Yemen in the News

Our actions have consequences. The United States of America is a baby nation compared to most other countries. Stewardship of the land has been disrespected since white man first invaded America and now corporate outsourcing is sending bad business practices into other people’s back yards.
Why would citizens in Yemen want a pipeline that takes their limited resources, most of the profit and ruins their land? Some of them don’t like the pipeline that is owned and operated by foreigners but is located in their backyard.

  • A suicide bomber was killed along with 90+ Yemeni soldiers. The Al Queda response stated that the attack was in  “retaliation for the Yemeni army’s attacks and U.S. drone strikes in the southern part of the country.” [link(5/21/12)]
  • A spy infiltrated an Al Queda cell and brought out a bomb by pretending to be a suicide bomber. [link(5/8/2012)]

The law of supply and demand suggests that the Al Queda resistance won’t stop until the demand for freedom from foreign occupation is addressed.

/Disclaimer: This information is provided for educational purposes within the guidelines of fair use./

Prostate and breast cancer and omega 6s and 3s

     A study [1] found significant differences in the amount of omega-6 and omega-3 polyunsaturated fatty acids levels in tissue taken from benign and malignant prostate cancer tumors from within the same prostate specimen. Malignant tissue samples were found to have less total omega-6 fatty acids then the benign samples. The tissue levels of the specific types were also different.
The malignant tissue had more of the dihomo-gamma-linolenic acid (DGLA) (C20:3w6) an omega 6 fatty acid and precursor to other omega 6 metabolites. There was significantly less of two omega 6 fatty acids. Arachidonic acid (AA) (C20:4w6), and adrenic acid, (C22:4w6) were at lower levels  in cancer tissue that was malignant compared to tissue that was benign. The abstract to the study concludes with the statement “These findings provide additional evidence that dietary fat is associated with prostatic carcinogenesis.”
     It seems to me that if the samples were simply from different areas of the same specimen that the same human would have been eating the same dietary fats. The two types of tissue from within the same gland would have received the same blood flow and nutrients. So  the malignant tissue had less AA and adrenic acid and less total omega 6 fatty acids but more DGLA than the benign tissue. So something is happening in that malignant tissue that isn’t happening in the benign tissue and the net effect is loss of total omega 6 content. Something else has to be associated with the malignant prostatic carcinogenesis because the dietary fat is going to both the benign and the malignant tissue.
     Elsewhere information has been discovered that malignant prostate cancer cells can make an enzyme that can convert Arachidonic acid into a form usable as a food source for the malignant growth. Increased intake of CLA and ginger may help preserve arachidonic acid from being converted to 5-HETE which the cancer cells can use as an energy source. [Ginger slows prostate cancer growth] (10/20/2011) So targeting the enzyme  that converts AA to 5-HETE would make more sense than wondering what omega 6 and omega 3 ratio on the person’s plate might turn malignant cells back into benign ones. /speculation – The fat ratio in meals may have some effect  on slowing or speeding the growth rate of the cancer cells but it is unlikely to be able to change it back to benign. Some information suggests that malignancy might be preventable and that cancer metastasis might be reduced by avoiding animal products that are rich in free AA. donmatesz
AA forms part of the structure of membranes under normal conditions. AA can be converted from lecithin and combined with ethanolamine to become anandamide, an endogenous cannabinoid (eCB). Lab tests find free AA after it has been broken down from eCBs in response to inflammatory signals.
     The eCBs in times of health are part of the membrane structure and there would be little free AA. Controlling the diet for excess calcium and glutamates may help in addition to adding conjugated linolenic acid (CLA) and ginger. The omega 3s and omega 6s are groups of various chemicals that do not have the same functions and their risks and benefits may vary based on individual differences.
Adequate omega 3 fatty acid is important for heart health and mental health. They have been found helpful for depression, diabetes (ALA) and other diagnoses.
     /speculation/ Linolenic acid and omega 6’s may have gotten a bad name partially because larger research studies may not have excluded people with undiagnosed prostate or breast cancer. Their negative responses to a diet high in LA may have skewed the results of other people with normal tolerance for foods with LA or animal products rich in lecithin or AA (chicken, eggs and beef are the richest sources).
/speculation #2/ Over cooking the food source may increase the amount of free AA that is released. Differences in how foods were prepared for the different studies may have modified the results.
  1. A comparative study of tissue ω-6 and ω-3 polyunsaturated fatty acids (PUFA) in benign and malignant pathologic stage pT2a radical prostatectomy specimens.Schumacher MC, Laven B, Petersson F, Cederholm T, Onelöv E, Ekman P, Brendler C.  Urol Oncol. 2011 Mar 31. Department of Molecular Medicine and Surgery, Karolinska Institutet Department of Urology, Stockholm, Sweden.PMID: 21414816  [ncbi.nlm.nih.gov/pubmed/21414816]
  2. ***infertile men had more omega 6 (AA) and less omega 3  than fertile men. [ncbi.nlm.nih.gov/pubmed/19666200]
  3. ***supplementation with GLA in attempt to modify inflammatory blood chemistry. It worked somewhat.  [ajcn.org/content/77/1/37.full]
  4. [walnuts.org/alphalinolenic-acid/]
Disclaimer: This is provided for informational purposes only. Please see a health professional for individual health care purposes.

original Prilosec warning edited

A recently released government statement states that some people using proton pump inhibitors for more than a year may end up with low magnesium levels. [1] Low magnesium can be life threatening but it can also just be tiring and painful. Magnesium helps block over active muscle cramping and reduces headaches and diabetic nerve pain. It is essential for white blood cell function and prevention of osteoporosis.

The proton pump inhibitor medications may be inhibiting the active absorption of magnesium in the intestines in some individuals. In other words, the drug may be blocking proton pumps in the intestinal cell membrane that are necessary to actively move magnesium from the intestines into the cell. Some people were not able to improve their magnesium levels  with supplements until after the medication was stopped. Magnesium levels dropped again when the medication was re-started.

A simple serum magnesium test only shows acute deficiency. If you are concerned about your risk of chronic magnesium deficiency then ask for a red blood cell or muscle cell biopsy lab test to check intracellular serum levels.  The serum lab test that is commonly used usually doesn’t show a chronic magnesium deficiency. Only one percent of the body’s magnesium is found in the blood serum. The concentration is carefully regulated and deficiency would be severe or acute before serum levels of magnesium would drop.
Basing a decision on observable symptoms may be more helpful and budget friendly. Skip the blood tests or look at calcium level in the CBC panel. Hypocalcemia is a protective measure the body will adopt if possible when magnesium is low. Potassium levels can also be low. [3]

If you are having symptoms then a magnesium foot soak or bath in Epsom salts can bypass the intestinal absorption problems and provide some relief- while you are working on stopping the medication with your medical provider. Magnesium containing skin creams like the Ahava line may also provide relief. (I still like the body lotion but had to stop the face product – sensitivity reaction).

I have recently started using a Magnesium Glycinate supplement that I found at my local Food Coop . The tablet is quite large and sweet because it is a glyco-compound  which should help it dissolve and absorb better.  (See my blogs about the glycocalyx for more information about benefits of glyco-nutrients.) However it is more expensive than my mixed magnesium caplet, which contains magnesium oxide, citrate and malate. The only negative side effect that may occur with magnesium supplements is temporary loose stools (not explosive diarrhea, unless it was a really big dose like Milk of Magnesia, just really soft BM). The glycinate form may not trigger the smooth muscle fiber relaxation the way the free ions would. It is the rapid relaxation of the intestinal muscle lining that can trigger diarrhea/loose stools, so the magnesium glycinate may cost a bit more ($17 vs $6)  but if it is better absorbed and is less likely to cause side effects than it seems like a fair deal.

Click here to read more about magnesium and how six dollars a month could restore more function while reducing symptoms (aka side effects of dysfunction) 

A Government Statement you may not hear about [1, 2]:
Proton Pump Inhibitor drugs (PPIs): Drug Safety Communication – Low Magnesium Levels Can Be Associated With Long-Term Use
Prescription PPIs include Nexium (esomeprazole magnesium), Dexilant (dexlansoprazole), Prilosec (omeprazole), Zegerid (omeprazole and sodium bicarbonate), Prevacid (lansoprazole), Protonix (pantoprazole sodium), AcipHex (rabeprazole sodium), and Vimovo (a prescription combination drug product that contains a PPI (esomeprazole magnesium and naproxen).
Over-the-counter (OTC) PPIs include Prilosec OTC (omeprazole), Zegerid OTC (omeprazole and sodium bicarbonate), and Prevacid 24HR (lansoprazole).
[Posted 03/02/2011]
AUDIENCE: Consumer, Gastroenterology, Family Practice
ISSUE: FDA notified healthcare professionals and the public that prescription proton pump inhibitor (PPI) drugs may cause low serum magnesium levels (hypomagnesemia) if taken for prolonged periods of time (in most cases, longer than one year). Low serum magnesium levels can result in serious adverse events including muscle spasm (tetany), irregular heartbeat (arrhythmias), and convulsions (seizures); however, patients do not always have these symptoms. Treatment of hypomagnesemia generally requires magnesium supplements. In approximately one-quarter of the cases reviewed, magnesium supplementation alone did not improve low serum magnesium levels and the PPI had to be discontinued.
BACKGROUND: PPIs work by reducing the amount of acid in the stomach and are used to treat conditions such as gastroesophageal reflux disease (GERD), stomach and small intestine ulcers, and inflammation of the esophagus.
RECOMMENDATION: Healthcare professionals should consider obtaining serum magnesium levels prior to initiation of prescription PPI treatment in patients expected to be on these drugs for long periods of time, as well as patients who take PPIs with medications such as digoxin, diuretics or drugs that may cause hypomagnesemia. For patients taking digoxin, a heart medicine, this is especially important because low magnesium can increase the likelihood of serious side effects. Healthcare professionals should consider obtaining magnesium levels periodically in these patients. For additional information, refer to the Data Summary section of the FDA Drug Safety Communication.
Healthcare professionals and patients are encouraged to report adverse events, side effects, or product quality problems related to the use of these products to the FDA’s MedWatch Safety Information and Adverse Event Reporting Program:
  • Complete and submit the report Online: www.fda.gov/MedWatch/report.htm1
  • Download form2 or call 1-800-332-1088 to request a reporting form, then complete and return to the address on the pre-addressed form, or submit by fax to 1-800-FDA-0178
_____________________________________________________________________________
Bibliography

2. http://www.medscape.com/viewarticle/738442, PPI-Related Hypomagnesemia: Putting it in Perspective, David A. Johnson, MD, Posted: 03/07/2011, From: Medscape Gastroenterology > Johnson on Gastroenterology

3.    http://jasn.asnjournals.org/content/20/11/2291.long  Kevin J. Martin,  Esther A. González and Eduardo Slatopolsky, Clinical Consequences and Management of Hypomagnesemia,  doi: 10.1681/ASN.2007111194 (JASN November 1, 2009 vol. 20 no. 11 2291-2295)

Stomach and duodenal ulcer diet, herbs, vitamins, natural treatment with diet, supplements and home remedy by Ray Sahelian, M.D.
“Melatonin or l-tryptophan accelerates healing of gastroduodenal ulcers in patients treated with omeprazole. Three groups (A, B and C) of 14 patients in each treatment group with gastroduodenal chronic ulcers were treated with omeprazole (20 mg twice daily) combined either with placebo (group A), melatonin (group B) or with Trp (group C). On day 7, omeprazole by itself (group A) had not healed any ulcers, but four ulcers were healed with omeprazole plus melatonin and two with omeprazole plus tryptophan. At day 21, all ulcers were healed in patients treated with melatonin or Trp, but only 10-12 ulcers were healed in placebo-treated patients. Plasma gastrin level also rose significantly during treatment with omeprazole plus melatonin or Trp, but it was also significantly increased in patients treated with omeprazole plus placebo. Plasma ghrelin levels did not change significantly after treatment with melatonin or Trp, while plasma leptin increased significantly in patients treated with melatonin or Trp but not with placebo. We conclude that melatonin or Trp, when added to omeprazole treatment, accelerates ulcer healing and this likely depends mainly upon the significant increments in plasma melatonin. J Pineal Res. 2011.”
“Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.).
Ataturk University, Erzurum, Turkey.
J Ethnopharmacol. 2004.
In this study, water extract of stinging nettle (Urtica dioica L.) was studied for antioxidant, antimicrobial, antiulcer and analgesic properties. The antioxidant properties of stinging nettle were evaluated using different antioxidant tests, including reducing power, free radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, and metal chelating activities. Stinging nettle had powerful antioxidant activity. The 50, 100 and 250 microg amounts of stinging nettle showed 39, 66 and 98% inhibition on peroxidation of linoleic acid emulsion, respectively, while 60 microg/ml of alpha-tocopherol, exhibited only 30% inhibition. Moreover, stinging nettle had effective reducing power, free radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, and metal chelating activities at the same concentrations. In addition, total phenolic compounds in the stinging nettle were determined as pyrocatechol equivalent. Stinging nettle also showed antimicrobial activity against nine microorganisms, antiulcer activity against ethanol-induced ulcerogenesis and analgesic effect on acetic acid-induced stretching.”5. http://www.raysahelian.com/methylmethioninesulfonium.html
***cysteine and MMSC (methylmethionine sulfonium chloride) supplementation for ulcers6. http://www.gihealth.com/newsletter/previous/071.html

***This 2007 newsletters is assuring us of the safety of the PPI’s for the heart (but turns out not for everybody’s heart – the genetic canaries who handle magnesium and calcium a little differently do need to avoid PPI use.  The increased fracture risk reported would be related not just to decreased calcium absorption but also to the decreased magnesium absorption in the genetically more at risk individuals.

“There was one study reported from England last year that suggested that acid suppression from PPI treatment may reduce calcium absorption from the diet and increase the risk of hip fracture, especially in the elderly. The study found a similar but smaller risk of hip fractures for another class of acid-fighting drugs called H2 blockers. Those drugs include Tagamet, Zantac, Axid and Pepcid. So far, this conclusion seems true, but most doctors feel that this risk can be averted by properly monitoring the bone density of elderly people taking the drugs and recommending calcium-rich diets to all patients.”

 Vladimir Chubanov *Siegfried Waldegger , Michael Mederos y Schnitzler *Helga Vitzthum , Martin C. Sassen Hannsjörg W. Seyberth , Martin Konrad , and  Thomas GudermannDisruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia doi: 10.1073/pnas.0305252101 PNAS March 2, 2004 vol. 101 no. 9 2894-2899§ To whom correspondence should be addressed at: Institute for Pharmacology and Toxicology, Philipps University Marburg, Karl-von-Frisch Strasse 1, 35033 Marburg, Germany. E-mail: guderman@staff.uni-marburg.de.
Magnesium references From Bibliography for Dietitian Recommends Stop Vitamin D and Calcium ASAP 

 

8. http://www.ijkd.org/index.php/ijkd/article/view/140 Assadi, F., Hypomagnesemia, An Evidence-Based Approach to Clinical Cases, (Iranian Journal of Kidney Diseases, Vol 4, No 1 (2010)
18. http://www.ncbi.nlm.nih.gov/pubmed/20081245 Magdalena Bujalska, Helena Makulska-Nowak, Stanis³aw W. Gumuka Magnesium ions and opioid agonistsin vincristine-induced neuropathy , Department of Pharmacodynamics, Medical University of Warsaw, Krakowskie Przedmieoecie 26/28, PL 00-927 Warszawa, Poland
19. Magnesium: an emerging drug in anaesthesia, , Editorial I, M. F. M. James, British Journal of Anaesthesia, 103 (4): 465-7 (2009) DOI:10.1093/bja/aep242
23. http://www.ncbi.nlm.nih.gov/pubmed/17823441 Dai Q, Shrubsole MJ, Ness RM, Schlundt D, Cai Q, Smalley WE, Li M, Shyr Y, Zheng W., The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk. ( Am J Clin Nutr. 2007 Sep;86(3):743-51)
24. Joan L Caddell, Geriatric cachexia: a role for magnesium deficiency as well as for cytokines?, Letter to the Editor, , (Am J Clin Nutr 2000;;71:844-53. pp 851-853)
25. Carl J Johnson, M.D., Donald R. Peterson, M.D., Elizabeth K. Smith, PhD, Myocardial tissue concentrations of magnesium and potassium in men dying suddenly from ischemic heart disease, (Am J Clin Nutr 32: MAY 1979, pp 967-970)
29. Geeta Sharma and Charles f Stevens, A mutation that alters magnesium block of N-methyl-D-aspartate receptor channels, Pub: Proceedings of the National Academy of Sciences of The united States 93.n17 (August 20, 1996): pp9259+. InfoTrac General Science Collection.
30. Beasley R, Aldington S, Magnesium in the treatment of asthma..Medical Research Institute of New Zealand, Wellington, New Zealand., Richard.Beasley@mrinz.ac.nz, Curr Opin Allergy Clin Immunol. 2007 Feb;7(1):107-10
32. Maged M. Costantine, MD, Steven J. Weiner, MS, Effects of Antenatal exposure to Magnesium Sulfate on Neuroprotection and Mortality in Preterm Infants: A Meta Analysis, Obstet Gynecol. 2009 August; 114(2 Pt 1): 354-364 DOI:10.1097/AOG0b013e3181ae98c2
33. Burton M. Altura, Bella T. Altura and Anthony Carella., Magnesium deficiency-induced spasms of umbilical vessels: relation to preeclampsia, hypertension, growth retardation. Pub:Science, 221 (July 22, 1983): pp376(2)
34. Burton M. Altura, Bella T. Altura, Asefa Gebrewold, Harmut Ising and Theo Gunther, Magnesium deficiency and hypertension: correlation between magnesium-deficient diets and microcirculatory changes in situ.,. Pub: Science, 223.(March 23, 1984): pp1315(3).
37. http://ahavaus.com/site/dead_sea_wonders.html Line of skin care products containing magnesium.
42. Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. (elderly health), Kathryn M. Ryder, Ronald I Shorr, Andrew J. Bush, Tamara Harris, Katie Stone and Frances A Tylavsky. Journal of the American Geriatrics Society, 53.11 (Nove 2005): p1875-1881. Academic One File. Web. 13 Dec. 2010
43. DASH Diet May Cut Heart Disease Risk, – source John Hopkins Medicine, Today’s Dietitian, Vol . 12, No. 10, Oct. 2010, p 25
44. Christine Feillet-Coudray, Charles Coudray, Zjean-Claude Tressol, Denise Pepin, Andrzej Mazur, Steven A Abrams, Exchangeable magnesium pool masses in healthy women: effects of magnesium supplementation, Yves Rayssiguier, Am J Clin Nutr 2002;75;72-8
45. http://www.highbeam.com/doc/1P3-2180507851.htmlResearchers Identify Protein that Regulates Magnesium and Can Restart Stem Cells.” Targeted News Service. Targeted News Service LLC. 2010. HighBeam Research. 16 Feb. 2011 . “An international team led by researchers at the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School has published new findings that demonstrate how a specific protein controls the body’s ability to balance magnesium levels. Magnesium is an essential element for good health and is critical to more than 300 biochemical reactions that occur in the body. “Currently more than half of the US population does not consume an adequate amount of magnesium in their diet,” said Alexey G. Ryazanov, Ph.D., one of the study’s authors and a professor of pharmacology and member of The Cancer Institute of New Jersey at UMDNJ-Robert Wood Johnson Medical School. “Magnesium deficiency may be associated with many medical disorders including hypertension, atherosclerosis, anxiety, asthma and a host of other disorders.” “The team of researchers from the United States, France and Poland demonstrated for the first time that a protein called TRPM7 plays a key role in the maintenance of magnesium homeostasis (balance within the body) and is essential for proliferation of embryonic stem cells.”
77. Neuromed Phamaceuticals and Merck & Co., Inc. Announce Agreement for Novel N-type Calcium channel Compounds, from Business Wire, March 20, 2006, High Beam Research – **Neuromed is a pharmaceutical company focusing on calcium channel blockers. “blocking pain signaling through the N-type calcium channel is a novel approach for the treatment of pain” said Christopher Gallen,MD, PhD, President and Chief Executive Officer of Neuromed. **Providing adequate magnesium would be a less novel way to block nerve pain caused by overexcitation by excess calcium. Citation #9 demonstrated that diabetic neuropathy pain could be reduced by magnesium injection alone – why bother with the opioid or the synthetic calcium channel blocker. They are an expensive and dangerous class of pharmaceuticals that would be pretty much not necessary if we weren’t being drained of magnesium reserves by excessive calcium and acidity intakes.
95 [also 3 above].      http://jasn.asnjournals.org/content/20/11/2291.long  Kevin J. Martin,  Esther A. González and Eduardo Slatopolsky, Clinical Consequences and Management of Hypomagnesemia,  doi: 10.1681/ASN.2007111194 (JASN November 1, 2009 vol. 20 no. 11 2291-2295)
96.      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639130/?tool=pubmed  Karl T. Weber, William B. Weglicki, and Robert U. Simpson, Macro- and micronutrient dyshomeostasis in the adverse structural remodelling of myocardium,  (Cardiovasc Res. 2009 February 15; 81(3): 500–508.) Published online 2008 October 3. doi: 10.1093/cvr/cvn261.
More Magnesium references:
  1. “Possible Interactions with: Magnesium,” http://www.umm.edu/altmed/articles/magnesium- 000968.htm.
  2. B Grimaldi, “The central role of magnesium deficiency in Tourette’s syndrome: causal relationships between magnesium deficiency, altered biochemical pathways and symptoms relating to Tourette’s syndrome and several reported comorbid conditions,” Medical Hypotheses 58, no. 1 (1, 2002): 47-60.
  3. G Eby, “Rescue treatment and prevention of asthma using magnesium throat lozenges: Hypothesis for a mouth–lung biologically closed electric circuit☆,” Medical Hypotheses 67, no. 5 (2006): 1136-1141.
  4. “Nut consumption and risk of coronary heart disease… [Curr Atheroscler Rep. 1999] – PubMed result,” http://www.ncbi.nlm.nih.gov/pubmed/11122711.
  5. “Magnesium deficiency and metabolic syndrome: stres… [Magnes Res. 2010] – PubMed result,” http://www.ncbi.nlm.nih.gov/pubmed/20513641.
  6. “Magnesium and the inflammatory response: potential… [Arch Biochem Biophys. 2007] – PubMed result,” http://www.ncbi.nlm.nih.gov/pubmed/16712775.
  7. “[Magnesium and inflammation: lessons from animal m… [Clin Calcium. 2005] – PubMed result,” http://www.ncbi.nlm.nih.gov/pubmed/15692164.
  8. P Chambers, “Lone atrial fibrillation: Pathologic or not?,” Medical Hypotheses 68, no. 2 (2007): 281-287.
  9. “Complementary vascular-protective actions of magnesium and taurine: A rationale for magnesium taurate,” http://www.medical-hypotheses.com/article/S0306-9877(96)90007-9/abstract.
  10. Abe E. Sahmoun and Brij B. Singh, “Does a higher ratio of serum calcium to magnesium increase the risk for postmenopausal breast cancer?,” Medical Hypotheses 75, no. 3 (9, 2010): 315-318.
  11.  “Epidemiological evidence associating dietary calci… [Am J Nephrol. 1986] – PubMed result,” http://www.ncbi.nlm.nih.gov/pubmed/2950755.
  12. “High fructose consumption combined with low dietar… [Magnes Res. 2006] – PubMed result,” http://www.ncbi.nlm.nih.gov/pubmed/17402291.
  13. ..AppDataRoamingMozillaFirefoxProfiles5z5xh8vb.defaultzoterostorage4MGSRXSW9789241563550_eng.pdf   Cotruvo J, Bartram J, eds. Calcium and Magnesium in Drinking-water : Public health significance, Geneva, World Health Organization, 2009.
  14. “Protein peroxidation, magnesium deficiency and fib… [Magnes Res. 1996] – PubMed result,” http://www.ncbi.nlm.nih.gov/pubmed/9247880.
  15. E Planells et al., “Effect of magnesium deficiency on vitamin B2 and B6 status in the rat,” Journal of the American College of Nutrition 16, no. 4 (August 1997): 352-356.
  16. Sivan Ben-Avraham et al., “Dietary strategies for patients with type 2 diabetes in the era of multi-approaches; review and results from the Dietary Intervention Randomized Controlled Trial (DIRECT),” Diabetes Research and Clinical Practice 86 Suppl 1 (December 2009): S41-48.
  17. “Utility of magnesium as antiarrhythmic agent reviewed. – Health & Medicine Week | HighBeam Research – FREE trial,” http://www.highbeam.com/doc/1G1-121345520.html.
  18. Barbara Chipperfield and JohnR. Chipperfield, “Relation of Myocardial Metal Concentrations to Water Hardness and Death-Rates from Ishchaemic Heart Disease,” The Lancet 314, no. 8145 (October 6, 1979): 709-712.
  19. Barbara Chipperfield et al., “Magnesium and Potassium Content of Normal He3art Muscle in Areas of Hard and Soft Water,” The Lancet 307, no. 7951 (January 17, 1976): 121-122.
  20. “Regulation of Contraction in Striated Muscle — Gordon et al. 80 (2): 853 — Physiological Reviews,” http://physrev.physiology.org/cgi/content/full/80/2/853.
  21. “Potassium, calcium, magnesium, and sodium levels i… [Clin Lab. 2010] – PubMed result,” http://www.ncbi.nlm.nih.gov/pubmed/21086788.
  22. “Magnesium: Its proven and potential clinical significance.(Statistical Data Included) – Southern Medical Journal | HighBeam Research – FREE trial,” http://www.highbeam.com/doc/1G1-82553295.html#.
  23. “Magnesium Treatment for Sudden Hearing Loss – The Annals of Otology, Rhinology & Laryngology | HighBeam Research – FREE trial,” http://www.highbeam.com/doc/1P3-679636211.html#.
  24. “Magnesium supplementation decreases oxidative stress in diabetic rats. – Biotech Week | HighBeam Research – FREE trial,” http://www.highbeam.com/doc/1G1-104471960.html#.
  25. “Magnesium requirement of kittens is increased by high dietary calcium – The Journal of Nutrition | HighBeam Research – FREE trial,” http://www.highbeam.com/doc/1P3-37651279.html#.
  26. Daniel G. Chausow et al., “Experimentally-induced magnesium deficiency in growing kittens,” Nutrition Research 6, no. 4 (April 1986): 459-468.
  27. Yuhei Kawano et al., “Effects of Magnesium Supplementation in Hypertensive Patients : Assessment by Office, Home, and Ambulatory Blood Pressures,” Hypertension 32, no. 2 (August 1, 1998): 260-265.
  28. Robert E. Kleiger et al., “Effects of chronic depletion of potassium and magnesium upon the action of acetylstrophanthidin on the heart,” The American Journal of Cardiology 17, no. 4 (April 1966): 520-527.
  29. Andrew D Hershey, “Current approaches to the diagnosis and management of paediatric migraine,” The Lancet Neurology 9, no. 2 (2, 2010): 190-204.
  30. A M Gordon and E B Ridgway, “Cross-bridges affect both TnC structure and calcium affinity in muscle fibers,” Advances in Experimental Medicine and Biology 332 (1993): 183-192; discussion 192-194.
  31. Karin Ladefoged and Kikki Hagen, “Correlation between concentrations of magnesium, zinc, and potassium in plasma, erythrocytes and muscles,” Clinica Chimica Acta 177, no. 2 (October 14, 1988): 157-166.
  32. “Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 ( TRPM6 and TRPM7 ), magnesium intake, and risk of type 2 diabetes in women.(Research article)(Report) – BMC Medical Genetics | HighBeam Research – FREE trial,” http://www.highbeam.com/doc/1G1-193482837.html#.
  33. M Fu et al., “Association between Unhealthful Eating Patterns and Unfavorable Overall School Performance in Children,” Journal of the American Dietetic Association 107, no. 11 (11, 2007): 1935-1943.
  34. “Antenatal magnesium treatment and neonatal illness severity as measured by the Score for Neonatal Acute Physiology (SNAP) – Journal of Maternal – Fetal & Neonatal Medicine | HighBeam Research – FREE trial,” http://www.highbeam.com/doc/1P3-856244151.html#.
  35. “Acid-Base Status Affects Renal Magnesium Losses in Healthy, Elderly Persons1 – The Journal of Nutrition | HighBeam Research – FREE trial,” http://www.highbeam.com/doc/1P3-1123831511.html#.
  36. “Ancient Minerals Launches Comprehensive Online Magnesium Health Resource. – PRWeb Newswire | HighBeam Research – FREE trial,” http://www.highbeam.com/doc/1G1-241203537.html#.
  37. K Michaelsen, “Inadequate Supplies of Potassium and Magnesium in Relief Food? Implications and Countermeasures,” The Lancet 329, no. 8547 (6, 1987): 1421-1423.
  38. “High Dietary Intake of Magnesium May Decrease Risk of Colorectal Cancer in Japanese Men1,2 – The Journal of Nutrition | HighBeam Research – FREE trial,” http://www.highbeam.com/doc/1P3-1998563311.html.
  39. “Magnesium – The Clinical Advisor : For Nurse Practitioners | HighBeam Research – FREE trial,” http://www.highbeam.com/doc/1P3-2195246591.html.
  40. “Magnesium prevents chemotherapy side effects.(Editorial)(Report) – Townsend Letter | HighBeam Research – FREE trial,” http://www.highbeam.com/doc/1G1-206620332.html#.
  41. J Caddell, “Magnesium Deprivation in Sudden Unexpected Infant Death,” The Lancet 300, no. 7771 (8, 1972): 258-262.
  42. “Magnesium builds bones in pre-pubertal and adolescent girls.(ABSTRACTS OF INTEREST)(Clinical report) – Original Internist | HighBeam Research – FREE trial,” http://www.highbeam.com/doc/1G1-166995340.html#.
  43. J D Potter, S P Robertson, and J D Johnson, “Magnesium and the regulation of muscle contraction,” Federation Proceedings 40, no. 12 (October 1981): 2653-2656.

The Arthritis Foundation, Juvenile RA and minocycline

Close-mindedness can be hard on oneself, other people and for the planet.

[arthritistoday.org/magazine]

I got irate last night reading a free magazine but I kept going and found some helpful information and even reinforcement of my recommendation for use of antibiotics for an autoimmune condition. The complimentary magazine that arrived was, Arthritis Today, Advice from the Experts You Trust, which is published by the Arthritis Foundation. Their motto is, “Take Control, We can help”. The cover story is about a medically disabled 26 year old veteran, Mike Jackson, whose photo makes me think cannabinoid deficit not ibuprofen deficit – although ibuprofen does help reduce breakdown of endogenous cannabinoids. He suffered through ten years of military service with osteoarthritis and was given cortisone shots and ibuprofen and later on shoulder surgeries.

I would have given him green leafy vegetables and nutmeg, beans, nuts and seeds, and ibuprofen. The magazine does have an article about cooking with quinoa for gluten avoidance and four recipes that use cocoa powder.

The gluten article mentions that only an estimated 5% of people with celiac disease have been diagnosed. There is a lab test for aiding in diagnosis. Primary symptoms include bloating, digestive pain and constipation is frequently an issue. Joint pain has also been found to be a symptom because the overactive white blood cells from the intestines can travel and cause problems elsewhere in the body.
/Speculation/ Celiac disease may be an autoimm

Another nutrition article discusses portion control when using healthy fats or foods that are rich sources like walnuts (1/4 cup sv size) or avocado (one sixth of an avocado sv size). “Go to ArthritisToday.org/MA12 to learn more about the differences between good and bad fats.” I went – I don’t agree with the article’s grouping of all saturated fats as equally “bad” as trans fats. That is a very brief article with a brief list of a few foods and a few risks or benefits. The portion control article was more accurate.

Article on glucosamine was helpful about which chemical form may provide more relief. A 2005 Cochrane Review of trials regarding effectiveness of the supplements found that glucosamine sulfate (GS) trials had more consistantly positive results than trials that used glucosamine hydrochloride (GH). That makes perfect sense to me, although the article mentions that “Oliver Grundmann, PhD, . . .  says it isn’t clear why the two have different effects.” Our average diet is lower in sulfur containing foods than chloride or chloride containing additives. Chloride can interfere with the thyroid gland in a way similar to bromide and fluoride. So thanks for complimentary magazine – I have early symptoms of osteoarthritis but I don’t think it was ever added as an official diagnosis yet as I have been actively fighting the degeneration for over a decade with the regular use of magnesium, glucosamine, and Methylsulfonylmethane (MSM) among other things. Veterinarians use MSM regularly.[arthritis-msm-supplements.com/msm_for_horses_dmso.htm]

This quote fills me with wrath:

“Even if methotrexate leads to ‘clinical remission’ (defined here as no more than three swollen joints) in RA, a new study shows the joints might still be eroding.” – Shahreen Abedin,     Source: Annals of the Rheumatic Diseases, Nov. 7, 2011

The suggestion is to add more DMARD’s in addition to the methotrexate and if there are any slow healing wounds then the article next to it suggests that following the aggressive immune suppressants with skin-graft surgery would make that wound healing problem go away. Reminder – DMARD is a fancy acronym meaing we are using some chemotherapy drugs in an off label use – not for cancer. And the article on the next page encourages parents to use an aggressive mixtures of the immune suppressing drugs in their young children with a diagnosis of Juvenile Rheumatoid Arthritis.

“Disease-modifying antirheumatic drugs (DMARDs), as the name suggest, are drugs designed to modify the course of rheumatic diseases.” (Gee, vasculitis is part of the group of diagnoses that DMARDs are recommended for. and Minocycline is actually on the list with the note that it is not currently approved for arthritis by the FDA.) Article, “What you need to know about DMARDs”

Why is Benicar plus antibiotics and avoiding excess vitamin D, calcium and free glutamates such a horrible treatment suggestion compared to drugs that make one’s hair fall out. Should four year olds be bald – no.

Two young girls diagnosed with Rheumatoid Arthritis were 2012 Arthritis Walk National Honorees along with Mike Jackson. Unlike osteoarthritis which I think has to do with a genetic susceptibility to problems with disruption of nerve and muscle signals that result in the degeneration over time, Rheumatoid Arthritis has been proven to be related to cell wall deficient bacteria by research scientist, Lida Mattman. I posted links and a little more about her work, 2/17/2012: [https://transcendingsquare.com/2012/02/17/cell-wall-deficient-pathogens-l-forms/]

[lymebook.com/cell-wall-deficient-forms-mattman]

An excerpt that I posted within that article:

“Dr. Hoekstra’s mentor, Lida Holmes Mattman, Ph.D., also of Wayne State (now professor emeritus of biology), confirmed the causal role of P. acnes in a laboratory experiment. Dr. Mattman extracted the bacteria from the synovial fluid (which lubricates joints) of human arthritis patients, and injected it into chicken embryos. The chicks then exhibited symptoms of rheumatoid arthritis. When she treated the chicks with antibiotics known to disable P. acnes, the disease disappeared.”

Original Source: Lida H. Mattman, Ph.D., Cell Wall Deficient Forms–Stealth Pathogens, 2nd Edition, CRC Press (1993), CRC Press, 2000 Corporate Blvd. N.W., Boca Raton, FL 33431. I found the excerpt posted within a Lyme’s disease article: [shoptown.com/Dean/ALS2Lyme.htm] [4]

I knew a preschool child with juvenile rheumatoid arthritis whose mother was curious about the possibility of alternative treatments but she was never able to talk her Medicaid doctor into trying antibiotics instead of methotrexate. She did find moderate use of vitamin D and calcium foods and increased magnesium foods helpful for reducing the number of bad days her child experienced. I don’t know how they are doing now. I don’t think Minocycline would help an adult with osteoarthritis but it would be likely to help the two little girls with Juvenile RA more than Methotrexate would in the long run. Immune suppression will not support the healthy white blood cell’s ability to find the cells that have been colonized by the cell wall deficient forms of the Propioni acnes bacterium.

In the case of rheumatoid arthritis, a hallmark of conventional medical treatment is the use of steroids, which can provide symptomatic relief, but no cure. The danger here, cautions Dr. Hoekstra, is that such drugs “give a free and clear run to the bacteria involved (Propioni bacterium acnes). If such a patient is ever to subdue this microorganism, they must have a competent immune system, and to have this, they must be off the steroids.”[link #4]

Gluten intolerance and celiac disease can have overactive white blood cells causing damage in the joints and  in osteoarthritis damage to joints results over time. Genetic differences may be triggering more food allergen recognition in white blood cells in sensitive people. So elimination diets can help identify which foods are better to limit for life and to consider as treats. Over use of the trigger foods can increase coagulation of the allergen protein clumps in joints and inflammation damage occurs over time.

The girls with Juvenile RA on the other hand may be sensitive briefly during disease flair up when there are too many white blood cells for other reasons (P. acnes) and they start reacting to more foods and other external allergens but get rid of the infection and the food sensitivities would gradually go away as the intestines healed and the number of white blood cells returned to a normal number. So avoiding gluten or other flair up foods while treating the underlying cell wall deficient bacterial infection might eventually lead to fewer flair ups with less severe symptoms and the treats might become a normal food to use again.

Some people can be gluten intolerant genetically and some can be gluten intolerant while having sensitive digestive problems for other reasons. Just like lactose intolerance some people have it for life and some only have it after a digestive sickness.

Juvenile RA means one is born with problems. I was never able to breathe well and was covered with eczema blotches during my infancy. Born with problems from birth will really reduce life expectancy when methotrexate is chosen, but even with generally good control the later degeneration is somewhat inevitable as the CWD bacteria continue to parasitize preferred organs and tissue types. Based on the life cycle of the T. cruzi and T. brucei in a chronically infected human then 20 years plus 15 years is the expected timeline for early cardiac or CNS symptoms to start appearing. The spirochetes of syphilis have been linked to megalomania / obsessive compulsive tendencies in the later stages of the disease. At age 45 almost 46 I am actually doing pretty well if my mother’s Rocky Mountain Spotted Fever was lingering in her system.

This is not a pleasant thought but wouldn’t treatment options for a 2 and 4 year old that didn’t involve eventual hair loss be a prettier thought?

So as defined earlier the goal of therapy with DMARDs is to achieve ‘clinical remission’ or to get the pain narrowed down to only three swollen joints – or fewer – but not necessarily all the way to zero. And so swollen painful areas are considered a normal part of clinical remission and, worse, the irreversible degeneration was found to be ongoing even during this wonderful state of ‘clinical remission’.

A potential side effect of many of the immune suppressing drugs is osteoporosis.

I enjoyed the article with tips for packing for a major move with less pain (more organized = less work = less pain) near the end of the magazine – I think I will enroll in the Arthritis Foundation and continue getting their magazine. I do have one toe with loss of range of movement where an old injury had occurred.

Update: After examining both feet, the broken toe actually isn’t that different from the other foot’s toe now. Early calcification is reversible with a change in diet and hormonal balance.

Their motto “Take Control, the Arthritis Foundation can help.” I did find some helpful info, recipes and other tips that will assist me in my continued battle to control my chronic degenerative condition. First impressions can close a mind, going back for a second look can open doorways and minds. I don’t have to agree with everything to find value in some things.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes. Thanks.