Probiotics, vitamin K and calcification

Vitamin K is made with the help of probiotics and our ‘good guy’ intestinal bacteria.  Adequate vitamin K may help prevent calcification of soft tissue and potentially reduce the risk for heart disease and some types of cancer. Healthy intestinal bacteria can make vitamin K in a form that is well absorbed compared to the form found in vegetables and a few other foods.Vitamin K1 is more common in the diet in many green vegetables but it is poorly absorbed. Vitamin K2 is found in foods made with active bacterial cultures like yogurt, sauerkraut, kim chee and some cheeses.

The richest food sources of vitamin K include green leafy vegetables like spinach, kale, Brussels sprouts and broccoli. It is also found in small amounts in egg yolk, some meats, flatfish and eel. Dairy products like yogurt or cottage cheese may contain vitamin K as a side product of the active cultures. Natto, miso, tempeh, kim chee and other live cultured products may also be a source of vitamin K depending on the type of bacteria used in processing. Sauerkraut and dill pickles sold from a refrigerated case may be a source of the live ‘good guy’ bacteria. The fermented products provide some vitamin K and provide the good guy bacteria that can keep making more vitamin K while protecting against yeast and less friendly bacteria. Spoilage does occur with live products. Food safety guidelines and ‘use by dates’ should be followed. [4] [6]

Probiotic supplements are also available that are designed to provide some of the good guy bacteria in a capsule. Check the source for quality control standards and storage recommendations.

Vitamin K helps the body make the hormone, osteocalcin, which helps signal calcium to enter bone tissue [4] and is important for regulating blood sugar levels.[13] Adequate vitamin K helps the calcium stay in the bone tissue and reduces the risk of soft tissue calcification. Hardening of the breasts may not lead to heart attacks, a risk with arteriosclerosis, or the hardening of arteries from calcium/cholesterol deposits, [910] but the condition isn’t likely to be comfortable either. Calcium is electrically active inside of the cell and can signal membranes to break down. Calcium deposits in soft tissue may be enclosed in fatty cholesterol deposits to help prevent the risk of inflammatory membrane break down.

Vitamin K is essential for blood to clot but it is also very important for preventing calcification of soft tissue. Calcium deposits add to hardening of the arteries or arteriosclerosis but abnormal calcification is also seen in some cases of breast cancer. [3] Calcification of soft tissue becomes more common in people over 50 and is frequently considered a normal part of aging. However soft tissue calcification can be a symptom of excess vitamin D intake and can be a symptom of vitamin K or magnesium deficiencies.

A study found less incidence of prostate and lung cancer in participants who reported more intake of vitamin K foods. The link with breast or colon cancer was less clear but the study was based on self reported intake of common foods and cheese was the richest food source of vitamin K reported (cheese is also a source of calcium). None of the study participants had an estimated intake of vitamin K that met the RDA. In the U.S. 120 mcg is recommended for men and 90 mcg for women. In the study 24,340 adults were followed for ten years and averaged less than 100 mcg/day. [7] A cup of carrots has about 15 mcg, a cup of kale has 1054 mcg (but the form is not well absorbed) and a cup of sauerkraut has 81 mcg. [8]

Bacteroides is a family of bacteria that are commonly found in the intestines. Some helpful bacteria are known to make vitamin K. Some of the Bacteoides family are more helpful to health than others. Having a variety of bacteria in the intestines can reduce the growth of other more deadly bacteria and helps prevent excessive yeast growth. Intestinal health is not a pleasant topic but intestinal ill health is even less pleasant.

A study about celiac disease risk tested for types of Bacteroides species in newborns. A difference in intestinal species was noted based on the genetic differences between the infants and whether they were fed with human milk or commercial infant formula. Infants without the high risk genotype and infants receiving human milk feedings had more of the healthier species of Bacteriodes. [1] This suggests that some infants and people may be more at risk than others for intestinal imbalance which can result in poor nutrient absorption and deficiencies. Probiotics from foods or supplements could be helpful as part of the daily diet.

Probiotic supplements can not supply all types of healthy bacteria in a shelf stable form. Freshly prepared fermented foods may be a better source of some types of the healthy bacteria. [12]  Kefir is a type of active culture beverage that is made from milk similar to the way that yogurt is made. Infant formula possibly could be prepared with the healthy Bacteroides species to help establish healthy digestion and vitamin K. Kefir and other active culture products spoil more rapidly so food safety risks would need to be tested with any new products. Infants typically are given supplemental vitamin K at birth because there is little found in the breast milk. The healthy bacteria that are promoted by the human milk feeding could be providing the vitamin K infants need once the good guy bacteria are established in the intestines of the infant. (unpleasant to think about but healthy for digestion and strong bones).

Digestive issues may be helped by vitamin K and probiotic foods or supplements. And having adequate vitamin K can help prevent calcification of the soft tissue and osteoporosis of the bones. While calcification itself is not proven to be a cause of cancer or heart disease, calcium deposits are found in tumors and in arteriosclerotic plaque which suggests that excess calcium is involved.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Reference List

  1. Sanchez E., et.al., “Influence of Environmental and Genetic Factors Linked to Celiac Disease Risk on Infant Gut Colonization by Bacteroides Species” Applied and Environmental Microbiology, Aug. 2011, p. 5316–5323 pdf: [ncbi.nlm.nih.gov] *an increased prevalence of B. vulgatis was found in infants with the HLA-DQ genotype that is associated with increased risk for developing celiac disease. An increased prevalence of B. uniformis was associated with infants without the high risk genotype and with infants who received breast milk feedings.
  2. Itzhak Brook, “Bacteroides Infection,” Medscape.com: [emedicine.medscape.com]
  3. Johnson K., “Breast Calcifications.” (last reviewed Oct. 28, 2012) webmd: [women.webmd.com]
  4. Vermeer C., “Vitamin K: the effect on health beyond coagulation an overview.” Food & Nutrition Research 2012. 56: 5329 – DOI: 10.3402/fnr.v56i0.5329 pdf, full article: [ncbi.nlm.nih.gov]
  5. Lev M., “Sphingolipid biosynthesis and vitamin K metabolism in Bacteroides melaninogenicus.” Am J Clin Nutr. 1979 Jan;32(1):179-86. Full article [ajcn.nutrition.org/content/32/1/179.long] * This link is really about a different topic. Vitamin K may be important for assembling phospholipids that are used in membranes.
  6. King-Nosseir A., “Eating Well: Bones need more than just calcium,”  (5/16/2012) abqjournal.com: [abqjournal.com]
  7. Higher vitamin K intake tied to lower cancer risks.” (March 31, 2010) Reuters: [reuters.com] *This discusses the results of a large study but the vitamin K intake was based on self reported food intake and cheese was the primary source they mention tracking.
  8. Vitamin K Content of Common Foods.” University Healthcare Thrombosis Service, My Warfarin Therapy, healthcare.utah.edu [healthcare.utah.edu]
  9. Hardening of the Arteries.” (June 3, 2012) pubMed: [ncbi.nlm.nih.gov]
  10. Howenstine J., “Arteriosclerosis Can Be Reversed, Part 1.” (7/24/2008) [newswithviews.com]
  11. Cuomo M.I., “A World Without Cancer, The making of a new cure and the real promise of prevention.” (2012, Rodale Press, New York) [Amazon] *breast cancer tumors are described as a chalky white that stands out from the surrounding tissue. Diagnostic screening was described that differentiates between abnormal and normal calcification of the breast. ** My position is that calcification of the breast or arteries is abnormal and is related to long term nutrient deficiencies or sometimes parathyroid cancer or other unusual disease rather than being a normal part of aging.
  12. Myhill S., “Probiotics – we should all be taking these all the time and double the dose following antibiotics and gastroenteritis.”  [drmyhill.co.uk]
  13. Osteocalcin hormone can regulate glucose levels: Research” (July 23, 2010) [news-medical.net]

Foods for preventing cancer and chronic illness

Food and health tips for helping prevent prostate and breast cancer and other chronic disease:1.  The active ingredient in baby aspirin is also found in many fruits, vegetables and spices. A baby aspirin a day and/ or foods rich in salicylic acid like curried peas and carrots helps inhibit the growth of breast and prostate cancer cells.

2. Ginger extract, roughly just a ¼ tsp per day, reduces prostate cancer growth.

3. Carrots have an additional active phyto-chemical that protects against cancer.

4. Iodine is essential for reducing symptoms associated with any glandular problem – our national diet is too full of chemicals that compete with iodine and there is too little iodine. The average traditional Japanese diet provides ~88 times the amount of iodine that our nation’s nutrient guidelines recommend. (***advanced stages of chronic malnutrition or malfunctioning thyroid may leave some people at risk for over sensitivity to iodine supplementation *** Iodine overload symptoms include: metallic taste in mouth, eczema -especially if patches are on knees or elbows, watery nasal discharge (runny nose but just little drips), persistent cough, changes in vision – stop taking the supplement and symptoms go away.)

5. Just two Brazil nuts per day provide the recommended amount of Selenium for cancer prevention and for thyroid support. It is crucial take selenium along with iodine when replenishing iodine stores. The enzyme that breaks down excess thyroid hormone will not function without selenium.

6. More vitamin C rich foods –or supplements- will help protect against many problems including cancer. (not all nutrients are effective in supplement form but vitamin C is – a buffered form will be less acidic to the stomach at larger doses.) Greater than RDA doses may be helpful. The RDA is the minimum to prevent deficiency not necessarily an optimum amount.

7. Bright orange and red fruits and vegetables are rich in vitamin A and C and other cancer fighters like lycopene, lutein and zeathanthin. Lots of produce: Watermelon, papaya and mango, persimmons, “pre-ripened” peaches, nectarines,  and apricots. Cantaloupe, red grapefruit, broccoli and other dark green veggies. Cauliflower, cabbage and other cruciferous ones, too.

8.  Healthy white blood cells armed with plenty of magnesium is nature’s insurance plan. White blood cells patrol the intestines and body on the look out for infected or decaying cells, or other cancerous cells. A healthy white blood cell will link membranes with the bad cell and give it a blast of enzymes that turn the bad cell’s interior to goo. The white blood cell can then engulf the waste. The material can be detoxified or recycled for growing or repairing other cells.

9.  We all have stem cells that the WBC’s can direct into growing as needed  for any organ or skin or brain cell (hippocampus at least). We don’t need petri dishes for growing brain cells, we just need better nutrition information guiding our food supply and health care industry.

10. How could I have forgotten – activated hormone D3 /calciferol / 1,25D feeds prostate and breast cancer and TB/Lyme’s/sarcoidosis and a type of resistant pneumonia. The infected or mutated cells have learned which enzyme converts vitamin D3 / cholecalciferol / 25D into the active hormone. This chemical is actually formed out of cholesterol and is in the steroid family. [atsu.edu/] (look at mycoplasma and L-Forms – Pneumonia strains need a sterol rich environment and they use up arginine supplies. Arginine is an amino acid that is used to fortify specialty products designed for improved wound healing.)

11. Glutamates are an essential food for a cell wall deficient form of E coli – a pathogen that can be common but can be deadly. [discoverymedicine.com/]  this same link has been on a couple blogs in a row.

Ginger slows prostate cancer growth
 Carrots, spices and baby aspirin help prevent cancer and inflammation
Disclaimer: Eat to live, not eating doesn’t end well. I hope to have helped, not harmed. A blog spot is for informational purposes only and is not the same thing as individual counseling. Abruptly stopping medications can result in death. *This information is being provided for educational purposes within the guidelines of Fair Use. It is not intended as individualized health guidance. Seek a health care provider for individual care.

Dietitian Recommends less Vitamin D and Calcium

We can cure the epidemic of ill health and obesity that has seized our nation and the world. The food supply is low on some important nutrients and has too much focus on calcium. Calcium is important but health is built on a variety of essential nutrients, and clean air and water of course.
We can have health if we seek to rebuild instead of hunt for a disease to name and for a magic bullet cure. There will always be a need for acute care but we are overloading the medical system with chronic degenerative disease. Chemotherapy kills and so do corticosteroids. They are powerful drugs that are aimed at the disease but our bodies get in the way. Food that nourishes with a full range of essential nutrients in forms that can be absorbed and used can help us heal ourselves from within.
We are designed to fight cancer and to rebuild organs using our own stem cells and white blood cells but we can only do that if they are working right. White blood cells protect us by patrolling for old, pre-cancerous or infected cells. The bad cells can be mercy-killed in a process called apoptosis. We grow new skin cells every day and new intestinal cells weekly. New cells of whatever type we need can be rebuilt from our own stem cells. Any organ can be ours for the making – if we have the essential nutrients in our food supply in a mixture that we can absorb.
Our food supply isn’t providing us with the variety of nutrients that we need, in ratios that we can absorb well. Our nutrient guidelines were developed in the 1940’s to help make K-rations that could keep our soldiers strong and healthy under conditions of war.  The original work has been reviewed and modified by the Institute of Medicine. The calcium guidelines were increased in 1997 and while they have been reviewed they haven’t been changed since. The increase was based on an estimation of how much calcium might be needed for better bone absorption.
Do we have stronger bones now as a nation then we did in 1996? That is a simple question with a simple answer – no.Our nation’s diet was changed in 1997 and since then chronic illness, obesity and osteoporosis rates have been expanding quicker than our budgets or belts.
We can’t grow strong bones out of excessive calcium and vitamin D supplements. Bones do require some vitamin D and calcium but we also need magnesium, strontium, vitamin K, and water to name a few essential nutrients.
Calcium is being consumed at levels that our bodies are not able to excrete. The kidneys actively save calcium and use magnesium to remove acidic wastes and some of the excess calcium. Diuretics and alcohol use also increase magnesium losses. Magnesium is lost in sweat but many brands of electrolyte beverages don’t contain it. Our food supply is low in magnesium and high in calcium from dairy products, fortified foods, and supplements.
The dairy products available in our U.S. food supply in the year 2007 provided 716 milligrams of calcium in just 351 calories of cheese and milk per day. Many people eat more than 351 calories of dairy products daily. On average we are consuming more cheese and less milk than we did prior to 1970. Cheese is a more concentrated source of fat and calcium than liquid milk.
Toddlers (n=925) usual intakes from food, beverages, and supplements as reported in FITS 2008 provided on average 892 mg/day of calcium and 160 mg/day of magnesium.
The abnormal vitamin D levels have been misunderstood. Low lab values are linked to ill health and obesity but more of the vitamin won’t fix the underlying problem. The mega-dose is a short term fix but not a long term cure for chronic illness and cancer. It is considered safe for everyone but it is only safe for those with healthy kidney control over the activation of vitamin D to hormone D. High levels of the active hormone D can cause health problems to worsen over time, adding to chronic degeneration.
Vitamin D has two forms and two lab tests of interest, and one test is more expensive. The cheap lab test for 25 hydroxy D (Dᴣ), is what most of the research is based on. It is the inactive form of the vitamin and is available as a supplement. It is considered safe at higher doses because it is assumed that all people, not just healthy people, have very good kidney control over the activation of the vitamin to the hormone. The enzyme needed for activation to 1,25 dihydroxy D is being produced uncontrollably by inflammatory white blood cells and it has been shown to be produced by some cancer cell strains as well.
We are not deficient in vitamin D and haven’t been since milk fortification was begun. The average American’s serum 25-D levels were normal, above 20 ng/ml and Canadian’s had average levels around 24 ng/ml, also normal, from a 2009 Institute of Medicine report. An increased risk of fractures has not been observed at these levels. [4]
Lack of sunlight is not a problem either, according to the research by Dr. James Norman. He has put together a database of over 10,000 patients with hyper-para-thyroidism from around the world who live under a wide range of sunlight conditions. Their vitamin 25-D levels average 19.4 ng/ml, but their active hormone, 1-25 D levels and calcium levels are very high no matter where they live. As soon as their para-thyroid tumor is removed their bodies’ 25-D and 1-25 D balance normalize, no matter where they live.
Dr. Norman, does not recommend supplementing with vitamin D. The supplements push the patient’s lab values for 1-25 D and calcium even higher. He has multiple case examples where stroke or sudden illness occurred after vitamin D supplementation was begun by the patient’s endocrinologist. His seminar about it is on Youtube, listed under ParaThyroid TV, and is posted on my webpage.
I recently started working at an assisted living facility and many of the residents were started on high doses of vitamin D by their individual doctors about a year ago when this research was first getting popular. I read charts cover to cover – and I saw their quality of life deteriorate, their pain levels increase, and worsening of their weakness, cardiac symptoms and dementia, and one death. High doses of vitamin D may not be safe for unhealthy people.
Our public health initiatives have been successful at preventing rickets in the majority; we already won the battle against vitamin D deficiency. Many foods are now fortified with vitamin D not just milk. I met about 4000 babies in fifteen years as a WIC dietitian and only one showed early symptoms of rickets. He was exclusively breast fed and he and his mother both had severe milk protein allergies. They both took to sardines which are an excellent natural source of vitamin D, and supplements were never even needed for the little boy.
We are not vitamin D deficient but we do have a sub-population of chronically ill and obese people with depressed levels of the inactive form of the vitamin. The inactive vitamin Dᴣ is being activated at an unlimited rate in some cancer cells and by white blood cells in wound and inflammatory conditions, resulting in elevated levels of the active hormone form.
Increased levels of the active hormone cause movement of calcium and magnesium out of the bone which eventually leads to osteoporosis of the bone and calcification of everything else. It increases intestinal absorption of calcium and it can increase levels of cortisol, the stress hormone. [39] Too much cortisol can increase abdominal weight gain but it also acts like corticosteroid drugs on the immune system.
Activated hormone D leads to increased cortisol and a short term reduction in inflammatory symptoms because it kills off the overactive white blood cells. However it also kills off the healthy ones. Mega doses of vitamin D are being used in a way similar to corticosteroids. Ultimately the immune system is functioning even worse. The current increase in allergic sensitivities to foods like gluten and peanut butter is due to the over active white blood cells. If we kill off the white blood cells then we won’t get the allergic symptoms as bad but we may get more colds, skin infections, and other illnesses.
Mega-dosing with vitamin D is like paying for Prednisone, if we’re sick and for an expensive cholesterol supplement if we’re healthy. 
Vitamin D is actually a very powerful steroidal hormone based on cholesterol. The average American is making enough vitamin D from their stored cholesterol. Vitamin D is an expensive cholesterol supplement if you don’t need it.[1]  If you are worried about whether you need a supplement or currently are supplementing with vitamin D, then ask your medical provider for both lab tests, cheap and expensive, 25 hydroxy D and 1, 25 dihydroxy D.  The good news is that the combined test result comparison will serve as a biomarker to show who does have chronic inflammatory conditions – proving that fibromyalgia isn’t all in our heads.
Low levels of 25-D combined with high levels of 1,25 D is an abnormal balance that is not seen in the healthy person with good kidney control.It occurs due to the increased production of the activating enzyme in the cancer cells or infected cells. Autoimmune disease may be due to a variety of chronic infections that are not readily identifiable by today’s standard lab tests.
Excessive levels of the active vitamin D cause the bone to lose calcium and magnesium. Too much calcium can cause muscle cramps, increase pain, and can cause anxiety, irritability and headaches.
We need less calcium then we are getting on average and more magnesium. If we limit our intake to 800 mg calcium we should absorb magnesium better, but we still need about twice as much magnesium as we are currently getting. Nuts, beans, seeds and greens are all excellent sources of magnesium and so is chocolate. Just two and a half dairy servings per day, about what is recommended already, would provide adequate calcium for strong bones without overloading our intestines. Too much calcium is causing magnesium to be poorly absorbed in the intestines and to be wasted in urinary losses.
Magnesium blocks calcium channels in cell membranes and would protect the brain cells from being over-flooded with calcium and being overworked to the point of cell death. The over-excitation of the brain cells causes anxiety and irritability and may be underlying the increase in rates of bullying and violence. PMS is another name for magnesium deficiency that is associated with excessive irritiability and chocolate cravings (a good source of magnesium).
Magnesium provides power inside of the cell – fatigue is a common symptom of magnesium deficiency. Anemia and edema are early symptoms of magnesium deficiency. It is essential for the growth of mature red and white blood cells in bone marrow. It is used by over 300 enzymes and it is essential for apoptosis – the mercy killing of infected and precancerous cells. Hypertension and increased serum cholesterol and insulin are also symptoms. If I were writing the books, then Metabolic Syndrome would be called magnesium deficiency and so would pre-eclampsia.
We can heal ourselves, if we learn how to feed ourselves better and repair the food supply and nutrient guidelines.I recommend stopping the push to supplement with vitamin D and calcium and instead I would encourage trying the DASH diet plan. It was a primary education tool that I used successfully to prevent pre-eclampsia reoccurrence in high risk women. The DASH diet provides a good supply of magnesium from the Bean, Nut and Seed food group. The plan has been found helpful for weight loss as well as reducing hypertension.
I propose ten steps for turning around our epidemic of chronic illness and obesity
  1.  Look for health in Food First, treating symptoms does not restore function.
  2. Increase Magnesium in water and other electrolyte beverages. Softened water adds salt to our daily intake and sucks magnesium from our bones.
  3.  Increase magnesium rich foods. They also give us fiber that builds a healthy glycocalyx lining and stronger immune system. Beans, nuts, seeds, greens, whole grains and chocolate are good sources and there is a little in everything else.
  4. Sub-populations need to be identified and informed about their individual nutrient needs, whether increased or decreased from the average person’s to promote optimal health and quality of life.
  5. Poor intestinal absorption of magnesium is part of the problem. We can deliver nutrients from other directions. Skin lotions and Epsom salt (MgSO4) baths are low budget, low risk and very effective methods. [35, 36, 37]
  6.  Nutrients can be delivered by inhalation in an aerosolized  form that would be safer than intravenous magnesium use. [30, 31]
  7.  Limit calcium intake – more is not better. We will retain more when we consume less. The research on strong bones and calcium supplements were for people whose native diet averaged 300 mg calcium per day – not our current RDA of 1000 mg.
  8. Don’t worry about D deficiency and if you are worried then ask for both tests, the inactive and active form of the most powerful hormone in our body.
  9. Ask your government representatives to support food labeling reform. Neotame and free amino acids may be causing migraines, seizures and lead to dementia.
  10. We need our Nutrient Guidelines – the math – checked by a multi-disciplinary team of scientists who use the numbers – food scientists, dietitians, and biochemists should be involved. The math makes our infant formulas and cafeteria menus and when it is wrong then we all suffer.
All nutrients are equally essential. Currently our food supply and health care messages are over-loaded with calcium and vitamin D and it is hurting us. Draining the magnesium from our bones is draining the energy and fluid from our cells and leaves us puffy and pale from anemia. Without magnesium we can’t grow proper blood cells and without healthy white blood cells we can’t protect ourselves from infections and we can’t breakdown decaying, pre-cancerous cells for normal recycling.
Cancer occurs from old cells mutating. Healthy white blood cells can kill the active cancer too. The Linus Pauling Institute successfully treats tumors with high doses of vitamin C. The Gerson Clinic successfully uses a raw foods approach and detoxification with coffee enemas Not too pretty sounding but chemotherapy isn’t pretty either. Why do we continue to hurt people with harsh chemicals when nature gave us what we need in whole foods and the potent herbs and spices. Cinnamon, oregano and rosemary have shown promise in chronic illness. Spice up your lives and enjoy.
Our bodies can do it, we just have to feed ourselves an absorbable balance of a wide variety of essential nutrients.

See Bibliography on the page with this title. I will continue to add to it as I get it organized .

Disclaimer: This information is provided for educational purposes within the guidelines of fair use. Please see an individual health care professional for individualized health care services. If you have questions or comments please contact me at: jenniferdepew@jenniferdepew.com