Tag: Cytokine Storm

Posted on

Snake venom like toxin is more exposed on free S1 subunit.

There is a cobra toxin-like gene sequence in the chimeric spike protein of either the SARS-C0V-2 virus, or the CoV injection’s spike sequence. (1) It likely can paralyze the function of nAChR clolinergic receptors, (4), . . . and medical world seems to be ignoring or denying that.

The solution is simple, though controversial – just start nicotine – OOOH, BUT THEN -> ADDICT! True, better off -> dead?

The dysfunction may be involved in the excessive menstrual bleeding or severe colitis like diarrhea. The cholinergic receptors also help modulate immune function to not produce too many inflammatory cytokines.

Chimeric – made of many species. The SARS-CoV-2 spike protein, and the sequence used for the CoV injections, also have similar genetic sequences to a wasp toxin, and it has genes from HIV and MERS. Chimeric – like the many headed hydra of mythology – they can all bite, and all may need to be dealt with to achieve health.

Summary:

  • Spike protein or the S1 subunit have a snake venom toxin like sequence which can block nAChRs receptors, and it disrupts the function of the nAChRs. (1, 4)
  • Nicotine is protective of the function of nAChR receptors, it is an agonist, an activator. It is addictive, yes, so is health.
  • The alpha 7 nAChRs are involved in preventing cytokine storm over-immune reactions, (2) ;
  • nAChRs are also involved in: menstruation/endometrial tissue (3); regular bowel movements; sperm motility; and functioning nAChRs are critical for prenatal and child development of the retina and eyes, and throughout life for retinal health, (5); nAChRs are needed to be able to send nerve signals from the ears to the brain – ie – to be able to “hear”. (7)

TRP channels are also needed to be able to hear, they are in the inner ear hair cells. (10) They are also throughout the body, needed for fetal development, (11), and magnesium absorption in the intestines, ().

Reports of harm to vision & hearing of children have been reported to VAERS.

VAERS reports of adverse reactions involving CoV injections include reports of children going blind or deaf. (6) That may involve cholinergic dysfunction of the nAChR receptors. (5, 7)

Spontaneous abortion/miscarriage in the first trimester has also been reported for most women who received CoV injections during the first trimester. (ref to add)

Lack of magnesium due to TRP channel dysfunction in the GI tract may be a factor in risk to a fetus if the TRP channels’ function is loss – which resulted in death, in a genetic animal study.

“Genetic inactivation of Trpm7 in mice results in early embryonic death17, 19. Conditional tissue-specific inactivation of Trpm7 in mice showed that TRPM7 plays a critical role in morphogenesis of various internal organs19,20,21.” (12)

Hearing & TRP channels: Hearing loss likely also involves damage to the inner ear hair cells. The TRP channel’s ankyrin repeat domains can be affected by the spike protein. (10) TRP channels with long stretches of ankyrin repeat domains are abundant in inner ear hair cells as they form a coil like area that can sense mechanical pressure and activate the TRP channel if a strong enough force is exerted on it. (8, 9) The open area of the ion channel is usually formed as an empty space between two very large protein subunits – similar building blocks put together in a circular pattern that can leave an open channel in the middle.

Simple solution – soak in magnesium sulfate and it enters the body through hair follicle pores – larger than TRP channels.

Epsom salt soaks are the simple solution to bypass the poor absorption of magnesium in the digestive tract. Both the magnesium and the sulfate are protective to the inner ear hair cells and the rest of the body. The hydrated form of a bath or foot soak may aid in the absorption. Magnesium sulfate was well absorbed from a bath relative, based on change in blood levels of magnesium. There have been less good results seen in topical magnesium chloride studies.

One to two cups of Epsom salt for a half-full bath, soak for 20-40 minutes. One cup or so in a large bucket or bin so more than the feet can soak, and soak for 20-40 minutes. Depending on the severity of magnesium deficiency a soak 1-3 times per week may be needed to help prevent muscle cramps or anxiety/anger. Low magnesium can affect depression risk or psychosis also.

Blocking nAChRs may add to risk of excess cytokines -sepsis; they help prevent an over-active production.

The retina is the area in the back of the eye where light sensing rod and cone cells are located. Activating the alpha7 nAChR type of receptors lead to improved cell survival in a model of glaucoma, (5) possibly aided by the anti-inflammatory role.

“Retinal ganglion cells treated with the α7 nAChR agonist [such as nicotine] alone demonstrated a 28.0% (± 12.8%) increase in cell survival over untreated control.”

The cholinergic nAChR receptors are involved in modulating an inflammatory cytokine response – so that it isn’t excessive and producing an over-active amount of cytokines as seen in sepsis.

“Due to its role in the downregulation of the production of pro-inflammatory cytokines, 33–35, it has been suggested that the α7 nAChR may be involved in the hyper-inflammation response that can be caused by SARS-CoV-2. 9, 36” (2)

So the more obvious colitis or excessive menstrual bleeding symptoms experienced from being around recently CoV injected people, may be an indicator that other excessive inflammatory responses are also happening throughout the body – and the solution is the same: nicotine activates the nAChRs and is protecting them, taking up the open spot in the receptor so S1 or Spike protein can not lodge in the spot instead – blocking its immunomodulatory or other functions.

Snake toxin sequence more exposed on the freed S1 subunit portion of the chimeric spike protein.

The chimeric spike protein can split into parts and both parts of the main spike are able to interact with cell receptors, S1 and S2. The gene sequence that is similar to a snake and snail type of toxin becomes more exposed on the separate S1 subunit – meaning it is likely then more interactive with nicotinic Acetylcholine Receptors.

“Notably, the exposure of this motif and its close sequential neighbors is further accentuated in the S1 trimer (Fig. 2C) shed after cleavage by the human proteases (TMPRSS2 or furin) to enable the activation of the fusion trimer of S2 subunits.” (1)

The ability to split into parts, at the Furin Cleavage Site (FCS), is unique to the chimeric spike protein. Other coronavirus spike proteins do not have that capability.

Furin Cleavage Site

Chimeric spike protein is unlike any other CoV spike in that it can break into parts, subunits, at the Furin Cleavage Site (FCS), leaving S2 attached to the base part and freeing S1, both elongated halves of the spike: /\_ -> / and \_ .

The full spike can interact with ACE2 and various receptor types – and the S1 and S2 subunits can also, they are elongated. The base parts are smaller. Receptors are like a keyhole, & the spike, S1, & S2 are like a key that can fit in, but jam it -> no function, or dysfunction.

The S2 and base, \_ , stays attached to the human cell membrane if produced by a CoV injected person, (which would never happen in a real viral infection); or it would stay on the viral membrane in an CoV infection.

The S1, / , is freed, loose, floating in extracellular fluid… and the gene sequence that is cobra toxin like, PRRA, is more exposed on the freed S1, than it is in the full spike. The freed S1 could then travel to other areas of the person & block their nAChR receptors, or it might be excreted in sweat or breathed out.

The fact that un-CoV-injected people are getting symptoms after being around CoV-injected people suggests that it is an aerosolized risk. Standard fabric face masks would not be protective but better quality KN95 masks seem helpful.

People getting menstrual bleeding symptoms after being around recently injected people is likely because S1 exposure in a large enough load to be paralyzing the function of nAChR receptors in endometrial tissue (uterus). That link mentioned smokers are less at risk for endometreosis (excess menstrual blood but internal clotting), & that nAChR agonists might be a therapy to consider. (3)

Health Aids for Special Times – foods, phytonutrients and nutrients, and some lifestyle habits that may help protect against chimeric protein issues.

This document includes a lengthy section titled Excessive Menstrual Bleeding with information about nicotine, and colitis related to spike exposure may also be related to nAChR disruption and benefit from nicotine treatment – that is the problem it helped me with. The document also has information on Sleep and Iodine/Thyroid, in addition to chimeric protein related aids. When many types of receptors can be disrupted – they all need to be protected ideally. My website jenniferdepew.com has page Nutrients and page Cofactors with dosing details about a variety of other nutrients not specified in the document.

Disclaimer: This information is being shared for educational purposes within the guidelines of Fair Use. It is not intended to provide individual medical guidance. Please seek a health care provider for that purpose, such as a functional health nutritionist or practitioner.

Reference List

  1. Mary Hongying Cheng, She Zhang, Rebecca A. Porritt, Magali Noval Rivas, Lisa Paschold, Edith Willscher, Mascha Binder, Moshe Arditi, Ivet Bahar. Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation. Proceedings of the National Academy of Sciences. Sep 2020, 202010722; DOI: 10.1073/pnas.2010722117 https://www.pnas.org/content/early/2020/09/25/2010722117
  2. Oliveira, A., Ibarra, A. A., Bermudez, I., Casalino, L., Gaieb, Z., Shoemark, D. K., Gallagher, T., Sessions, R. B., Amaro, R. E., & Mulholland, A. J. (2020). Simulations support the interaction of the SARS-CoV-2 spike protein with nicotinic acetylcholine receptors. bioRxiv : the preprint server for biology, 2020.07.16.206680. https://doi.org/10.1101/2020.07.16.206680 https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7386492/
  3. Wu Y, Wang LP, Pan JQ. Nicotinic acetylcholine receptor agonists may be a novel therapy for endometriosis. Med Hypotheses. 2011 Nov;77(5):745-7. doi: 10.1016/j.mehy.2011.07.028. Epub 2011 Aug 10. PMID: 21835554. https://pubmed.ncbi.nlm.nih.gov/21835554/
  4. Farsalinos, K.; Eliopoulos, E.; Leonidas, D.D.; Papadopoulos, G.E.; Tzartos, S.; Poulas, K. Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications. Int. J. Mol. Sci. 2020, 21, 5807. https://doi.org/10.3390/ijms21165807 https://www.mdpi.com/1422-0067/21/16/5807/htm
  5. Lyons Leah, Neuroprotective Effect of an Α-7 Nicotinic Acetylcholine Receptor Agonist and a Positive Allosteric Modulator in an In Vitro Model of Glaucoma. (2014) Masters Thesis, http://scholarworks.gvsu.edu/theses/740 https://www.dropbox.com/s/v8jrb56w1iwzs1u/physician_assistant_studies_thesis.pdf?dl=0
  6. Stew Peters Show, CHILD JAB INJURIES – FIRST NUMBERS REPORTED, SERIOUS DANGER! THEY ARE KILLING THE CHILDREN. https://www.bitchute.com/video/HIEsLK1BO1bQ/ via “VAERS reports include children going blind and deaf after Covid-19 v@ccine.” https://twitter.com/awakenindiamvmt/status/1443547600460738568?s=20
  7. Moglie Marcelo J., Marcovich Irina, Corradi Jeremías, et al., Loss of Choline Agonism in the Inner Ear Hair Cell Nicotinic Acetylcholine Receptor Linked to the α10 Subunit. Frontiers in Molecular Neuroscience. 14 (2021) pp 5, DOI=10.3389/fnmol.2021.639720 https://www.frontiersin.org/articles/10.3389/fnmol.2021.639720/full
  8. Gaudet R. A primer on ankyrin repeat function in TRP channels and beyond. Mol Biosyst. 2008;4(5):372-379. doi:10.1039/b801481g https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3006086/
  9. Phelps CB, Huang RJ, Lishko PV, Wang RR, Gaudet R. Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry. 2008;47(8):2476-2484. doi:10.1021/bi702109w https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3006163/
  10. Halim Maaroufi, Interactions of SARS-CoV-2 spike protein and transient receptor potential (TRP) cation channels could explain smell, taste, and/or chemesthesis disorders. 15 Jan 2021, https://arxiv.org/abs/2101.06294
  11. TRPM7 channels are needed in embryo development and also have an ankyrin repeat sequence. Jingjing Duan, Zongli Li, Jian Li,  et al., Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. Proceedings of the National Academy of Sciences Aug 2018, 115 (35) E8201-E8210; DOI: 10.1073/pnas.1810719115 https://www.pnas.org/content/115/35/E8201
  12. Ferioli, S., Zierler, S., Zaißerer, J., et al. TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg 2+ and Mg ATP. Sci Rep 7, 8806 (2017). https://doi.org/10.1038/s41598-017-08144-1 https://www.nature.com/articles/s41598-017-08144-1

Notes related to specific health aids that may protect against epigenetic changes, or in other ways.
Posted on

EPIGIRL 2

EpiGirl is a fictional character in the SPARS epidemic scenario that was published in 2017. EpiGirl collates the adverse reaction reports from VAERS and other patient forums and it seems worse. The scenario works through that issue by suggesting it was duplicated records.

2017 SPARS Report –

A database is needed, collecting data is needed – that is basic to experimental design – collect data, all the data. And in this case, all the data includes adverse reactions in the experimental group or in those with passive exposure reactions. That is even stated in the branded experimental design literature. In this case data is not being collected and definitions are being changed so the data that is being collected does not match the redefined label.

A whistleblower nurse shared what is happening with the data regarding who is in the hospitals with Covid currently – the experimental group (vac) or the control group (unvac)? The definition was changed to call anyone within 14 days of an injection unvaccinated, allegedly because their antibodies wouldn’t be expected to be elevated enough to be protective yet. That may be true but it doesn’t change the fact the person was in the experimental group – did receive an injection, or a second injection – they are no longer in the ‘unvaccinated’ control group immediately after getting the first injection.

The adverse reactions tend to occur early also, within the first few days after an injection, or second one, according to the nurse. See the full story here: twitter.com/AxelSavage4/status/1437624425281511429?s=20.

From the replies:

“Benny Nomad@BennySeattle· Replying to @AxelSavage4 : “Have you considered that what you are describing is fraud? They are calling everyone who has had their first shot un-vaxxed, and if they have had the second shot, for the following 14 days they are still considered un-vaxxed. How is that not fraud?

LibertySavage@AxelSavage4· “That’s exactly what it is”

The first injection or exposure can prime an allergy-like over response of the immune system to occur the next time the antigen is present in the body. People who were already sick with CoV may be at more risk of an over-reaction to an injection, because their immune system was primed by the earlier sickness.

Another medical professional shared concerns over underreporting of adverse reactions, to the US VAERS adverse reaction database. Doctors are being threatened to not report cases to the system. See: EXCLUSIVE: COVID Whistleblower Claims the VAERS Reporting Database Tracking Vaccine Complications is WRONG and Undercounting by a Factor of 100! (thegatewaypundit.com/2021/09)

170,000 comments about adverse reactions have been submitted to a news website:
https://twitter.com/LetUsUniteHere/status/1438348203334766598?s=20

News article about the ABC website postings: Unexpected and heartbreaking: Thousands flood ABC affiliate’s Facebook page with vaccination horror stories. (Sept 13, 2021, worldtribune.com) “39,000 responses (as of mid-day Sept. 13)“

We need reliable data that has been double checked for identity, confidentially, in order to prevent duplication of record entries. We need reliable data that is contained in a cybersecure location on a hosting platform that is independent from technology that may be compromised regarding reliability, on Linux systems for example.

  • *Guidance is being provided on Telegram, if you are interested in learning about using Linux instead of Windows type systems. Sign up on Telegram first, and then search for and follow ‘Jeffrey Peterson,’ in his pinned posts look for the discussion Chat room link: @jptchat. People are helping each other get set up and Jeffrey also provides guidance and has tutorials.
  • Invite link: JP’s technology chat: https://t.me/jptchat

EPIGIRL 2 will need funding and a lot of volunteers around the world. These adverse reactions are happening around the world. The injection batches were not claimed to be or required to be, all the same product, so different locations may have been test cases for different experimental batches. Adverse reactions may cluster by batch/location, not just by ethnic/genetic or health differences. Without reliable data at an international level, those patterns will not be revealed. Giving us the need for EPIGIRL 2 – Epidemiologic Patterns in Genetics; Injection Reaction Log – an Extremely Professional, International, Giant, Injection Reaction Log. EPIGIRL squared – two names to represent the two strands of the double helix of a DNA molecule.

The recommendations made by the committee investigating adverse reactions should be included as the basis of EPIGIRL 2 (from the last post, Chimeric Spike, with Prion-like areas). If we are to follow the ‘science’ – that is what the science says:

Immunization Safety Review Committee

  • Surveillance of adverse events related to vaccines is important and should be strengthened in several ways:
  • The committee recommends that standardized case definitions for adverse events be adopted.
  • The committee recommends that formal guidelines or criteria be developed for using VAERS data to study adverse events.
  • The committee recommends the continued use of large-linked databases, active surveillance, and other tools to evaluate potential vaccine-related adverse events.
  • The committee supports the development of Clinical Immunization Safety Assessment (CISA) centers to improve understanding of adverse events at the individual level.
  • One area of complementary research that the committee continues to recommend is surveillance of ASD* as exposure to thimerosal declines. (*Autism Spectrum Disorder)
  • The committee recommends increased efforts to quantify the level of prenatal and postnatal exposure to thimerosal and other forms of mercury in infants, children, and pregnant women. 
  • 2. Excerpt : Immunization Safety Review: Vaccines & Autism, BOX 2, Comm. Conclusions & Rec. Institute of Medicine (US) Immunization Safety Review Committee. Washington (DC): National Academies Press (US); 2004. https://www.ncbi.nlm.nih.gov/books/NBK25349/#a2000af8fddd00068

The SPARS report predicted an EpiGirl – we need her, badly, desperately – truthfully. This is dangerous, and is a genocide because some are more at risk than others.

Methylation: Anyone with methylation gene defects would be more at risk for epigenetic gene changes which can lead to conditions like POTS. See: Epigenetic changes may also be involved in Covid19 or LongCovid, Nov 18, 2020. They would be healthier by not taking standard B supplements which have unmethylated forms of B12 and folate. Instead seek out food sources that aren’t the supplement fortified types, and/or methylated forms of folate and B12 (not folic acid or cyanocobalamin – yes the standard form of B12 used in the US contains cyanide and taking too much of it for too long can lead to cyanide poisoning – does it make sense to use cyanide in a dietary supplement? NO, but that is off-topic.).

BHMT: People with a BHMT gene allele would also be more at risk for inflammatory membrane break-down. There is an ethnic difference in rate – people with Caucasian or African ancestry are more likely to have a defective BHMT gene allele than people of Asian ancestry. See: Cannabinoids are made with the BHMT gene (and others). Feb, 25, 2021.

Glyphosate: Glyphosate residue is also likely a factor in rate of severe reactions in CoV illness or injection reactions. See: Glyphosate and COVID-19, Oct 25, 2020, it has dietary tips for trying to reduce glyphosate intake and improve the negative effects. Glyphosate can increase the risk of misfolded proteins and may be adding to the out of control inflammation. It also likely is increasing the risk of low vitamin D and minerals such as manganese and the amino acid methionine. Manganese is really essential for mitochondria to function normally. Tracking patterns of severity of illness over geographic regions that produce or use more biofuel made with biomass from glyphosate crops is a need. Asking people with adverse reactions, and the control group, those without, to have a urine test for glyphosate residue, is a need. Reliable data requires collecting data in a method that is consistent and has quality control standards to assure the results are reliable. How a sample is taken, stored, and tested, all may affect quality of the results.

Citric Acid Cycle Nutrients & Cofactors: The spike protein is harming mitochondria, which then the debris from the mitochondria, harms our cells. We need to protect our mitochondria as cancer and other chronic degenerative disease is preceded by dysfunction of mitochondria. They switch from using oxygen and the Citric Acid Cycle. For mitochondria to be able to perform the chemical reactions of Citric Acid Cycle they require that we have nineteen different nutrients and cofactors available to them – and in balance and in adequate amounts – not just ‘one’ nutrient. One problem/one cure – is not how the body works or how nutrition works.)

Cytokine storm risk: Ten to fifteen percent of the population are estimated to be at great risk for a severe cytokine storm reaction to ANY severe immune challenge, whether a vaccine or an infection. (5) See: Cytokine Storm, SIDS, autism and Vitamin C, March 29, 2020. Their bodies do not react normally to infection. Genetic screening is needed to identify the genes involved and then screen for those at risk.

In the meantime, high dose intravenous vitamin C (Marik Protocol) therapy does work well to reduce the cytokine storm from escalating and prevent the damage that can be caused by it. See: Bitter taste receptors in the lungs & Hesperidin’s decongestant properties. April 7,2020 < the food and supplement recommendations are still valid.

“You can lead a horse to water, but you can’t make it drink.” Self care – includes the word self, because oneself, is in charge of self care. It is not about spa treatments or getting disabling nail extensions applied with potentially toxic chemicals. That is not self care in any kind of health sense.

The only problem with that plan is that the FDA is preventing use of the treatment for Covid related care. It does not have risky side effects and has a large amount of supportive research for similar cytokine conditions. There is no sensible reason to not approve it for use during an alleged pandemic emergency – if we have an emergency, then we should be providing emergency care to those who need it – NOT WITH-HOLDING IT, or criminalizing the use of it by independent physicians who deem it in their patient’s best interest.

Vitamin C given in advance of a vaccine may also help reduce the risk of an over-reaction of the immune system – even for animals that can make some of their own vitamin C (we can’t make any). From the post: “Giving extra vitamin C before vaccines was found to be protective even in lab animals that genetically can make vitamin C. (4)“

If health is the goal – then why hasn’t everyone been told that taking vitamin C in advance of a vaccine can help prevent an over-reaction of the immune system?

If health is the goal – then why don’t we screen for the 10-15% who will have a very severe reaction, which may result in a neurological condition that lasts the rest of their life, and EXCLUDE them from being given an immune challenge? They likely would never get exposed to tetanus or many of the other rare conditions that many vaccines are designed to protect against.

If health is the goal – then why did 170,000 people reply to a news-site about the death of someone they know that occurred after a CoV injection? If the VAERS system is only collecting 1% of adverse reactions, and currently shows a death count of ~14000 (check this, yes, almost 15,000 now, and over 19,000 people were left permanently disabled after CoV injections).

If health is the goal – then why are the CoV injections seeming to be used as a euthanasia device?

Adverse reaction entry to VAERS, shared by AMM MD on Telegram, invite link if you are on Telegram:

AMM, MD
Covid vaccine AEs and other hidden truths
https://t.me/AMM_MD

“WHY VACCINATE PEOPLE IN THE LAST DAYS OF THEIR LIFE? 🤬” (- AMM MD)
71 yo F “In her end days of lung cancer was not eating and drinking very little for 3d before vaccination was given. She became very ill as she was told she might and was unresponsive and in the hospice 2d later. [Died 6d after vax.]. The adverse effects of this vaccine served no purpose to be administered to an imminent end to this dying woman. The vaccines effects would never have gotten in her body till after she had died and only made her more sick and weak then she needed to be.
Write-up: Suddenly more weak , exhausted, all around much worse then she had been feeling as she was in her last days of lung cancer. Within hours of the vaccine she was worse and in 2d unresponsive and in a hospice. 4d [later] she died.” 1637303″ (quoted from VAERS, the US adverse reaction database).

Health doesn’t seem to be the goal to me.

15 Signs That You Might Be an Abusive Government (or Relationship).
– guidance about emotional manipulation- domestic violence often dies not include outright hitting, may just be threats or verbal abuse, or silent treatment to ‘punish’ the victims.

American Frontline Doctors is a group working towards making early treatment available to anyone who wants it. Their site has a proposed Vaccine Bill of Rights: https://americasfrontlinedoctors.org/take-action/the-vaccine-bill-of-rights/

EPIGIRL 2 is needed, with a giant team, for a giant project, because a giant massacre is happening, and being lied about – ask yourself “What would Viktor Fankl do?”

Answer – take notes, really good notes.

More info: Viktor Frankl on the Human Search for Meaning, Maria Popova, (brainpickings.org).

I have begun a Protocol on a supplement dispensing site – people who enroll as clients could order at a discount from the items I’ve prescreened and added dosing details for, or browse the catalog. People who enroll as clients could be later added to an EPIGIRL 2 database. Starting is a place to start.

The Protocol: Health Aids for Special Times – it has a lot of food and general health info also. I maxed out the memory and need to copy it over to a pdf though, and probably break the supplements and protocol into smaller groups. Important point to add – to detox – don’t overeat regularly. The body needs to get a little hungry to have the time and need for white blood cells to go looking around for cellular debris to clear up and reuse for nutrients. When we overeat the body and blood cells are busy coping with storing all the excess nutrients as fat or cholesterol plaque or excreting some of it.

Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Posted on

Cytokine Storm, SIDS, autism and Vitamin C

The over-reaction of the immune system to any infectious stimulant whether an infection or vaccines, may be a cause of Sudden Infant Death Syndrome (SIDS) (1) and the encephalopathy (2) that is a frequent factor in later development of autism. (3)

Sudden Infant Death Syndrome may be a toxin overload as success was achieved with mattress covers in Australia that prevented volatile chemicals or mold spores from reaching the baby. Crib mattresses often contain vinyl or fire retardants and a used mattress likely has mold even if not obvious. It can be healthy for infants to sleep on their belly as helps with even muscle development and skull shape. Babies that are held or left in the same position all the time can development flattened areas on the skull and limit muscle development. See previous post1, post2, post3.

Giving infants and children vitamin C prior to vaccines orally with juice may be protective against the harmful excess production of inflammatory cytokines. Giving a larger amount intravenously for adverse reactions may also be protective against the cytokine overreaction from worsening as the larger amount of vitamin C has an inhibitory effect on the production of them as well as helping as an antioxidant to detoxify the ones already made in excess. Giving extra vitamin C before vaccines was found to be protective even in lab animals that genetically can make vitamin C. (4)

Cytokine Storm over-reactions may be more of a risk due to genetic differences in as many as 10-15% of the population. (5) Symptoms of a Cytokine Storm reaction can include: “high fever, enlarged spleen, excessive bleeding, low counts of all types of blood cells (red, white and platelets) and, potentially, multiple organ failures.” (5) Diarrhea is unpleasant and can kill if it continues for long however multiple organ failures is more deadly.

Providing vitamin C as a protection against the risk of an overreaction of the immune system would be low cost and has had a low risk of side effects. Diarrhea occurs if excess is taken by mouth so there is little risk of too much being absorbed in the GI tract, and adverse reactions to higher doses of vitamin C given as intravenous therapy have not been prevalent (1%) in studies using the treatment as an addition to chemotherapy treatments. (6)

“Phase I studies of IV C alone & in combination with chemotherapy have reported excellent safety profiles 1–8,33. A survey of providers who used IVC for 9328 patients reported an adverse event rate of 1.0% 68..side effects of IVC…nausea, dizziness, dry mouth, perspiration, & weakness. 6,7” (6)

Giving vitamin C to infants and children would be providing them with a nutrient than most animals can produce for themselves. Humans had a genetic change that caused a loss of the ability. Giving vitamin C to infants and children might also help protect against a potentially fatal or brain damaging over-reaction of the immune system. If 10-15% of the population are genetically more at risk for the excess production of cytokines, (5) , then a government policy that mandates vaccinations would be genetically targeting those individuals for increased risk of an adverse reaction or death – a genocide.

Learning more about the gene differences involved in the increased risk for a Cytokine Storm reaction, and screening the population for the genes would also be helpful so those individuals would know that they have increased risk of death if they have an infection or strong immune reaction to something.

The Committee  to Review Adverse Effects of Vaccines that was asked to assess the research on autism and vaccines did not say there was no risk of autism from vaccines – they said there was a lack of evidence – more research was needed.

“The committee particularly counsels readers not to interpret a conclusion of inadequate data to accept or reject causation as evidence either that causation is either present or absent. Inadequate data to accept or reject causation means just that—inadequate. It is also important to recognize what our task was not. We were not charged with assessing the benefits of vaccines, with weighing benefits and costs, or with deciding how, when, and to whom vaccines should be administered.“

Committee to Review Adverse Effects of Vaccines
Board on Population Health and Public Health Practice, Institute of Medicine (7)

Disclaimer: This information is provided for educational purposes within the guidelines of Fair Use. It is not intended to provide individual guidance. Please seek a health care provider for individualized health care guidance.

Reference List

  1. Siri Hauge Opdal, PhD., Chapter 30: Cytokines, Infection, and Immunity, from the book SIDS Sudden Infant and Early Childhood Death: The Past, the Present and the Future. Duncan JR, Byard RW, editors., Adelaide (AU): University of Adelaide Press; 2018 May. https://www.ncbi.nlm.nih.gov/books/NBK513388/
  2. Cytokine Storm, ScienceDirect.com, https://www.sciencedirect.com/topics/medicine-and-dentistry/cytokine-storm
  3. Kern JK, Geier DA, Homme KG, Geier MR. A ten year longitudinal examination of the incidence rate and age of childhood encephalopathy diagnoses in an autism spectrum disorder diagnosed cohort. Acta Neurobiol Exp (Wars). 2020;80(1):66–75. https://pubmed.ncbi.nlm.nih.gov/32214276/
  4. C. Alan B. Clemetson, M.D., Rapid Response: The prevention of vaccine reactions. BMJ 2004;328:51 https://www.bmj.com/rapid-response/2011/10/30/prevention-vaccine-reactions
  5. University of Alabama at Birmingham, Here’s a playbook for stopping deadly cytokine storm syndrome. Nov 11, 2019, theivcenter.net, https://theivcenter.net/wp-content/uploads/2018/05/Vit-C-and-Cancer-Support.pdf
  6. E. Klimant, H. Wright, D. Rubin, et al, Intravenous vitamin C in the supportive care of cancer patients: a review and rational approach. Curr Oncol. 2018 April;25(2):139-148, https://theivcenter.net/wp-content/uploads/2018/05/Vit-C-and-Cancer-Support.pdf
  7. Institute of Medicine (U.S.). Committee to Review Adverse Effects of Vaccines.  Adverse effects of vaccines : evidence and causality / Committee to Review Adverse Effects of Vaccines, Board on Population Health & Public Health Practice ; Kathleen Stratton … [et al.], eds.  ISBN 978-0-309-21436-0 (PDF)  https://www.nap.edu/read/13164/chapter/1
Posted on

Updates/ Vitamin C Infusion is helping CoV-19 patients in New York.

Addition – Food sources of vitamin C, quercetin, and zinc are at the top of this document, which includes this blog post and a few others on the topic of COVID-19 (Antivirals in Foods) Eating good sources several times a day may help the body prevent infection or have a less severe case.

Virus enter a cell and are replicated to the cell’s capacity to produce them, at that point the cell bursts releasing the newly formed virus which go and infect other cells and force those cells to make even more virus to the cell’s capacity, and they all burst, releasing yet more virus – in an exponentially increasing number. Each time a cell bursts and releases the viral load, the cell dies. So the sooner you can help your body stop the viral replication the sooner you are protecting your cells from being killed by the process.

Megadoses of the nutrients that help stop viral replication may not be needed. Moderate amounts of good food sources may help the body fight the infection before it has spread to numerous cells and caused significant cell damage. Reducing infection load may also help prevent an over-reaction of the immune system to the infection. An over-reaction of the immune system can be deadly as the inflammatory chemicals can attack healthy cells and lead to organ failure and eventually death. The next section is about a nontoxic treatment that might help if an over-reaction of the immune system leads to a Cytokine Storm/sepsis reaction.

Foods contain antivirals that work in a similar manner to the chloroquine medications that we have been hearing about in the news. More production is needed before they are available for widespread use, and they are somewhat expensive and can be dangerous. Quercetin is a phytonutrient that is readily available in vegetables and fruits and as a bulk or individual supplement.

Nursing homes and hospitals could be adding the bulk supplement powder to a food at each meal and including zinc food sources. The zinc is carried into infected cells by the quercetin (or chloroquine) and the zinc disrupts viral replication. The chloroquine, quercetin, or zinc are not killing virus. White blood cells are the body’s patrol for killing and removing infected cells.

Health takes work and work takes nutrients.

  • Vitamin C helps the immune system fight infection. Good sources include: cabbage, tomatoes, green peppers, broccoli, asparagus, peas, kale, & citrus, strawberries, kiwi, papayas, cantaloupe. (Vit C Fact Sheet)
  • Good food sources of quercetin include: red onion, onion, garlic, kale, tomatoes, asparagus, broccoli, capers, nuts and seeds, red grapes, cherries, olive oil. Herbal supplements also containing quercetin include St John’s Wort, Gingko biloba, and American Elder. (WebMd) 
  • Good food sources of zinc include oysters, meats, poultry, dairy, cashews, pumpkin seeds. Other beans, nuts and seeds would also have some as vegan sources. Meats have more than the vegan sources, while oysters have so much zinc that it might risk excess if eaten regularly in large servings.  (Zinc Fact Sheet).

There are no guarantees in life, but trying a nontoxic strategy is at least safe. Medications may have risks of side effects – always see a medical professional for individualized health care guidance.

Vitamin C Infusion for Cytokine Storm immune overreactions.

Good news updates – a hospital chain in New York has found the use of high dose intravenous Vitamin C Infusions helpful for patients infected with the SARS-CoV-2 (COVID-19) novel coranovirus. “Dr. Andrew G. Weber, a pulmonologist and critical-care specialist affiliated with two Northwell Health” is providing his patients who have sepsis/cytokine storm symptoms an intravenous drip with 1500 mg of vitamin C three or four times per day. (1) Patients getting the Vitamin C treatment have been helped more than patients who did not according to Dr. Weber. A spokesperson for the Northwell Health system said that vitamin C is being “widely used” at their hospitals where 700 patients approximately are being treated for SARS-CoV2, however it varied by patient need and the clinician’s plan of care. (1, 2)

“The patients who received vitamin C did significantly better than those who did not get vitamin C,” Weber said. (1)

The protocol for the treatment also includes vitamin B1 generally but that news article doesn’t mention that ingredient of the IV mixture. The treatment is a much larger amount of vitamin C than the daily recommendation for a normal diet, however a patient with an overactive immune response is not in normal health. The treatment is used for patients who have had an overactive immune response to the infection and their own immune cytokines become produced in excessive amounts. The cytokines can then start damaging the patient’s own organs which can lead to organ failure and result in death.

The damaging immune chemicals in a normal response to infection would only attack the infected cells. The excessive amounts however use up all supplies of vitamin C in the patient’s body, and supplying vitamin C in high doses is then very helpful for protecting the patient from harm by the excess.

Quercetin plus zinc is a zinc ionophore, and is being tested as an anti-viral in human clinical trials for the treatment of SARS-CoV2 (COVID-19).

Good news update regarding quercetin and zinc as a zinc ionophore – the combination had already made it through animal trials for use against Ebola, and SARS-CoV(1) and was approved by the FDA for human clinical trials. Plans were underway for it to be trialed in China for patients with SARS-CoV2 (COVID-19). I haven’t found results yet.

  • CBC News Interview with “Dr. Michel Chrétien’s team at the Clinical Research Institute of Montreal” : Canadian team invited to do clinical trials in China for antiviral drug. Feb 28, 2020, (youtube).

UK What to do if at home with a Potential Infection, Guidance:

Stay at home: guidance for households with possible coronavirus (COVID-19) infection. Updated 24 March 2020, (gov.uk).

*The UK guidance recommends isolating for seven days after symptom onset, – it might be wise to use caution longer than, especially if trying to protect people in your home who are in a high risk group, which includes: Senior Citizens, people with asthma or other lung conditions, smokers, people with hypertension, and immune-compromised people.

While the infectious stage seems to start prior to symptom onset and to have the most risk of spreading the infection during the early days of symptoms, when a fever is also often a symptom, that might not be consistently true and not everyone infected with SARS-CoV-2 gets a fever. The longest a patient has been found to be infectious was 37 days and the shortest was eight days. The average for patients with severe symptoms being treated in a hospital to be infectious was 19 days and for patients with critical symptoms the average was 24 days to remain infectious. (4)

Sensible precautions if sharing a home with infected and non-infected people include:

  • Cover your coughs or wear a mask or bandana to catch respiratory droplets from your breath, coughs or sneezes. Try to avoid being in the same room with non-infected people if possible, at least during the highest risk days during the early onset of symptoms, or positive test result.
  • Wash hands often and sanitize or wash with soap any commonly used surfaces such as door knobs, kitchen and bathroom areas.
  • Don’t prepare raw foods for non-infected people if you can avoid it. Otherwise wash hands thoroughly or wear food preparation gloves if possible after the initial week or two of more severe feverish symptoms has passed.
  • US CDC guidance for home care of a person infected with SARS-CoV2 https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-prevent-spread.html

This is doable – the quercetin rich foods mentioned in the last post plus sinc supplements or foods may provide a protective effect against getting a viral infection. Stay calm and eat sauteed onions or citrus with a little of the peel left on, plus pumpkin seeds or meats. Best wishes for everyone’s health!

Request for plasma donations from people recently recovered from SARS-CoV2, Mount Sinai

There is a request for people who have recently recovered from SARS-CoV2 (COVID-19) and who would be willing to donate plasma if they have antibodies against the infection to contact Mount Sinai’s medical team. Antibody rich plasma can be given to severely ill patients with the infection to help them fight the virus. They can check for the presence of antibodies. Contact: COVIDSerumTesting@mountsinai.org, see (Statement from Mount Sinai Chief Medical Officer, (via @MikeDelMoro/via @joshchafetz).

Mount Sinai medical system has developed a test for checking for CoV-19 antibodies within hospitals and are sharing the technique: BREAKING: The First U.S. Test to Detect If a Person Has Potential Immunity to COVID-19 Was Just Developed (leapsmag.com)

Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Reference List

  1. Lorena Mongelli and Bruce Golding, New York hospitals treating coronavirus patients with vitamin C. March 24, 2020, NYPost.com, https://nypost.com/2020/03/24/new-york-hospitals-treating-coronavirus-patients-with-vitamin-c/?utm_campaign=SocialFlow&utm_medium=SocialFlow&utm_source=NYPTwitter
  2. Dan Lyman, Coronavirus Patients Being Treated With Vitamin C at New York Hospitals. March 25, 2020, https://www.newswars.com/coronavirus-patients-being-treated-with-vitamin-c-at-new-york-hospitals/
  3. CBC News Interview with “Dr. Michel Chrétien’s team at the Clinical Research Institute of Montreal” : Canadian team invited to do clinical trials in China for antiviral drug. Feb 28, 2020, (youtube).
  4. Fei Zhou, Ting Yu, Ronghui Du, et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet, March 11, 2020, DOI:https://doi.org/10.1016/S0140-6736(20)30566-3 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30566-3/fulltext#back-bib33
  5. Kira Peikoff, BREAKING: The First U.S. Test to Detect If a Person Has Potential Immunity to COVID-19 Was Just Developed. March 22, 2020 leapsmag.com, https://leapsmag.com/breaking-the-first-u-s-test-to-detect-if-a-person-has-potential-immunity-to-covid-19-was-just-developed/?fbclid=IwAR2z_hl9VZfsrjz2JL03Sze2cPscdqGTFD0VyBrSbUvx-bOP8f5lmz9BgdU