Tag: Sepsis

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Snake venom like toxin is more exposed on free S1 subunit.

There is a cobra toxin-like gene sequence in the chimeric spike protein of either the SARS-C0V-2 virus, or the CoV injection’s spike sequence. (1) It likely can paralyze the function of nAChR clolinergic receptors, (4), . . . and medical world seems to be ignoring or denying that.

The solution is simple, though controversial – just start nicotine – OOOH, BUT THEN -> ADDICT! True, better off -> dead?

The dysfunction may be involved in the excessive menstrual bleeding or severe colitis like diarrhea. The cholinergic receptors also help modulate immune function to not produce too many inflammatory cytokines.

Chimeric – made of many species. The SARS-CoV-2 spike protein, and the sequence used for the CoV injections, also have similar genetic sequences to a wasp toxin, and it has genes from HIV and MERS. Chimeric – like the many headed hydra of mythology – they can all bite, and all may need to be dealt with to achieve health.

Summary:

  • Spike protein or the S1 subunit have a snake venom toxin like sequence which can block nAChRs receptors, and it disrupts the function of the nAChRs. (1, 4)
  • Nicotine is protective of the function of nAChR receptors, it is an agonist, an activator. It is addictive, yes, so is health.
  • The alpha 7 nAChRs are involved in preventing cytokine storm over-immune reactions, (2) ;
  • nAChRs are also involved in: menstruation/endometrial tissue (3); regular bowel movements; sperm motility; and functioning nAChRs are critical for prenatal and child development of the retina and eyes, and throughout life for retinal health, (5); nAChRs are needed to be able to send nerve signals from the ears to the brain – ie – to be able to “hear”. (7)

TRP channels are also needed to be able to hear, they are in the inner ear hair cells. (10) They are also throughout the body, needed for fetal development, (11), and magnesium absorption in the intestines, ().

Reports of harm to vision & hearing of children have been reported to VAERS.

VAERS reports of adverse reactions involving CoV injections include reports of children going blind or deaf. (6) That may involve cholinergic dysfunction of the nAChR receptors. (5, 7)

Spontaneous abortion/miscarriage in the first trimester has also been reported for most women who received CoV injections during the first trimester. (ref to add)

Lack of magnesium due to TRP channel dysfunction in the GI tract may be a factor in risk to a fetus if the TRP channels’ function is loss – which resulted in death, in a genetic animal study.

“Genetic inactivation of Trpm7 in mice results in early embryonic death17, 19. Conditional tissue-specific inactivation of Trpm7 in mice showed that TRPM7 plays a critical role in morphogenesis of various internal organs19,20,21.” (12)

Hearing & TRP channels: Hearing loss likely also involves damage to the inner ear hair cells. The TRP channel’s ankyrin repeat domains can be affected by the spike protein. (10) TRP channels with long stretches of ankyrin repeat domains are abundant in inner ear hair cells as they form a coil like area that can sense mechanical pressure and activate the TRP channel if a strong enough force is exerted on it. (8, 9) The open area of the ion channel is usually formed as an empty space between two very large protein subunits – similar building blocks put together in a circular pattern that can leave an open channel in the middle.

Simple solution – soak in magnesium sulfate and it enters the body through hair follicle pores – larger than TRP channels.

Epsom salt soaks are the simple solution to bypass the poor absorption of magnesium in the digestive tract. Both the magnesium and the sulfate are protective to the inner ear hair cells and the rest of the body. The hydrated form of a bath or foot soak may aid in the absorption. Magnesium sulfate was well absorbed from a bath relative, based on change in blood levels of magnesium. There have been less good results seen in topical magnesium chloride studies.

One to two cups of Epsom salt for a half-full bath, soak for 20-40 minutes. One cup or so in a large bucket or bin so more than the feet can soak, and soak for 20-40 minutes. Depending on the severity of magnesium deficiency a soak 1-3 times per week may be needed to help prevent muscle cramps or anxiety/anger. Low magnesium can affect depression risk or psychosis also.

Blocking nAChRs may add to risk of excess cytokines -sepsis; they help prevent an over-active production.

The retina is the area in the back of the eye where light sensing rod and cone cells are located. Activating the alpha7 nAChR type of receptors lead to improved cell survival in a model of glaucoma, (5) possibly aided by the anti-inflammatory role.

“Retinal ganglion cells treated with the α7 nAChR agonist [such as nicotine] alone demonstrated a 28.0% (± 12.8%) increase in cell survival over untreated control.”

The cholinergic nAChR receptors are involved in modulating an inflammatory cytokine response – so that it isn’t excessive and producing an over-active amount of cytokines as seen in sepsis.

“Due to its role in the downregulation of the production of pro-inflammatory cytokines, 33–35, it has been suggested that the α7 nAChR may be involved in the hyper-inflammation response that can be caused by SARS-CoV-2. 9, 36” (2)

So the more obvious colitis or excessive menstrual bleeding symptoms experienced from being around recently CoV injected people, may be an indicator that other excessive inflammatory responses are also happening throughout the body – and the solution is the same: nicotine activates the nAChRs and is protecting them, taking up the open spot in the receptor so S1 or Spike protein can not lodge in the spot instead – blocking its immunomodulatory or other functions.

Snake toxin sequence more exposed on the freed S1 subunit portion of the chimeric spike protein.

The chimeric spike protein can split into parts and both parts of the main spike are able to interact with cell receptors, S1 and S2. The gene sequence that is similar to a snake and snail type of toxin becomes more exposed on the separate S1 subunit – meaning it is likely then more interactive with nicotinic Acetylcholine Receptors.

“Notably, the exposure of this motif and its close sequential neighbors is further accentuated in the S1 trimer (Fig. 2C) shed after cleavage by the human proteases (TMPRSS2 or furin) to enable the activation of the fusion trimer of S2 subunits.” (1)

The ability to split into parts, at the Furin Cleavage Site (FCS), is unique to the chimeric spike protein. Other coronavirus spike proteins do not have that capability.

Furin Cleavage Site

Chimeric spike protein is unlike any other CoV spike in that it can break into parts, subunits, at the Furin Cleavage Site (FCS), leaving S2 attached to the base part and freeing S1, both elongated halves of the spike: /\_ -> / and \_ .

The full spike can interact with ACE2 and various receptor types – and the S1 and S2 subunits can also, they are elongated. The base parts are smaller. Receptors are like a keyhole, & the spike, S1, & S2 are like a key that can fit in, but jam it -> no function, or dysfunction.

The S2 and base, \_ , stays attached to the human cell membrane if produced by a CoV injected person, (which would never happen in a real viral infection); or it would stay on the viral membrane in an CoV infection.

The S1, / , is freed, loose, floating in extracellular fluid… and the gene sequence that is cobra toxin like, PRRA, is more exposed on the freed S1, than it is in the full spike. The freed S1 could then travel to other areas of the person & block their nAChR receptors, or it might be excreted in sweat or breathed out.

The fact that un-CoV-injected people are getting symptoms after being around CoV-injected people suggests that it is an aerosolized risk. Standard fabric face masks would not be protective but better quality KN95 masks seem helpful.

People getting menstrual bleeding symptoms after being around recently injected people is likely because S1 exposure in a large enough load to be paralyzing the function of nAChR receptors in endometrial tissue (uterus). That link mentioned smokers are less at risk for endometreosis (excess menstrual blood but internal clotting), & that nAChR agonists might be a therapy to consider. (3)

Health Aids for Special Times – foods, phytonutrients and nutrients, and some lifestyle habits that may help protect against chimeric protein issues.

This document includes a lengthy section titled Excessive Menstrual Bleeding with information about nicotine, and colitis related to spike exposure may also be related to nAChR disruption and benefit from nicotine treatment – that is the problem it helped me with. The document also has information on Sleep and Iodine/Thyroid, in addition to chimeric protein related aids. When many types of receptors can be disrupted – they all need to be protected ideally. My website jenniferdepew.com has page Nutrients and page Cofactors with dosing details about a variety of other nutrients not specified in the document.

Disclaimer: This information is being shared for educational purposes within the guidelines of Fair Use. It is not intended to provide individual medical guidance. Please seek a health care provider for that purpose, such as a functional health nutritionist or practitioner.

Reference List

  1. Mary Hongying Cheng, She Zhang, Rebecca A. Porritt, Magali Noval Rivas, Lisa Paschold, Edith Willscher, Mascha Binder, Moshe Arditi, Ivet Bahar. Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation. Proceedings of the National Academy of Sciences. Sep 2020, 202010722; DOI: 10.1073/pnas.2010722117 https://www.pnas.org/content/early/2020/09/25/2010722117
  2. Oliveira, A., Ibarra, A. A., Bermudez, I., Casalino, L., Gaieb, Z., Shoemark, D. K., Gallagher, T., Sessions, R. B., Amaro, R. E., & Mulholland, A. J. (2020). Simulations support the interaction of the SARS-CoV-2 spike protein with nicotinic acetylcholine receptors. bioRxiv : the preprint server for biology, 2020.07.16.206680. https://doi.org/10.1101/2020.07.16.206680 https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7386492/
  3. Wu Y, Wang LP, Pan JQ. Nicotinic acetylcholine receptor agonists may be a novel therapy for endometriosis. Med Hypotheses. 2011 Nov;77(5):745-7. doi: 10.1016/j.mehy.2011.07.028. Epub 2011 Aug 10. PMID: 21835554. https://pubmed.ncbi.nlm.nih.gov/21835554/
  4. Farsalinos, K.; Eliopoulos, E.; Leonidas, D.D.; Papadopoulos, G.E.; Tzartos, S.; Poulas, K. Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications. Int. J. Mol. Sci. 2020, 21, 5807. https://doi.org/10.3390/ijms21165807 https://www.mdpi.com/1422-0067/21/16/5807/htm
  5. Lyons Leah, Neuroprotective Effect of an Α-7 Nicotinic Acetylcholine Receptor Agonist and a Positive Allosteric Modulator in an In Vitro Model of Glaucoma. (2014) Masters Thesis, http://scholarworks.gvsu.edu/theses/740 https://www.dropbox.com/s/v8jrb56w1iwzs1u/physician_assistant_studies_thesis.pdf?dl=0
  6. Stew Peters Show, CHILD JAB INJURIES – FIRST NUMBERS REPORTED, SERIOUS DANGER! THEY ARE KILLING THE CHILDREN. https://www.bitchute.com/video/HIEsLK1BO1bQ/ via “VAERS reports include children going blind and deaf after Covid-19 v@ccine.” https://twitter.com/awakenindiamvmt/status/1443547600460738568?s=20
  7. Moglie Marcelo J., Marcovich Irina, Corradi Jeremías, et al., Loss of Choline Agonism in the Inner Ear Hair Cell Nicotinic Acetylcholine Receptor Linked to the α10 Subunit. Frontiers in Molecular Neuroscience. 14 (2021) pp 5, DOI=10.3389/fnmol.2021.639720 https://www.frontiersin.org/articles/10.3389/fnmol.2021.639720/full
  8. Gaudet R. A primer on ankyrin repeat function in TRP channels and beyond. Mol Biosyst. 2008;4(5):372-379. doi:10.1039/b801481g https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3006086/
  9. Phelps CB, Huang RJ, Lishko PV, Wang RR, Gaudet R. Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry. 2008;47(8):2476-2484. doi:10.1021/bi702109w https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3006163/
  10. Halim Maaroufi, Interactions of SARS-CoV-2 spike protein and transient receptor potential (TRP) cation channels could explain smell, taste, and/or chemesthesis disorders. 15 Jan 2021, https://arxiv.org/abs/2101.06294
  11. TRPM7 channels are needed in embryo development and also have an ankyrin repeat sequence. Jingjing Duan, Zongli Li, Jian Li,  et al., Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proceedings of the National Academy of Sciences Aug 2018, 115 (35) E8201-E8210; DOI: 10.1073/pnas.1810719115 https://www.pnas.org/content/115/35/E8201
  12. Ferioli, S., Zierler, S., Zaißerer, J., et al. TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg 2+ and Mg ATP. Sci Rep 7, 8806 (2017). https://doi.org/10.1038/s41598-017-08144-1 https://www.nature.com/articles/s41598-017-08144-1

Notes related to specific health aids that may protect against epigenetic changes, or in other ways.
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Updates/ Vitamin C Infusion is helping CoV-19 patients in New York.

Addition – Food sources of vitamin C, quercetin, and zinc are at the top of this document, which includes this blog post and a few others on the topic of COVID-19 (Antivirals in Foods) Eating good sources several times a day may help the body prevent infection or have a less severe case.

Virus enter a cell and are replicated to the cell’s capacity to produce them, at that point the cell bursts releasing the newly formed virus which go and infect other cells and force those cells to make even more virus to the cell’s capacity, and they all burst, releasing yet more virus – in an exponentially increasing number. Each time a cell bursts and releases the viral load, the cell dies. So the sooner you can help your body stop the viral replication the sooner you are protecting your cells from being killed by the process.

Megadoses of the nutrients that help stop viral replication may not be needed. Moderate amounts of good food sources may help the body fight the infection before it has spread to numerous cells and caused significant cell damage. Reducing infection load may also help prevent an over-reaction of the immune system to the infection. An over-reaction of the immune system can be deadly as the inflammatory chemicals can attack healthy cells and lead to organ failure and eventually death. The next section is about a nontoxic treatment that might help if an over-reaction of the immune system leads to a Cytokine Storm/sepsis reaction.

Foods contain antivirals that work in a similar manner to the chloroquine medications that we have been hearing about in the news. More production is needed before they are available for widespread use, and they are somewhat expensive and can be dangerous. Quercetin is a phytonutrient that is readily available in vegetables and fruits and as a bulk or individual supplement.

Nursing homes and hospitals could be adding the bulk supplement powder to a food at each meal and including zinc food sources. The zinc is carried into infected cells by the quercetin (or chloroquine) and the zinc disrupts viral replication. The chloroquine, quercetin, or zinc are not killing virus. White blood cells are the body’s patrol for killing and removing infected cells.

Health takes work and work takes nutrients.

  • Vitamin C helps the immune system fight infection. Good sources include: cabbage, tomatoes, green peppers, broccoli, asparagus, peas, kale, & citrus, strawberries, kiwi, papayas, cantaloupe. (Vit C Fact Sheet)
  • Good food sources of quercetin include: red onion, onion, garlic, kale, tomatoes, asparagus, broccoli, capers, nuts and seeds, red grapes, cherries, olive oil. Herbal supplements also containing quercetin include St John’s Wort, Gingko biloba, and American Elder. (WebMd) 
  • Good food sources of zinc include oysters, meats, poultry, dairy, cashews, pumpkin seeds. Other beans, nuts and seeds would also have some as vegan sources. Meats have more than the vegan sources, while oysters have so much zinc that it might risk excess if eaten regularly in large servings.  (Zinc Fact Sheet).

There are no guarantees in life, but trying a nontoxic strategy is at least safe. Medications may have risks of side effects – always see a medical professional for individualized health care guidance.

Vitamin C Infusion for Cytokine Storm immune overreactions.

Good news updates – a hospital chain in New York has found the use of high dose intravenous Vitamin C Infusions helpful for patients infected with the SARS-CoV-2 (COVID-19) novel coranovirus. “Dr. Andrew G. Weber, a pulmonologist and critical-care specialist affiliated with two Northwell Health” is providing his patients who have sepsis/cytokine storm symptoms an intravenous drip with 1500 mg of vitamin C three or four times per day. (1) Patients getting the Vitamin C treatment have been helped more than patients who did not according to Dr. Weber. A spokesperson for the Northwell Health system said that vitamin C is being “widely used” at their hospitals where 700 patients approximately are being treated for SARS-CoV2, however it varied by patient need and the clinician’s plan of care. (1, 2)

“The patients who received vitamin C did significantly better than those who did not get vitamin C,” Weber said. (1)

The protocol for the treatment also includes vitamin B1 generally but that news article doesn’t mention that ingredient of the IV mixture. The treatment is a much larger amount of vitamin C than the daily recommendation for a normal diet, however a patient with an overactive immune response is not in normal health. The treatment is used for patients who have had an overactive immune response to the infection and their own immune cytokines become produced in excessive amounts. The cytokines can then start damaging the patient’s own organs which can lead to organ failure and result in death.

The damaging immune chemicals in a normal response to infection would only attack the infected cells. The excessive amounts however use up all supplies of vitamin C in the patient’s body, and supplying vitamin C in high doses is then very helpful for protecting the patient from harm by the excess.

Quercetin plus zinc is a zinc ionophore, and is being tested as an anti-viral in human clinical trials for the treatment of SARS-CoV2 (COVID-19).

Good news update regarding quercetin and zinc as a zinc ionophore – the combination had already made it through animal trials for use against Ebola, and SARS-CoV(1) and was approved by the FDA for human clinical trials. Plans were underway for it to be trialed in China for patients with SARS-CoV2 (COVID-19). I haven’t found results yet.

  • CBC News Interview with “Dr. Michel Chrétien’s team at the Clinical Research Institute of Montreal” : Canadian team invited to do clinical trials in China for antiviral drug. Feb 28, 2020, (youtube).

UK What to do if at home with a Potential Infection, Guidance:

Stay at home: guidance for households with possible coronavirus (COVID-19) infection. Updated 24 March 2020, (gov.uk).

*The UK guidance recommends isolating for seven days after symptom onset, – it might be wise to use caution longer than, especially if trying to protect people in your home who are in a high risk group, which includes: Senior Citizens, people with asthma or other lung conditions, smokers, people with hypertension, and immune-compromised people.

While the infectious stage seems to start prior to symptom onset and to have the most risk of spreading the infection during the early days of symptoms, when a fever is also often a symptom, that might not be consistently true and not everyone infected with SARS-CoV-2 gets a fever. The longest a patient has been found to be infectious was 37 days and the shortest was eight days. The average for patients with severe symptoms being treated in a hospital to be infectious was 19 days and for patients with critical symptoms the average was 24 days to remain infectious. (4)

Sensible precautions if sharing a home with infected and non-infected people include:

  • Cover your coughs or wear a mask or bandana to catch respiratory droplets from your breath, coughs or sneezes. Try to avoid being in the same room with non-infected people if possible, at least during the highest risk days during the early onset of symptoms, or positive test result.
  • Wash hands often and sanitize or wash with soap any commonly used surfaces such as door knobs, kitchen and bathroom areas.
  • Don’t prepare raw foods for non-infected people if you can avoid it. Otherwise wash hands thoroughly or wear food preparation gloves if possible after the initial week or two of more severe feverish symptoms has passed.
  • US CDC guidance for home care of a person infected with SARS-CoV2 https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-prevent-spread.html

This is doable – the quercetin rich foods mentioned in the last post plus sinc supplements or foods may provide a protective effect against getting a viral infection. Stay calm and eat sauteed onions or citrus with a little of the peel left on, plus pumpkin seeds or meats. Best wishes for everyone’s health!

Request for plasma donations from people recently recovered from SARS-CoV2, Mount Sinai

There is a request for people who have recently recovered from SARS-CoV2 (COVID-19) and who would be willing to donate plasma if they have antibodies against the infection to contact Mount Sinai’s medical team. Antibody rich plasma can be given to severely ill patients with the infection to help them fight the virus. They can check for the presence of antibodies. Contact: COVIDSerumTesting@mountsinai.org, see (Statement from Mount Sinai Chief Medical Officer, (via @MikeDelMoro/via @joshchafetz).

Mount Sinai medical system has developed a test for checking for CoV-19 antibodies within hospitals and are sharing the technique: BREAKING: The First U.S. Test to Detect If a Person Has Potential Immunity to COVID-19 Was Just Developed (leapsmag.com)

Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Reference List

  1. Lorena Mongelli and Bruce Golding, New York hospitals treating coronavirus patients with vitamin C. March 24, 2020, NYPost.com, https://nypost.com/2020/03/24/new-york-hospitals-treating-coronavirus-patients-with-vitamin-c/?utm_campaign=SocialFlow&utm_medium=SocialFlow&utm_source=NYPTwitter
  2. Dan Lyman, Coronavirus Patients Being Treated With Vitamin C at New York Hospitals. March 25, 2020, https://www.newswars.com/coronavirus-patients-being-treated-with-vitamin-c-at-new-york-hospitals/
  3. CBC News Interview with “Dr. Michel Chrétien’s team at the Clinical Research Institute of Montreal” : Canadian team invited to do clinical trials in China for antiviral drug. Feb 28, 2020, (youtube).
  4. Fei Zhou, Ting Yu, Ronghui Du, et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet, March 11, 2020, DOI:https://doi.org/10.1016/S0140-6736(20)30566-3 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30566-3/fulltext#back-bib33
  5. Kira Peikoff, BREAKING: The First U.S. Test to Detect If a Person Has Potential Immunity to COVID-19 Was Just Developed. March 22, 2020 leapsmag.com, https://leapsmag.com/breaking-the-first-u-s-test-to-detect-if-a-person-has-potential-immunity-to-covid-19-was-just-developed/?fbclid=IwAR2z_hl9VZfsrjz2JL03Sze2cPscdqGTFD0VyBrSbUvx-bOP8f5lmz9BgdU
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Immune support against viral infection.

The concern about the Coronavirus outbreak is valid as the infection seems more dangerous than a winter flu season. People who smoke or have a chronic lung condition, or are elderly or have other chronic conditions, or who are obese, may be at increased risk of having a more severe case of Coronavirus.

*This blogpost is continued in a longer podcast / transcript, Fear and Immunity.

Symptoms can be non-noticeable or similar to a cold or mild flu. Digestive symptoms might occur in addition to lung symptoms, dry, non-productive cough, and chest pain, hot and cold feverish chills, and extreme tiredness. Smoking increases risk of lung symptoms developing into pneumonia. Recovery seems to take longer than for a cold or flu with some people needing hospital care for weeks with a ventilator for breathing. (World/national Coronavirus Statistics) Approximately 2-14 days from exposure to symptom onset, gradually developing symptoms with a cough and chest discomfort, fever, and shortness of breath/difficulty breathing being common symptoms. (Graphic by Robert Roy Britt)

Some people may be infectious without having developed symptoms yet, or at all possibly for the 20-29 year old age bracket based on South Korea’s more extensive testing of their population. (graphic-South Korea & Italy rates of COVID-19)

People seem to be most contagious before symptom onset and in the first week of illness. (link) Twenty days infectious is average and generally is reduced by the time coughing symptoms are over. Thirtyseven days infectious is the longest measured. (Zhou et al., 2020) Wearing a face mask while infectious might help protect others but is generally not recommended as necessary for people who are not sick. A Public Service video about reducing rate of infection by hand washing, staying home, focusing on not infecting others while we don’t know who might be contagious but not showing symptoms yet. (@thejuicemedia)

Contagion risk also seems worse than the flu or a cold as the virus can survive on surfaces longer than average, possibly a week or more. Respiratory droplets may be the usual route of infection however there also may be a risk of infection from an infected person’s bowel movement. Thorough hand washing with soap and plenty of water is more likely to disrupt the cell membrane of virus and remove them physically than depending on hand sanitizers which are designed for bacteria not virus.

Alcohol in the hand sanitizer may also be drying to the skin which also can increase risk of open sores which can allow infection to enter the body more easily. Moisturize with a hand lotion while the skin is still damp to seal in some of the water. Hand lotions don’t replace moisture, they add to an oily coating on the skin that helps prevent moisture loss.

Strengthening Immune Function – food and nutrients, rest, and water, cut down on sweets, increase positive thinking & stress coping habits.

*Nutrition is not a guarantee of not becoming infected with something but it can increase the likelihood of not becoming infected or not developing as severe symptoms, as seen in the Ebola outbreak (see embedded link) and with research on vitamin D and respiratory infection rate (see video link).

  • Sugar and high fructose corn syrup generally reduce immune health and may provide simple calories that support infectious microbes more than our own health. (Defeating the Coronavirus with Immunity & Hydrotherapy, Dr. Eddie Ramirez, Youtube)
  • Sleep helps the body recover and cope with healing or fighting infection.
  • Water is essential for the body to be able to have a thin protective layer of mucous in which white blood cells can more easily find and remove infected cells.
  • Positive feelings of hope and love are more likely to support health than fear and anxiety. Doris Day’s attitude in the song lyric may be more helpful, “Whatever will be, will be, que sera sera,” along with common sense health habits.
  • Vitamin C and/or zinc lozenges may be soothing for the throat and help immune function. Elderberry is also rich in antioxidants and may also be available in immune supporting lozenges.
An orange peeled so the white pith remains.
The orange zest layer of the orange peel can be trimmed to leave the white pith to be eaten with the sweet orange wedge. The white membrane is a source of nobiletin.
  • The white pithy membrane of an orange peel has beneficial phytonutrients and is also fairly mild like the inner peel of a pomegranate. Use a vegetable peeler or sharp knife to trim off just the outer layer of orange zest and then the sweetness of the orange sections will taste okay along with the white membrane.
    • The orange peel pith contains a phytonutrient, nobiletin, that may help with weigh loss too. (Orange Juice Molecule May ‘Drastically’ Reduce Obesity, Arterial Placque, slashgear.com)
    • Nobiletin is a chemical that promotes our circadian cycles and may be protective against metabolic syndrome. Genetic studies on animals suggest that differences in the CLOCK circadian protein can cause symptoms of metabolic syndrome – obesity, high blood lipids and blood sugar, low insulin levels, fatty liver, and respiratory uncoupling. (He, et al, 2016) Respiratory uncoupling changes the way mitochondria produce energy and if the changes continue for long may lead to worse dysfunction of the mitochondria which may lead to cancer (Seyfried, et al, 2014), or other chronic health problems. (Ruiz-Ramirez, et al., 2016) Research with nobiletin as a cancer treatment suggests that it stops cancer growth by deactivating cancerous genes. (plantmedicines.org)
    • Orange peel extract has also been studied for use against Coronavirus and it helped reduce replication of the virus. (Ulasli, et al., 2014)
    • Chen Pi, dried tangerine peel, is a traditional Chinese medicinal product sold as an anti-viral and digestive support. (alibaba.com/Chen Pi) Improving bioaccessibility of nobiletin with peanut protein nanoparticle encapsulation, for anti-cancer potential as a medication: (Ning, et al., 2019) Chen Pi is traditionally used as a digestive aid and for respiratory conditions that involve too much thick mucous. Chen Pi is thought to help thin the mucous and promote a more productive cough. (esgreen.com/Chen Pi)
  • Other immune supporting nutrients that may help against a Coronavirus infection include Nrf2 promoting sulfarophane and resveratrol. Elderberry is a good source of anthocyanins and other antioxidant phenols, blueberries and black beans would also be rich sources. Zinc and selenium are minerals with antioxidant function. (selenium sources) Having adequate Vitamin A and D is essential for immune function. NAC and lipoic acid are antioxidants. Nrf2 pathways increase our own internal production of antioxidants. (Other foods: Nrf2 Promoting Foods)
  • Both high dose vitamin C and zinc are listed as potential therapeutics for treatment of patients with COVID-19 and Chloroquine, the anti-malarial that was found helpful for treatment of the infection in China, is a zinc ionophore. (14) Zinc ionophores help with autophagy and apoptosis – the killing and engulfing of infected cells by white blood cells. (15)

Cytokine Storm Syndrome & Vitamin C Infusion, — webinar for medical professionals.

An over-reaction of the immune system called Cytokine Storm Syndrome or sepsis shock can be the cause of death from COVID-19 infection rather than the breathing problems and pneumonia symptoms. Some people may be more genetically at risk of having the inflammatory over-production of cytokines. (Cytokine Storm Syndrome/genetics) They are involved in killing infected cells but an excess can cause organ failure and lead to death. Intravenous Vitamin C Infusion can be safe and nontoxic for treating sepsis shock (Fowler 2014) and may improve survival rates (ScienceDaily) and is a strategy that was used in Wuhan, China for COVID-19 patients. (Video update by Dr. Cheng) (Clinical Trial/Peng) (Protocol used in China for Vitamin C Infusion IV treatment) A free webinar for medical professionals is being offered March 26 regarding Intravenous Vitamin C Infusion for COVID-19 treatment, see this for registration information. The webinar is now available as a video that can be viewed at any time, see the website: isom.ca. The Vitamin C Infusion technique is being used for COVID19 patients in a large hospital chain in New York, based on the improved survival rate seen in Shanghai China, (NYPost)

Patients from Wuhan with COVID-19 who were in the ICU had more cytokines, (“IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNFα.”, (Huang, et al, 2020)), than patients who weren’t sick enough to be admitted to the ICU. Other possible guidance to check for cytokine storm besides the cytokine levels is C-Reactive Protein and serum ferritin levels. (Teachey 2016) The medication Anakinra may be treatment. (comment)

From a nutrition care perspective – the Nrf2 promoting foods also tend to inhibit the inflammatory NfKb pathway which leads to increased production of TNFalpha and other cytokines.

Chloroquine phosphate, 500 mg BID, was used as a treatment in China per a comment on a medical site. (Detailed document with specific recommendations, may be helpful medication as a preventive or treatment.) It is an anti-malarial drug. and the virus seems to be interfering with heme in red blood cells, a little similar to malaria taking over red blood cells. ( Dr’s summary; and his ref list) Artemisinin is an extract of the herb woodruff that is used to treat malaria. It is available as an herbal supplement. (nobelprizemedicine/pdf)

With a new strain of virus we are learning how to treat it and how it spreads and being brand new, no one has immunity against it. Being a coronavirus puts it in the same group as colds and flus which can mutate slightly and we can catch the illness more than once.

The COVID-19 may also be able to be infectious to people who already recovered. (LATimes) The cases of reinfection may also be the same infection in the patient seeming to get better and then relapsing again.

Prevention is safest. Wash hands and surfaces thoroughly and regularly. Soap, water, and scrubbing physically helps break down virus membranes and remove the virus from skin and other surfaces. Hand sanitizer is not more effective than thoroughly washing with soap and water. antibacterial ingredients are designed against bacteria, not virus.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

“Supplements thought to be useful in the prevention of coronavirus infection include NAC, elderberry, spirulina, beta-glucan, glucosamine, selenium, zinc, lipoic acid, sulforaphane, resveratrol, vitamin D, Bifidobacterium bifidum strain probiotics and sporebiotics. ”

– Dr. Joseph Mercola (Essential Nutrition to Protect Yourself from Coronavirus) *

Origins – not a bat in China, genetically traced to the US around Aug/Oct 2019.

*That link includes some speculation about origins of the current Coronavirus strain – supporting the immune system and reducing infection rate and severity of disease is necessary whether the strain was from bats in the wild or a lab or from a lab manipulation of a strain from bats – saving lives needs to be a goal now.

(statement from Robert Kennedy Jr) “He [Taiwan Virologist] demonstrated that only the US has all the five known strains of the virus (while Wuhan and most of China have only one, as do Taiwan and South Korea, Thailand and Vietnam, Singapore, and England, Belgium and Germany), constituting a thesis that the haplotypes in other nations may have originated in the US. Korea and Taiwan have a different haplotype of the virus than China, perhaps more infective but much less deadly, which would account for a death rate only 1/3 that of China. [*so infection rates from South Korea may not be represent the risk for all ares] Neither Iran nor Italy were included in the above tests, but both countries have now deciphered the locally prevalent genome and have declared them of different varieties from those in China, which means they did not originate in China but were of necessity introduced from another source. It is worth noting that the variety in Italy has approximately the same fatality rate as that of China, three times as great as other nations, while the haplotype in Iran appears to be the deadliest with a fatality rate of between 10% and 25%. (7) (8) (9)” (globalresearch.ca) (news stories). (transcript of a video) There seems to be at least two strains, more information is needed to understand the significance of that (abcnews.com).

Reference List – incomplete, see links within the blogpost also.

  1. Protocol used in China for Vitamin C Infusion treatment for COVID19 , translated from Chinese on Google Translate – https://docs.google.com/document/d/1f21o4uqO0QmrF8e1d8JKMhE6NU7k8im5bVKqwROreTc/edit?usp=sharing
  1. Vitamin C for the Treatment of Coronavirus (COVID-19), free webinar scheduled for March 19, 2019, International Society for Orthomolecular Medicine, https://isom.ca/vitamin-c-coronavirus/
  2. Wen-Bin Yu, Guang-Da Tang, Li Zhang, Richard T. Corlett. Decoding the evolution and transmissions of the novel pneumonia coronavirus (SARS-CoV-2) using whole genomic data. https://www.dropbox.com/s/se41lvl8esbr40l/202002.00033v2.pdf?dl=0 
  3. Xiaolu Tang, Changcheng Wu, Xiang Li, Yuhe Song, Xinmin Yao, Xinkai Wu, Yuange Duan, Hong Zhang, Yirong Wang, Zhaohui Qian, Jie Cui, Jian Lu, On the origin and continuing evolution of SARS-CoV-2, National Science Review, , nwaa036, https://doi.org/10.1093/nsr/nwaa036 https://academic.oup.com/nsr/advance-article/doi/10.1093/nsr/nwaa036/5775463?searchresult=1
  4. Jon Cohen, Wuhan seafood market may not be source of novel virus spreading globally. ScienceMag.org,  Jan. 26, 2020, https://www.sciencemag.org/news/2020/01/wuhan-seafood-market-may-not-be-source-novel-virus-spreading-globally
  5. Other links until I complete this list are in the post Immune Support Against Viral Infection, https://transcendingsquare.com/2020/03/12/immune-support-against-viral-infection/
  6. The ASCO Post Staff, Pulmonary Pathology of Early COVID-19 Pneumonia Identified Retrospectively in Two Patients With Lung Cancer, ascopost.com, March 5, 2020 https://ascopost.com/news/march-2020/pulmonary-pathology-of-early-covid-19-pneumonia-identified-retrospectively-in-two-patients-with-lung-cancer/
  7. Chloroquine guidance for COVID19, as preventive or treatment of infection, https://docs.google.com/document/d/e/2PACX-1vTi-g18ftNZUMRAj2SwRPodtscFio7bJ7GdNgbJAGbdfF67WuRJB3ZsidgpidB2eocFHAVjIL-7deJ7/pub
  8. expert reaction to reports that the French Health Minister recommended use of paracetamol for fever from COVID-19 rather than ibuprofen or cortisone, March 16, 2020 https://www.sciencemediacentre.org/expert-reaction-to-reports-that-the-french-health-minister-recommended-use-of-paracetamol-for-fever-from-covid-19-rather-than-ibuprofen-or-cortisone/
  9. Fehr AR, Perlman S. Coronaviruses: an itoverview of their replication and pathogenesis. Methods Mol Biol. 2015;1282:1–23. doi:10.1007/978-1-4939-2438-7_1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369385/
  10. Roujian Lu, Xiang Zhao, Juan Li, et al.,  Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. January 29, 2020, https://doi.org/10.1016/S0140-6736(20)30251-8 https://www.cdc.gov/coronavirus/2019-ncov/downloads/genomic-characterization-of-2019-nCoV-Lancet-1-29-2020.pdf 
  11. Diagnostic detection of Wuhan coronavirus 2019 by real-time RTPCR. https://www.who.int/docs/default-source/coronaviruse/wuhan-virus-assay-v1991527e5122341d99287a1b17c111902.pdf 
  12.   http://www.aabb.org/advocacy/regulatorygovernment/Documents/Impact-of-2019-Novel-Coronavirus-on-Blood-Donation.pdf
  13. Sy Mukherjee, China’s high smoking rate may be exacerbating the coronavirus outbreak,  Feb. 19, 2020, Forbes.com, https://www.google.com/amp/s/fortune.com/2020/02/19/coronavirus-china-smoking-rate-men/amp/
  14. COVID-19 Science Report: Therapeutics, NUS Saw Swee Hock School of Public Health, March 12, 2020, https://sph.nus.edu.sg/wp-content/uploads/2020/03/COVID-19-Science-Report-Therapeutics-13-Mar.pdf
  15. Xue J, Moyer A, Peng B, Wu J, Hannafon BN, Ding W-Q (2014) Chloroquine Is a Zinc Ionophore. PLoS ONE 9(10): e109180. https://doi.org/10.1371/journal.pone.0109180 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109180