The links I collect may include research studies that don’t seem to be directly about the point I made – sometimes research hasn’t been performed yet and I’m referring to background information in the article to which I linked or I’m drawing inferences from the research that the research authors did not include. Frequently research studies are focused on finding ways to make a medication or technique that can be patented. I am trying to figure out how normal and abnormal physiology may be affected by diet or lifestyle.
Read and live at your own risk. Medical doctors practice the provision of medicine – at least so I was informed by one medical doctor. My training was regarding diet for the lifespan in health and sickness, from perinatal/prenatal, through lactation and introduction of solid foods, to childhood and teen growth spurts through adulthood and into the typical changes in metabolism that occur with aging. Chronic disease is not a typical part of aging but a slowing down of metabolism and reduced need for total calories in combination with an increased need for protein and other trace nutrients is normal. Reduced appetite and thirst signals may also be normal so remembering to eat and drink enough can be a problem during aging.
I care a lot but there are only so many reading hours in a day.
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes. Thanks.
P38 MAPK can be activated by insulin. (1) Insulin is also a growth factor; it is not just a hormone involved with sugar metabolism. Blocking Cannabinoid Receptor type 1 was found to inhibit the activation of P38 MAPK by insulin or insulin-like growth factor. (2) Malfunction of insulin’s growth factor function may be involved in Alzheimer’s Disease (3) as almost 200 pharmaceuticals designed to decrease levels of amyloid or tau protein have not been found effective for treatment of the disease in humans. (See previous post.) Mouse models may not be representative of the disease process in humans.
/Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes. Thanks./
Bouaboula M, Perrachon S, Milligan L, Canat X, Rinaldi-Carmona M, Portier M, Barth F, Calandra B, Pecceu F, Lupker J, Maffrand JP, Le Fur G, Casellas P. A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions. J Biol Chem. 1997 Aug 29;272(35):22330-9. https://www.ncbi.nlm.nih.gov/pubmed/9268384 (2)
In a previous post recently I briefly discussed habits and working towards change. Three weeks to build a habit is an educational message – translational research – that has been shown to be inaccurate. Newer research suggests that two months may be more realistic – an average of 66 days.
I haven’t read the original research for either recommendation however a discussion of how habits can save energy while the use of will power actually seems to deplete our energy, and can lead to less ability to stick to a plan and act impulsively, is available here: Strengthen Your Willpower by Creating New Habits, by Isaiah Hankel, Ph.D. (https://www.isaiahhankel.com/strengthen-your-willpower-by-creating-new-habits)
/Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes. Thanks./
The rate of autism in the 1970s was around 1 child in 10000. Prior to the 1930s the disease was barely heard of and only a few children, fewer than ten, had even been documented in psychiatric medical records as having any symptoms similar to the autism spectrum symptoms. (Denial/Blaxill, Olmsted)
Around 1999 to 2000 there was a sharp increase in the rate of autism diagnosed. Changes in awareness and/or diagnosis criteria may have some impact on short term changes but the increase in rate from the 1970s is significant. Extrapolating into the future following the recent rate of change in the rate of children diagnosed with autism takes us to an estimated rate of 1 in 34 children in the year 2042. We all need to ask ourselves if now is a better time to try to prevent autism from occurring in our nation’s children or if we should wait until 2042. There are multiple risk factors including specific timing during the infant’s prenatal development, exposure to certain toxins, and nutrient deficiency and/or genetic susceptibility – complex, yes, but complex just takes a little more work to handle.
Autism Rate, U.S., Actual : 1970s-2018, Extrapolated from 2018 to 2042U.S. Autism Rate Soars to 1 in 59 Children, SafeMinds.org
Improved screening for risk factors of mothers during perinatal and prenatal care and screening of infants and toddlers before symptoms occur could help provide individualized guidance to help reduce known risk factors associated with increased risk of developing autism.
On another website I have a start on self care steps for preventing autism and other chronic illnesses for different stages of life:
This series of pages titled as Step 1, Step 2, etc. is a draft of steps for how to prevent autism or other chronic illnesses:
(Biomarkers are ways to tell that the baby’s body chemistry, lab tests, are different than typical using the umbilical cord blood sample that is already being collected and used for other screening purposes – it would just add expense, so first set of five simplest tests would be done on all infant’s samples and those who had the differences noted in children who later in life developed autism, would be screened for the second set of five and those who continued to have the noted differences in lab values would have the third set of five lab tests performed on the cord blood sample; the series of testing provides increased accuracy of results while saving some time and money on the number of biomarkers involved. It is a complex problem, requiring complex strategies. The infants who tested with the differences could then have nutrient deficiency and genetic screening tests done for the known risk factors and social and lifestyle factors could be evaluated in the home (things like vinyl flooring and poor air circulation, especially if there is a smoker in the house or large numbers of decorative candles).
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
