Phosphonutrients, infant formula, & brain health

Good news, work on a phosphoprotein (osteopontin), found naturally in human and other mammal milk, has been refined from bovine (cow) milk and successfully used in early clinical trials with human infant formula. Babies were found to have improved immune development and reduced days with fever. See (Pediatric Ingredients: Osteopontin, by Arla Foods Ingredients, 8) for more information on the potential benefits of osteopontin as an infant formula additive for the health and development of infants.

/Disclosure: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes./

  1. Nutritional Cognitive Neuroscience Research at the Crossroads of Nutrition, Psychology, and Neuroscience,
  2. Reddan Jeffery M., White David J., Macpherson Helen, Scholey Andrew, Pipingas Andrew, Glycerophospholipid Supplementation as a Potential Intervention for Supporting Cerebral Structure in Older Adults. Frontiers in Aging Neuroscience, Vol. 10. 2018. DOI=10.3389/fnagi.2018.00049 ISSN=1663-4365
  3. Gimenez MS, Oliveros LB, Gomez NN. Nutritional Deficiencies and Phospholipid Metabolism. International Journal of Molecular Sciences. 2011;12(4):2408-2433. doi:10.3390/ijms12042408. (3)
  4. Jiang R, Lönnerdal B. Biological roles of milk osteopontin. Curr Opin Clin Nutr Metab Care. 2016 May;19(3):214-9.
  5. Bruun S, Jacobsen L N, Ze X, et al., Osteopontin Levels in Human Milk Vary Across Countries and Within Lactation Period: Data From a Multicenter Study. Journal of Pediatric Gastroenterology and Nutrition: Aug. 2018 – Vol. 67 – Issue 2 – p 250–256 doi: 10.1097/MPG.0000000000002004
  6. Camilia R. Martin,Pei-Ra Ling, George L. Blackburn, Review of Infant Feeding: Key Features of Breast Milk and Infant Formula. Nutrients 2016, 8(5), 279; doi:10.3390/nu8050279
  7. Lönnerdal B, Biological effects of novel bovine milk fractions. Nestle Nutr Workshop Ser Pediatr Program. 2011;67:41-54. doi: 10.1159/000325574
  8. Pediatric Ingredients: Osteopontin, Arla Foods Ingredients,