n = 1 health care & self-controlled studies.

Evidence-based” healthcare mushes everyone into one average group who all get the same guidance – that is flawed. It was intended to be general guidance that is individualized further as needed.

A couple quick Substack links and points – “Anything other than N-of-1 medicine is a crime against humanity.” Toby Rogers

  • uTobian, The Great Regression
  • I. The Mass Poisoning of Society For the last 140 years, coal-fired power plants have spewed mercury into the air, water, and soil — and it then makes its way up the food chain into larger and larger animals. American cities first started adding fluoride…” · Toby Rogers

Clinical trials use “n=__” as typical jargon to show how big the study was. Larger studies generally are more reliable – bigger group, may more represent “average”. But what is average? No one person is “average”. It is just a math concept. Evidence-based guidance designed to best help the “average” person may not help everyone or anyone. Individual variables may leave some people harmed by the “average” solution.

It is like the Mom-ism – “But mom…… everyone is doing it” – “But child…you are not everyone…if they all are jumping off a cliff are you going to jump off a cliff too?” – “Oh, no I guess not mom, thanks.” The bungee jumping fad proved that many people would jump off a cliff just because everyone else seems to be doing it.

Human instincts are to flock together – to fit in with the group and mimic each other. That doesn’t mean it is always a good idea or even sensible.

Self-controlled studies are less average focused, and more individual focused. Instead of having an experimental group of people and a control group of people which has the difficulty of trying to randomly match both groups for variables like age, gender, socio-economic and health status, a self-controlled study has time periods as the experimental and control phases and all participants are tracked over time. Like a Before and After phase – what were their health parameters before an experimental event and what happened to their health after the experimental event?

Jessica Rose has a SubStack today that describes the self-controlled study concept when used for a vaccine type trial. The experimental time period is considered 28 days after the vaccine in the example she provides. Other experiments might designate a longer window to watch for health changes to check for a temporal association with an experimental procedure. Other studies might look at anything that happens after an experimental procedure as the follow-up phase. The value in the study design is that there isn’t a need to match for variables – each person is their own control, so their individual variables are an exact match for their own individual variables.

My Retinoid Toxicity/Histamine Excess research proposal is a self-controlled study design. With conditions that are characterized by being heterogenous – varied – trying to mash everyone together into one average is not helpful – the condition itself doesn’t have an “average”. Many birth issues, congenital differences, seem to have a cluster of varied gene alleles that may have some similarities across the individuals, but it heterogenous – not consistently the same gene alleles.

In order to both understand the problem better, and to help the individuals, then we need to look at them all as individuals with a varied and unknown group of gene alleles that may be negatively impacting their health by causing metabolic dysfunction or increased inflammation or chronic nutrient deficiencies. Their health may be able to be helped a lot, but not with an “average” treatment. Their condition is not “average” – it is genetically heterogenous.

A crime against humanity and all of nature is taking place with mRNA and CRSPR gene technology. Decoding the human genome was supposed to be a huge breakthrough – leading to wonderful new medications – or something. The tone is big disappointment – the genes had more “nonsense” than expected and more variability – one gene doesn’t do one thing – typically. The tone in my opinion should be joyous – we can easily screen and identify individuals for metabolic gene alleles that could be helped by dietary changes – and yet we are not doing that, or rarely. Methylation gene differences may be screened for but it is not done as a first step usually and not for everyone.

Unfortunately, my research paper topic is too vast for me to finish by the deadline this week. I have made a lot of progress and will post an updated draft soon but currently I have two papers written that are complimentary, rather than collated. The first half is posted and focuses on the histamine excess and Retinoid toxicity and the second half is in the works. I posted some of the Tables, but the “That is not a Table!” Table is still an enormous run-on Not-A-Table still.

Tables of data help us see patterns – that is what I do – see patterns in data trends. Organizing it into a neat Table or graph makes it easier for other people to see the patterns too. Mathing it all up in neat statistical graphs, though, is not what I do. Figuring out what is for dinner and how to prepare it, out of all that data, for an individual’s needs, is my focus. And the question is more difficult than picking a favorite restaurant – in our modern times, and for individual people with varied health conditions, what we choose to eat may be very harmful to our health. Processed foods are frequently designed to be somewhat addictive or very addictive and often are seriously depleted in nutrients beyond carbohydrate and fat calories.

Pain means you are doing something wrong – it might have been okay when you were younger, but now it is no longer working for you. Change is needed. Pain means change is needed and the individual needs to figure out what changes are needed in order to restore normal function – which is not supposed to hurt. If something hurts, then you are over-exerting or your body has changed and can no longer keep up with your previous pace – something is wrong, whether it is age, or infection, or stress load – something needs to be changed. And that change is probably not going to be as simple as “Take this pill once a day.” However, the medical model is based on the concept that health can be restored if you just “Take this pill once a day.”

The myth of a single medication “cure” was based on the early success of antibiotics, but also the resounding success of discovering “nutrients”. Early food processing changes left entire populations with nutrient deficiencies. Once the nutrient was discovered and the food processing methods were modified to reduce the lost nutrients, or foods were fortified with the removed nutrient, then the entire population suddenly was “cured” of the deadly or disabling “condition”.

The medical industry has come so far that they have lost their roots – scurvy – vitamin C deficiency – is missed in modern health care – left untreated as a mystery condition until someone hopefully recognizes the old sailor disease – scurvy. We all need vitamin C every day. That is a biological fact. Medical doctors need to take their blinders off – the body is not made out of medicine. Not a single medicine is a “nutrient need”. We have no deficit of aspirin in biology, but we might have a lack in our diet. We can get plenty of salicylates in our herbs and spices – nature provides us aspirin in our foods.

  • Oldie, but a goldie: Carrots, spices and baby aspirin help prevent cancer and inflammation, Oct. 21, 2011, (transcendingsquare.com).
  • Newer: Being grateful for our bitter sensing tastebuds, Jan. 3, 2018, (transcendingsquare.com).

My Problem Solving episodes in my How Are You Feeling? podcast series gets into more detail about the genetics of bitter taste perception and how it may conveniently be more sensitive in people like me who need an external source of bitter tasting cannabinoids and phospholipids. The transcripts and audio links to the series are on this webpage: Peace-is-happy.org/How are you feeling?.

Bitter taste receptors turned out to be critically important for COVID19 treatments. Bitter phytonutrients or medications can get mucus thinned and flowing during congestion – but adequate zinc is needed first. In order to make the bitter or other types of taste and odor receptors.

Mother Nature gave us a medicine cabinet and an ability to taste the dose that will be most effective without being excessive (starts to taste bad instead of good) – and “medical doctors” need to get out of the way.

Be an n=1 self care provider and pay attention to your own body and it may help guide you towards less pain and better quality of life. The negative symptoms tend to be later that night or next day after eating inflammatory foods or doing inflammatory activities so the patterns can be easy to miss if there is a lot of variability in a person’s routine habits and diet choices.

The paper and Tables that I have been working on will hopefully make it easier to see what individually is helping or hurting. I will post another update this week but it isn’t quite blog ready, let alone journal submission ready.

green and white labeled bottle
“Bitters” have been a medical standard for centuries or longer in Traditional Chinese Medicine. Photo by micheile dot com on Unsplash

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Joy is healing and may need a little help.

We can not always choose our attitude – just smile and be happy – nutrient deficiencies can cause mood changes that are not going to change without getting the nutrients. Then the change to a better mood can happen rapidly sometimes, within 20 minutes for magnesium if needed.

Hunger, sleepiness, stress or anger, loneliness, all may interfere with mood or mood control. Patience is a virtue, and practice helps. So does a good night’s sleep. Low blood sugar can lead to irritability or poor concentration, so can poor sleep. Briefly resting can help recharge things towards a better mood, and sometimes a walk may help.

Nature or images of nature cam help sooth stress and walking was found more beneficial in natural surroundings than in urban settings for relieving stress.

Brighter lighting indoors can help mood if sunshine isn’t available. Sunshine helps our circadian cycle and helps make vitamin D, surprise also water soluble forms of vitamin A and D. Full spectrum lighting might be a good health and mood supplement during winter months.

Salt crystal lamps can help improve air quality for mood due to negative ions being released. These may also help improve air quality by helping remove odor particles or mold. When the salt is warmed it releases negative ions and possibly a little ozone, but not much based on sites selling other types of air cleaners. Ozone is safe if it is not in excessive amounts and it can also have a positive effect on mood.

The negative ions or ozone help air quality by clumping with air particles which causes them to drop from the air. Then just sweep it up.

http://www.natural-salt-lamps.com/negative-ions.html * I am unaffiliated with this site but as personal testimonial – I went upstairs to get my lamp because the basement smelled musty and unpleasant. Using the salt lamp several hours a day does give it a fresh feeling and salty ocean aroma instead of musty.

This helps with mold spores or odor particles or secondhand smoke chemicals and odor. Too much ozone can cause headaches, but the salt crystal doesn’t produce much, not compared to ozone producing air cleaners. The negative ions may build up, so leaving the lamp warming all day may be more than you want. I do reach a point where I want to turn off the lamp after it had been on for hours.

The reddish glow may have health benefits as light therapy if other lights are turned off. In the evening having dimmer lighting can help the body adjust to getting ready for sleep. Bright screen blue light is too much like sunny day light and keeps our circadian cycle genes set to active awake mode. Blue light blocking glasses are available to wear for the last 3 hours before sleep time, to help the circadian cycle switch gears.

We need that to happen for growth and repair genes to be activated and the active awake, inflammatory functions are turned off for the night. The two systems share a protein, so they have to take turns. We can’t use both pathways at the same time if they both need the same assembly line machine.

Himalayan Salt Cystal lamp, it has a dial so it can be darker and cooler, less ozone released.

Joy can be practiced. The feeling of gratitude and connection to others or the planet can be a support when things are tough. Pausing to look for beauty, or snap an image, smell a flower, pet a friendly animal, all can be an island of joy in an otherwise busy day.

Tiger lilies and wild goldenrod.

My site peace-is-happy.org is my art escape with posts that are generally shorter than are found on this site. It also has sustainable building information and biodiversity- peace is living within a community of friends, family, and wildlife. Peace is clean air, water, and food. Peace is shelter on a cold day, or a shady canopy on a sunny summer day. Peace is caring for oneself, and the community as an extention of oneself. Peace is lending a hand and accepting one when in need.

Peace is a warm puppy, or a comfortable baby. Hat-tip to Charles Schultz and his book “Love is a Warm Puppy.” The titles on the peace-is-happy.org site are based on his simple and beautiful little book.

Love is a soft blanket,

to surround oneself or others.

Peace is love for oneself and others,
even when annoying or annoyed.

The peace-is-happy.org site has a page with links to a podcast series I did last year regarding our feelings or mood and what those feelings might mean. They may not mean anything beyond, you need a nap or a snack. Or they might mean the snack you had was not a great choice for your later mood. But in either case – might not mean that someone else was purposely trying to irritate you. You – might just be feeling irritable.

The podcast is called: How Are You Feeling? The webpage has links to the audio and to transcripts with references and occasionally additional information. https://www.peace-is-happy.org/how-are-you-feeling

Disclaimer: This information is being shared for educational purposes within the guidelines of Fair Use and are not intended to provide individual health care guidance. Please seek an individual health care provider for individualized health care guidance.

Hope – is the future, is teamwork to build a better future.

“Nothing that is worth doing can be achieved in our lifetime; therefore we must be saved by hope.

Nothing which is true or beautiful or good makes complete sense in any immediate context of history; therefore we must be saved by faith.

Nothing we do, however virtuous, can be accomplished alone; therefore we must be saved by love.

No virtuous act is quite as virtuous from the standpoint of our friend or foe as it is from our standpoint. Therefore we must be saved by the final form of love which is forgiveness.”

― Reinhold Niebuhr, The Irony of American History (goodreads.com)

We are blessed,
a loving eye in the sky
Shines forth, glory is ours.

Teamwork – requires communication and working together in spite of differences. Diversity within a team can improve the variety of skills, experience and ideas available to the team. Teams do not all have to be best friends to work together, adult maturity looks at that long view, the whole is greater than any of the parts.

In the recent post: Strategic Mindset & Grit – try, try, try again, but a little bit better each time, we learned that the people who built Stonehenge (U.K.) took approximately 1175 years to complete the various phases of its development into the world’s largest astronomical calendar. Now that is teamwork, and dedication. They may have hoped to improve crop production due to a lengthy change in the weather to cooler temperatures that supported fewer crops. The people of the time increased their use of grazing animals for their survival during the long cold snap (~700 years or more, I’m not a historian).

Miracles exist
In our hearts and in our minds,
One life at a time.
Many lives over all of time.

None of us is as smart as all of us” – Ken Blanchard

We got this, the world
In the palms of our hands, all
Joined together, One.

On the other side of darkness is light – let there be light for growth and discovery, and let there be darkness for rest and recovery.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Travel photos require traveling.

New year, time to gather some new photos. New year, new website also, my Christmas present to myself and anyone interested in ocean health, quantum physics, or pretty pictures, Earth-Ocean.info : www.earth-ocean.info

While climate change isn’t currently a U.S. national priority it is still happening and many nations and individual businesses,nonprofits, local goverments, and individual people are concerned. Ideas can grow from seeing other people’s projects or ideas, sharing knowledge can help promote more ideas and more action. Ocean health is the focus so far on the new site but our air,ground water and surface water are all connected with the oceans, which are also all connected. When one nation polluted or has fires or bomb explosions the pollution spreads across the oceans to other continents. War is not healthy for anyone. Dust storms also can spread unhealthy nanoparticles across oceans and climate change is causing increase in frequency of dust storms in some areas.

Quantum physics involves the movement of subatomic particles and very small molecules which may include nanoparticles. Einstein’s E=M C2 is about the energy that a mass would need to be able to move at quantum speed, roughly, I’m still learning. Our health and that of other life forms does involve quantum movement of subatomic particles and small atoms or molecules for mitochondria, photosynthesis and in some other ways.

On the home page of the new website I give a few examples of the difference in weight of subatomic particles and my own weight. New Year’s resolution, lose some weight, (this is a semi-serious joke, my mass times the speed of light squared was something like 790,000,000,000, I forget how many zeros, — getting healthier is the bigger goal, losing a few pounds of mass would likely occur along with getting healthier) however in my physical form I will always be too heavy to move at quantum speed and will need to try to remain within the posted speed limit.

The planet is in all our hands.

Disclaimer: Information provided for educational purposes within the guidelines of fair use.