Snake venom like toxin is more exposed on free S1 subunit.

There is a cobra toxin-like gene sequence in the chimeric spike protein of either the SARS-C0V-2 virus, or the CoV injection’s spike sequence. (1) It likely can paralyze the function of nAChR clolinergic receptors, (4), . . . and medical world seems to be ignoring or denying that.

The solution is simple, though controversial – just start nicotine – OOOH, BUT THEN -> ADDICT! True, better off -> dead?

The dysfunction may be involved in the excessive menstrual bleeding or severe colitis like diarrhea. The cholinergic receptors also help modulate immune function to not produce too many inflammatory cytokines.

Chimeric – made of many species. The SARS-CoV-2 spike protein, and the sequence used for the CoV injections, also have similar genetic sequences to a wasp toxin, and it has genes from HIV and MERS. Chimeric – like the many headed hydra of mythology – they can all bite, and all may need to be dealt with to achieve health.


  • Spike protein or the S1 subunit have a snake venom toxin like sequence which can block nAChRs receptors, and it disrupts the function of the nAChRs. (1, 4)
  • Nicotine is protective of the function of nAChR receptors, it is an agonist, an activator. It is addictive, yes, so is health.
  • The alpha 7 nAChRs are involved in preventing cytokine storm over-immune reactions, (2) ;
  • nAChRs are also involved in: menstruation/endometrial tissue (3); regular bowel movements; sperm motility; and functioning nAChRs are critical for prenatal and child development of the retina and eyes, and throughout life for retinal health, (5); nAChRs are needed to be able to send nerve signals from the ears to the brain – ie – to be able to “hear”. (7)

TRP channels are also needed to be able to hear, they are in the inner ear hair cells. (10) They are also throughout the body, needed for fetal development, (11), and magnesium absorption in the intestines, ().

Reports of harm to vision & hearing of children have been reported to VAERS.

VAERS reports of adverse reactions involving CoV injections include reports of children going blind or deaf. (6) That may involve cholinergic dysfunction of the nAChR receptors. (5, 7)

Spontaneous abortion/miscarriage in the first trimester has also been reported for most women who received CoV injections during the first trimester. (ref to add)

Lack of magnesium due to TRP channel dysfunction in the GI tract may be a factor in risk to a fetus if the TRP channels’ function is loss – which resulted in death, in a genetic animal study.

Genetic inactivation of Trpm7 in mice results in early embryonic death1719. Conditional tissue-specific inactivation of Trpm7 in mice showed that TRPM7 plays a critical role in morphogenesis of various internal organs19,20,21.” (12)

Hearing & TRP channels: Hearing loss likely also involves damage to the inner ear hair cells. The TRP channel’s ankyrin repeat domains can be affected by the spike protein. (10) TRP channels with long stretches of ankyrin repeat domains are abundant in inner ear hair cells as they form a coil like area that can sense mechanical pressure and activate the TRP channel if a strong enough force is exerted on it. (8, 9) The open area of the ion channel is usually formed as an empty space between two very large protein subunits – similar building blocks put together in a circular pattern that can leave an open channel in the middle.

Simple solution – soak in magnesium sulfate and it enters the body through hair follicle pores – larger than TRP channels.

Epsom salt soaks are the simple solution to bypass the poor absorption of magnesium in the digestive tract. Both the magnesium and the sulfate are protective to the inner ear hair cells and the rest of the body. The hydrated form of a bath or foot soak may aid in the absorption. Magnesium sulfate was well absorbed from a bath relative, based on change in blood levels of magnesium. There have been less good results seen in topical magnesium chloride studies.

One to two cups of Epsom salt for a half-full bath, soak for 20-40 minutes. One cup or so in a large bucket or bin so more than the feet can soak, and soak for 20-40 minutes. Depending on the severity of magnesium deficiency a soak 1-3 times per week may be needed to help prevent muscle cramps or anxiety/anger. Low magnesium can affect depression risk or psychosis also.

Blocking nAChRs may add to risk of excess cytokines -sepsis; they help prevent an over-active production.

The retina is the area in the back of the eye where light sensing rod and cone cells are located. Activating the alpha7 nAChR type of receptors lead to improved cell survival in a model of glaucoma, (5) possibly aided by the anti-inflammatory role.

Retinal ganglion cells treated with the α7 nAChR agonist [such as nicotine] alone demonstrated a 28.0% (± 12.8%) increase in cell survival over untreated control.”

The cholinergic nAChR receptors are involved in modulating an inflammatory cytokine response – so that it isn’t excessive and producing an over-active amount of cytokines as seen in sepsis.

Due to its role in the downregulation of the production of pro-inflammatory cytokines, 33–35, it has been suggested that the α7 nAChR may be involved in the hyper-inflammation response that can be caused by SARS-CoV-2. 9, 36” (2)

So the more obvious colitis or excessive menstrual bleeding symptoms experienced from being around recently CoV injected people, may be an indicator that other excessive inflammatory responses are also happening throughout the body – and the solution is the same: nicotine activates the nAChRs and is protecting them, taking up the open spot in the receptor so S1 or Spike protein can not lodge in the spot instead – blocking its immunomodulatory or other functions.

Snake toxin sequence more exposed on the freed S1 subunit portion of the chimeric spike protein.

The chimeric spike protein can split into parts and both parts of the main spike are able to interact with cell receptors, S1 and S2. The gene sequence that is similar to a snake and snail type of toxin becomes more exposed on the separate S1 subunit – meaning it is likely then more interactive with nicotinic Acetylcholine Receptors.

Notably, the exposure of this motif and its close sequential neighbors is further accentuated in the S1 trimer (Fig. 2C) shed after cleavage by the human proteases (TMPRSS2 or furin) to enable the activation of the fusion trimer of S2 subunits.” (1)

The ability to split into parts, at the Furin Cleavage Site (FCS), is unique to the chimeric spike protein. Other coronavirus spike proteins do not have that capability.

Furin Cleavage Site

Chimeric spike protein is unlike any other CoV spike in that it can break into parts, subunits, at the Furin Cleavage Site (FCS), leaving S2 attached to the base part and freeing S1, both elongated halves of the spike: /\_ -> / and \_ .

The full spike can interact with ACE2 and various receptor types – and the S1 and S2 subunits can also, they are elongated. The base parts are smaller. Receptors are like a keyhole, & the spike, S1, & S2 are like a key that can fit in, but jam it -> no function, or dysfunction.

The S2 and base, \_ , stays attached to the human cell membrane if produced by a CoV injected person, (which would never happen in a real viral infection); or it would stay on the viral membrane in an CoV infection.

The S1, / , is freed, loose, floating in extracellular fluid… and the gene sequence that is cobra toxin like, PRRA, is more exposed on the freed S1, than it is in the full spike. The freed S1 could then travel to other areas of the person & block their nAChR receptors, or it might be excreted in sweat or breathed out.

The fact that un-CoV-injected people are getting symptoms after being around CoV-injected people suggests that it is an aerosolized risk. Standard fabric face masks would not be protective but better quality KN95 masks seem helpful.

People getting menstrual bleeding symptoms after being around recently injected people is likely because S1 exposure in a large enough load to be paralyzing the function of nAChR receptors in endometrial tissue (uterus). That link mentioned smokers are less at risk for endometreosis (excess menstrual blood but internal clotting), & that nAChR agonists might be a therapy to consider. (3)

Health Aids for Special Times – foods, phytonutrients and nutrients, and some lifestyle habits that may help protect against chimeric protein issues.

This document includes a lengthy section titled Excessive Menstrual Bleeding with information about nicotine, and colitis related to spike exposure may also be related to nAChR disruption and benefit from nicotine treatment – that is the problem it helped me with. The document also has information on Sleep and Iodine/Thyroid, in addition to chimeric protein related aids. When many types of receptors can be disrupted – they all need to be protected ideally. My website has page Nutrients and page Cofactors with dosing details about a variety of other nutrients not specified in the document.

Disclaimer: This information is being shared for educational purposes within the guidelines of Fair Use. It is not intended to provide individual medical guidance. Please seek a health care provider for that purpose, such as a functional health nutritionist or practitioner.

Reference List

  1. Mary Hongying Cheng, She Zhang, Rebecca A. Porritt, Magali Noval Rivas, Lisa Paschold, Edith Willscher, Mascha Binder, Moshe Arditi, Ivet Bahar. Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation. Proceedings of the National Academy of Sciences. Sep 2020, 202010722; DOI: 10.1073/pnas.2010722117
  2. Oliveira, A., Ibarra, A. A., Bermudez, I., Casalino, L., Gaieb, Z., Shoemark, D. K., Gallagher, T., Sessions, R. B., Amaro, R. E., & Mulholland, A. J. (2020). Simulations support the interaction of the SARS-CoV-2 spike protein with nicotinic acetylcholine receptors. bioRxiv : the preprint server for biology, 2020.07.16.206680.
  3. Wu Y, Wang LP, Pan JQ. Nicotinic acetylcholine receptor agonists may be a novel therapy for endometriosis. Med Hypotheses. 2011 Nov;77(5):745-7. doi: 10.1016/j.mehy.2011.07.028. Epub 2011 Aug 10. PMID: 21835554.
  4. Farsalinos, K.; Eliopoulos, E.; Leonidas, D.D.; Papadopoulos, G.E.; Tzartos, S.; Poulas, K. Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications. Int. J. Mol. Sci. 202021, 5807.
  5. Lyons Leah, Neuroprotective Effect of an Α-7 Nicotinic Acetylcholine Receptor Agonist and a Positive Allosteric Modulator in an In Vitro Model of Glaucoma. (2014) Masters Thesis,
  6. Stew Peters Show, CHILD JAB INJURIES – FIRST NUMBERS REPORTED, SERIOUS DANGER! THEY ARE KILLING THE CHILDREN. via “VAERS reports include children going blind and deaf after Covid-19 v@ccine.”
  7. Moglie Marcelo J., Marcovich Irina, Corradi Jeremías, et al., Loss of Choline Agonism in the Inner Ear Hair Cell Nicotinic Acetylcholine Receptor Linked to the α10 Subunit. Frontiers in Molecular Neuroscience. 14 (2021) pp 5, DOI=10.3389/fnmol.2021.639720
  8. Gaudet R. A primer on ankyrin repeat function in TRP channels and beyond. Mol Biosyst. 2008;4(5):372-379. doi:10.1039/b801481g
  9. Phelps CB, Huang RJ, Lishko PV, Wang RR, Gaudet R. Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry. 2008;47(8):2476-2484. doi:10.1021/bi702109w
  10. Halim Maaroufi, Interactions of SARS-CoV-2 spike protein and transient receptor potential (TRP) cation channels could explain smell, taste, and/or chemesthesis disorders. 15 Jan 2021,
  11. TRPM7 channels are needed in embryo development and also have an ankyrin repeat sequence. Jingjing Duan, Zongli Li, Jian Li,  et al., Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proceedings of the National Academy of Sciences Aug 2018, 115 (35) E8201-E8210; DOI: 10.1073/pnas.1810719115
  12. Ferioli, S., Zierler, S., Zaißerer, J., et al. TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg 2+ and Mg ATP. Sci Rep 7, 8806 (2017).

Notes related to specific health aids that may protect against epigenetic changes, or in other ways.

Spike production & Info Page Links

 In people who received a CoV injection (mRNA-1273 vaccine, Moderna) the spike protein was found to be produced within a day or two, peaking at day five, and still present for about two weeks. (114)

*Blogging trivia – Spike Protein Risks & Aids – Summary List – is too long to update any longer. It has material in the Resources section that aren’t in the document, otherwise, the document is much longer with a lot of uncollated notes at the end: Spike Risks & Aids/document.

Butyrate helps with detox, inflammation removal, just like niacin, but more specifically is protecting the colon. Lots more info on how to increase resistant starch and butyrate on my webpage – I had to start a 2nd one for ‘How much?’ Butyrate How Much? / Page one: Resistant Starch/Butyrate is a discussion of how adequate butyrate may be helping prevent severe COVID. The Microbiome page includes more about helping our symbionts – our beneficial bacteria and microbes in our digestive tract. The Zinc page also touches on microbiome health – the beneficial species need zinc. Spending time in forests or on a beach may also help our microbiome and immune function. Omega 3 fatty acids also help, see DHA & Forest Bathing.

The Nutrients page lists dosing ranges for vitamins, minerals and a few other nutrients. The RDA/AI is for adult male, which is generally equal to, or slightly more than the recommendation for adult females, and lower than the recommendation for pregnant or breastfeeding women. Nutrient recommendations are generally based on weight hen calculated individually, so a tiny child might need a 1/4 of an adult dose, a grade schooler may need a 1/2, and a middle schooler might need 3/4, while a teenager may need a little more, especially for an active large male. The Cofactors page is a beginning, it has cofactors used in the Citric Acid Cycle, so far. Magnesium is so important, it also gets its own page.

Pomegranate, juice or peel, Nrf2 Promoting Foods, and many Phytonutrients are protective of health and promote a balanced immune response, instead of underactive or overactive (and an allergy or autoimmune risk). Immunomodulators are discussed in a post about arteminsinin and iron chelators for anemia of chronic inflammation. Citrus peel is also a strong anti-viral and decongestant/anti-asthmatic, helps with digestion and appetite/weight control and blood sugar stability, – however, for people with Mast Cell Overactivity Syndrome, or MCAS/Histamine excess, citrus peel may cause symptoms of histamine excess which can be extreme and odd, behavior and mental changes.

Dielectric orgone blankets, How-To post, are something you can make yourself or order online. They can help relieve pain and inflammation.

Growth of Physicians and Administrators, 1970-2009, US Bureau of Labor Statistics, – 3000% increase in Hospital Administrators, in the same time there has been minimal increase in the number of Physicians. Administrators, don’t take care of patients. What are they doing?

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Reference List

  1. Alana F Ogata, Chi-An Cheng, Michaël Desjardins, Yasmeen Senussi, Amy C Sherman, Megan Powell, Lewis Novack, Salena Von, Xiaofang Li, Lindsey R Baden, David R Walt, Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients, Clinical Infectious Diseases, 2021;, ciab465,

Spike summary spreadsheet; telomerase, Circadian cycle & Nrf2

The spike protein may be rapidly increasing aging by affecting the length of telomerase, a topic discussed in a previous post with potential dietary/phytonutrient aids. EGCG and other nutrients that promote the Nrf2 gene or protein have protective effects growth and repair and immune function. In the process of reorganizing the Spike protein Risks & Aids – Summary List into a spreadsheet,* a pattern emerged in the various phytonutrient and other aids – they promote Nrf2 and inhibit NFkB along with the rest of the circadian cycle promoting lifestyle factors.

  • *Spike protein Risks & Aids – Summary List into a spreadsheet, * To read each box of the table click on the box and a drop down window should appear with all the text whether brief or a long list of references.
  • The vitamins, minerals, and TMG & DMG, have dosing details listed now on a new page of my site with dosing ranges and links for food sources and more info if interested.
  • I will add another page for the phytonutrients, antioxidants, and cofactors, or maybe a few pages. goals
  • Various covid19 protocols are listed on this site:

*Addition – 8/30/2021 article about the senescence effect of the spike protein: Le SARS-COV2 accélérerait l’âge biologiqueSARS-COV2 would accelerate biological age, (FranceSoir), translated from French, written by a group that includes Nobel Prize winning scientist Luc Montagnie, (2008 Nobel Prize in Medicine) and Walter Chesnut whose work is included in earlier posts on this site; Xavier Azalbert, Anne-Typhaine Bouthors, Michel Brack, Dominique Cerdan, Walter Chesnut, Gérard Guillaume, Jean-François Lesgards, Luc Montagnier, Jean-Claude Perez for FranceSoir.


Modern life seems to be the underlying theme of what is a risk factor and what might help – return to more ancient darkness for sleep, get full spectrum light with UV for 15-30 minutes per day, in the morning hours of your day may be ideal. Adequate iodine and magnesium is needed to help the body not have a calcified pineal gland and the pineal gland is needed to make melatonin. Melatonin is needed for immune function and has a role in energy production and inflammation removal involving niacin and the Citric Acid Cycle. Melatonin can be taken as a supplement however, then your body may be even less likely to make its own – working on improving pineal health and nighttime darkness (eye mask if need be, but covering the skin is needed too, we can sense light with photosensitive skin receptors).

Metabolic Syndrome involves magnesium deficiency, which increases hypertension and insulin resistance. The Citric Acid Cycle uses glucose to provide ATP for cellular energy or to be released as heat by a special type of adipose tissue called brown fat. People living in cold climates who spend time in the cold tend to have larger amounts of brown fat then people living in warm climates. The niacin receptor is involved in ‘uncoupling’ the Citric Acid Cycle from producing ATP as energy storage units and instead releasing it directly as warmth. The heat and reddening of the skin during a niacin flush is an example of the release of energy as heat.

There are many cofactors necessary for the Citric Acid Cycle, the chemical pathways used by mitochondria for the release of energy from glucose. The cofactors almost all also are promoters of the anti-inflammatory Nrf2 pathways, although the levels of a few minerals are regulated by Nrf2. Excess copper or iron can be inflammatory. So making sure the diet has plenty of the food sources or supplements of all the various cofactors is helping the body remove inflammation directly within mitochondria to be released as a little extra warmth, and also to produce energy for cellular use, and your thinking and daily activity.

It may also be protective during times of infection to have adequate Nrf2 and Citric Acid Cycle capacity, and also adequate uncoupling capacity: adequate niacin and/or butyrate to activate the GP109 receptors that are involved in the mitochondrial energy uncoupling, so the excess energy from oxidative stress chemicals or free iron, can be released as fairly harmless heat instead of transferred to ATP molecules. The heat during a fever is from a different cause than the temporary warmth experienced after taking a high dose of niacin – which gets milder after having been using it for a while, and is milder when there is adequate melatonin present.

About the spreadsheet & reading it – the organization style.

This is the very initial stage of writing, and many of the references are new additions. I am sharing it early because it may help people and: Pain hurts, health is better, and health is worth some effort, even a lot of effort.

The spreadsheet has categories of What? is the problem, symptom, negative effect of the spike protein, in rows. Each category often had more than one and sometimes many aids that might help or be a negative factor, so the spreadsheet is extended into many columns so each aid or lifestyle factor could have its own individual column. The columns have an ‘x‘ for the category if it is an aid and there may be a note if the item is otherwise affected by the category. Some aids may help many types of problems, inflammation and direct anti-viral for example, so there would be an ‘x‘ in the inflammation category and an anti-viral category. Each box in the columns has references about that aid and how it relates to the category. Eventually this will be useful for writing an organized reference list and document or app of some sort.

Yes this is complex, not just one or two supplements to take – breaking news – life is a miracle, it is amazing that any of us function at all. Given that, we do know a lot about what might help prevent illness or chronic degeneration, if we are allowed to put it into individual self care practice. Individualized care means – Pay attention to what seems to help and stick with that, possibly with breaks occasionally or rotating things over days, weeks or months, in season or what seems particularly good at that time.

Rotating favorites can be protective, or herbal supplements too maybe. Sensitivities to foods or substances are more likely to occur with something eaten every single day or very often. On average wheat and corn, eggs and dairy are in foods commonly eaten at every meal.

Other nutrient supplements are needed daily because they are water soluble. Some are found in many common foods and generally are rarely deficient – except during times of severe malnutrition or infection – thiamine, B1, is one of those. Vitamin C needs are also incredibly increased during severe infection or inflammation, in part because our own production of antioxidants is reduced, we normally make far more than we would ever get from a vitamin C food or capsule (equivalent to 300 orange’s worth of vitamin C, approximately per day for normal health, but glutathione and other antioxidants).

The B vitamins and C are water soluble and magnesium is readily lost in sweat and urine so we need that daily similarly to potassium and sodium, like an electrolyte – to help maintain good fluid balance. We also need calcium regularly but the bones are storage account for both magnesium and calcium so an acute or chronic deficiency is less obvious than for sodium and potassium. Very acute magnesium deficiency can occur during strenuous exercise on a hot day, and cause death from a stroke. Ischemic stroke led to death due to any reason more often in hospitalized patients with lower magnesium levels, than for those with higher levels. (ref)

Via @DGrouf Dr Grouf

Early or preventive treatment for viral infection, per Dr. Grouf.

via Dmitry Katz, PhD: Niacin, NA, within a cell, graphic. The green oval is an endolysosome, (hopefully removing spike protein), and it is complex… :-)

Niacin helps with endolysomes which are like grocery or garbage sacks for engulfing cellular debris or pathogens to be processed into usable nutrients or waste removal. (Reference needed) via

Protocol by Dmitry Katz, PhD focuses on melatonin and recommends a high dose of it. There may be a risk that a person starts making less of their own. Focu

Also using blackout curtains at night with no little lights or alarm clock, or using an eyemask during sleep can help us make our own melatonin. Supplements might be useful if there was a lack of sleep night. The melatonin helps the niacin flush reaction be milder. I have found high dose niacin helpful, see an earlier post for more information, and some precautions.

Niatonin Protocol by Dmitry Katz, PhD, *His website:

How to get started on the niacin part of the protocol and cautions about potential side effects and medications that may increase risk of side effects is available in this post: Niacin, & early treatment in general for SARS-CoV-2 is sensible, reduces hospitalization and mortality rate. Jan 22, 2021.

Disclaimer: Information shared for educational purposes within the guidelines of Fair Use. It is not intended as individual health guidance, please see a health care professional for individualized guidance. ‘Functional medicine’ practitioners work to restore normal function, nutritional adequacy and modify other lifestyle factors that might be part of a health problem.

Reference List

  1. You S, Zhong C, Du H, Zhang Y, Zheng D, Wang X, Qiu C, Zhao H, Cao Y, Liu C, -F: Admission Low Magnesium Level Is Associated with In-Hospital Mortality in Acute Ischemic Stroke Patients. Cerebrovasc Dis 2017;44:35-42. doi: 10.1159/000471858

Short list Dosing details – ranges with selfcare guidance.

Yes, even my short lists are too long – health is complicated. Zero cells of the body are made out of medicine – all of them are made out of nutrients, and may also contain toxins or medications that haven’t been excreted by the body.

Evidence-based medicine” has been proven to be an unreliable mix of real science, real results, real effort to find truth, and corporate funded “ghostwritten” work that is basically product advertisement written by a company with the name of a scientist who was paid to have their name used. See: Perspectives on the Pandemic | “The Illusion of Evidence Based Medicine” | Episode 13 Remastered, Leemon McHenry, PhD. March 9, 2021, (youtube)

Another video to watch – the Spike protein itself is a toxin and damages mitochondria, (~6:00 minutes), which are the energy producers for cells. Ryan Cole MD (

Short list – is a list of things to prioritize for self care – which simply means, taking good care of yourself, not a day at a spa to get toxic chemicals applied to your fingernails, that is something else.

Ordering these is a little arbitrary:

  1. Protein – nothing else works in the body without adequate protein with all the needed amino acids. Metabolic differences may interfere with digestion and supplements of specific amino acids may be needed.
  2. Water – we are a watery life form, 60-70%. To work right, we also need all the electrolytes including magnesium, calcium, sodium, potassium, phosphorus, chloride; and we need them in balance with each other. And we need movement, regular rhythmic movement of the whole body, full range of motion, to help move fluid through the capillaries, lymphatic vessels and be detoxified by lymph nodes and the kidneys. And we need good quality sleep, with blackout curtains or eye-mask during sleep, in cool conditions, to help promote optimal brain detoxing. At night our brain activity slows and the tissue literally shrinks in size so there is more fluid movement around the brain within the glymphatic system. The blackout curtain conditions helps promote better melatonin production which has anti-inflammatory and immune benefits.
  3. Stop eating/breathing/drinking toxins – this is a bigger point in modern life than people or corporations care to admit. Even the supplements that you buy thinking they will help, may be made with a capsule or other additive ingredient that is itself a source of inflammation or a potential toxin.
    1. Commercially grown foods or ingredients have agricultural chemical residue in greater amounts than food grown to ‘organic’ standards. Glyphosate may be a significant risk to vitamin D and mineral status and a couple amino acids. It is a mineral chelator and antibiotic by disrupting a pathway that also is involved in amino acid digestion. Glyphosate may be inhibiting enzymes involved in vitamin D metabolism and causing widespread low levels of vitamin D in populations that have plenty of vitamin D in many foods.
    2. Subclinical hypothyroidism seems common. Iodine intake may be too low in comparison to the amount of goitrogens in the diet or medications or water, (potassium bromide as an anti-caking agent in flour, fluoride and bromide is in many medications, and fluoride is in water, perchlorates as an environmental toxin is also a halide risk. Iodine is a larger atom of a similar chemical type, halides, as bromide, chloride, and fluoride. The body may put at atom of one of those three in place of iodine in a larger molecule such as the thyroid hormone, but then the molecule is dysfunctional, though lab tests might indicate ‘normal’ levels.
    3. Smog, air pollution, third-hand smokeformaldehyde and other lingering toxins from secondhand smoke. Simply poor ventilation also is unhealthy, and if humid, mold may cause significant health problems. Keep air moving, keep air fresh. Some models of air cleaners use a UV light attachment to kill mold and other pathogens.
  4. Eat more healthy foods, that don’t inflame your particular body chemistry – this may be something brand new to people or an immediate, “okay, got it.” If feeling very unwell with mystery symptoms, an elimination diet can help identify whether foods are a factor. Eliminate everything except a list of odd foods that are least allergy prone, and most people don’t eat that often anyway – eat that for about three weeks – give the intestines a chance to heal (takes a week at least), and try to get to a baseline of “I feel better” – then gradually add back one food (or sometimes a group) for a few days and see if the “I feel better” gets worse again, if not, continue with that added food and add another one, wait a few days…if okay add another one, wait… etc – that is slow but it can work in a very individual way that lab tests can’t. Lab tests are about ranges based on group averages. No one person is a group average.
  5. Nutrient and herbal supplements can help too, but nutrient dense food is the priority step. One nutrient can’t do much all on its own. The nutrients to focus on – for the mitochondria to perform the Citric Acid Cycle to burn sugar aerobically, with oxygen – include:
    1. B vitamins: B1 (Thiamin) (3) , B2 (Riboflavin) (4), B3 (Niacin) (810), B5 (Pantothenic acid) (5), B6 (Pyridoxine) (67), B7 (Biotin), B9 (Folate) (9),
    2. Minerals (17): Mg++ (Magnesium) (111213), Mn++ (Manganese), K+ (Potassium) (13), Zinc (1415), Iron (16), Copper, Sulfate,
    3. Amino acids: Carnitine (derived from lysine), Cysteine,
    4. Antioxidants: CoQ10, Glutathione, Alpha-Lipoic Acid (ALA).
    5. Based on a graphic by Dmitry Katz PhD, see post for image: Niacin may help reduce chronic migraines.
    6. *Some of the reference links are to posts with food and supplement info about the nutrient or cofactor molecule.

Those are nice start, but there are more nutrients that are important too, and the question of dose to take treads dangerously closely to the mindset that “If I take this pill, then I will be better.” – and then that simple idea doesn’t work, of course, and the person gives up on ‘nutrition’.

Are you drinking enough water? Any water? How is your sleep? Stress level on maximal? Do you eat protein foods? vegetables? Daily? — people really don’t eat ‘normally’ far more often than realized. Or ‘normal’ is not that healthy…

Some guidance for dosing details is possible, but ranges are better for open-ended education: What amount is safe? What amount is typically taken for research shown benefits, and it that the amount that is typically available or do I need to look for a bulk supplement and use a spoonful? What is recommended regarding gradual increase, or gradual withdrawal? Herbal supplements and nutrients in high doses can act in medicinal ways – cause a positive and/or negative medical effect within the body that presents as a symptom in some form, mood or physical changes.

Those are the questions that I try to answer in educational guidance that I provide – with the disclaimer to seek individualized health care professionals for individualized guidance.

Food serving guidance is also of value.

  • Nutritional yeast flakes or deactivated baking yeast sold as a supplement powder can provide a day’s goal of many B vitamins, some amino acids, nucleotides, and beta-glucan which is a protective type of fiber/starch — in just two teaspoons.
  • 1/3 cup of mushrooms would provide a similar amount of beta-glucan. Supplements of it may be available as a 500 mg capsule.
  • Meats, shellfish, dairy products also provide nucleotides. Shellfish are a good source of many trace minerals.
  • Omega 3 fatty acids are found in fatty fish, fish oil, krill oil and algae sourced oil. 300 mg DHA/EPA to1500 mg (depression research) may be beneficial. Excess intake may cause too easy bruising or bleeding problems to occur, vitamin E, ginger, and some other herbals may add to a risk of anti-coagulation – bleeding instead of clotting. Lack of vitamin K would increase risk of bleeding, occurring within the brain or intestines most commonly – so a silent problem adding to risk of brain inflammation from microbleeds.
  • Green leafy veggies – provide vitamin K, trace minerals, sulfur phytonutrients, fiber for our microbiome – who we want helping us as symbionts on our team, instead of pathogens adding to an inflammatory condition. *I literally do try to have a salad everyday, or kale in soup, or spoonfuls of dried basil, tarragon, oregano, cilantro if fresh veg isn’t available.

Dosing – how much may vary with how sick or well you are.

With an Elimination diet, the foods that were still a problem during initial healing may become more tolerable again once you have been healthy for a while. The healed intestinal lining is also less likely to allow allergenic particles to enter the body. Rotating questionable foods you eat over a four day cycle, roughly, can reduce risk of a food sensitivity reoccurring. Things we eat every single day, forever…, are more likely to become an allergen or autoimmune risk.

Picky eater test for parents – Does your child [or you…] eat more than 15 different foods regularly? Toast, saltine crackers, Wheaties, pasta, pizza crust, waffle, Cream of Wheat – all equal “1” – wheat. Spaghetti sauce, salsa, tomato slices – all equal “1” – tomatoes. The oregano, basil, onion, garlic, cilantro, lime, would be an additional six foods. Herbs and spices do have similar but also variable phytonutrient content and can add to your daily intake when used generously. Cardamom may have particular health benefits in a few ways and is similar to cinnamon without a same headache risk (cinnamaldehyde triggers TRP channels and can be a migraine trigger).

Autoimmune conditions may improve, however foods that are avoided because of autoimmune molecular mimicry (gluten/thyroid hormone) would have to be continued to be avoided for life. Memory immune cells to the gluten/thyroid hormone exist once the autoimmune condition occurred. Strictly avoiding the food/ingredient for six months can get the active antibodies to go away (naturally occurs), but any little taste or serving again can cause a reactivation of the memory cell and production of a bunch of new antibodies against gluten/thyroid hormone – which you don’t want, trust me on that ;-)

This is what I got so far re dosing details – the middle still needs to be completed (8-12-2021), I have been working on the document version, Spike Protein Risks & Aids – Summary List, rather than the blogpost version:

Short list-Dosing and other details:

  • Beta-glucan~ supplement as a powder, likely least expensive what to supplement with beta-glucan, example: (134). A teaspoon of a powder is roughly five grams, 5000 milligrams. An eighth teaspoon would be roughly 625 milligrams.; Medical research has used 100-500 mg of beta-glucan for immune support research and 3 grams for cholesterol reduction. (41) In mushroom equivalents? – 0.21 – 0.53 grams per 100 grams of mushrooms (42) 1/3 cup mushrooms would be about 100-150 grams. Medicinal mushrooms may have more benefits than standard mushrooms and tend to be what research uses as the experimental substance, however they all have similar starch content; or 2 teaspoons Nutritional yeast flakes ~ 2 grams beta-glucan and alpha-mannan, also beneficial –
  • Nutritional Yeast Flakes also provide Nucleotides which plus NAG, n-acetylglucosamine may help us make more sialic acid, needed particularly for platelets and the intestinal lining, but also throughout the body. 
    • N-acetylglucosamine (NAG) is a specific form of glucosamine and more standardly available glucosamine supplements would not be the same. Example of a bulk powder available: (135). 
    • N-Acetylglucosamine (GlcNAc), 2-acetamino-2-deoxy-β-d-glucose or 2-(acetylamino)-2-deoxy-d-glucose, is a monosaccharide derivative of glucose and is widely distributed worldwide.” […] “In plants, GlcNAc has been found in bromelain, ricin agglutinin* [*castor beans, also the source of ricin toxin] and abrus agglutinin** [7,3537]. In humans, GlcNAc is frequently observed in glycoproteins, such as tissue plasminogen activator [38]. It is also detected in mammalian growth factors and hormones [35], including follicle-stimulating hormone (FSH), luteinizing hormone (LH), human menopausal gonadotropin (hMP), pregnant mare serum gonadotropin, thyroid-stimulation hormone (TSH) and human chorionic gonadotropin (hCG).” (136)  
    • **Abrus agglutinin is from a medicinal plant used in India, and it may be helpful against cancer. (137)
  • Dandelion tea leaf/root; &/or Pine/evergreen needle tea (but not yew) 3 tablespoons of needles per cup, steep in hot but not boiling water (~175’F) for 20 minutes or overnight for a stronger tea. Fennel seed in the tea adds flavor and softens the seeds, and has health benefits, included later. Star Anise may have similar phytonutrient potential as the evergreen needles and a few pieces adds a nice flavor and sweetness.
    • Amount recommended: 2-3 cups per day, of either, having some of both if tolerated may be helpful, or alternate. Diuretic effect may occur, have earlier in the day and drink plenty of water to help it wash through, removing toxins! Diuretics can be helpful if not excessive. 
    • Signs of excessive acidity or tannins along with too little water, dehydration, may be an urge to urinate then only producing a small amount of urine that has a burning sensation. Drink more water, cut back on the diuretics.
  • NAC – glutathione precursor, 500-600 mg may be recommended preventatively, or higher doses may be given intravenously to hospitalized patients (112, 133), Vit. C, zinc, selenium, magnesium sulfate, sulfur rich foods, garlic, cruciferous, and glutathione rich foods: asparagus, okra, avocados, greens; whey protein for cysteine (caution glutamate source), Milk thistle, turmeric; sleep & exercise!
  • Glycine (DMG) (daily needs may be as much as 10 grams per day, I take about five grams, a teaspoon in water daily along with methionine, another amino acid I need due to a gene difference. It may also be helpful in a glyphosate rich world.; possibly heme-oxygenase-1, an anti-inflammatory enzyme that may be negatively affected by glyphosate residue in our food supply, along with tryptophan, manganese and other trace minerals (138); also taurine & serine, both are protective within the brain.
  • Niacin, thiamine, riboflavin, other B vitamins, D and/or sunshine. Trace minerals., boron, manganese, . . . except iron if elevated ferritin.
  • Quercetin, resveratrol, curcumin, artemisinin, Pomegranate peel & Goji berries (catechins/EGCG) – iron chelator and other benefits, lactoferrin – also an iron chelator. If excess ferritin/iron is a concern – which it tends to be with Spike issues, avoid high iron foods.
  • Bromelain – serratiopeptidase – clears mucus, protects blood vessels. I take a 500 mg capsule daily, and an extra one if I feel congested. Raw pineapple, including the core, is a natural source of bromelain. Thin slices of the core are edible, or could be blended into a smoothie mixture.
  • Acetaminophen, loratadine (anti-histamine).
  • Omega 3 fatty acids. 300-1500 mg several times per week or daily. Cut back if bruising tendency increases. Liquid fish, krill or algal oil is the easiest way to get the larger 1000-1500 mg dose.
  • Nicotine – patch lozenge, gum, may have fewer toxins and lung risks than smoking or vaping – the nicotine itself is still addictive but could help protect against spike issues affecting the nicotinic Acetylcholine Receptors (nAChRs). I use a half a patch a day for gradual dosing equal to about a half a pack, (10.5 mg nicotine), plus occ bits of lozenge equalling .5-1 mg nicotine. To reduce addictive behavior risk I avoid using too much at once, nicotine & other drugs associated with addiction cause a dopamine surge that can be ‘fun’, but is like mania, really. Lobelia may be a non-addictive substitute that also protects the nAChRs.
  • If legal, THC products for anti-phospholipid issues.
  • Butyrate, Resistant Starches, Probiotic & Prebiotic foods – 2-5 grams per day butyrate may be the goal, based on what a healthy microbiome and resistant starch rich diet might provide. Short-chain fatty acids (SCFAs): 5-15% of our total calories and the epithelial cells lining our colon need even more – 60-70% or their energy use is from SCFAs. (123) How much resistant starch to eat? More probably, then we are eating on average. I try to have something with resistant starch everyday, sometimes more than once, maybe with every meal would be ideal – our colon cells like to eat all day long! Potato or pasta salad, polenta or chilled amaranth would provide resistant starch, and Bubble tea! More info: Resistant Starch/Butyrate.
    • Fennel seeds – available as a flour or the seeds are eaten like an after dinner mint in some cultures, a pinch or two (½-1 teaspoon) is chewy and flavorful, aids digestion and freshens breath while leaving a few seeds stuck in your teeth to enjoy later!
  • Detox aids: Bentonite clay (spoonful of a premade mix in glass of water – 15 ml hydrated Bentonite – Great Plains Bentonite Detox), and/or Activated Charcoal, (500 mg with meals – Natural Elements Activated Charcoal). – with meals or once or twice per day to help clear toxins in the GI tract. 

*addition “(It is important to note that a TMPRSS2 inhibitor is BROMEXINE).” – @BidoliNicola

Niacin dosing, and gradual increase to a high dose info is in this post, with graphics by Dmitry Katz, Ph.D: Niacin, & early treatment in general for SARS-CoV-2 is sensible, reduces hospitalization and mortality rate.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.