Therapeutic goal overview

Problem:

The whole alternative point about there being “no virus” because of Koch’s Postulates – is simply wrong regarding RNA type viruses. RNA viruses – they  are a group of variants rather than all being genetically the same organism, like a malaria parasite is always a malaria parasite in some stage of growth. And there is definitely a chimeric spike protein which was patented in 2018, – in the US by Ralph Baric out of University of North Carolina.

The chimeric spike protein has the characteristics of a computer sequenced molecule with many hazardous sequences that are also patented. It is bioweapon-like in the changes, rather than natural mutations, which tend to be single nucleotide changes rather than a short string of nucleotide changes that happen to be specific patented sequences for known toxins. All of the CoV injections use the same modified version of that chimeric spike protein, which NIH gave a modified sequence of to all the vaccine companies – and they all used it.

The bat coronavirus used as a carrier for the chimeric spike protein, in itself, is not that big a problem to a person of reasonable health, compared to anything designed to include the chimeric spike, because that is toxic to us in many ways and the injection version seems to be a worse cholinergic blocker – the snake venom toxin part is a paralytic – Ralph Baric’s patent, modified by the U.S. NIH.

References – Spike Protein Risks & Aids – Summary Page, (47)

and David Martin’s work on the patent trail:

A key driver is the media… Investors will respond if they see profit…, Daszak stated.”

– via https://twitter.com/David32856757/status/1472365176775188489?s=20

Hope and selfcare are the solutions.

Therapeutic Strategies and Goals:

  1. Fibrinolytic – protects against blood clotting risks and can help reduce congestion. Bromelain, serratiopeptidase, nattokinase, others. 
  2. Iron-chelator / Antimicrobial-anticancer-anti-inflammatory – reduces damage from oxidative stress and free iron, or identifies iron rich cells for removal. – Artemisinin, Sweet Wormwood tea, many others.
  3. Antioxidant support – infection and inflammation increases need for antioxidants. Spike also can inhibit our own antioxidant production pathways – Nrf2. Phytonutrients in many common foods and beverages can help promote Nrf2. Vitamin C, liposomal glutathione, NAC/whey protein/Aged Garlic Extract, alpha lipoic acid,
  4. Methyl B12*, folate*, choline*, (*methyl donors), thiamine, (B1), niacin, (B3), and all the other B vitamins – inflammation and infection greatly increases need for B vitamins and spike may reduce methyl Bs and increase neuropathy risk – tingling fingers. Methyl donors help protect against DNA damage. Niacin can help reduce inflammation and increase endolysosomal removal of cellular debris, like spike or virus or dead cell particles which increase oxidative damage risk.
  5. Topical magnesium sulfate – the sulfate and magnesium help cardiovascular risks. Spike reduces absorption of magnesium in the GI tract. Low magnesium increases risk of stroke or heart attack, and muscle cramps, tinnitus, headaches, anxiety, depression or a short temper and anger.
  6. Vitamin D & sunshine & blackout curtain darkness at night (or cloth to cover the eyes). Our circadian cycle has many functional changes every wake/sleep cycle in addition to melatonin production at night. Dosing of vitamin D is best as a prevention, daily attention to a healthy baseline. Megadoses should not be needed – just in advance of an allergy or autoimmune risk is the key factor. 
    • Autoimmune problems are for life as soon as they develop. Remission can occur with less of a daily symptom problem but then can flare up if re-exposed to the antigen. Avoidance of the trigger food or toxin is needed – which means spike protein too. 
    • While making our own melatonin means we are also helping all the other circadian repair and growth functions, the high dose niacin/melatonin protocol can help to fight infection and reduce inflammation. Gradual increase in dosing over months is needed ideally but short term immediate use for an infection may be needed. The gradual use as prevention or LongCovid symptoms may help by allowing the body to have time to cope with the level of inflammation that is present. Only so much cellular crud can be removed in any one night/day cycle. 
  7. Protein – Biology seems like magic but is little machinery made out of proteins, carbohydrates, fats and other nutrients and chemicals. We need adequate protein to make the little machines, and enzymes or cellular structure proteins. In severe inflammation with Covid, a ketone based diet may be helpful or at least low carbohydrate intake in comparison to the calories from fats and protein. If kidney damage is present then excessive protein is also to be avoided, but some is still important.
  8. Nucleotides to make RNA or DNA are plentiful in a diet with animal products but would be a need in a vegan diet. Nutritional Yeast Flakes or Deactivated Yeast (wheat product- gluten). We need to make RNA regularly in order to make any other protein from the DNA pattern. So for growth and repair or to make antibodies, we need to make RNA first.
  9. Mushrooms or the edible yeasts would help with spike risk to the Dectin-1 receptors. Th Beta-glucan in the edible fungus activates them, as they protect against fungus. In a normal fungal infection avoiding mushrooms would be recommended, but in spike situations it is protecting the receptors from spike lodging in them instead. It would keep them functioning to protect against other fungal infections. Medicinal mushrooms can also help immune function in other ways too. Avoiding glyphosate would be protective as it increases risk for fungal infections and a low carbohydrate diet would be protective as fungus grow on carbs. *Prevention is key, fungal infections are very difficult to get rid of once established.
  10. Sialic Acid is decreased by spike. Making more is the need, we can’t really get it through the digestive system. It is electrically active and needs to be made, or replaced with soluble sialic acid that is in the area. It helps prevent the rouleaux stacking of blood cells. Adequate nucleotides in the diet help and N-acetylglucosamine (NAG) – available in supplements or insects. Grow your own with supplies from a pet store – after you learn more about it first maybe.
  11. Frequency/vibration therapy can help or harm. Certain frequencies can break the delicate membrane of a virus or bacteria while not harming the human cells, (Rife). Other frequencies can help our own quantum health and well feeling. Strong EMF can increase inflammation though and may increase risks from graphene oxide in the CoV injected people. In general it is good to turn off EMF sources during the healing sleep hours of your life. Faraday cages are available that help reduce EMF from WiFi routers.
    • Example Rife healing frequencies for autoimmune conditions – I did find this helpful on a flare-up day: Autoimmune Diseases Cure Healing – Rife Frequency | Pure Isochronic Binaural Beats – Sound Therapy (youtube)
  12. Omega 3 fatty acids – EPA & DHA. They help reduce inflammation, are needed for membrane and eye health and are part of our quantum health – our energy fields. Vegan or vegetarian sources are likely inadequate as the conversion rate to the DHA/EPA forms is low. Krill oil or algal oil are sources in addition to fatty fishes like salmon, tuna and sardines. 

There are more. Trace minerals are important, and microbiome health – which means zinc, fiber and resistant starch are important. SARS-CoV2 can infect bacteria and the GI tract and appendix are potentially a risk for ongoing relapses. The injected LNPs may be entering microbes too and adding chimeric spike to their surfaces too. There has been an increase in appendicitis cases since CoV injection rollout.

We don’t know what isn’t allowed to be researched. Thankfully some independent researchers persist anyway.

There are many things that can help health, and many modern foods and habits that are harming our health. Avoiding processed foods helps reduce pesticide and herbicide intake and reduces inflammation as ultra-processed foods promote Metabolic Syndrome and weight gain per recent research. (43)

  • Health Aids for Special Times – Protocol (document) has a link to a Spanish translation.
  • Histamine Food Lists – also categories for food senstivities that are frequently causes of increased inflammation. (document)
  • DHA – a quantum molecule. (document)
  • Blue Iodine – Recipe & References, shared from social media (document)
Webpages on jenniferdepew.com include Microbiome, Resistant Starch/Butyrate, How Much Butyrate?,
DHA & Forest Bathing, Membranes & Inflammation, and MCAS/Histamine.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a <functional or orthomolecular> health professional for individual health care purposes.

Reference List

43 Hall KD, Ayuketah A, Brychta R, et al., Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake. Cell Metabolism. 2019 May 10. pii: S1550-4131(19)30248-7. doi: 10.1016/j.cmet.2019.05.008. [Epub ahead of print]. PMID: 31105044. https://pubmed.ncbi.nlm.nih.gov/31105044/

https://ijvtpr.com/index.php/IJVTPR/article/view/23

Vak Spike vs Viral Spike and Exosomes

#EarlyTreatmentWorks – prevention regularly is best bet as early means first 3-5-7 days of first symptoms ~a cold, not let it get a week later & you went to work throughout. Increasing dosing frequency rather than megadosing at once->24/7 protection ~ 3-4 x~8 hrs or 6 hrs apart

Basic treatment info and dosing guidance here: Short List Dosing Details ranges with selfcare guidance. Also on jenniferdepew.com, page Nutrients and page Cofactors.

Questions I was asked: How Bad Is The Sp!ke? – (@_nikolakii_)

How bad is the actual virus vs how bad is the vaccine?

  1. The actual virus is not that bad except for the chimeric spike added to it. Those who get infected and are unvaccinated without comorbidities have an approximately 99 percent recovery rate. 
    • However the lingering LongCovid rate is more significant and frequently disabling. People have had difficulty getting help or answers.
    • Autoimmune antibodies against receptors that spike was lodged in may have been formed leading to self destruction of whatever protein or receptor type it was when antibodies against it were created by the person’s immune cells.
    • Allergy like or other excess histamine symptoms might result from overactive mast cells. Over production of retinoic acid, the active form of vitamin A, might also lead to symptoms of mast cell overactivity. The dietary solutions can help a lot but are big changes – avoid all vitamin A foods and rich carotenoid sources of fruits and vegetables – seriously, but can help prevent long term liver and kidney damage and neurologic symptoms. Histamine producing or containing foods also need to be avoided, again, it can help a lot though.
    • Fatigue from anemia of chronic inflammation is likely, and elevated ferritin levels with fairly normal to low hemoglobin level might be lab results. Iron chelator herbs can help fairly quickly, then continue. Artemisinin is the one I used, am and pm for a few months and then once a day for a year or more.
      1. Now I have been using Wormwood in tea with some better tasting medicinal herbs & (small piece or a couple) pomegranate and (can be several larger pieces, is mild and fruity) mango peel. Sweet Wormwood is less bitter and no thujone which can be a seizure risk if too much is consumed. I add thyme to balance the GABA effects from the Wormwood/thujone, fennel seed adds flavor, and dandelion leaf & root for anti-prion help.
    • Nerve tingling or pain in fingers and toes or pain, turning to reddening and swollen is a hypoxia of the tissue problem. Gentle exercise helps keep circulation going.
      1. Epsom salt soaks help with a well absorbed form of magnesium and sulfate, both beneficial for cardiovascular and tissue health.
      2. An imbalance of cannabinoids is present due to the inflammation, so CBD alone would make the imbalance worse. THC products would help provide the type that is needed, and it helps reduce the hypoxia.
      3. Thiamine, B1, is also needed in amounts greater than available in food when there is inflammation and it can help hypoxia at the higher doses, 300 mg or more, seek guidance for larger amounts. Other Bs should also be taken in to provide balance – Bs are a team, work together within the mitochondria and in other functions. Niacin and other info in this: Spike Summary Spreadsheet, Telomerase, Circadian Cycle and Nrf2, (and niacin, also a link at the end to a post focused on niacin & melatonin).
      4. Malnutrition in general is a risk factor for demyelination nerve damaging conditions. Low CoQ10 is also a risk factor. G12. Demyelination.
  2. The vaccines are worse in a variety of ways with the most basic being that the spike used in all the brands of injections was modified, supposedly to be better, but it has worse health effects as it is on the surface of the human cells – it would not be there in an infection, only on the virus, or within a cell being formed to make virus with. Virus hijack the cell machinery for replication of it instead of normal functions. See last post: Adaptive Immunity, ADE, and Antibodies.
    1. The modified spike is a worse nicotinic acetyl choline receptor blocker – the gene sequence has a section like snake venom toxin which causes paralytic effects by inhibiting cholinergic messaging (acetylcholine is a brain neurotransmitter it also activates choline receptors). Blocking nAChR receptors – would lead to the hearing and vision problems, excessive menstrual bleeding, colitis, miscarriage, myocarditis. The cholinergic blocking #nAChRs can cause sperm motility issues and the excessive menstrual symptoms may indicate risk of female infertility/early menopause.
      • Nicotine activates function and would protect-block- the nicotinic acetylcholine receptors from spike protein. Choline might work too, but for me, I needed nicotine to resolve my colitis-like symptoms.
    2. Exhaled breathe or sweat from vaccinated people may contain free S1 subunit of spike proteins and can spread passively to non-vaccinated people. Exosomes, membrane packets with spike on the surface, may also carry the genetic directions within.
      • Exosomes are similar to pheromones and act as messengers within the body from one part to another but also can be exuded to share with the outer world too. There has to be a matching surface marker for another person’s cells to accept the exosome or pheromone, or on a cell within a person if it was acting as a messenger between different areas of the body.
    3. The spike affects ACE2 in a way that leads to pneumonia-like edema of lung tissue
      • Citrus peel or pomegranate peel can help. The Citrus Peel is more effective for clearing congestion and opening airways. The Pomegranate peel helps protect ACE2 receptors. G13. Pomegranate. G14. Citrus Peel.
    4. The vaccines increases the risk of fungal infections, other viral infections or flare up of Herpes or shingles, and cancer risk.
      • Dectin-1 receptors protect against fungal infections and spike blocks them, eating mushrooms or Nutritional Yeast Flakes would activate them instead, lodging and protecting them from being available to spike protein. *this is spike specific and to prevent fungal infections, rather than being a standard treatment for fungal infections – which might include a recommendation to avoid eating mushrooms.
      • CD8+ T killer cells are reduced in number and lymphocyte count might be low on a lab test. CD8 cells help fight virus and cancer cells.
    5. Cancer risk is also increased by inhibition of the Toll Like Receptors. (2)
      • Magnesium and methyl donor B vitamins, Nrf2 promoting phytonutrients, pomegranate and citrus peel, and most of the other things mentioned, also would be protective against cancer risks.
      • Reducing sugar and total carbohydrates helps Covid infection or cancer risk.
      • Reducing glutamate seasonings would also reduce cancer risk. Those are also usually histamine problem foods – may need to kick them out of the diet anyway – headaches may be a symptom if that is a problem.
    6. The vaccines contain prion like sections, so misfolding protein conditions may be a risk Parkinson’s disease ( clumps called Lewy Bodies, 1), Alzheimer’s & CJD/Mad Cow Disease.
      • Delphinidin (black beans, black sesame seeds or rice, Blue Lotus or Blue Butterfly Pea flowers) and pomegranate peel, dandelion leaf or root and/or pine needle tea may reduce this risk.
      • Avoiding organophosphate pesticide and glyphosate herbicide residue may also help reduce risk.
    7. The jab increases toxicity of bacteria endotoxin LPS & SEB. Spike has a SEB like endotoxin sequence. Both endotoxins increase inflammation.
    8. Rapid aging –  damage repair of DNA is inhibited, affecting immune cell differentiation in addition to increased risk for cancer and mitochondrial disorders such as Parkinson’s Disease.
      • Methyl donor B vitamins, folate and hydroxy or methyl B12 and choline may help.
      • Nrf2 promoting foods and phytonutrients may help. (G10. Nrf2 Promoting Foods)
    9. Inflammation is increased in many ways by the spike destruction of tissue, changes to receptor function, the bacterial endotoxin SEB and LPS from negative species of the microbiome. 
      • Nrf2 promotors would help reduce inflammation; vitamin C and alpha lipoic acid, other mitochondria support and high dose niacin/melatonin protocol could also.
    10. SARS-CoV-2 can infect bacteria, so again, a healthy microbiome is critical in a number of ways. Beneficial, zinc fed, species also help colon health and reduce infection risk with butyrate production. Butyrate can activate the niacin receptor and can also help reduce inflammation and increase removal of cellular crud, like free spike protein, by white blood cells with endolysomes, see earlier link for an image. Spike Summary Spreadsheet, Telomerase, Circadian Cycle and Nrf2
      • Vegetables and high fiber grains, beans, nuts, seeds, can help the microbiome flourish along with zinc and iron – though avoiding iron rich foods is helpful for other inflammatory issues mentioned in the first section in the discussion of LongCovid.
    11. TRP channel disruption – at the ankyrin repeat domains.
      •  Risk to hair cells in hearing and the vestibular system (sense of balance and steady tracking of vision – following the bird in the sky).
      • Epsom salt soaks, for a well absorbed topical source is needed as TRP channels in the GI tract are needed to absorb magnesium ions and spike disrupts them.
    12. Others – this document has an earlier version and other sections, including one on exosomes topic, references for that are included: https://docs.google.com/document/d/1tnhDPY59_NXG5dcCHVsIicgR5W_hDCSoJ9j9QIlwtrY/edit?usp=sharing 

The increased risk of autoimmune antibodies forming against receptors the spike is lodged in on the cells means that there can be a life long autoimmune attack on those receptors afterwards. If anti-phospholipid antibodies formed, then the person’s own immune cells would be led to attack and remove endocannabinoids, – phospholipid molecules. And symptoms of the numb fingers and toes may involve endocannabinoid disruption during LongCovid. See: Cannabinoids & blood vessels – and LongCovid. Anti-phospholipid antibodies could by breaking down even more endocannabinoids than the inflammation had caused.

See Membranes & Inflammation for more about tissue damage in inflammation and what may help.

Boosters every 3-six months may keep the person in an autoimmune-like flair up all of the time practically as the vaccine spike is formed on human cells, so immune cells may be attacking the person’s own cells and causing massive dysfunction and tissue damage which might be seen as skin rash or bruising. See the last post: Adaptive Immunity, ADE, and Antibodies.

More treatment info and dosing guidance here: Short List Dosing Details ranges with selfcare guidance. Also on jenniferdepew.com, page Nutrients and page Cofactors.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Reference List

  1. Tracking the spread of Parkinson’s proteins from gut to brain. July 23, 2019, nih.gov, https://www.nih.gov/news-events/nih-research-matters/tracking-spread-parkinsons-proteins-gut-brain
  2. Manik, M, Singh, RK. Role of toll-like receptors in modulation of cytokine storm signaling in SARS-CoV-2-induced COVID-19. J Med Virol. 2021; 1- 9. doi:10.1002/jmv.27405 https://onlinelibrary.wiley.com/doi/10.1002/jmv.27405

Reference list needs a little help. – this has quite a bit of background info and reference list: Spike protein risks & aids – summary page

https://ijvtpr.com/index.php/IJVTPR/article/view/23

Adaptive Immunity, ADE, and Antibodies

ADE & Neutralizing Vs Non-Neutralizing Antibodies 

The CoV “vaccines” cause the person’s own cells to make spike protein and put it on the surface of the human cell – this would never happen in an actual viral infection. In viral replication the virus with spike are made within the host cell and then burst forth, killing the host cell and possibly also using part of the host cell membrane as part of the membrane of the many replicated virus. The cellular debris from the cell being killed by the exit of the virus leaves inflammatory chemicals in the extracellular fluid.

In the case of the gene therapy “vaccines” the human cell itself has spike proteins produced on the surface – which may be identified by immune cells as an actual foreign protein with viral origin and neutralizing antibodies would be made that attack as if it is a virus – neutralizing the virus from being infectious. Or since it is a human cell, non-neutralizing antibodies might be made that recognize it as a ‘self’ protein – it is on human cell after all.

When the injected person’s immune cells recognize the viral protein on the human cell surface, they make antibodies against the spike protein, and eventually, those antibodies, whether neutralizing type or non-neutralizing, would connect with the spike proteins located on the surface of the human cells – throughout the body, wherever spike is being produced. Depending on the type of antibodies that had been made, other immune cells will either attack the human cell as if it is viral or cause the human cell to die – they were neutralizing antibodies – but instead of neutralizing an infectious pathogen a human cell was killed instead. The immune cells will also be extra busy with all that work, recognizing and killing all human cells that have the spike protein on the surface, so any other random infection may be ignored simply because the immune system is too busy attacking the human cells that have spike – whether a cold, flu, or SARS-CoV2.

Or, if non-neutralizing antibodies had been made, the other immune cells would leave the human cells with spike protein alone. That might seem good, but it also means that a real coronavirus infection might also be ignored by the immune cells, primed with non-neutralizing antibodies that think spike protein is ‘self’ now. 

Neutralizing antibodies are the goal of a vaccine because they would help prevent infection or symptoms from the infectious pathogen – neutralizing it from doing harm. In the case of the CoV “vaccines” though, neutralizing antibodies are also causing the human cells with spike on their surface to be killed by immune cells – as if the human cells are a foreign virus. That is similar to autoimmune disease except for many different types of cells throughout the body may all be involved instead of more specific autoimmune antibodies against thyroid tissue and gluten for example (molecular mimicry – similar chemical shape). 

Non-neutralizing antibodies are not the goal of vaccines but animal research with mRNA vaccine found that it was a big problem. Eventually all the animals died once exposed to the wild type virus. This is referred to in medical research as Antibody-Dependent Enhancement, (ADE), and more recently has been called as Vaccine Enhanced Disease. 

If the non-neutralizing antibodies encounter a SARS-CoV2 virus, any variant with a closely matching spike protein, they will bind with the spike. However the non-neutralizing antibodies are labeling it as ‘self’ and immune cells will ignore the virus as if it was a human cell – not neutralizing the virus. The non-neutralizing antibodies also would not be causing the killing of any human cells that have spike protein being produced on their surface. 

People with minimal symptoms after the jabs may have been one of the lucky ones to get the ~30% saline solution batches, or they may be more at risk for ADE infections to any coronavirus that has somewhat similar spike proteins.

Vaccine Enhanced Disease is a descriptive name. The vaccine caused the formation of non-neutralizing antibodies which accept the pathogen as ‘self’, instead of neutralizing ones that would be protective. The infection is able to grow freely, unstopped by the immune cells – which means the disease process was ‘enhanced’ – the infection will be much worse than if there hadn’t been a vaccine inducing non-neutralizing antibodies.

ADE reactions generally lead to death of the research animal with mRNA gene therapy research, and there is limited information regarding the condition in humans as adverse vaccine reactions tend to be called other things rather than performing autopsies and finding out in more detail. A nasal infection leading to lung infection would show more damage in the upper area of the lungs. An ADE infection would likely have damage more throughout the lungs and body.

In the case of an RSV vaccine and later infection, the ADE reaction was “termed vaccine-associated enhanced respiratory disease.” (1)

Recent research is showing a disease enhancement effect occurring with the CoV gene treatments. Infection rate is higher in the injected than those who have not had the CoV injections:

“Earlier, I had published and announced in a public speech (Harrisburg) that the vaccine program had failed, in part based on my findings that the number of new cases was highest in countries with highest vaccine uptake (See article here). The Israeli and UK data showed more cases in the vaccinated than in the unvaccinated, and my analysis yesterday should silence the pedestrian response “that’s because there are more people who are vaccinated”. I’ve pointed out (as have others) that Fauci’s “go home until you are sick enough to need emergency care” makes people variant incubators.

Now a new study has found the specific mutations by which the SARS-CoV-2 lineages have escaped the vaccine. The study, which is behind a paywall (US$40), reports that these mutations lead to less infectivity compared to the original SARS-CoV-2, but, according to the authors, “can disrupt existing antibodies that neutralize the virus“.

That sounds like disease enhancement to me.” – James Lyons-Weiler (2)

People getting CoV injections are supposed to be informed of increased risk of infection being possible as a result, rather than protection. Research focused on whether they are being informed of the risk of ADE or Vaccine enhanced disease found that there was insufficient awareness. (3)

Variants with a spike modification that evades the antibodies, whether neutralizing or non-neutralizing may also be an increased risk of the leaky gene treatments, (4), called vaccines by the new definition of the word.

Adaptive immunity – ability to make new types of antibodies & more B or T immune cells.

Adaptive immunity means our ability to make new types of antibodies whenever we need, and allow the transformation of undifferentiated immune cells into the active B or T cell type that is ready to make antibodies (B), or fight infection (T). Without the DNA repair function the immune cell differentiation can not occur either. Lack of DNA repair also is a problem because DNA changes can lead to cancer or mitochondrial dysfunction conditions which can include Parkinson’s disease (PD). (5

The viral infection leads to inflammation, oxidative stress, and that leads to increased DNA damage, which might be random. Adequate nutrients can help correct the oxidative stress chemical imbalance before damage occurs. After DNA damage occurs, it may be too late to correct DNA changes that were replicated in a large enough number of defective mitochondria or cells to cause noticeable symptoms.

Consistent with our results, clinical observations also show that the risk of severe illness or death with COVID–19 increases with age, especially older adults who are at the highest risk [22]. This may be because SARS–CoV–2 spike proteins can weaken the DNA repair system of older people and consequently impede V(D)J recombination and adaptive immunity. 

In contrast, our data provide valuable details on the involvement of spike protein subunits in DNA damage repair, indicating that full–length spike–based vaccines may inhibit the recombination of V(D)J in B cells, which is also consistent with a recent study that a full–length spike–based vaccine induced lower antibody titers compared to the RBD–based vaccine [28]

This suggests that the use of antigenic epitopes of the spike as a SARS–CoV–2 vaccine might be safer and more efficacious than the full–length spike. Taken together, we identified one of the potentially important mechanisms of SARS–CoV–2 suppression of the host adaptive immune machinery. Furthermore, our findings also imply a potential side effect of the full–length spike–based vaccine.” (6)

DNA Damage can lead to cancer or mitochondrial conditions, like Parkinson’s Disease, PD.

DNA damage can be prevented more easily then it can be changed back to healthy – unless it is just an epigenetic change. Methyl groups are an atom of oxygen and hydrogen that can be added to the side of DNA sequences where they act kind of like a bottle cap to keep the DNA in a closed or off position.

Epigenetic changes where a gene is active when it should be inactive, can change back when adequate methyl donor vitamins are available (methyl or hydroxy B12, folate, and choline). Some people may need extra due to a genetic inability somewhere in the methylation steps, or because inflammation/infection caused an big increase in need for the nutrients.

Other phytonutrients may also help with DNA damage and protect against cancerous changes. 

Recently, we have shown that dietary phytochemicals such as quercetin, rutin, rosmarinic acid, luteolin, and others not only protect DNA damage but also stimulate DNA repair in liver and colon cell lines (Lima et al., 2006; Ramos et al., 2008; Ramos et al., 2010b; Ramos et al., 2010a). These effects may contribute to their anti-carcinogenic effects” (Ramos et al, 2011) (7)

See jenniferdepew.com page Phytonutrients for food sources and more information about quercetin, rutin, rosmarinic acid, luteolin and other phytonutrients.

The menu and beverage ideas for Nrf2 Promoting Foods (G10) on effectivecare.info would also be helpful for DNA repair, and Pomegranate (G13) or Citrus Peel (G14). Zinc is also important, food sources on (G15), or see reference (8).

Thiamine, vitamin B1, is also needed in larger amounts during severe inflammation or infection and possibly for a long time aferwards, a LongCovid personal story: (9). Riboflavin, B2, is important to take along with it, and niacin/nicotinic acid, B3, pantothenic acid, B5, and the other methyl donors, folate, methyl or hydroxy B12, and choline. Betaine, TMG, may also be beneficial to take and CoQ10 and alpha lipoic acid, both cofactors for mitochondrial use of the citric acid cycle (see post Niacin for preventing migraines) for converting glucose into usable energy or as heat, which can reduce inflammation. (see post Niacin & Early Treatment)

Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a [*functional] health professional for individual health care purposes.

Reference List

  1. Arvin, A.M., Fink, K., Schmid, M.A. et al. A perspective on potential antibody-dependent enhancement of SARS-CoV-2. Nature 584, 353–363 (2020). https://doi.org/10.1038/s41586-020-2538-8 https://www.nature.com/articles/s41586-020-2538-8
  2. James Lyons-Weiler. Spike-Only Vaccine a Colossal Blunder: Michigan State University Shows SARS-CoV-2 Vaccine Escape is Due to Vaccination. Dec. 8, 2021, https://popularrationalism.substack.com/p/spike-only-vaccine-a-colossal-blunder
  3. Timothy Cardozo, Ronald Veazey. Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease. Int J Clin Pract. 2021;75:e13795. DOI: 10.1111/ijcp.13795 https://onlinelibrary.wiley.com/doi/pdf/10.1111/ijcp.13795
  4. Wang R, Chen J, Wei G-W. Mechanisms of SARS-CoV-2 Evolution Revealing Vaccine-Resistant Mutations in Europe and America. J. Phys. Chem. Lett. 2021, 12, XXX, 11850–11857, December 7, 2021 https://doi.org/10.1021/acs.jpclett.1c03380
  5. Park JS, Davis RL, Sue CM. Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives. Curr Neurol Neurosci Rep. 2018;18(5):21. Published 2018 Apr 3. doi:10.1007/s11910-018-0829-3 https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5882770/
  6. Hui Jiang, Ya-Fang Mei. SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Viruses 2021, 13(10), 2056; DOI: 10.3390/v13102056 https://www.mdpi.com/1999-4915/13/10/2056/htm 
  7. Alice A. Ramos, Cristóvão F. Lima and Cristina Pereira-Wilson, Chapter: DNA Damage Protection and Induction of Repair by Dietary Phytochemicals and Cancer Prevention: What Do We Know? October 26th 2011, DOI: 10.5772/22125, From: Selected Topics in DNA Repair. Ed. Clark Chen, U of California, San Diego, USA, DOI: 10.5772/1749 https://www.intechopen.com/chapters/22717
  8. Song Y, Leonard SW, Traber MG, Ho E. Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats. J Nutr. 2009;139(9):1626-1631. doi:10.3945/jn.109.106369 https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3151020/
  9. Barb Check, Recovering from Long Covid with Thiamine. Sept. 1, 2021, https://www.hormonesmatter.com/recovering-from-long-covid-with-thiamine/
https://ijvtpr.com/index.php/IJVTPR/article/view/23

Individual Nutrition assessment – an example chart note

What is health care? What is included in an individualized health care appointment?

The answer varies with the type of specialist you are seeing – and what they are allowed to do within their facilities’, or the individual’s insurance plans protocols.

My nutrition counseling experience was in prenatal/early childhood, and residential (nursing home) facilities.

Chart notes would be written for high risk clients when working in either role. Occasionally the nutrition assessment and recommendations note would be sent to the physician directly if very high risk.

As a preventive health focused prenatal/early childhood counselor, or for residential facility chart review (nutrition assessments of all nursing home residents considered high risk nutritionally, occasionally would include an in person visit with the resident to visually observe and ask further questions about their health and diet symptoms.

Patients typically do not see a chart note. They might be given the ‘Problem’ and ‘Assessment’ sections as an action list of recommendations on a simpler handout. The medical chart has a Care Plan section where recommendations for a daily change in care might be added – such as adding a high protein snack in the evening.

I would typically spend a half hour to an hour per client and writing a good note might take an additional 15 minutes. Current insurance standards have been set which limit physicians to 15 minutes per patient appointment – and only scheduling/discussing one symptom per appointment. That would make a differential diagnosis fairly impossible.

  • The entirety of a person’s symptoms – and what makes the problems worse, and what seems to improve things – is what provides clues to the underlying issues that may have led to the increased inflammation and/or decreased function.
  • Health is a balance of not too much inflammatory response -> autoimmune or allergies – or too little -> rampant infection and catching every cold.
  • Health is also a balance of enough nutrients and not too many toxins to cope with, whether from air, water, food, or touch, or from internal production of stress chemicals caused by emotional or physical stress.

Autoimmune issues are particularly challenging because many odd symptoms can occur, and more than one type of autoimmune antibody may be involved – not just one ‘autoimmune disease’ – several. Low vitamin D makes autoimmune issues more likely to occur, and low magnesium can make low vitamin D more likely – even with supplements of vitamin D.

Low magnesium also increases inflammation symptoms, pain, and anxiety, depression or anger and irritability.

A physician might look at my example note (below) and think: ‘but this is not my field‘ — exactly — please refer to the specialist – a registered dietitian or clinically trained nutritionist. Caution, there are many ‘nutrition certification’ programs online which are not equivalent to a college education, internship, and the equivalent of a lawyer’s Board Exam.

The client gave permission to share the write-up for educational purposes or maybe to help someone. Patients know that pain hurts, and that health is better. Too often I hear from physicians something like ~ ‘we don’t know what is causing this, … so the patient will probably die‘ – but it is regarding symptoms that likely involve nutrient deficiency.

Even sick patients need to eat or be fed and their nutrient needs are likely increased, or decreased, due to the illness, for a few specific nutrients affecting or being used in excess by the underlying issue. Telling a patient there is no hope is providing a nocebo – a negative expectation. Saying “I don’t know,” – when that is the true situation – would at least not be setting up a roadblock for the patient to seek further information or a second opinion.

If in reading my example chart note*, as a physician, you think, ‘but this is not my field‘ — exactly — you are correct – but it is the patient’s whole health that matters, not just symptoms that may be temporarily controllable by medications.

SOAPE note

The SOAPE chart note* below, is an extended version compared to what would be likely to be written in a patient chart. SOAPE note: Subjective, what the client said; Objective, what the clinician observed; Assessment; what the clinician believes may be underlying issues; Problem/Plan, recommendations being made by the clinician; Evaluation – an opinion statement about the likelihood of positive change, based on the overall attitude or motivation the client is presenting and social factors that may impact the client positively or negatively.

I included extra information that might be in a report to the client, with the education they might need to understand the reasoning for the recommendation, or how to proceed. Complex strategies can take several weeks of a class like setting possibly with cooking and tasting demonstrations. My web pages and posts try to provide self care guidance so a motivated learner could just try things and see if they help.

I added some additional info links for the version in this post, to pages or posts that provide some next step guidance, Gluten Free diet? what is that? The products on the market are not ideal suppliers of nutrients in my personal and professional opinion and learning how to bake gluten free can be healthier and less expensive for the nutrient value. My websites are my file cabinet of patient handouts, some of it.

While working as a public health nutrition counselor I did occasionally write a very thorough note for someone with a complicated case, and send it to the client’s physician on their or their child’s behalf.

Nutrient deficiencies can lead to death (niacin/pellagra example) – and can turn around dramatically very shortly after the nutrients and any cofactors are provided (nutrients are a team – refeed gradually and in balance).

Sometimes nutrition care is a life or death situation. Continue the nutrient deficiencies and deterioration can be rapid, and death can be the result. Niacin deficiency, pellagra, has a nickname for symptoms – the four D’s: “Pellagra defines systemic disease as resulting from a marked cellular deficiency of niacin. It is characterized by 4 “D’s”: diarrhea, dermatitis, dementia, and death.” (1) If there is severe lower leg rash and edema – suspect a B vitamin deficiency.


Nutrition assessment

Subjective:

  1. CoV like symptoms, mild, ~ early outbreak mid 2020, left a new problem, 2. swollen throat, reflux like pain/not quite reflux though, flair up of CoV symptoms again later when family had it 2021, again not too bad. 
  2. Swollen throat symptoms – has had labs showing autoimmune thyroid condition.
  3. Thyroid symptoms had improved a year or so earlier after stopping use of wheat/gluten and dairy. Recently started using ginger tea for the throat problem and it sooths. Hasn’t used long term, recent addition. 
  4. Reading about eosinophilic esophagitis did not sound like the problem. 
  5. Reading about histamine/MCAS symptoms did sound like it might be a problem. Tomato/salsa particularly, chicken causes congestion. Likes to drink orange juice.

Objective:

  1. Pale complection, may suggest magnesium deficiency/low vitamin D, low level anemia of chronic inflammation possibly.
  2. Throat visibly enlarged in pattern of enlarged thyroid gland 

Assessment: 

  1. CoV, even with mild symptoms, may have increased autoimmune antibodies, or created new types. Pale complection may suggest magnesium deficiency/low vitamin D, low level anemia of chronic inflammation possibly.
  2. Enlarged thyroid gland would be likely to cause difficulty swallowing at times, particularly if a food flair of the underlying autoimmune antibody sensitivity. (The thyroid gland presses inwards also and can narrow the throat significantly – *personal experience from also being an autoimmune thyroid patient, swallowing a large supplement can be very painful, and may feel stuck even.)
    1. Eosinophilic esophagitis might also be adding to swallowing symptoms if early stages, wouldn’t be causing as severe reflux symptoms as a more advanced case which is more likely to be what is described in articles about the problem. Food sensitivities are the most frequent cause and include gluten, dairy, eggs, and other common food sensitivity foods.
  3. Autoimmune thyroiditis can be a gluten molecular mimicry problem – the thyroid hormone chemically is similar to the gluten molecule. 
  4. Autoimmune antibodies to other food chemicals might also flair up an underlying autoimmune overactive eosinophile problem, white blood cells. Ginger contains a chemical similar to albumin and an egg sensitivity might be triggered by a sudden increase in use of ginger – or chicken – or eggs, or any animal product containing albumin. *also learned from personal experience – this can be a significant problem – I developed sensitivity to eggs and gradually realized I needed to exclude all sources of albumin or my symptoms would flair up again (non healing rash, not quite eczema – more wounds, lack of skin regrowth).
    1. An apparent ‘wheat/gluten’ sensitivity might be an albumin sensitivity, see one of my early posts with the information about plant albumin in wheat and ginger: Wheat is rich in albumin – so are ginger and egg whites.
  5. Histamine sensitivity seems a problem worth working on by decreasing trigger foods. Orange juice could be an additive problem food. The total load is part of the problem but even small amounts can set off the allergy cells that increase inflammatory cytokines and pain/inflammation signals – swollen, itchy, sore throat, dry eyes, but it can also effect mood when a more severe problem – extreme anxiety and fear, or out of control, hyper-excitable.

Problem:

  1. Elevated iron and symptoms of anemia of chronic inflammation may be a lingering CoV effect or of autoimmune conditions – it can be common to have several types of autoimmune antibodies also, and there has been cases of LongCovid where autoimmune antibodies were found. The spike lodges in a receptor and antibodies are made against the receptor, instead of against spike.. 
    1. Iron chelators may help mitigate chronic inflammation damage, restore energy level if that is a problem. The quercetin is one, continue regularly, opposite the niacin protocol if following that., or eat more of the good plant sources of a few, EGCG, pomegranate peel, green tea, oregano, olive leaf extract, there are many see the Iron chelator section of this Resources & Iron Chelators list
    2. Epsom salt soaks for a topical source of magnesium, help immune function, energy level, fluid balance. Continue if already using or start 1-3 times a week.
    3. Sunshine or Full spectrum light 20-30 minutes per day and or a moderate dose vitamin D3 ~ 600-1000 IU. 
    4. Avoid glyphosate residue. Consider supplementing with DMG, dimethylglycine, bulk powder, 1/2 spoonful once or twice a day in water or with a little juice and water. (too much juice is not really good for us).
  2. Thyroid problems in the modern world are likely related to excess fluoride and bromide and too little iodine. Cautiously increasing iodine and 200 mcg selenium may be helpful. Higher dose for one month can help the body to dump fluoride, bromide and chloride. When there is a lack of iodine the body will build molecules with the other halides, but then the thyroid hormone or other chemical won’t work right. Lab tests may show ‘normal’ levels of thyroid hormone but symptoms of hypothyroidism may still be present.
    1. In autoimmune conditions, when possible, it is essential to identify the trigger foods and strictly avoid them. It can take 6 months for antibodies to fade away, at which point symptoms should improve, but memory B cells still exist so even little tastes of the problem foods can set off a new 6 month batch of autoimmune antibodies that will attack the thyroid gland, or esophagus, or wherever else the problem point is located. 
    2. In this case eggs/chicken/ animal products/ ginger/ albumin /*hemp kernels too then/, may be part of the problem foods – 
    3. Elimination type diets that start with the least risky foods and gradually reintroduce things one at a time can be the best way to individualize what is the problem for you the individual. 
  3. Gluten was definitely identified as a part of the thyroid problem by removing, it already had helped to stop that. Dairy has a variety of allergens, and also would have albumin. Removing food triggers strictly, can help a swollen thyroid gland reduce in size – versus get more swollen when trigger foods are eaten.
    1. Gluten free baking recipes and tips for converting recipes: effectivecare.info – G8. Cookies & Bean Soup. -> and it mentions that increasing corn or corn flour instead, is not ideal either. Corn or gluten can increase zonulin which also increases leaky membranes in the gut or blood brain barrier, and more open membranes can increase risk of allergens entering undigested from the diet. See: What is Zonulin? (2)
    2. A quick mix recipe that can be used for pancakes or muffins, a post: Pancakes in a Jiffy – Quick Bread Mix.
  4. Eosinophilic esophagitis may be related to food sensitivities, so as food elimination is attempted it would also be helpful to pay attention to the swallowing symptoms to see if change occurs other than the swollen pressure feeling of the enlarged thyroid gland.
    1. Research shows a strong connection between food allergies and eosinophilic esophagitis (EOE). These six foods are most commonly associated with this allergic response: dairy, wheat, soy, eggs, nuts, and seafood/shellfish. Unfortunately, there is no accurate test to identify food allergies* connected with EOE.” (3
    2. *The food sensitivity is not the same type as tested for people who get hives to peanut butter or eggs or are allergic to bee stings. It is food sensitivity that activates white blood cells though, called eosinophils. 
    3. During normal function eosinophils fight parasites for us. So …. Maybe they are doing something in ‘autoimmune disease’ that involves their normal function too fighting an unidentified parasite – or they are responding to chemicals of the six foods listed above in an allergy-like way. 
    4. Asthma and allergies involve increased eosinophil activity, which can lead to inflammation symptoms and tissue damage: “Eosinophils can consume foreign substances. For example, they fight substances related to parasitic infection that have been flagged for destruction by your immune system. Regulating inflammation. Eosinophils help promote inflammation, which plays a beneficial role in isolating and controlling a disease site.” […] “…eosinophils play a key role in the symptoms of asthma and allergies, such as hay fever. Other immune system disorders also can contribute to ongoing (chronic) inflammation.” (4
  5. Eliminating common histamine problem foods may help anxiety and inflammatory symptoms. Orange juice, tomatoes, fermented foods, or older leftovers, cranberries, others, it is a lengthy list but can make a huge difference *personal issue for me also.
    1. More info on page MCAS/Histamine, jenniferdepew.com: MCAS/HIstamine.
    2. Summary of foods to avoid, or a few helpful in an over-reaction: Histamine Food Lists. it is a document (6)

Evaluation:

Client seems motivated and capable of making positive changes for improving health, cheerful and confident amid a complex set of problems, and has support of family.


So does my disclaimer make more sense now?

  • Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

My professional and personal expectations of individualized health care guidance does not include a 15 minute appointment limited to discussing one symptom. In seeking a health care provider I recommend searching for ‘functional health’ or possibly holistic but that is less precisely used than ‘functional’. The orthomolecular approach is also whole body and restoring function oriented.

*am I taking clients? I am working in that direction but I am still in initial stages of having a system set up.


Change is easiest by just practicing the desired habit and the more often it is remembered, practiced, then the more that brain pathway will be strengthened and the old one is gradually deactivated, becomes harder for the nerve cells to fire instead of being an automatic habit like happens without even thinking consciously – to change that ingrained of a habit takes substituting a new pattern rather than trying to ‘attack’ with ‘will power’. Work with nature and it will work with you. Attack and it tends to have an undesired ripple effect.

Pain hurts, health is better.

We all die, the question is quality of life while living – and enjoying that life while living.

Namaste – the soul in me, sees the soul in you.

We are all children, under the care of Mother Nature and Father Sun.

Where there is light there is life, and there is hope.

Reference List

  1. Hegyi J, Schwartz RA, Hegyi V. Pellagra: dermatitis, dementia, and diarrhea. Int J Dermatol. 2004 Jan;43(1):1-5. doi: 10.1111/j.1365-4632.2004.01959.x. PMID: 14693013. https://pubmed.ncbi.nlm.nih.gov/14693013/
  2. What is Zonulin? https://www.creative-diagnostics.com/blog/index.php/what-is-zonulin/
  3. 6 Food Elimination Eosinophilic Esophagitis, oregonclinic.com, https://www.oregonclinic.com/6-Food-Elimination-Eosinophilic-Esophagitis-EOE 
  4. Eosinophilia, symptoms, mayoclinic.com, https://www.mayoclinic.org/symptoms/eosinophilia/basics/causes/sym-20050752

Documents, Posts & Pages

  1. Wheat is rich in albumin – so are ginger and egg whites, post transcendingsquare.com
  2. Resources & Iron Chelators list, document https://docs.google.com/document/d/1XiwJBPoFUnUTQKcRAW_8NMriQMt8b31zjeTY4zV0wJo/edit?usp=sharing
  3. effectivecare.info – G8. Cookies & Bean Soup, webpage
  4. Pancakes in a Jiffy – Quick Bread Mix. post transcendingsquare.com
  5. MCAS/Histamine. webpage, jenniferdepew.com
  6. Histamine Food Lists. document, https://docs.google.com/document/d/17iz9lsJyGqIUUjF0p-totXp4R2GhgRi2Na4gYueisTM/edit?usp=sharing