What autoimmune hyperinflammation looks like – LongCovid/FLCCC Conference.

Excerpt from The Epoch Times gives another warning to be cautious of psychiatric referrals. Autoimmune patients are used to being called hypochondriacs & sent to talk therapy. Now more are at risk.

  • Via COVID-19 Vaccine Injury, Syndrome Not a Disease: FLCCC Conference Shares How to Treat It, by Marina Zhang, Oct 17, 2022, The Epoch Times, (Zhang/theepochtimes):

[Dr. Ryan Cole] “Cole presented biopsies that showed spike protein presence and inflammation in small blood vessels, muscles, heart muscles, brain tissue, lungs, spleen, and many more.

Most of the biopsies presented damaged cells that expressed only spike protein, rather than other SARS-CoV-2 proteins. This suggests spike injuries are caused by vaccination and not natural infection, because in infection other SARS-CoV-2 proteins including nucleocapsid proteins [the base subunit S2 is connected to Nucleocapsid subunits] are present in addition to the spike protein.

[Dr. Paul Marik, co-founder and Chief Science Officer of the Frontline COVID-19 Critical Care Alliance (FLCCC),]

Cole’s findings fed into Marik’s lecture on symptoms and treatment options for long COVID and post-vaccine injury syndrome.” (Zhang/theepochtimes)

  • React19 is a science-based non-profit offering financial, physical, and emotional support for those suffering from longterm Covid-19 vaccine adverse events globally. (react19.org/about

“Evaluating React19 survey data from people suspecting vaccine injuries, Marik found the most common symptoms of spike protein-induced diseases.” (Zhang/theepochtimes)

Ten most commonly reported symptoms of people surveyed about suspected CoV vaccine injury.

“This included fatigue, exercise intolerance, brain fog, heart palpitations, muscle weakness, tingling, dizziness, muscle aches, sleep disturbances, and joint pain.” (Zhang/theepochtimes)

Epoch Times Photo
Dr. Paul Marik’s slides presented at the FLCCC Conference in Orlando Florida (Courtesy of the FLCCC) (Zhang/theepochtimes)

““Believe it or not … the average number of symptoms reported is 23,” said Marik.

However, because most patients complain of an extensive list of symptoms not found in any disease, “[patients] will go to the doctor with all these complaints … and the doctor will say it’s all in your head,” said Marik.

Marik said that many patients are thus referred to psychiatric specialties rather than physicians who understand and can treat their disease.

The vaccine-injured are vast,” said Kory, “the numbers are massive … they are underserved and their needs are not being met.”” (Zhang/theepochtimes)

Brain fog experienced by 71.5% of people who suspect they were CoV vak injured. (Zhang/theepochtimes)

Substack: Pomegranate Peel Prep.
Ways Pomegranate protects against spike, (transcendingsquare.com)

Wormwood and artemisinin have also been part of my self-care arsenal. The pomegranate peel helps a lot but when I had post CoV infection fatigue and any flair ups since, artemisinin and then Wormwood tea more recently has helped fairly quickly. The artemisinin got more expensive, so I switched when I ran out of the 6 bottles I had bought online in 2020 when my symptoms felt like anemia of chronic inflammation/infection. It worked, I used it am and pm, 200 mg, for a few months and then once a day for the next year. The Wormwood tea is harsh on the gut, and I use it for flair-ups, any worsening of cold symptoms, swollen lymph nodes, achy body pain, or night sweats (a sign of worse autoimmune/inflammation/cancer).

Addition: Sweet Wormwood leaves is what I should have bought. Wormwood has thujone and is used in absinthe. Too much is a GABA disruptor and can cause seizures. Neither is recommended during pregnancy or child-bearing years. Artemisia afra is used I believe as an anti-malarial preventive in endemic regions of Africa. Artemisia afra does not have the same phytonutrients as the other Artemisia/wormwoods (and mugworts), but trials have had positive results. (du Toit and van der Kooy, 2019)

I used an old browser url to open my transcendingsquare.site and it was synchronicity – pertinent: Neuropathy can be a cause of extreme tiredness, 8/Dec/2016, with a helpful list of possible things to try. (transcendingsquare.com)

What I wanted was this post, I wrote about it more and of my use for my extreme fatigue: Artemisinin, arteannuin-B, sgp130Fc and COVID-19, 25/June/2020. The extreme fatigue needs an iron chelator to help the body recover balance after an infection causes a shift of iron from hemoglobin into storage as free iron or ferritin. If too much is free the storage becomes an issue and if it leaks to extracellular tissue, it causes oxidative damage and more inflammation.

The protein sgp130Fc may also be helpful but I have not seen much followed up on that topic.

  • SARS-CoV-2 and COVID-19: Is interleukin-6 (IL-6) the ‘culprit lesion’ of ARDS onset? What is there besides Tocilizumab? SGP130Fc. (Magro, 2020)

This article is mostly about the medications but mentions the sgp130Fc, a normal protein that would be protective, but during inflammation/infection we would need five times more. My post includes more description in a later section. Artemisinin, arteannuin-B, sgp130Fc and COVID-19

There has been increased interest in employing the inhibitory agents tocilizumab, siltuximab and sarilumab in COVID-19 patients, with a series of clinical trials being registered and launched in different countries. In addition, the use of anti-IL-6 drugs is associated with an increased risk of some adverse reactions [8]. The use of metalloproteinase 17 (ADAM17) or soluble glycoprotein 130 fused chimera (sgp130Fc) to specifically inhibit pathological IL-6 trans-signaling in patients with severe COVID-19 promises to be a more effective and safer strategy to ameliorate disease states.” (Du, et al, 2021)

When I talk about membrane damage, realize that also means nerve membranes – myelination which makes our nerve signaling more rapid and accurate. (effectivecare.info/G12. Demyelination) I never got back to finish that page – a very revealing trend that I meant to move onto next was general malnutrition seems to be a big risk for demyelination. If the body gets hungry enough it starts using muscle tissue for protein and likely breaks down myelin for fatty acids.

My fingers get more pins and needles numb when I forget my methyl B12 too often or go too long between Epsom salt soaks. CoQ10 is on my Don’t forget list, and I have been.

Seeking help from people that dismiss your long list of aches and pains as hypochondria or psychosomatic is a bad idea. Complaining about it/their treatment, to them, may be a worse idea, as it may lead to a psychiatric commitment against your will and psychiatric medications that are likely to speed up the chronic degeneration and worsen the neurological damage.

This is serious. The powers in charge are forcing this through (CoV vak and other mRNA vak-to-be or other treatments) and ignoring all evidence of the harm of the mRNA process and the LNPs. Banging your head against a locked door (metaphorically) is not sensible . . . asking or demanding help from the people who are harming and denying harm and threatening mental illness diagnosis for people talking negatively about the causal substance . . . is not sensible.

A social media acquaintance literally escaped from a lock facility after their family had them committed for apparent craziness about Covid and posting too much online (late 2021). The person was put on medications that made the escape more difficult and surreal – a family member got a doctor to prescribe something and then swapped it for an antibiotic that was needed (so combined surreal issues from pain and an untreated infection). Psychiatric medications are dangerous, to many people at least, and we aren’t supposed to talk about that. Family members who are all “concerned” about you can also be very dangerous as they have sway with medical or legal officials.

Seek help from more reliable sources like the FLCCC or the World Health Council, or people who have lived it and survived to tell the tale (of life as an autoimmune patient), like me, and try to find a functional practitioner for local/individual support which is also a need.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes. 

Reference List

(Du, et al, 2021) Du P, Geng J, Wang F, Chen X, Huang Z, Wang Y. Role of IL-6 inhibitor in treatment of COVID-19-related cytokine release syndrome. Int J Med Sci 2021; 18(6):1356-1362. doi:10.7150/ijms.53564. https://www.medsci.org/v18p1356.htm

(du Toit and van der Kooy, 2019) du Toit A, van der Kooy F. Artemisia afra, a controversial herbal remedy or a treasure trove of new drugs? J Ethnopharmacol. 2019 Nov 15;244:112127. doi: 10.1016/j.jep.2019.112127. Epub 2019 Jul 31. PMID: 31376515. https://pubmed.ncbi.nlm.nih.gov/31376515/

(Magro, 2020) Magro G. SARS-CoV-2 and COVID-19: Is interleukin-6 (IL-6) the ‘culprit lesion’ of ARDS onset? What is there besides Tocilizumab? SGP130Fc. Cytokine X. 2020 Jun;2(2):100029. doi: 10.1016/j.cytox.2020.100029. Epub 2020 May 14. PMID: 32421092; PMCID: PMC7224649. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224649/

(Zhang/theepochtimes) Zhang, M., COVID-19 Vaccine Injury, Syndrome Not a Disease: FLCCC Conference Shares How to Treat It, Oct 17, 2022, The Epoch Times https://www.theepochtimes.com/health/covid-19-vaccine-injury-syndrome-not-a-disease-flccc-conference-shares-how-to-treat-it_4802240.html?utm_source=ccpvnoe&src_src=ccpvnoe&utm_campaign=2022-10-22&src_cmp=2022-10-22&utm_medium=email&est=h3HkAlm43%2BDIe%2B07H1ta0iH8VBZ7KkUK%2Bxcm5tGy%2B55oYn%2BV1pE3L%2BhsfYtQXE7lup4bXoNAsiiz%2FnY%3D

Ways pomegranate protects against spike.

Includes chimeric spike gene sequences involved in fusion entry of cells, and Ehden Biber’s latest post with FOIA information from Pfizer including the Omicron BA.1 (“Riltozinameran”) genetic sequence.

Hard to understand info for non-geneticists from Ehden – thanks for sharing maybe some geneticists will translate for us: The Sequence; We now have Pfizer’s Omicron BA.1 (“Riltozinameran”) genetic sequence, alongside other important information, thanks to a FOI request to the UK’s regulatory body, the MHRA. – by Ehden Biber – Sense of Awareness (substack.com)

I had just added a gene sequence image to something I had written, and was searching posts and not finding it (and getting frustrated ;-) when I remembered where it was – Gp41 in SARS-CoV-2 spike, so here we are back with the delicious and royal fruit.

Pomegranate is so awesome it can take on a multi-fanged genetic chimera:

1) Blocks entry at the ACE2 receptors and preserves ACE2 function.

Pomegranate peel extract blocks entry at the ACE2 receptor which also helps protect the function of ACE2 receptors, and pomegranate extract also inhibited “the activity of the virus 3CL protease.” (Tito, et al, 2020) Lung edema and other symptoms of severe Covid19 are also symptoms of lack of ACE2 function. As the infection spreads to cells with ACE2, the spike blocked receptor is dysfunctional. The juice/fruit likely helps but the peel is more potent, more concentrated in phytonutrients and has additional hydrolyzable tannins.

2) Inhibits NET formation, and inflammasome creation.

Inhibits NET formation (Kirchner, et al, 2013) which would promote inflammasome production – which kills good cells when it is an over-reaction. The SARS-CoV-2 virus spike protein, the E protein section, causes activation of NLRP3 Inflammasome creation, and the resulting increase in inflammation can also signal further creation of them. (Wong and Saier, 2021) An allergy like sensitization seems to occur. Macrophages from people who had been sick with COVID-19 reacted to exposure to the SARS-CoV-2 spike protein and inflammasome production occurred. Cells from people who had not been pre-exposed to SARS-CoV-2 did not react to cause inflammasome creation. (Theobald, et al, 2021)

3) Inhibits fusion of HIV-1 and entry into cells by membrane fusion. It may do the same for SARS-CoV-2.

*I am not sure if “HIV-1 entry inhibitor” is the same as fusion inhibitor for preventing the splitting of S1 from the S2 portion of spike. (Neurath, et al, 2004)

  • Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide.” (Neurath, et al, 2004)

If it is, pomegranate phytonutrients could inhibit the fusion cleavage site from opening and freeing the S1 subunit which then can block nAChR function and has prion like domains and a galectin-3 like sequence. So, preventing S1 release would protect cholinergic function, reduce misfolded protein risks, and reduce risk of galectin-3 over-stimulating excess angiogenesis (blood vessel formation or doubling/splitting).

It was noted by (Wu Zhang and Leng Yap, 2004) that HIV-1 gp41 and SARS-CoV(1) S2 proteins are similar in structure. The gp41 protein helps HIV-1 fuse directly with cells in order to infect them, (Chen, 2019), which SARS-CoV-2 can also do. The S2 portion of spike forms a wedge like shape and directly invades a cell’s bilipid membrane layer for the purpose of membrane-to-membrane fusion with the viral particle. The sequence “GB1” is discussed and a Spike SARS-CoV-2 Fusion peptide, see Fig. S1. (Koppisetti, Fulcher, Van Doren, 2021) If pomegranate can prevent HIV-1 membrane fusion than maybe it is preventing separation of the S1 from the S2 subunit – more research is needed.

Fig. S1. (Koppisetti, Fulcher, Van Doren, 2021)

Background info by (Wu Zhang and Leng Yap, 2004) on the roles of the two parts of a coronavirus species’ spike protein – S1 (“cellular reception recognition”) and S2 (fusion of the viral and host cell membranes for entry):

“Coronavirus spike protein plays a very important role in virus entry, virus–receptor interaction, variations in host range and tissue tropism. The S proteins of majority of coronaviruses are cleaved into two functional subunits, S1 and S2. Liu et al. [1] indicated that the S protein of SARS-associated coronavirus (SARS-CoV) also forms S1 and S2 domains. The peripheral S1 portion is responsible for cellular receptor recognition, while the membrane-spanning S2 portion mediates the fusion of viral and cellular membrane, hence S protein determines the specificity of host and virulence of coronavirus [2]. Similarly, there are two non-valently associated subunits in the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein, gp120 and gp41, gp120 directs target-cell recognition and viral tropism through interaction with the cell-surface receptor CD4, while the membrane-spanning gp41 promotes fusion of the viral and cellular membranes so that viral contents are released into the host cell [3].” (Wu Zhang and Leng Yap, 2004)

The chimeric S1 subunit can be free and effect receptors elsewhere in the body or be released in exosomes in exhaled breath or sweat, and body fluids. It has the snake venom toxin-like nAChR cholinergic blocking effect and has a galectin-3 look alike sequence. Preventing S1 separation would reduce harm.

4) Acts as a modulator for inflammation & immune function,, promoting or inhibiting as needed for the situation.

Acts as a modulator and can increase Nitric oxide production if low or reduce Nitric oxide production if it excessive. Modulatory benefits for oxidative stress – pomegranate peel can help increase Nitric oxide by promoting eNOS (Delgado, et al, 2017), (de Nigris, et al, 2007a), (Wang D, et al, 2018), or reduce excess by promoting iNOS. (Kandeil, et al, 2019)

5) Protects against misfolded protein conditions.

Protects against misfolded protein conditions – the delphinidin (Noda, et al, 2002) and other anthocyanidins (Masci, et al, 2016), (Qu, et al, 2015) that give pomegranate its purple red hue, may help stabilize proteins as allosteric modulators and many phytonutrients or nutrients can act on receptors as agonists or reverse agonist (less often). (Silva, et al, 2019)

6) Promotes Nrf2 which helps promote DNA damage repair, glutathione production, and immune function.

Promotes Nrf2 which helps promote glutathione production, immune function, and DNA damage repair and inhibits inflammatory cytokines including IL-6 (Karwasra, et al, 2019) and NFkB. (Rasheed, et al, 2009). Nrf2 and pomegranate peel inhibit mast cell degranulation which would reduce inflammation, cytokines, and histamine. (Parisio, et al, 2020) Antihistamines tend to help in CoV treatment. Nrf2 inhibits mast cell degranulation by promoting SIRT4. (Hu B et al, 2020)

7) Contains potent antioxidants in addition to promoting Nrf2 and our own glutathione production.

Pomegranate peel contains potent antioxidants and diuretics (the tannins/EGCG/catechins) which help with detox – have several servings earlier in the day if ill and drink plenty of water, or once a day as a preventive.

The fruit juice and seeds provide some of the benefits for reducing inflammation and protecting the brain, but the peel contains more of the phytonutrients with potent antiviral and antioxidant function. Antioxidant power so strong, pomegranate peel extract can be used as an anti-corrosive for steel. (Rashid, et al, 2017) Too much is a pro-oxidant, use in moderate amounts. The diuretic effect is a clue when you may be getting too much, or just a good amount if puffiness is a problem.

8) Protects against liver, kidney, and brain damage risks from hyperinflammation.

Protects against liver, kidney, (Middha, et al, 2013) and brain damage risks from (spike) hyperinflammation. (Ahmed, et al, 2014) (Morzelle, et al, 2016) With a healthy microbiome, metabolites urolithin A and B can cross the blood brain barrier and reduce neuroinflammation. (Kujawska, et al, 2019) EGCG helps promote new growth of hippocampal cells. (Itika, et al, 2020) Urolithin A may be helpful against aging, metabolic dysfunction, IBD, and neurodegenerative disorders by promoting mitophagy and removal of defective mitochondria leading to improved health of mitochondria. (Singh, et al, 2022)

Species that help produce urolithin A and B may include Firmicutes, Clostridiales and Ruminococcaceae family and Akkermansia muciniphlia. Having more Bacteroides in ratio to Firmicutes was associated with non-production of urolithin A in response to 8 oz of pomegranate juice. A 500 mg supplement product, MitoPure, led to much greater increases in plasma levels of urolithin than the juice, in a crossover self-controlled clinical study. (Singh, et al, 2022)

Firmicutes are the main butyrate producing species, Ruminococcaceae also produce it, and Akkermansia muciniphlia produce other short-chain fatty acids. They are anaerobes fermenting undigested starches within the colon and the short chain fatty acids help feed the colon cells. (Parada Venegas, et al, 2019) *Probiotics provide species that populate the small intestines. We need to eat adequate resistant starches and zinc to support the anaerobe of the colon.

9) Improves gut health, membrane and cardiovascular health and promotes a beneficial microbiome balance of butyrate producing species.

Improves gut health, (Zhang, et al, 2017) membrane health, and cardiovascular health. (Wang et al, 2018)  (Sadeghipour, et al, 2014) (Salwe, et al, 2015) . (Yang, et al, 2018) (Asgary, et al, 2017). Improved endothelial function in the placenta for a diabetic pregnancy animal model, eNOS -/- knockout mice and wild-type were used. (El-Sayyad, et al, 2019)

  • Tip – think of skin health, gut health and blood vessel/cardiovascular health as all connected – similar tissue, slightly different issues.

Promotes balance between Firmicutes and Bacteroides species, butyrate producing microbial species in the gut. Excess Firmicutes is associated with obesity and excess Bacteroides with Inflammatory Bowel Disease. Pomegranate led to a decrease in Firmicutes in an animal-based study about a gut pathogen. (George, et al, 2019)

  • “These results suggest that consumption of pomegranate polyphenols altered the microbiome, making it more resistant to displacement by infection with Cr, indicating that pomegranate polyphenols may mitigate the pathogenic effects of food‐borne bacterial pathogens.” (George, et al, 2019)

When we protect our gut, we are also protecting our brain, because they are connected via the large vagus nerve. It can act as a superhighway and allow chemicals to enter the brain from the gut or enter the gut from the brain. Parkinson’s Disease seems to involve this connection. Pomegranate peel extract helped a brain inflammation condition by modulation of the species in the gut. (Lu, et al, 2020)

  • “Pomegranate peel extract ameliorates the severity of experimental autoimmune encephalomyelitis via modulation of gut microbiota.” (Lu XY, et al, 2020)

Promotes the microbiome. Sepsis – did not help in one animal model. Pretreatment for a month with pomegranate may have increased gut microbiome leaving the animals at increased risk of sepsis effects when surgery was performed.  (Tavasoli, et al, 2014)

Pomegranate in a market. Photo by Jonas Renner on Unsplash.

Summary: The juice/fruit provide many of these benefits but not all, the peel is more potent in the anti-viral & other benefits.

  1. Pomegranate peel extract blocks entry at the ACE2 receptors and preserves ACE2 function.
  2. Inhibits NET formation which leads to (killer) inflammasome creation.
  3. Inhibits fusion of HIV-1 and entry into cells by membrane fusion. It may do the same for SARS-CoV-2.
  4. Acts as a modulator for inflammation and immune function, promoting or inhibiting as needed for the situation – restoring balance.
  5. Protects against misfolded protein conditions (prions).
  6. Promotes Nrf2 which helps promote DNA damage repair, glutathione production, and immune function.
  7. Pomegranate contains potent antioxidants in addition to promoting Nrf2 and our own glutathione production.
  8. Protects against liver, kidney, and brain damage risks from hyperinflammation.
  9. Improves gut health, membrane and cardiovascular health; and promotes a beneficial microbiome balance of butyrate producing species.
  10. The juice/fruit provide many of these benefits but not all, the peel is more potent in the anti-viral benefits.

Ellagic acid/EGCG alternatives:

If pomegranate/peel is not available to you, then sumac/Zataar contains similar phytonutrients and so do Goji berries, and red raspberries a smaller amount and maybe black raspberries too: “The seeds of raspberries contained 87.8% of the ellagic acid,” (Daniel, et al, 1989), strawberries had more in the pulp than the seeds. Green tea also contains some of the catechin benefits ~ 3 cups per day provides about 200 mg of EGCG which is a typical amount found in supplements of EGCG. If gut issues are also an issue though, green tea may cause discomfort due to the oxalate content.

We should listen to Geert Vanden Bossche, PhD, DVM:

  • Geert says we need to treat everyone prophylactically to stop breakthrough infections & slow the mutation rate. (substack.com) a post on my SubCtack links to his audio/post.

Early treatment works – we need to prophylactically treat everyone with the basic Z-Stack or preferred equivalent. Preventively taking supplements means you are treating somewhat at the first exposure. Then if signs of a cold occur, increase the vitamin C and anti-viral/iron chelators like quercetin, pomegranate peel product/tea and/or black seed oil.

I also include intranasal rinse or spray, and negative ionizers for air quality control in addition. Stop the exposure in the nose where the body has IgA antibodies that react against any coronavirus. Once the RNA species reach the lung, they have mutated somewhat and are harder for the body to fight.

Negative ionizers are something that should be in public places.

Anyone in power over a facility – please see what you can do to add it. CoV spike is positively charged and will clump and fall from the air. Sweep and mop more often. Part of the risk is the air above big crowds – think of it as a circulating swamp of everyone’s mutation variants, which then all can rapidly mingle and the whole swarm can quantumly it seems, all mutate to a new (worse) variant and make the whole crowd sick. Karl Sirotkin, PhD’s work.

  • Golden Silkworms in Pandora’s Box – by Harvard2TheBigHouse (substack.com)

Pomegranate peel and fruit is an “antidote” for many diabolical features of the patented computer-generated sequence that is causing harm. It happens to be pomegranate season in the Northern Hemisphere. Are we collectively going to start using the fruit and peel for its full benefits? Or continue waiting for a rich person to suggest it? Or wait for Tedros and the WHO to use a little money to research pomegranate peel extract against SARS-CoV-2?

If you want medical doctor/researcher recommendations about the benefits of pomegranate, read this open access peer-reviewed book: Pomegranate, (IntechOpen), 2021. In a chapter on the antimicrobial benefits, Celiksoy and Heard did a phenomenal job creating extensive Tables of research trials showing antimicrobial potential of pomegranate peel extract or whole fruit extract. The Tables include which species were targeted using pomegranate extract of what dose, standardized to 13% ellagic acid, or other extraction method details are listed. (Celiksoy and Heard, 2021) It is just one Chapter in an open access peer-reviewed (long) book: Pomegranate, (IntechOpen), 2021.

Pomegranate and early treatment can work – if you use it.

It can’t work if you don’t use it.

Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Geert says we need to treat everyone prophylactically to stop breakthrough infections & slow the mutation rate.

We should listen to Geert. He is correct and has been correct.

Geert Vanden Bossche, PhD, DVM, has been warning us all along that the CoV ‘vaccines’ would just push the virus towards variants that escape the antibodies being created by the CoV jabs – and he was right. He is alarmed that the vaccine community is still talking about yet more vaccine modifications for the yet more variants. He likes the variant collecting to stamp collecting – get your name on a publication and maybe name another variant too! Oh, joy! Not really joyous.

I did get sick to what seemed like a different variant, Omicron maybe, this spring while visiting a nursing home on a daily basis – until they had an outbreak. The symptoms were a little different – less respiratory, more of a bad migraine, and extreme fatigue and napping and sleeping A LOT. The good news – upping the Basic Stack, having some extra Pomegranate peel/Plus tea, helped me recover within a week and adding the Basic Stack for my sister helped her within two weeks (worse risk factors and hadn’t been taking the supplements in advance). I gave extra supplements to my mother also and she also got better somewhere between the one to two weeks. The news has emphasized that “Covid19” is a death sentence, but realistically it is the US funded vent-and-sedate and Remdesivir protocols that are death sentences.

Geert tries to explain to us the problem in a way that we can understand – nice attempt – still not easy. The take home point though – what to do next? Treat everyone preventively/prophylactically. Stop the infection by establishing real herd immunity – where enough people do have natural immunity antibodies that the pressure on the viral species to create escape variants is reduced. Creating more and more vaccines will push the viral species to make an increasing range of escape variants that can bypass the jab antibodies. The jab antibodies can then even become a liability where they mark the infectious variant as “self” – ignore this protein – it is safe. > Roughly, this is tough topic, but he has not been wrong, all along. We should listen to Geert. He has provided audio or text:

Voice for Science and Solidarity by Geert Vanden Bossche, It is 5 past 12 !Hello everyone. My name is Geert Vanden Bossche. I’m a seasoned vaccinologist with background in veterinary medicine, in biology, immunology, microbial diseases. I have been sending out video messages before and this is probably the last one I’m going to do. I will still write articles, I will still do interviews…” · Geert Vanden Bossche

It is 5 past 12!” – Geert Vanden Bossche

Our Cinderella outfit and couch turned back into a pumpkin maybe?

What to do? “Treat prophylactically with antivirals that are broadly accessible and affordable, says Geert:

So how can we avoid vaccine breakthrough disease? Of course, by diminishing the infection rate!

When we diminish the infection rate we avoid breakthrough diseases. We will avoid recall of these less to non-neutralizing antibodies.  But we need to do better. We not only need to avoid vaccine breakthrough disease. We would need to reduce the infection level to an extent that we can even avoid vaccine breakthrough infection because as soon as we will have an infection the virus will break through the innate immune response and – in previously vaccine-primed individuals- automatically recall antibodies that are completely obsolete; antibodies that have no longer neutralizing capacity. So how can we do this? Of course, the infection rate can only be reduced via chemoprophylaxis with safe and effective antivirals that on top are broadly accessible and affordable. So, I don’t care which antivirals but they need to comply with those criteria.” – Geert Vanden Bossche, PhD, DVM

Geert goes on to say that staying on antivirals long term would not be good either but is needed to prevent more variants that evade the CoV jab antibodies. SARS-CoV-2 is an RNA coronavirus species which mutate quite readily – it is part of how the species functions within a host. The dominant variant changes as the species spreads further into the body where there are differences in average warmth or acidity or other chemical levels. RNA viral species are more like interchangeable Lego blocks than “one” specific gene sequence.

If mass prophylactic prevention is his recommendation, then there are two steps to include, or three:

  1. Negative ionizers in public and private spaces to help remove positively charged spike exosomes or particles from the air.
  2. Intranasal rinse at the end of the day or after being in a public space.
  3. Preventive nutrient/phytonutrient or anti-viral medications, on a daily basis and increase to treatment levels at the very first signs of a cold or flu-like body aches. In my own experience with post CoV and post passive exposure to CoV jabs illness – keep treating long-term preventively and keep a moderate pace. Relapse is quite likely as this pathogen issue seems to be a latent intracellular risk which will need long-term care.

Antivirals that are broadly accessible and affordable include citrus and pomegranate peel, Star anise, evergreen needle tea, dandelion leaf or root tea, and many other things found in Mother Nature’s cabinet.

What is frustrating Geert Vanden Bosche and many others who have tried to speak out is that this all seems by design rather than an accident. Waiting for the “authorities” to wake up to their “mistake” is likely a huge mistake. Waiting for the authorities to approve and recommend safe and affordable antivirals for widespread preventive or prophylactic use, is a fool’s game in my opinion.

(Effectivecare.info/g13-Pomegranate) (transcendingsquare.com Pomegranate Covid19) (Health Aids for Special Times, document)) (Spike protein risks & aids – summary page. *longest blog post ever… also is a document that is longer) (Protocol Collation and Therapy Goals, live document this one is even longer and newer but the Spike protein Risks and Aids includes some other information)

It is pomegranate season on the Northern Hemisphere. The pomegranate fruit wears a crown because an ancient royal wanted a crown that looked like the pomegranate fruit. The pomegranate is revered in the Bible and other ancient texts. That is an evidence trail suggesting efficacy to me.

Ways pomegranate protects against spike:

  • Blocks entry at the ACE2 receptor. Helps reduce the dysfunction of reduced ACE2 function.
  • Inhibits NET formation and inflammasome production – which kills good cells when it is an over-reaction.
  • Inhibits the fusion cleavage site from opening and freeing the S1 subunit which then can block nAChR function and has prion like domains and a galectin-3 like sequence.
  • Protects against liver, kidney, and brain damage. With a healthy microbiome, metabolites urolithin A and B can cross the blood brain barrier, reduce neuroinflammation, and promote new growth of hippocampal cells.
  • Promotes Nrf2 which helps promote glutathione production, immune function, and DNA damage repair.
  • Protects against misfolded protein conditions.
  • Improves gut health, membrane health, and cardiovascular health.
  • Acts as a modulator and can increase Nitric oxide production if low or reduce Nitric oxide production if it excessive.
  • Pomegranate peel contains potent antioxidants and diuretics which help with detox – have several servings earlier in the day if ill and drink plenty of water, or once a day as a preventive.
  • The fruit juice and seeds provide some of the benefits for reducing inflammation and protecting the brain, but the peel contains more of the phytonutrients with potent antiviral function.

If pomegranate/peel is not available to you, then sumac/Zataar contains similar phytonutrients and so do Goji berries. Green tea also contains some of the catechin benefits ~ 3 cups per day provides about 200 mg of EGCG which is a typical amount found in supplements of EGCG. If gut issues are also an issue though, green tea may cause discomfort due to the oxalate content.

*My pomegranate paper is needed, I will keep working on it.

This recent post has my Basic Stack graphics:

  • deNutrients – News to Use, Terrain theory and early treatment/prevention. “Bad news – SARS-CoV-2 has yet another way that it can enter endothelial cells “through an αvβ3 Integrin-Mediated Endocytosis” – and it bypasses the CoV vak neutralizing antibodies. This is not good news, but it is repetitive news. SARS-CoV-2 has a ridiculously long list of ways it can enter cells – including direct fusion…” · Jennifer Depew, R.D.

This post has a pdf of the Tables that I have more complete (not the pomegranate phytonutrient or medical benefit Tables are done yet though).

And the first half, or second half that I wrote first, of my academic paper project:

  • deNutrients – News to Use, My research paper, initial progress “Pomegranate phytonutrients for mast cell inhibition to reduce the pain and suicide risk associated with histamine excess in neurologic conditions, drug related akathisia or post infection illness. Abstract Problem – Retinoic acid deficiency or excess and histamine excess are seen in many neurological c…” Jennifer Depew, R.D.

And the “That’s not a Table” post:

Excerpt from Spike Protein Risks and Aids:

About Cellular Serial Passage for bioengineering viral mutations:

We don’t have a smoking gun, we have a smoking mink pandemic – serial passaging in ferrets and mice must have been used to develop the ACE2 receptor mutations in the SARS-COV-2 spike sequence. Ferrets are very similar to minks, and mink populations have been the only ones that have been very susceptible to the SARS-CoV-2 virus – and they were very susceptible – suggesting that ferrets were used to increase the reactivity of the spike protein with the ACE2 receptors in humans and ferrets. Ferrets were chosen because there are close similarities to humans in the reactions to SARS coronavirus.

  • SARS-CoV-2 has extensive capacity to evolve to evade neutralizing antibodies targeting a small number of antigenic regions.” – Dr. John B. @DrJohnB2 https://twitter.com/DrJohnB2/status/1412482410143436804?s=20
  • This topic was discussed in part, in the introduction – the CoV injections are more likely to promote mutations due to the limited number of proteins included (the spike protein), as well as being likely to induce a non-neutralizing type of antibody that would make a future infection more dangerous instead of a neutralized non-risk – ADE, Antibody-dependent enhancement [of virulence].

Karthik K, Senthilkumar TMA, Udhayavel S, Raj GD. Role of antibody-dependent enhancement (ADE) in the virulence of SARS-CoV-2 and its mitigation strategies for the development of vaccines and immunotherapies to counter COVID-19. Hum Vaccin Immunother. 2020 Dec 1;16(12):3055-3060. doi: 10.1080/21645515.2020.1796425. Epub 2020 Aug 26. PMID: 32845733; PMCID: PMC7484565. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484565/

Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

n = 1 health care & self-controlled studies.

Evidence-based” healthcare mushes everyone into one average group who all get the same guidance – that is flawed. It was intended to be general guidance that is individualized further as needed.

A couple quick Substack links and points – “Anything other than N-of-1 medicine is a crime against humanity.” Toby Rogers

  • uTobian, The Great Regression
  • I. The Mass Poisoning of Society For the last 140 years, coal-fired power plants have spewed mercury into the air, water, and soil — and it then makes its way up the food chain into larger and larger animals. American cities first started adding fluoride…” · Toby Rogers

Clinical trials use “n=__” as typical jargon to show how big the study was. Larger studies generally are more reliable – bigger group, may more represent “average”. But what is average? No one person is “average”. It is just a math concept. Evidence-based guidance designed to best help the “average” person may not help everyone or anyone. Individual variables may leave some people harmed by the “average” solution.

It is like the Mom-ism – “But mom…… everyone is doing it” – “But child…you are not everyone…if they all are jumping off a cliff are you going to jump off a cliff too?” – “Oh, no I guess not mom, thanks.” The bungee jumping fad proved that many people would jump off a cliff just because everyone else seems to be doing it.

Human instincts are to flock together – to fit in with the group and mimic each other. That doesn’t mean it is always a good idea or even sensible.

Self-controlled studies are less average focused, and more individual focused. Instead of having an experimental group of people and a control group of people which has the difficulty of trying to randomly match both groups for variables like age, gender, socio-economic and health status, a self-controlled study has time periods as the experimental and control phases and all participants are tracked over time. Like a Before and After phase – what were their health parameters before an experimental event and what happened to their health after the experimental event?

Jessica Rose has a SubStack today that describes the self-controlled study concept when used for a vaccine type trial. The experimental time period is considered 28 days after the vaccine in the example she provides. Other experiments might designate a longer window to watch for health changes to check for a temporal association with an experimental procedure. Other studies might look at anything that happens after an experimental procedure as the follow-up phase. The value in the study design is that there isn’t a need to match for variables – each person is their own control, so their individual variables are an exact match for their own individual variables.

My Retinoid Toxicity/Histamine Excess research proposal is a self-controlled study design. With conditions that are characterized by being heterogenous – varied – trying to mash everyone together into one average is not helpful – the condition itself doesn’t have an “average”. Many birth issues, congenital differences, seem to have a cluster of varied gene alleles that may have some similarities across the individuals, but it heterogenous – not consistently the same gene alleles.

In order to both understand the problem better, and to help the individuals, then we need to look at them all as individuals with a varied and unknown group of gene alleles that may be negatively impacting their health by causing metabolic dysfunction or increased inflammation or chronic nutrient deficiencies. Their health may be able to be helped a lot, but not with an “average” treatment. Their condition is not “average” – it is genetically heterogenous.

A crime against humanity and all of nature is taking place with mRNA and CRSPR gene technology. Decoding the human genome was supposed to be a huge breakthrough – leading to wonderful new medications – or something. The tone is big disappointment – the genes had more “nonsense” than expected and more variability – one gene doesn’t do one thing – typically. The tone in my opinion should be joyous – we can easily screen and identify individuals for metabolic gene alleles that could be helped by dietary changes – and yet we are not doing that, or rarely. Methylation gene differences may be screened for but it is not done as a first step usually and not for everyone.

Unfortunately, my research paper topic is too vast for me to finish by the deadline this week. I have made a lot of progress and will post an updated draft soon but currently I have two papers written that are complimentary, rather than collated. The first half is posted and focuses on the histamine excess and Retinoid toxicity and the second half is in the works. I posted some of the Tables, but the “That is not a Table!” Table is still an enormous run-on Not-A-Table still.

Tables of data help us see patterns – that is what I do – see patterns in data trends. Organizing it into a neat Table or graph makes it easier for other people to see the patterns too. Mathing it all up in neat statistical graphs, though, is not what I do. Figuring out what is for dinner and how to prepare it, out of all that data, for an individual’s needs, is my focus. And the question is more difficult than picking a favorite restaurant – in our modern times, and for individual people with varied health conditions, what we choose to eat may be very harmful to our health. Processed foods are frequently designed to be somewhat addictive or very addictive and often are seriously depleted in nutrients beyond carbohydrate and fat calories.

Pain means you are doing something wrong – it might have been okay when you were younger, but now it is no longer working for you. Change is needed. Pain means change is needed and the individual needs to figure out what changes are needed in order to restore normal function – which is not supposed to hurt. If something hurts, then you are over-exerting or your body has changed and can no longer keep up with your previous pace – something is wrong, whether it is age, or infection, or stress load – something needs to be changed. And that change is probably not going to be as simple as “Take this pill once a day.” However, the medical model is based on the concept that health can be restored if you just “Take this pill once a day.”

The myth of a single medication “cure” was based on the early success of antibiotics, but also the resounding success of discovering “nutrients”. Early food processing changes left entire populations with nutrient deficiencies. Once the nutrient was discovered and the food processing methods were modified to reduce the lost nutrients, or foods were fortified with the removed nutrient, then the entire population suddenly was “cured” of the deadly or disabling “condition”.

The medical industry has come so far that they have lost their roots – scurvy – vitamin C deficiency – is missed in modern health care – left untreated as a mystery condition until someone hopefully recognizes the old sailor disease – scurvy. We all need vitamin C every day. That is a biological fact. Medical doctors need to take their blinders off – the body is not made out of medicine. Not a single medicine is a “nutrient need”. We have no deficit of aspirin in biology, but we might have a lack in our diet. We can get plenty of salicylates in our herbs and spices – nature provides us aspirin in our foods.

  • Oldie, but a goldie: Carrots, spices and baby aspirin help prevent cancer and inflammation, Oct. 21, 2011, (transcendingsquare.com).
  • Newer: Being grateful for our bitter sensing tastebuds, Jan. 3, 2018, (transcendingsquare.com).

My Problem Solving episodes in my How Are You Feeling? podcast series gets into more detail about the genetics of bitter taste perception and how it may conveniently be more sensitive in people like me who need an external source of bitter tasting cannabinoids and phospholipids. The transcripts and audio links to the series are on this webpage: Peace-is-happy.org/How are you feeling?.

Bitter taste receptors turned out to be critically important for COVID19 treatments. Bitter phytonutrients or medications can get mucus thinned and flowing during congestion – but adequate zinc is needed first. In order to make the bitter or other types of taste and odor receptors.

Mother Nature gave us a medicine cabinet and an ability to taste the dose that will be most effective without being excessive (starts to taste bad instead of good) – and “medical doctors” need to get out of the way.

Be an n=1 self care provider and pay attention to your own body and it may help guide you towards less pain and better quality of life. The negative symptoms tend to be later that night or next day after eating inflammatory foods or doing inflammatory activities so the patterns can be easy to miss if there is a lot of variability in a person’s routine habits and diet choices.

The paper and Tables that I have been working on will hopefully make it easier to see what individually is helping or hurting. I will post another update this week but it isn’t quite blog ready, let alone journal submission ready.

green and white labeled bottle
“Bitters” have been a medical standard for centuries or longer in Traditional Chinese Medicine. Photo by micheile dot com on Unsplash

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.