Calcium can not make strong bones if nothing is keeping it from leaking out in response to the stress chemicals’ fight or flight messages. People suffer from osteoporosis and weak bones along with hardening of the arteries and organs – excess calcium and vitamin D might be part of the problem. Too much active vitamin D can add to calcium imbalance because it signals the bones to let go of stored calcium and magnesium.
The minerals are also released during stress reactions in case there is a need to run from danger or heal a wound. White blood cells around wounds have the enzyme needed to activate vitamin D to the hormone form.
What do you know – it is important to mellow out and de-stress to help keep bone tissue hard and organ tissue soft.
- [jasn.asnjournals.org/content/15/12/2959.full] Vascular Calcification Mechanisms, by Cecilia M. Giachelli, doi: 10.1097/01.ASN.0000145894.57533.C4 JASN December 1, 2004 vol. 15 no. 12 2959-2964
“In a landmark study, Goodman et al. (24) found that coronary artery calcification occurred in young patients with ESRD (end stage renal disease) decades before this pathology was observed in the normal population. Furthermore, progression of vascular calcification in this group was positively correlated with serum P levels, Ca x P, and daily intake of Ca (24).”
***Vascular calcification has been correlated to higher intakes of calcium and phosphorus in this research article. Cardiovascular deaths are common among end stage renal disease and/or diabetic patients – I suggest they should be limiting calcium and phosphorus and increasing their magnesium intake in order to reduce risks of calcium overload. In the average human the kidneys favor calcium absorption and retention and waste magnesium.
Over the course of mankind the body adapted to a food and water supply that was abundant in magnesium and limited in calcium content. Calcium is important for strong bones but only in combination with other nutrients. Vitamin K (brown rice, green leafy vegetables and good guy bacteria in our intestines are sources) is essential for blood clotting and for healthy bones. Strontium is a trace mineral that may be essential to healthy bones and of course magnesium is the trace mineral that helps keep calcium inside of the bone where it belongs. Excessive levels of active vitamin D tell the bone to release the stored minerals. Active vitamin D (a very strong steroid based hormone in actuality) can switch on and off 900+ genes.
The study found (unsurprisingly) that the end stage renal disease patients who were treated with the typical phosphate binding medications that contained calcium had 28% progression of calcification compared to the experimental group who were given a phosphate binding agent that didn’t contain calcium. 
Let’s keep the calcium in the bone tissue where it belongs.
The article Vascular Calcification Mechanisms  presents four potential ways the soft tissue calcification may develop.
“First, human and mouse genetic findings have determined that blood vessels normally express inhibitors of mineralization, such as pyrophosphate and matrix gla protein, respectively, and that lack of these molecules (“loss of inhibition”) leads to spontaneous vascular calcification and increased mortality (10,29).”
Second – genetic/phontypic changes leading to production of bone proteins within the blood vessel may occur (the blood vessel cell switches on bone cell mechanisms).
“Third, bone turnover leading to release of circulating nucleational complexes has been proposed to explain the link between vascular calcification and osteoporosis in postmenopausal women (41–43).”
“Fourth, cell death can provide phospholipid-rich membranous debris and apoptotic bodies that may serve to nucleate apatite, especially in diseases where necrosis and apoptosis are prevalent, such as atherosclerosis (34,44,45).”
*** Magnesium deficiency could effect the enzyme production necessary for producing the “inhibitors” of bone formation produced in functioning blood vessels. Magnesium is crucial to over 300 enzymes. It is also essential for the growth of healthy white blood cells. A plentiful supply of white blood cells would engulf waste products of apoptosis and the dead cell material wouldn’t be left messing up vessel walls. Chronic magnesium deficiency will promote bone turnover in order to access the stored magnesium found within. Long term kidney problems may be reducing the amount of magnesium that the body can retain and further through off the calcium/magnesium balance.
Chronically elevated active D would chronically cause demineralization of the bones and also might be switching on and off genes in areas of the body (blood vessels for example) that shouldn’t be forming bone tissue. I would be very curious what the end stage renal disease patients’ 1, 25 D levels (hormone) are compared to their 25 D levels (vitamin). My 1, 25 D levels have been at the high end of normal and 25 D levels below normal (“deficient”) for five years of testing. I have been actively avoiding supplements and foods with vitamin D and much time in the sun during that time because I have found it reduces my symptoms of muscle knots (fibromyalgia), I also have taken magnesium supplements regularly.
A 200-500 mg supplement taken along with food generally will not cause the smooth muscles of the intestines to relax into a sudden bowel movement. Magnesium supplements are non-toxic but if absorbed too rapidly can cause too much muscle relaxation in the bowels or heart. Fluttery weak heart beats may result if you hang out in an Epsom salt bath for a long time due to the relaxation of too many of the muscle fibers at the same time. Magnesium taken with food or in the glycinate form does’t seem to have the over relaxing effect on the bowels.
Magnesium helps keep the calcium in the bone and out of the soft tissue. Use the calcium channel blocker that Mother Nature provided – magnesium. Eat more nuts, beans, seeds, green leafy vegetables. and chocolate every day for strong bones and soft organs!
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
From Vitamin D bibliography [link]:
10. Rutsch F, Ruf N, Vaingankar S, Toliat MR, Suk A, Hohne W, Schauer G, Lehmann M, Roscioli T, Schnabel D, Epplen JT, Knisely A, Superti-Furga A, McGill J, Filippone M, Sinaiko AR, Vallance H, Hinrichs B, Smith W, Ferre M, Terkeltaub R, Nurnberg P: Mutations in ENPP1 are associated with “idiopathic” infantile arterial calcification. Nat Genet 34: 379–381, 2003[CrossRef][Medline]
12. Sangiorgi G, Rumberger JA, Severson A, Edwards WD, Gregoire J, Fitzpatrick LA, Schwartz RS: Arterial calcification and not lumen stenosis is highly correlated with atherosclerotic plaque burden in humans: A histologic study of 723 coronary artery segments using nondecalcifying methodology. J Am Coll Cardiol 31: 126–133, 1998[Abstract/Free Full Text]
29. Luo G DP, McKee MD, Pinero GJ, Loyer E, Behringer RR, and Karsenty: G Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386(March 6): 78–81, 1997[CrossRef][Medline]
- Price PA, Caputo JM, Williamson MK: Bone origin of the serum complex of calcium, phosphate, fetuin, and matrix Gla protein: Biochemical evidence for the cancellous bone-remodeling compartment. J Bone Miner Res 17: 1171–1179, 2002[CrossRef][Medline]
- Price PA, Faus SA, Williamson MK: Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorption. Arterioscler Thromb Vasc Biol 21: 817–824, 2001[Abstract/Free Full Text]
- Price PA, June HH, Buckley JR, Williamson MK: Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D. Arterioscler Thromb Vasc Biol 21: 1610–1616, 2001[Abstract/Free Full Text]
- Proudfoot D, Skepper JN, Hegyi L, Bennett MR, Shanahan CM, Weissberg PL: Apoptosis regulates human vascular calcification in vitro: Evidence for initiation of vascular calcification by apoptotic bodies. Circ Res 87: 1055–1062, 2000[Abstract/Free Full Text]
- Schoen FJ, Tsao JW, Levy RJ: Calcification of bovine pericardium used in cardiac valve bioprostheses. Am J Pathol 123: 134–145, 1986[Abstract]
- [ajsonline.org/cgi/content/full/305/6-8/661] Nita Sahai, Modeling apatite nucleation in the human body and in the geochemical environment American Journal of Science, Vol. 305, June/September/October 2005, P.661-672; doi:10.2475/ajs.305.6-8.661
“Magnesium inhibits nucleation by adsorbing faster than calcium, as an outer-sphere surface complex, at the active site.”