulk powder available from protein supplement companies focused on the weight lifting industry. Betaine is the more common name for Trimethylglycine (TMG), it and Dimethylglycine (DMG) are available as supplements in tablets or powders. It may be helpful to have both as they are used for different purposes and are not exactly equivalent. DMG can cross the blood brain barrier so it is helpful when the calming inhibitory effects of glycine are needed within the brain. (2)

Dimethylglycine (DMG) is an amino acid found naturally in plant and animal cells and in many foods such as beans, cereal grains, and liver. It is used to improve energy, boost the immune system, and to manage seizures and autism. There are some positive reports of DMG efficacy on the immune system.” (3)

DMG may be helpful for people with seizure risk – it was found to help some patients but not showing conclusively positive results overall. Some patients may have a genetic difference and need an external supply. (3)

People with a BHMT gene allele (like myself) would need an external source of DMG as the BHMT enzyme is needed to breakdown betaine to DMG. You can see the chemical steps in a graphic here: (6). From a previous post: “DMG has been found helpful in ADHD, autism, allergies, alcoholism, drug addiction, and chronic fatigue syndrome among other chronic issues.” See #3. BHMT in this post: Methylation Cycle Defects – in me – genetic screening “for research purposes only” A more recent post goes into further detail about the BHMT enzyme’s role in the production and breakdown of endocannabinoids. Cannabinoids are made with the BHMT gene (and others).

I have a double BHMT gene allele – I need an external source of DMG and methionine and it helped my mood immensely. It helps me feel more cheerful as well as more energetic. I take about a half teaspoon of each once or twice a day. A teaspoon at a time was too much energetic, seemed to cause a racing heart rate. The total amount a person needs per day may be more than that. Capsules would be giving a smaller amount, I didn’t notice much effect at all from taking a little tablet supplement and the price was significantly larger. A half teaspoon of a powder is about 2.5 grams, a tablet is usually about 500 milligrams, 0.5 grams.

I am not taking enough DMG and I hadn’t realized TMG might be helpful too – what I also hadn’t realized is TMG is betaine – so I should be taking the DMG form, I get betaine from food and I don’t do well with too much of a good source (quinoa). We need about 10 grams of glycine per day from dietary sources, yet the typical diet only provides two grams. “Glycine produced by human metabolism is much lower than the cell’s needs giving a general glycine deficiency of 10 g/day in humans.” (1)

People who took ten grams of glycine per day as a supplement had fewer viral infections than the control group. (1) “Glycine intake at the afore-mentioned dose prevents the spread of viruses by strengthening the extracellular matrix barriers against their advance. ” (1)

Nutritional supplement, 10 g/day, Glycine, promotes young strong collagen, compared to old weak collagen formed from an un-supplemented diet (~2 gr/day) and our own metabolic pathways (~3 gr/day). Graphic from: “Glycine can prevent and fight virus invasiveness by reinforcing the extracellular matrix” (Meléndez-Hevia, et al., 2021) (1)

Gee, I do want “young, strong collagen” (see above image, (1)) , so I will have my glycine drink four times a day. Breaktime, be right back. I will be so cheerful it may be hard to recognize me. :-)

  • My “Cheerful Juice” drink reminds me of red wine without the alcohol, ~ 10 oz water, 1/2 teaspoon DMG, 1/2 tsp methionine; a little of my coffee sweetener mix: Stevia, powdered cardamom, sage and oregano; 2 ounces pomegranate juice. If I had taurine and creatine on hand I would try adding that too, but amino acids are acidic. The beverage is tart and I sip it slowly.

People with a genetic problem with methylation may have problems making a variety of proteins, as well as people with a diet deficient in the methyl donating nutrients folate, B12, betaine, choline, and the amino acid methionine. “Studies that simulated methyl-deficient diets reported disturbances in energy metabolism and protein synthesis in the liver, fatty liver, or muscle disorders.” […] “Hypomethylation has a wide spectrum of effects that include genetic, epigenetic, and metabolic alterations.” (5) Someone with a genetic problem with methylation would need to take the bioactive, methylated form of B12 and folate. The standard supplement of folic acid and cyanocobalamin are unmethylated forms and would be not helpful for someone unable to remethylate them.

Summary – to fight virus well, we need a healthy extracellular matrix for white blood cells to be able to patrol easily — and to have that we need adequate glycine in our diet and the genetic ability to digest it to Dimethylglycine (DMG).

  • We also need to stay well hydrated, and to have adequate sulfate, magnesium, protein and ATP for magnesium storage, and a wide variety of monosaccharides to make surface glycoproteins that say and do the correct functions as cell surface immune markers.
  • Epsom salt soaks may be helpful as a topical source of magnesium and sulfate for people with poor intestinal absorption of magnesium, or sometimes there can be a genetic difference limiting intestinal absorption for the person’s whole life.
  • Fiber rich plant foods are also needed to support the extracellular matrix – similar to how gelatin is supported by fruit pectin fibers when making jams.
  • We can’t do much without B vitamins – they are the body’s energy providers, essential for our mitochondria. Lack can lead to mitochondria switching to anaerobic glycolysis which may be a risk for later transition to cancer. Methylated forms of folate and B12 are needed by people with certain gene differences. Niacin in a much higher dose than would be available from the diet can help reduce inflammation, (niacin post) and also help preserve tryptophan stores for use to make serotonin and melatonin (see last post).

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Reference List

  1. Enrique Meléndez-Hevia, Patricia de Paz-Lugo, Guillermo Sánchez, Glycine can prevent and fight virus invasiveness by reinforcing the extracellular matrix. J Functional Foods, Vol 76, 2021, 104318, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2020.104318. https://www.sciencedirect.com/science/article/pii/S1756464620305429
  2. Is TMG or DMG more effective?, davincilabs.com, https://blog.davincilabs.com/blog/is-tmg-or-dmg-more-effective
  3. Dimethylglycine: Purported Uses, mskcc.org https://www.mskcc.org/cancer-care/integrative-medicine/herbs/dimethylglycine
  4. Kanyo, N., Kovacs, K.D., Saftics, A. et al. Glycocalyx regulates the strength and kinetics of cancer cell adhesion revealed by biophysical models based on high resolution label-free optical data. Sci Rep10, 22422 (2020). https://doi.org/10.1038/s41598-020-80033-6 https://www.nature.com/articles/s41598-020-80033-6
  5. Obeid R. The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. Nutrients. 2013;5(9):3481-3495. Published 2013 Sep 9. doi:10.3390/nu5093481 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798916/
  6. Glycine formation from betaine-trimethylglycine. image https://www.researchgate.net/figure/Glycine-formation-from-betaine-trimethylglycine-BHMT-betaine-homocysteine_fig5_320773132 from Adeva, María & Souto-Adeva, G. & Ameneiros-Rodríguez, E. & Fernández-Fernández, C. & Donapetry-García, C. & Domínguez-Montero, A.. (2018). Insulin resistance and glycine metabolism in humans. Amino Acids. 50. 10.1007/s00726-017-2508-0. https://www.researchgate.net/publication/320773132_Insulin_resistance_and_glycine_metabolism_in_humans
  7. Collagen Fiber, sciencedirect.com, https://www.sciencedirect.com/topics/medicine-and-dentistry/collagen-fiber see,
  8. Michal Miko, Ivan Varga, Chapter 6 – Histologic Examination of Peripheral Nerves, Editor(s): RS Tubbs, E Rizk, MM. Shoja, M Loukas, N Barbaro, RJ Spinner, Nerves and Nerve Injuries, Academic Press, 2015, Pages 79-89, ISBN 9780124103900, https://doi.org/10.1016/B978-0-12-410390-0.00006-8. https://www.sciencedirect.com/science/article/pii/B9780124103900000068
  9. Baral B, Mozafari MR. Strategic Moves of “Superbugs” Against Available Chemical Scaffolds: Signaling, Regulation, and Challenges. ACS Pharmacol Transl Sci. 2020;3(3):373-400. Published 2020 Apr 13. doi:10.1021/acsptsci.0c00005 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296549/

Epigenetic changes may also be involved in Covid19 or LongCovid

Epigenetic changes may be involved in Covid19 and LongCovid, which might be able to be changed back with the addition of plenty of methyl donor vitamins. People with methylation genetic alleles would be more at risk for epigenetic changes to DNA or actin protein filaments. Actin are semi flexible proteins in a double helix shape which support the fluid and organelles inside of cells and around cells and organs of our bodies. Actin also is involved in guiding the work of DNA replication and growth and development of cells or infants.

Methylation is the addition of a methyl group – one carbon atom and three hydrogen atoms, to genes, or actin filaments. A methylated gene is not active for encoding proteins while a demethylated gene is available to be transcribed into a messenger mRNA to be made into a matching protein. Actin filaments are a double helix shape like DNA but do other functions throughout our body. Some have methyl groups also that seem to be essential for proper function of the actin protein whether in muscle contraction or in guiding chemicals within cells to make DNA or do other work. Actin filaments add structure to the jelly like fluid around and in cells and may tether chemicals in place for chemical reactions or guide cellular organization during growth and development.

Actin may be involved with energy fields of our body along with microtubules also, but that is not discussed in greater detail in this post (more information about quantum energy fields and actin is included in Cracking Nature’s Code (2019) (1), and in several posts on another site of mine first in the series, 2nd, 3rd, 4th).

Viral infection and epigenetic changes with a focus on Postural Orthostatic Tachycardia Syndrome and possible dietary and lifestyle changes that may help reverse epigenetic changes is the focus of this post – which got long. It is also available as a section of this document that includes the series on Mast Cells and Histamine. Current standard of treatment for patients with POTS symptoms may leave them unwell for years – a few get better more rapidly. I got better on my own within a few months – twice. More about possible strategies for improvement of epigenetic changes will be included later in the post. More about the epigenetics involved in POTS is included in the Genetics/Epigenetics chapter of my book draft which is available on a platform where you can get an e-copy early (minimum price Free, Leanpub/Tipping The Clock Toward Health) and then be informed of updates with an email subscription.

Viral infection can cause Epigenetic changes.

Bacterial (Pacis et al., 2015, 2) and viral infection (Lichinchi et al., 2016, 3) directly impact methylation patterns, most likely orchestrated by actin since it is universally hi-jacked in viral infectivity (Cudmore et al. 1997, 4; Ohkawa and Volkman, 1999, 5; Lu et al., 2004, 6; Marek et al., 2011, 7).

page 34, JB Head, PhD, Cracking Nature’s Code (2019) (1)

I found I have methylation gene alleles in a genetic screening (post: Methylation Cycle Defects – in me – genetic screening “for research purposes only”). Since finding out I stopped taking standard supplements of B12 and folic acid because they are not methylated, not bioactive. I take methyl B12 & methyl folate supplements now. Postural Orthostatic Tachycardia Syndrome (POTS) (9) has been a problem for me in past years a couple times and I got better. Symptoms include a rapid heart rate, tachycardia, and feeling faint or blacking out, especially when getting up quickly from a seated or laying down position to standing. (9) I have heard anecdotal reports of it being a symptom for some LongCovid survivors who had never had the problem before.

To slow the rapid heart rate during an episode I found it helpful to stop and sit or lay down with my feet above my heart if possible and just wait a couple minutes for the rapid heart rate to slow again. Continuing to exercise would make the rapid heart rate worse. Preventing the faintness upon rapidly getting up required trying to remember to slow down and have a support ready to hold if I felt wobbly. I did faint once, odd to find yourself on the floor unexpectedly.

POTS has been found to potentially involve a genetic difference in the norepinephrine transporter gene (SLC6A2) sequence and it can also be an epigenetic problem with links to excess formaldehyde. (9) Formaldehyde can donate methyl groups to DNA that normally would be unmethylated – active. (10) Methylation of DNA is a little like a on/off switch for genes, or the cap on bottle – add the methyl groups and the DNA gene is inactive.

Formaldehyde as a methyl donor for the methylation of DNA, RNA, and histone acts as an epigenetic factor participating in the reversible and dynamic methylation. DNA demethylation elicits formaldehyde generation in the dividing cells and post-mitotic neurons.” (10) Memory formation involves methylation of DNA and cognitive impairment in older adults is associated with increased internal formaldehyde levels (self-made) and demethylation of DNA. Use of nutrients to remove formaldehyde helped improve memory in an animal based study. (10)

Formaldehyde can be prevalent in secondhand or thirdhand smoke in enclosed rooms, or smog, or we make our own during normal metabolism, and physical or emotional stress conditions may cause an increase, as well as the level potentially increasing in older adults. (11) Elevated levels of formaldehyde within cells causes more breakdown of sugar for energy and increased removal of an antioxidant out of the brain cells, which may increase risk for cognitive damage. “As excess formaldehyde accelerates glycolysis and glutathione export in neural cells, formaldehyde‐induced alterations in brain metabolism and oxidative stress may contribute to the pathological progression of neurodegenerative disorders.” (11)

Formaldehyde is very reactive and can use the methyl group to form links between protein groups or parts that wouldn’t normally be linked – like bungee cords holding parts together in places that would be separate in normal function. (11) Formaldehyde is used with tissue samples to preserve material for viewing under a microscope. Studies of the effect of formaldehyde on the actin protein of live cells that were low on blood sugar found that modifications to the protein did occur – the authors suggest any prior research on the actin protein in formaldehyde treated samples may be inaccurate. (12) Take home point – formaldehyde is not good for our brain cells and may effect the protein of our brain cytoskeleton structure. (12) Protein tangles in brain cells are associated with dementia and autism.

What is a cytoskeleton? We are mostly water, so how do we walk around? With a balance in tension between string like ligaments and muscles and rod like bones of our skeleton. Within the cellular environment, inside and outside the cell membrane – the tent wall, there are rod like microtubules and string like actin protein that is more flexible, it can change shape but isn’t stretchy as much as structurally able to modify in shape. Actin is a double helix, two spirals like DNA except without the ladder like steps joining the two lengths of protein. When force is applied the double helix can get a little longer or shorter as the coils compress or lengthen slightly – tensile strength – and the protein gets stiffer from a side to side direction – torsion – and is less flexible along the length, less able to bend sideways. (13)

The actin protein may act as torsion sensors – is the environment changing in pressure around that section of the protein length – from increased fluid or gas? How full is the balloon like membrane? (14) Channels in a membrane will open and start to leak rather than letting the membrane burst like an overfull balloon. This may seem like a silly discussion – however it is your brain and organs – leaking is better than bursting. Leaking membranes will release fluid and some types of chemicals while a bursting open, as when viral replication is complete and the virus exit a cell, the membrane bursts and all the remaining chemicals in the cell flood into the surrounding cytoskeleton and can cause inflammatory damage to surrounding cells.

These flexible yet firm cytoskeleton actin filaments also may act like guidelines for directing traffic or tethering organelles in place for activity such as replication of DNA during cell division (one cell doubles its DNA and then divides into two cells). Too much of the proteins within a cell nucleus will prevent DNA replication rather than guiding it. (15) Actin is also involved in muscle fiber motion. The double helix structure can also be methylated with methyl groups doing an unknown but critical function. Loss of methylation of actin in one location is associated with cancer and autism spectrum disorders, (16), loss of it in another location along the protein chain is associated with muscle changes that cause female animals to have delivery problems and fewer babies. (17, 18)

So actin is important stringy protein that effects muscle power, cell division, and the brain – and formaldehyde can cause demethylation of DNA, likely it can cause demethylation of actin also which may lead to autism spectrum disorders, cancer, and muscle problems that can affect a healthy delivery of infants (in an animal study). The visual – we want our jelly like insides to have a strong yet flexible tent membrane, tent poles (microtubules), and tie downs (actin) – without having so many tie downs it starts looking like a haunted house full of cobwebs. The amyloid beta protein associated with Alzheimer’s dementia and autism may be protective against a low level infection (post: Magnesium might help protect against beta amyloid placques) but also may increase changes in actin stress fibers (24) and an excess seems to add to chronic inflammatory damage over time.

How do we achieve this? Healthy actin?

It may help promote appropriate methylation of DNA and actin to have adequate antioxidants and methyl donor nutrients in our diet, to reduce oxidative stress chemicals and provide adequate methylation to DNA and actin. Avoiding excessive physical and emotional stress may also be an important strategy, so we aren’t embalming ourselves with self produced formaldehyde (the mummy in the haunted house being our own brain).

We also want to avoid formaldehyde in our environment, which would include improving air quality, especially during sleep hours when our body is focused on detoxification of the brain. Parkinson’s Disease is another chronic condition that may involve epigenetic changes and reducing formaldehyde exposure may be protective. More information is in this post with a link to a longer post about formaldehyde sources: The Cholinergic System

Increasing methyl donor vitamin rich foods and/or supplements should focus on the methylated form if unsure whether there is a genetic allele problem causing lack of methylation.

Methyl groups are important for numerous cellular functions such as DNA methylation, phosphatidylcholine synthesis, and protein synthesis. The methyl group can directly be delivered by dietary methyl donors, including methionine, folate, betaine, and choline.” … “Studies that simulated methyl-deficient diets reported disturbances in energy metabolism and protein synthesis in the liver, fatty liver, or muscle disorders.” … “Hypomethylation has a wide spectrum of effects that include genetic, epigenetic, and metabolic alterations.” (8)

Gastrointestinal problems have been found to be common among patients with Postural Orthostatic Tachycardia Syndrome (POTS) with malfunction or slowing, dysmotility, of the smooth muscle lining of the intestinal tract. “Case study 1: A 20-year-old woman presented to clinic for further evaluation of a several year history of fullness and epigastric discomfort associated with eating and irregular bowel habits. Her weight was stable. She also described frequent migraine headaches, episodic palpitations and lightheadedness with progressively increasing episodes of syncope. A systems review was notable for profound fatigue, dry eyes and mouth and intermittent flushing and pruritus.” (19) The patient’s symptoms include many in common with Mast Cell Activation Syndrome, however testing for mast cell activation was normal. Patients whose symptoms followed a viral infection tend to get better more often than patients with a family history of POTS. (19)  

A number of chronic conditions are frequently seen in patients with POTS and contribute to symptom burden and reduced quality of life. Common comorbidities include chronic fatigue syndrome, fibromyalgia, interstitial cystitis, and migraine headaches. Other unique conditions that seem to occur with increased frequency in POTS are autoimmunity, the hypermobile form of Ehlers-Danlos syndrome (HM-EDS), and mast cell activation disorder (MCAD).” (19)  

“Unlike mastocytosis, idiopathic mast cell activation [MCAD] occurs in the absence of mast cell proliferation and with episodic accumulation of mast cell mediators in the plasma or urine, usually present when symptomatic. Patients with MCAD typically present with episodic “attacks” of flushing, urticaria and pruritus accompanied by lightheadedness, dizziness, dyspnea, nausea, headache, diarrhea, and/or syncope; symptoms representative of the hyperadrenergic type of POTS with biochemical evidence of MCAD (20).” (19)

The patient in case study 2 had ongoing nausea, vomiting, abdominal pain, and weight loss continuing for years following a viral infection. She was found to have deficiency in iron, zinc, and vitamin B12 and gastroparesis (slow or little intestinal muscle action). Intravenous iron and B12 were provided and an oral zinc supplement. Nutrient levels improved however the GI symptoms and weight loss continued and the patient was given tube feedings which improved weight, however some intolerance to the tube feedings continued and abdominal pain persisted. (19)  

If demethylation of actin protein in the muscle tissue of the intestinal wall was a problem for the patient in case study 2, then it may have been a factor in the gastroparesis. Genetic screening for methylation defects is not mentioned. Supplements of B12 are often an unmethylated form, cyanocobalamin, and which include cyanide. (21) In a study of 12 patients by Huang et al, (22): “Disturbances in GI motility were found to involve not only the stomach, but also multiple segments of the gut spanning the esophagus to the anus.” (19) The commonly used treatments for GI symptoms associated with POTS (see Table 5) do not include nutrients and do include proton pump inhibitors, (19),  a medication that takes the place of magnesium as a calcium channel blocker, and which may lead to worse magnesium deficiency for some people, a genetic difference may be involved. See post: Original Prilosec Warning, edited.

Small intestinal bacterial overgrowth (SIBO) may occur along with GI problems and lead to fat and carbohydrate digestion and absorption problems and bloating from excessive bacterial growth. Changes in diet due to the discomfort are common in patients with POTS and these more severe GI symptoms and which may lead to deficiencies in fat soluble vitamins A, D, E and K. Megaloblastic anemia may result from deficiencies in iron, folate and vitamin B12. (19) Sulfate deficiency may be an underlying factor (23) and providing Epsom salt soaks of the lower legs and feet, or in a bath one to two times a week might help by providing a topically absorbed form of magnesium and sulfate. See post: To have optimal Magnesium needs Protein and Phospholipids too.

Zinc is also involved in DNA methylation and deficiency of the trace mineral can lead to epigenetic changes and gene transcription problems. Zinc is needed along with actin and other proteins to tell the cell nucleus and cell which genes to make into mRNA to be encoded into a protein. “Accumulating evidence has demonstrated that several key enzymes and zinc finger proteins with zinc atom(s) in the reactive center and binding site play important roles in DNA methylation and histone modifications. Therefore, zinc deficiency may disrupt the functions of these enzymes and proteins and result in epigenetic dysregulation. Furthermore, zinc deficiency may enhance inflammatory response and subsequently alter DNA methylation status of the genes involved in inflammation.” (20) Also see posts: Zinc – big news, CoV and other illness related, and Zinc, cancer, and bitter taste receptors.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Reference List

  1. JB Head, PhD, Cracking Nature’s Code: The Potential Answer to Everything. (Balboa Press, Bloomington, IN, 2019) https://www.balboapress.com/en/bookstore/bookdetails/792280-cracking-natures-code
  2. Pacis A, Tailleux L, Morin AM, et al., Bacterial infection remodels the DNA methylation landscape of human dendritic cells. Genome Res 2015. 25: 1801-1811 https://doi.org/10.1101/gr.192005.115 https://genome.cshlp.org/content/25/12/1801
  3. Lichinchi G, Zhao BS, Wu Y, et al. Dynamics of Human and Viral RNA Methylation during Zika Virus Infection. Cell Host Microbe. 2016;20(5):666-673. doi:10.1016/j.chom.2016.10.002 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155635/
  4. Cudmore S, Reckmann I, Way M. (1997). Viral manipulations of the actin cytoskeleton. Trends in microbiology. 5. 142-8. 10.1016/S0966-842X(97)01011-1. https://www.researchgate.net/publication/14077627_Viral_manipulations_of_the_actin_cytoskeleton
  5. Ohkawa T, Volkman LE, Nuclear F-Actin Is Required for AcMNPV Nucleocapsid Morphogenesis, Virology, Vol 264, Issue 1, 1999, Pages 1-4, ISSN 0042-6822, https://doi.org/10.1006/viro.1999.0008. https://www.sciencedirect.com/science/article/pii/S0042682299900089
  6. Lu, S., Ge, G. & Qi, Y. Ha-VP39 binding to actin and the influence of F-actin on assembly of progeny virions. Arch Virol149, 2187–2198 (2004). https://doi.org/10.1007/s00705-004-0361-4 https://link.springer.com/article/10.1007/s00705-004-0361-4
  7. Marek M, Merten OW, Galibert L, Vlak JM, van Oers MM. Baculovirus VP80 protein and the F-actin cytoskeleton interact and connect the viral replication factory with the nuclear periphery. J Virol. 2011;85(11):5350-5362. doi:10.1128/JVI.00035-11 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094977/
  8. Obeid R. The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. Nutrients. 2013;5(9):3481-3495. Published 2013 Sep 9. doi:10.3390/nu5093481 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798916/
  9. Richard Bayles, Harikrishnan KN, Elisabeth Lambert, et al., Epigenetic Modification of the Norepinephrine Transporter Gene in Postural Tachycardia Syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology. 2012;32:1910–1916 https://doi.org/10.1161/ATVBAHA.111.244343 https://www.ahajournals.org/doi/full/10.1161/atvbaha.111.244343
  10. Su, Tao & He, Rong-Qiao. (2017). Formaldehyde Playing a Role in (De)methylation for Memory. 10.1007/978-94-024-1177-5_3. https://www.researchgate.net/publication/320523716_Formaldehyde_Playing_a_Role_in_Demethylation_for_Memory
  11. Ketki Tulpule Ralf Dringen, Formaldehyde in brain: an overlooked player in neurodegeneration?, J. Neurochem. (2013) 127, 7– 21 https://onlinelibrary.wiley.com/doi/10.1111/jnc.12356
  12. Vasicova P, Rinnerthaler M, Haskova D, et al. Formaldehyde fixation is detrimental to actin cables in glucose-depleted S. cerevisiae cells. Microb Cell. 2016;3(5):206-214. Published 2016 Apr 12. doi:10.15698/mic2016.05.499 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349148/
  13. Effect of tensile force on the mechanical behavior of actin filaments. J Biomechanics (2011), 44(9): 1776-1781, 2011-06-03 , https://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/152437 https://core.ac.uk/download/pdf/39280196.pdf
  14. Hayakawa K, Tatsumi H, Sokabe M. Actin filaments function as a tension sensor by tension-dependent binding of cofilin to the filament. J Cell Biol. 2011;195(5):721-727. doi:10.1083/jcb.201102039 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257564/
  15. Hu, X., Liu, Z.Z., Chen, X. et al. MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation. Nat Commun10, 1695 (2019). https://doi.org/10.1038/s41467-019-09636-6 https://www.nature.com/articles/s41467-019-09636-6
  16. Seervai RNH, Jangid RK, Karki M, et al., The Huntingtin-interacting protein SETD2/HYPB is an actin lysine methyltransferase. Science Advances, 02 OCT 2020 : EABB7854 SETD2 regulates actin dynamics and cell migration via methylation of actin at Lys68 in a cellular complex containing Huntingtin. https://advances.sciencemag.org/content/6/40/eabb7854?Disruption of the SETD2-HTT-HIP1R axis inhibits actin methylation, causes defects in actin polymerization, and impairs cell migration. Together, these data identify SETD2 as a previously unknown HTT effector regulating methylation and polymerization of actin filaments and provide new avenues for understanding how defects in SETD2 and HTT drive disease via aberrant cytoskeletal methylation.“… “Loss of SETD2 and the H3K36me3 chromatin mark is embryonic lethal in Drosophila (7) and mice (8), and SETD2 defects have been linked to several diseases, including cancer (911) and autism spectrum disorder (1214).”
  17. Wilkinson, A.W., Diep, J., Dai, S. et al. SETD3 is an actin histidine methyltransferase that prevents primary dystocia. Nature 565, 372–376 (2019). https://doi.org/10.1038/s41586-018-0821-8, https://www.nature.com/articles/s41586-018-0821-8 lack of the methylation at histidine 73 seems to interfere with muscles and causes the genetically different animals to have fewer babies due to maternal delivery problems. Graphic from the article shows a CH3 methyl group being added to an actin filament at Histidine 73: https://twitter.com/anandb4/status/1073255833813671937?s=20
  18. Kwiatkowski S, Seliga AK, Veiga-da-Cunha M, et al., SETD3 protein is the actin-specific histidine N-methyltransferase. bioRxiv 266882; doi: https://doi.org/10.1101/266882Now published in eLife doi: 10.7554/elife.37921 https://www.biorxiv.org/content/10.1101/266882v1?platform=hootsuiteFinally, Setd3-deficient HAP1 cells were devoid of methylated H73 in β-actin and exhibited phenotypic changes, including a decrease in F-actin content and an increased glycolytic activity.
  19. DiBaise JK, Lunsford TN, Harris LA, Nutrition Issues in Gastroenterology, Series #187: The POTS (Postural Tachycardia Syndrome) Epidemic: Hydration and Nutrition Issues. June 2019, Practical Gastro, Vol XLIII, Issue 6 https://practicalgastro.com/2019/10/14/the-pots-postural-tachycardia-syndrome-epidemic-hydration-and-nutrition-issues/
  20. Gu H.F., Zhang X. (2017) Zinc Deficiency and Epigenetics. In: Preedy V., Patel V. (eds) Handbook of Famine, Starvation, and Nutrient Deprivation. Springer, Cham. https://doi.org/10.1007/978-3-319-40007-5_80-1 https://link.springer.com/referenceworkentry/10.1007%2F978-3-319-40007-5_80-1
  21. Dody Chiropractic, Why Do Vitamin B12 Supplements Contain Cyanide?, dodychiro.com,  https://www.dodychiro.com/why-do-vitamin-b12-supplements-contain-cyanide/
  22. Huang RJ, Chun CL, Friday K, et al. Manometric abnormalities in the postural orthostatic tachycardia syndrome: a case series. Dig Dis Sci 2013;58:3207-3211 https://pubmed.ncbi.nlm.nih.gov/24068608/
  23. Elliot Overton, Sulfate IV: Chronic SIBO/Gut Dysbiosis As A Protective Adaptation To Supply Sulfate. July 21, 2018, Eonutrition.co.uk, https://www.eonutrition.co.uk/post/sulfate-iv-chronic-sibo-gut-dysbiosis-as-a-protective-adaptation-to-supply-sulfate 
  24. Song C, Perides G, Wang D, Liu YF. beta-Amyloid peptide induces formation of actin stress fibers through p38 mitogen-activated protein kinase. J Neurochem. 2002 Nov;83(4):828-36. doi: 10.1046/j.1471-4159.2002.01182.x. PMID: 12421354. https://pubmed.ncbi.nlm.nih.gov/12421354/
  25. Frederic Dorandeu, Guilhem Calas, Gregory Dal Bo, Raafat Fares, Chapter 36 – Models of Chemically-Induced Acute Seizures and Epilepsy: Toxic Compounds and Drugs of Addiction, Editor(s): Asla Pitkänen, Paul S. Buckmaster, Aristea S. Galanopoulou, Solomon L. Moshé, Models of Seizures and Epilepsy (Second Edition),Academic Press, 2017, Pages 529-551, ISBN 9780128040669, https://doi.org/10.1016/B978-0-12-804066-9.00037-7. https://www.sciencedirect.com/science/article/pii/B9780128040669000377Alterations of the neuronal cytoskeleton, and more precisely disruption of actin dynamics, seem then to contribute to changes in brain excitability, but the mechanisms leading to these changes remain still unresolved (Spence and Soderling, 2015).” Excerpt viewable in F-actin, ScienceDirect, https://www.sciencedirect.com/topics/neuroscience/f-actin

Is Success Money? Happiness? Survival? Promoting Change?

The definition of success varies for different people. As a public health educator I always felt successful when I heard ideas I had recommended being recommended to me – smile and nod and say What a great idea, do you mind if I share that with others?

Survival with health issues or other types of crisis often means making changes to old ways of doing things. Learning what works for some people in some situations can help others in similar situations or may be the idea that leads to their own adaptation of the idea to better suit their needs. I’ve had health problems all of my life, not too severe but often effecting my daily ability to breathe or think or move comfortably. I’ve had to make many changes and recognize when something is better for me to avoid than to try. Reading about the experiences or research of others has helped me improve my own health.

Many people can have similar great ideas, thinking and trying things is free. Sharing great ideas can help increase the number of people or places benefiting from the information.

My goal for success is survival of the planet and as many of its species as possible. Tragedy is occurring too often. Wildfires are part of the natural cycle of forest growth but become more dangerous when more people live in the area. The risk of wildfires occurring in Southern California and elsewhere in the dry areas of the southwest are expected to double by 2050 with the changes occurring in climate patterns. “The risk of devastating fires in Southern California will double by 2050. Southeastern states will also see more wildfires in the coming years.”  See: 13 Dire Impacts Outlined in the New Climate Report, politicalchange.org.

  • Building or rebuilding with more disaster or wildfire resistant construction and landscaping (including a perimeter of no vegetation around the building) is a topic with more information available, some links available here: Peace is privacy and shelter from weather.  Learning from a children’s story – don’t build with straw or wood, build with brick if you want durable construction. Buildings are made with fire alarms and sprinkler systems to reduce risk of fire spreading. Watch towers are placed intermittently throughout forests with a person to watch for signs of fire. In the days of early settlers townpeople or individuals would make fire breaks around settled areas to reduce the risk of wildfires spreading into the settled area. Sod construction was messy but less of a risk for fire except for the thatched roof. (Sod House/Wikipedia) Building in floodzones risks frequent flooding, more people in those areas are building on stilts or building floating houses, or the areas are being rezoned for other construction or are being restored as wetlands which help protect nearby areas from flooding. Adapting to the changing times in advance saves money and trauma later. (Knightsen Wetland Restoration and Flood Protection Project, Balance Hydrologics)
  • Links regarding trauma and recovery here: Peace is recovering from trauma.
  • This month’s tragedy was also a previous year’s tragedy and the goal is to have better plans in place for the future as the risks increase with warmer drier weather patterns. Information about volunteering or donating money to help with the current wildfire crisis in California can be found here: (California Volunteers).
  • Ideas about improving the early warning system for wildfire risk is discussed in this article: Response to California Fires: A New Warning System?, Guy on Climate.
  • How climate change can affect wildfire risk on the west coast of the U.S. and severe snowstorm risk on the east coast at the same time is discussed in the article: Consequences of the November Dipole, Guy on Climate. It isn’t discussed in detail in that article but the air mass over the west coast is likely increasing drought (Causes of Extreme Ridges That Induce California Droughts, Journal of Climateit is complicated).

The human impact on the planet and its species is undeniable. Just how fast or how severe and whether the rate matches predictions or not is splitting hairs. The fact is extreme weather events are increasing in frequency and severity and the ocean is becoming warmer and more acidic and pollution is showing up basically everywhere on the planet that has been monitored.

Currently the air quality is not very safe for breathing in many areas of California where wildfires occurred. For my personal health it wasn’t that good to begin with in some areas. I was congested within six hours visiting the Los Angeles area – I later spent a lot of time thinking and then writing down some ideas of my own and others regarding large air purification systems: Imagining Windmills – Solar Sail Revolving Ones. I can’t think well when I don’t have clean air, let alone breathe well, or do any other activities. My favorite places to visit in California included some national forests and a shady countryside walk along a creek.  I cannot survive well in a polluted area or where it is too hot, dry and sunny. Heat adds to inflammation for people with autoimmune problems. People are unlikely to enjoy themselves if they are overheated or disoriented from bad air conditions.

Some points from previous posts about health and air quality:

  • Information about smog: (Causes and Effects of Smogconserve-energy-future.com)
  • Having adequate B vitamins which are important for all aspects of metabolism and energy production in the body may help reduce the harmful health effects of breathing smog-laden air: (Could a Daily Vitamin Curb Smog’s Health Effects? webMD.com)
  • Banning indoor smoking helps a lot. Some states have banned indoor smoking in all public places but some still allow. I’m updating this post in a location that allows it in a section of the building and the odor is obvious to me throughout the main area of the building. It is a health risk that may be worse for people who have deficiencies or metabolic differences in B vitamins such as folate and B 12 which are discussed in more detail later. Other tips for reducing formaldehyde are discussed in this post: formaldehyde-health-risks-and-environmental-and-dietary-sources/
  • Formaldehyde is a common chemical in polluted or smoky air and folate is needed to help the body detoxify and excrete formaldehyde. It may be an underlying factor in risk for autism development as housing with poor air circulation and/or some types of new vinyl flooring is associated with a greater risk for autism in the family. Other pollutants that may effect children are included in this post: environmental-toxins-and-neurodevelopmental-disorders-in-children/
  • Genetic screening might be helpful for people living in smog areas -methylation differences can leave people unable to use the common supplemental type of folate called folic acid or vitamin B12. Methylated forms of both are available or both can be found in some typically used foods but if you did have a genetic difference in ability to methylate then it is better to avoid using the supplemental folic acid or un-methylated B12. It is like filling the body with puzzle pieces that fill the receptor spots that are open but which then can’t connect properly to other pieces. The unusable forms compete with any methylated vitamin that was available from dietary sources of B12 or folate that had been eaten that day. (Selfpay, for research purposes onlygenetic screening panel that I have used – meaning it isn’t approved as a diagnostic tool that you could get your health insurance to cover or doctor to prescribe.) We need to try new strategies if we hope to get different results.

People value different things, and that is valuable and looking at different ways to do things can help us adapt to a changing world.

Experience nothing – Visit Padasjoki, Finland. (Padasjoki.fi/fi)

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes