Calciphylaxis usually includes an imbalance of calcium and phosphate and a deficiency of protein C may also be involved. Protein C deficiency may be caused by genetic or acquired reasons. Protein C is involved in blood clotting. Vascular and soft tissue calcification frequently is also present in patients with calciphylaxis symptoms. The mineral content of the calciphylaxis sores has been found to resemble the mineral balance of bone.
Imbalance in vitamin D and hormone D metabolism might affect magnesium levels in some unusual cases and may promote intestinal malabsorption of magnesium. However elevated magnesium is more typically found in patients who have calciphylaxis as a side effect of dialysis in end stage renal disease. The kidney disease causes an abnormal lack of hormone D because the kidneys in normal health are the only place where vitamin D is activated into the hormone D form.
These are copies of links that I was reading and Tweeted last night:
- Mineral substance of bone tissue and of experimental cutaneous calcinosis in rats: chemical analysis and ESR study. http://www.ncbi.nlm.nih.gov/pubmed/219946
- Calciphylaxis assoc w cholangiocarcinoma… /heparin & vit K didn’t help/ Thrombosis & protein C deficiency involved/ http://www.ncbi.nlm.nih.gov/pubmed/11444409
- Retrospective analysis of tissue plasminogen activator as an adjuvant treatment for calciphylaxis. /Ca P homeostasis/ http://www.ncbi.nlm.nih.gov/pubmed/23324758
- Calciphylaxis… “the reported median survival time is 2.6 months after diagnosis,” http://www.ncbi.nlm.nih.gov/pubmed/25210810
- Aggressive calciphylaxis in end-stage renal disease… /assoc w vascular & soft tissue calcification/ http://www.ncbi.nlm.nih.gov/pubmed/25566898
- Calciphylaxis is a cutaneous process without involvement of internal organs… /assoc w vascular calcification/ http://www.ncbi.nlm.nih.gov/pubmed/24096524
- Net-like pattern of calcification on plain soft-tissue radiographs in patients with calciphylaxis. – PubMed – NCBI http://www.ncbi.nlm.nih.gov/pubmed/22841657
- Is calciphylaxis best treated surgically or medically? – PubMed – NCBI http://www.ncbi.nlm.nih.gov/pubmed/11114631
- Calciphylaxis in a morbidly obese woman w RA presenting w severe weight loss & vit D def. /pamidronate & D tx worked/ http://www.ncbi.nlm.nih.gov/pubmed/21742604
- Calciphylaxis in the absence of end-stage renal disease. – PubMed – NCBI /low vit D but tx surgery/ http://www.ncbi.nlm.nih.gov/pubmed/16901796
- The surgical management of renal hyperparathyroidism. – PubMed – NCBI http://www.ncbi.nlm.nih.gov/pubmed/22101574
- Secondary hyperparathyroidism in children with chronic renal failure: pathogenesis and treatment. – PubMed – NCBI http://www.ncbi.nlm.nih.gov/pubmed/14580225
Vitamin D, parathyroid hormone, and acroosteolysis in systemic sclerosis. /low 25D w 2ndary hyperPTH in sunny climate http://www.ncbi.nlm.nih.gov/pubmed/18843781
Bone metabolism in celiac disease. – /following gluten free diet for 6 mo normalized 25D, calcium & PTH levels/ http://www.ncbi.nlm.nih.gov/pubmed/18534236
Hypomagnesemia. Suppression of secondary hyperparathyroidism in chronic renal failure. – PubMed – NCBI http://www.ncbi.nlm.nih.gov/pubmed/762831
- Magnesium deficiency: possible role in osteoporosis associated with gluten-sensitive enteropathy. – PubMed – NCBI http://www.ncbi.nlm.nih.gov/pubmed/9116391
- Recent data on magnesium & osteoporosis. “Mg def in post-menopausal osteoporosis, prob caused by Mg malabsorption.” http://www.ncbi.nlm.nih.gov/pubmed/3079205
- [The significance of magnesium in medicine. (II) Disturbances of Mg metabolism & their treatment (author’s transl)]. http://www.ncbi.nlm.nih.gov/pubmed/6780810
- Metabolic disorders of cattle. /pellagra discussed, zinc, B6 Cu Mg def, malabsorption, iron overload can deplete B3/ http://www.ncbi.nlm.nih.gov/pubmed/8394500
Why do I care? because even though my symptoms are unusual I feel that I still deserve individualized health care. As a dietitian I was taught to look up information about any unusual diagnoses that patients might have and to provide individualized guidance if available or provide background information to help patients be able to make more informed choices about their treatment plan.
I also care because I think women deserve individualized healthcare even if we may get emotional or moody. Physical and mental illness symptoms can be related to underlying issues and simply medicating a symptom not only fails to address the underlying issue but it also fails to look for an underlying issue which can be life threatening if care is delayed in acute situations:
- How Doctors Take Women’s Pain Less Seriously /”the trauma of not being seen.” – Rachel / http://www.theatlantic.com/health/archive/2015/10/emergency-room-wait-times-sexism/410515/ …
Whether male or female in a for-profit health industry being your own patient advocate or hiring a professional patient advocate may be life saving when navigating the increasingly complex health care system.
See the previous post for my own patient struggles with symptoms of hyperparathyroidism and calciphylaxis like sores: Secondary hyperparathyroidism and calciphylaxis symptoms; an update with lab values,
/Disclosure: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes./Calciphylaxis may be caused by several different nutrient issues by Jenny