Falseness of research – JPA Ioannidis, 2015

Dr. Robert Malone more recently published an article summarizing how media and research have added to wrong information being spread and believed about Covid19.

Phil Harper, of The Digger Substack & new podcast, did an interview with Pierre Kory, MD, a doctor with the Frontline doctors working to help CoV patients. He uses Ivermectin successfully and discusses the difficulties and biased or false research that has been used to discredit use of a medication with a long and safe history – including a Nobel Prize. Towards the end of the interview he also points out that all effective treatments and dietary supports have been suppressed or discredited. He goes further to say it is a long history of the same fraud to support pharmaceuticals and suppression of effective low budget care. The suppression of side effects of psychiatric and other medications was also mentioned. To listen you do need to be a paid or free trial subscriber. (Phil Harper/Substack/The Digger)

John P.A. Ioannidis reviews research about bias and other effects that seem to do with competitiveness in a field of study – who will be first? Larger group numbers and larger effects tend to be more accurate than studies with small group size which found minimally significant effects. Financial interest in the outcome of the study also seems to impact reliability of the results of the funded research.

Why Most Published Research Findings Are False – Abstract, Summary

There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of true to no relationships among the relationships probed in each scientific field. In this framework, a research finding is less likely to be true when the studies conducted in a field are smaller; when effect sizes are smaller; when there is a greater number and lesser preselection of tested relationships; where there is greater flexibility in designs, definitions, outcomes, and analytical modes; when there is greater financial and other interest and prejudice; and when more teams are involved in a scientific field in chase of statistical significance.

Simulations show that for most study designs and settings, it is more likely for a research claim to be false than true. Moreover, for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias.

In this essay, I discuss the implications of these problems for the conduct and interpretation of research.

Citation: Ioannidis JPA (2005) Why Most Published Research Findings Are False. PLoS Med 2(8): e124. https://doi.org/10.1371/journal.pmed.0020124 https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0020124

Published: August 30, 2005, Copyright: © 2005 John P. A. Ioannidis. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Meme shared by Dr. Malone recently in an email newsletter.

Regarding manipulation in media in Germany/Europe, a file from Wikileaks is in German, papers about or by Gunter Wallraff, German author and undercover journalist (en-academic.com): https://www.dropbox.com/s/bq3fet4izfq0y2s/wallraff-aufmacher-unzensiert.pdf?dl=0

Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Public bathing facilities was an option in Rome

Why not return to the days of public bath houses without the lead lined aqueducts of Roman times?

While traveling in warmer states I noticed that there does seem to be a larger percentage of homeless people than in colder areas and it would add to the need for housing and restrooms. Colder climates have warming rooms for the small numbers of homeless located in their areas – just spending one night at a rest stop in a warm urban area showed me that the transient sleep in the car population would overwhelm the warming room located in the rural location. Locating a camp ground style public bathing and rest room facility near areas where homeless people congregate/are allowed to congregate might support public health and the homeless person’s ability to find a job while trying to survive on limited income. It is hard to find a job when just trying to find a restroom is difficult.

Incorporating health research into the benefits of magnesium sulfate salt baths or foot-soaks for substance abuse and chronic illness or mental illness populations could be a coordinated goal that might help fund the facilities. Magnesium deficiency is associated with anxiety, paranoia and anger that can progress to rage and violence. Magnesium deficiency is also associated with many types of chronic illness conditions and is more of risk with a variety of commonly abused substances including alcohol. The advantage of providing it in a bath or foot-soak is that the intestines can become less adept at absorbing magnesium and the kidneys more prone to excreting it in favor of calcium being better absorbed by the intestines and retained by the kidneys.

Headaches and other types of chronic pain and muscle cramp conditions can also be relieved by a magnesium sulfate (Epsom salt) or magnesium chloride topical soak or hand-cream type mixture. Working with a healthcare or insurance provider to test the efficacy of simply providing easier access to topical magnesium sulfate or magnesium chloride could help subsidize a homeless bathing facility or making the facility simply a pay to use community park addition could help subsidize it. charge a small fee for use of the shower or bath stalls. Truck stops charge around $12-14 dollars for use of nice quality shower area – that would likely be too costly for a homeless/low income person to be able to use very often. It is likely that a more campground style bathing facility could be provided for a lower cost to the individual purchaser of time in the facility while supporting the goal of improved public health. Making it a fee for use facility could help support cleaning staff for maintenance of the facility.

If research goals were incorporated then more support staff would be required to educate and obtain permission from participants in the project. Ethical medical research requires full disclosure of any potential risks of a research project as well as obtaining consent from the participants. The topical use of magnesium in the form of a bath or foot-soak can become too much of a good thing if used excessively or someone fell asleep in the bath. Twenty to forty minutes every few days is a beneficial amount when about a cup of Epsom salt is used in a bath or foot-soak.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Medical marijuana is not the same as an addiction

The need for medical marijuana may be a daily need like any other medication and physical or mental withdrawal symptoms may occur when it is not available just like many other medication.

There can be genetic reasons that someone may need an external source of phospholipids or cannabinoids from food sources throughout their lives for best health or the need may arise during an illness or later in life due to changes associated with aging. The cannabinoid system is involved with many other functions of the body so symptoms can be diverse when there is a lack and cravings for something may occur which may be interpreted incorrectly and other substances may be overused in addictive ways. Overeating food, use of alcohol, nicotine and heroin/opiates products may all be problems that occur with an underlying dysfunction in the person’s ability to make cannabinoids internally the way people of normal physiology are capable. I discuss this topic in more detail and include some legal food sources that are naturally better sources of cannabinoids or phospholipids in an section I wrote for my newer website https://effectivecare.info/addiction-or-starvation%3F

which is also copied onto this site with a few additional details about the salad recipe: Is it Addiction or Starvation?

While I am past the age of having babies, and entered grand parent age the need to reschedule marijuana for the purpose of research may be important for the fertility of younger women and men. The cannabinoid system is essential for both female and male fertility, in a U-shape need – too little or too much can be problems. Overuse of medical or recreational marijuana could interfere with fertility but an underlying deficiency could also be a cause of infertility in either gender.

Infertility problems can be caused by a problem with cannabinoid receptors or an excess or inadequate supply of cannabinoids. Research in the cannabinoid system and its effects on physiology beyond toxicity and addiction are limited due to the federal listing of the cannabis/marijuana plant as a Schedule 1 substance, something considered to have no medical value. However the listing is in error and a number of medical officials and organizations have recommended changing the federal listing. An overview of the research that is available on the cannabinoid system’s role in female and male fertility and reproduction is available here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034092/

The system is involved in the fertilized egg successfully implanting in the woman’s uterus and the cannabinoid system is involved in the male reproductive system in a few ways including the motility of the sperm – are they able to effectively get to where they need to go? A variety of cannabinoids exist and some also have effects on hormonal controls that occur within the brain that effect male reproductive health. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651943/

The balance of cannabinoids is critical and too much use of an external source such as medical marijuana is linked to male infertility, however again a U shape need exists. Some is necessary, too much or too little is a problem.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.