Calcification of the pineal gland – some statistics and sleep habits

Calcification of the pineal gland was found to be less prevalent in a study collecting data on a group of people of black ethnicity. The following link and article suggest that black people genetically may be less at risk for calcification of the pineal gland.(The pineal gland is important because of hormones like melatonin that it is involved in the production of and calcification reduces function and less melatonin means less quality sleep.I suggest that the research being reviewed may have been performed on a population that did not eat the same as now or as mixed and as similar to each other (black population differences from Caucasian is being discussed in the link.) The review article is suggesting the differing lab findings reflect actual structural or genetic differences but if an assumption that the populations were on similar nutrient ratios compared to now or to each other has been made then the correlation can not be used to draw such a conclusion.

The study in reference was from 1967 in a population with African ancestry. The diet in 1967 was less processed then and calcium fortified products may not have been as common as they are now.

I think reading and reviewing older studies is important but from a questioning perspective – what variables were in play at the time of the research study that may have changed. What differences between then and now may have changed the expected outcome?

There are some fundamental differences between different groups of people so it is certainly possible that the pineal gland has a few differences as well as the kidneys – but in 1974 the Black American group may not have been consuming the same typical diet as the Caucasian group. The blending of cultures and the fast food lifestyle wasn’t as prevalent or as inexpensive compared to home cooking as it is now. (It actually is fairly expensive to put a full meal together compared to buying a similar load of “calories,” not necessarily comparing any other nutrients. Fewer homes had single parents or two working parents compared  to now. I don’t have statistics on that but they may exist.).

The study and article are interesting but  I would like to see it repeated on a group of individuals today.
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PS: calcification is somewhat reversible and the first step is taking in less of it – how can the body ever hope to use up the stored up reserves if too much or even if adequate for maintenance levels are eaten daily – to de-calcify or to run out of reserved calcium we need to dip into the bank account and spend some of it. Some calcium is excreted by the kidneys daily, but just not as much as magnesium losses equal.

On today’s diet, I think people of black ancestry are likely to be just as much at risk of calcification of the pineal gland as anyone else.
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Excerpt from “Pineal Gland: A Cognitive Advantage for Africans”:
By Bernie Douglas (January 17, 2008) [link]

Racial differences have been noted in the rate of pineal calcification as seen in plain skull radiographs. In Caucasians, calcified pineal is visualized in about 50% of adult skull radiographs after the age of 40 years (Wurtman et al, 1964); other scholars argue that Caucasians, in general, may have rates of pineal gland calcification as high as ­60-80% (King, 2001). Murphy (1968) reported a radiological pineal calcification rate of 2% from Uganda, while Daramola and Olowu (1972) in Lagos, Nigeria found a rate of 5%. Adeloye and Felson (1974) found that calcified pineal was twice as common in White Americans as in Blacks in the same city, strengthening a suspicion that there may be a true racial difference with respect to this apparatus. In India a frequency of 13.6% was found (Pande et al, 1984). Calcified pineal gland is a common finding in plain skull radiographs and its value in identifying the midline is still complementary to modern neuroradiological imaging.

There is a surprising rarity of calcified pineal gland on skull roentgenograms in West Africans. Adeloye and Odeku (1967) working from a hospital where an average of about 2,000 skull roentgenographic examinations were done every year, encountered less than 10 cases of roentgenologically visible calcified pineal gland in the Neurosurgery unit during a period of 10 years. In the tasks of daily life, calcification in the pineal gland affects our brain’s ability to function. Calcification of the pineal gland is shown to be closely related to defective sense of direction (Bayliss et al, 1985). In a tricentre prospective study of 750 patients lateral skull radiographs showed that 394 had calcified pineal glands. Sense of direction was assessed by subjective questioning and objective testing and the results noted on a scale of 0-10 (where 10 equals perfect sense of direction). The average score for the 394 patients with pineal gland calcification was 3.7 (range 0-8), whereas the 356 patients without pineal gland calcification had an average score of 7.6 (range 2-10). This difference was highly significant (p less than 0.01) (Bayliss et al, 1985). Also, the effects of disturbed sleep and memory are well documented.

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[bonus link]on sleep personality types, “What’s Your Alarm Clock Personality?” by Sharon Tanenbaum, (11/16/11) on everydayhealth.com – not nutrition related as much as clues about how we tend to meet the day and how that might reflect on how we look forward to life – or sleep quality may have more to do with pillow softness – not sure.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Calcification of soft tissue – hardening organs and softening bone

     Vascular calcification is better known as atherosclerosis. Cholesterol plaques in blood vessels are generally a mixture of calcium with the fat. Calcification also occurs in arthritis as bone spurs and calcium can collect in organs and glands and impair their function. The pineal gland is very tiny and located within the brain. It it responsible for the melatonin hormone that helps us sleep. A calcified pineal gland no longer helps with sleep but the condition may be reversible by limiting intake of calcium and increasing intake of magnesium.     Reversing calcification may start with reducing calcium intake. The following article mentions a link between higher intake of calcium and worsening of coronary artery calcification and numbers of deaths within a group of end stage renal disease patients. Magnesium is wasted by healthy kidneys and little is recycled/reclaimed the way calcium and sodium are conserved by healthy kidneys – add end stage renal disease and magnesium is leaking out faster then intestinal absorption can occur even if the magnesium was in the food or drink or supplement.

Calcium can not make strong bones if nothing is keeping it from leaking out in response to the stress chemicals’ fight or flight messages. People suffer from osteoporosis and weak bones along with hardening of the arteries and organs –  excess calcium and vitamin D might be part of the problem. Too much active vitamin D can add to calcium imbalance because it signals the bones to let go of stored calcium and magnesium.

The minerals are also released during stress reactions in case there is a need to run from danger or heal a wound. White blood cells around wounds have the enzyme needed to activate vitamin D to the hormone form.

What do you know – it is important to mellow out and de-stress to help keep bone tissue hard and organ tissue soft.

  1. [jasn.asnjournals.org/content/15/12/2959.fullVascular Calcification Mechanisms, by Cecilia M. Giachellidoi: 10.1097/01.ASN.0000145894.57533.C4 JASN December 1, 2004 vol. 15 no. 12 2959-2964

“In a landmark study, Goodman et al. (24)  found that coronary artery calcification occurred in young patients with ESRD (end stage renal disease) decades before this pathology was observed in the normal population. Furthermore, progression of vascular calcification in this group was positively correlated with serum P levels, Ca x P, and daily intake of Ca (24).”

***Vascular calcification has been correlated to higher intakes of calcium and phosphorus in this research article. Cardiovascular deaths are common among end stage renal disease and/or diabetic patients – I suggest they should be limiting calcium and phosphorus and increasing their magnesium intake in order to reduce risks of calcium overload. In the average human the kidneys favor calcium absorption and retention and waste magnesium.
Over the course of mankind the body adapted to a food and water supply that was abundant in magnesium and limited in calcium content. Calcium is important for strong bones but only in combination with other nutrients. Vitamin K (brown rice, green leafy vegetables and good guy bacteria in our intestines are sources) is essential for blood clotting and for healthy bones. Strontium is a trace mineral that may be essential to healthy bones and of course magnesium is the trace mineral that helps keep calcium inside of the bone where it belongs. Excessive levels of active vitamin D tell the bone to release the stored minerals. Active vitamin D (a very strong steroid based hormone in actuality) can switch on and off 900+ genes.
The study found (unsurprisingly) that the end stage renal disease patients who were treated with the typical phosphate binding medications that contained calcium had 28% progression of calcification compared to the experimental group who were given a phosphate binding agent that didn’t contain calcium. [12]

Let’s keep the calcium in the bone tissue where it belongs.

The article Vascular Calcification Mechanisms [1] presents four potential ways the soft tissue calcification may develop.

“First, human and mouse genetic findings have determined that blood vessels normally express inhibitors of mineralization, such as pyrophosphate and matrix gla protein, respectively, and that lack of these molecules (“loss of inhibition”) leads to spontaneous vascular calcification and increased mortality (10,29).”

Second – genetic/phontypic changes leading to production of bone proteins within the blood vessel may occur (the blood vessel cell switches on bone cell mechanisms).

“Third, bone turnover leading to release of circulating nucleational complexes has been proposed to explain the link between vascular calcification and osteoporosis in postmenopausal women (41–43).”

“Fourth, cell death can provide phospholipid-rich membranous debris and apoptotic bodies that may serve to nucleate apatite, especially in diseases where necrosis and apoptosis are prevalent, such as atherosclerosis (34,44,45).”

*** Magnesium deficiency could effect the enzyme production necessary for producing the “inhibitors” of bone formation produced in functioning blood vessels. Magnesium is crucial to over 300 enzymes. It is also essential for the growth of healthy white blood cells. A plentiful supply of white blood cells would engulf waste products of apoptosis and the dead cell material wouldn’t be left messing up vessel walls. Chronic magnesium deficiency will promote bone turnover in order to access the stored magnesium found within. Long term kidney problems may be reducing the amount of magnesium that the body can retain and further through off the calcium/magnesium balance.
Chronically elevated active D would chronically cause demineralization of the bones and also might be switching on and off genes in areas of the body (blood vessels for example) that shouldn’t be forming bone tissue. I would be very curious what the end stage renal disease patients’ 1, 25 D levels (hormone) are compared to their 25 D levels (vitamin).  My 1, 25 D levels have been at the high end of normal and 25 D levels below normal (“deficient”) for five years of testing. I have been actively avoiding supplements and foods with vitamin D and much time in the sun during that time because I have found it reduces my symptoms of  muscle knots (fibromyalgia), I also have taken magnesium supplements regularly.
A 200-500 mg supplement taken along with food generally will not cause the smooth muscles of the intestines to relax into a sudden bowel movement. Magnesium supplements are non-toxic but if absorbed too rapidly can cause too much muscle relaxation in the bowels or heart. Fluttery weak heart beats may result if you hang out in an Epsom salt bath for a long time due to the relaxation of too many of the muscle fibers at the same time. Magnesium taken with food or in the glycinate form does’t seem to have the over relaxing effect on the bowels.
Magnesium helps keep the calcium in the bone and out of the soft tissue. Use the calcium channel blocker that Mother Nature provided – magnesium. Eat more nuts, beans, seeds, green leafy vegetables. and chocolate every day for strong bones and soft organs!
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Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Reference List

From Vitamin D bibliography [link]:

10. Rutsch F, Ruf N, Vaingankar S, Toliat MR, Suk A, Hohne W, Schauer G, Lehmann M, Roscioli T, Schnabel D, Epplen JT, Knisely A, Superti-Furga A, McGill J, Filippone M, Sinaiko AR, Vallance H, Hinrichs B, Smith W, Ferre M, Terkeltaub R, Nurnberg P: Mutations in ENPP1 are associated with “idiopathic” infantile arterial calcification. Nat Genet 34: 379–381, 2003[CrossRef][Medline]
12. Sangiorgi G, Rumberger JA, Severson A, Edwards WD, Gregoire J, Fitzpatrick LA, Schwartz RS: Arterial calcification and not lumen stenosis is highly correlated with atherosclerotic plaque burden in humans: A histologic study of 723 coronary artery segments using nondecalcifying methodology. J Am Coll Cardiol 31: 126–133, 1998[Abstract/Free Full Text]

29. Luo G DP, McKee MD, Pinero GJ, Loyer E, Behringer RR, and Karsenty: G Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386(March 6): 78–81, 1997[CrossRef][Medline]

34. Tanimura A, McGregor DH, Anderson HC: Matrix vesicles in atherosclerotic calcification. Proc Soc Exp Biol Med 172: 173–177, 1983[CrossRef][Medline]

  1. Price PA, Caputo JM, Williamson MK: Bone origin of the serum complex of calcium, phosphate, fetuin, and matrix Gla protein: Biochemical evidence for the cancellous bone-remodeling compartment. J Bone Miner Res 17: 1171–1179, 2002[CrossRef][Medline]
  2. Price PA, Faus SA, Williamson MK: Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorption. Arterioscler Thromb Vasc Biol 21: 817–824, 2001[Abstract/Free Full Text]
  3. Price PA, June HH, Buckley JR, Williamson MK: Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D. Arterioscler Thromb Vasc Biol 21: 1610–1616, 2001[Abstract/Free Full Text]
  4. Proudfoot D, Skepper JN, Hegyi L, Bennett MR, Shanahan CM, Weissberg PL: Apoptosis regulates human vascular calcification in vitro: Evidence for initiation of vascular calcification by apoptotic bodies. Circ Res 87: 1055–1062, 2000[Abstract/Free Full Text]
  5. Schoen FJ, Tsao JW, Levy RJ: Calcification of bovine pericardium used in cardiac valve bioprostheses. Am J Pathol 123: 134–145, 1986[Abstract]
  • [ajsonline.org/cgi/content/full/305/6-8/661Nita Sahai, Modeling apatite nucleation in the human body and in the geochemical environment American Journal of Science, Vol. 305, June/September/October 2005, P.661-672; doi:10.2475/ajs.305.6-8.661

“Magnesium inhibits nucleation by adsorbing faster than calcium, as an outer-sphere surface complex, at the active site.”

We are what we eat.

The cattle are as good as the pasture in which they graze.
-Ethiopian proverb
We can build better bodies and better babies with normal healthy food. Tweaking ratios in our supplements and formulas would make it easier to get what we need but in the mean time moderate use of typical foods can feed us well. Babies would benefit from more human milk use whether from individual mothers or donated milk banks. It would help infant’s neuro-development and might help prevent some colic and sleepless nights. If infant formula is necessary than an occasional quarter teaspoon of Milk of Magnesia might prevent problems from the slightly high calcium/magnesium ratio (cow’s milk is quite a bit higher in calcium and protein than the modified formula product and is not suitable for use with young infants).
The levels of a  few nutrients in breast milk can be adversely affected by diet or health and magnesium is one of them. The average is around 30 mg/liter but the level can drop to the low 20’s and does in malnourished populations and teen moms and it can be elevated around 45 mg/liter in diabetic moms.
Young women, aka teen moms, are also more at risk for preeclampsia, as are mothers of twins. Both of these groups have increased nutrient needs – they are eating for baby plus more. These two sub-populations are linked with malnourished women in third world country studies by the unusually low magnesium levels in their breast milk. The high levels in the diabetic women suggests to me that the cell membranes are allowing too much out – that they have become leaky somehow.
We need more vegetables, nuts, seeds, and beans for magnesium but they also give us protein and fiber. The healthy starches are necessary for a strong protective intestinal lining. White blood cells patrol and pick off allergens, infection and other information and send it up to lymph nodes. At the lymph nodes more specialized work takes place to identify the foreign proteins and replicate defensive antibodies if needed. Nature provided us this natural oral vaccination method but healthy foods are necessary to build blood cells and make the glycocalyx jelly lining around the intestinal folds.

The United Kingdom recently released the nutrition recommendation to eat less red meat. Americans were told to eat less red meat a while ago . . . and we did, however we started eating more chicken, and cheese intake also increased — from a USDA report on 1909 to 2000 US nutrient intake. [2 -Table 32] Between 1970 and 2000 red meat use dropped fifteen percent! But chicken use increased 80 percent and cheese 150 percent. Chicken in the form of nuggets and other breaded and fried forms has become a staple that had been a special occasion food . The hidden added oil of fried chickend and the saturated fats of the cheese made “eat less red meat” a nutrition recommendation that worked and failed. We are eating less red meat than we used to in America but we are eating more cheese and chicken .

I would like to encourage a positive spin of less red meat and more beans, nuts and seeds for a protein source that also provides healthy fiber and many other trace nutrients. Having a variety of types of foods daily or throughout the week will generally provide more trace nutrients. We need hundreds of types of chemical compounds, not just ten or twenty vitamins and minerals. A few trace nutrients are considered essential for our health because our bodies can not create them out of other simpler chemicals. However other trace chemicals may become more important to consume in the diet or take as supplements if a person has a problem with some of the conversion steps necessary to make important enzymes or proteins or other more complex molecules. Eating liver and onions once a month may provide a boost to our health because it provides fully formed enzymes that can be more easily reassembled by the body after they are broken down and absorbed during digestion.

Using a variety of protein sources throughout the week or mixed in the meal may provide more variety of some of the more unusual types of essential sugars. A rich beef stock made from marrow rich bones will yield glucosamine, one of the essential sugars or glyco-nutrients. Many people use it as a supplement for arthritis pain. It can have a positive effect after taking it for a few weeks. Glucosamine is found in the synovial fluid that cushions the area between the bones of the knee and other joints in the body. A supplement recommendation is 1500 mg/day. [Synovial and plasma glucosamine concentrations in osteoarthritic patients following oral crystalline glucosamine sulphate at therapeutic dose, S. Persiani, Ph.D, et. al., Osteoarthritis and Cartilage, Volume 15, Issue 7, July 2007, Pages 764–772]
Supplements may be from a shellfish source as it is frequently derived from crustacean shells so people with shellfish allergies should look for a vegetarian source.
Glucosamine is also found in the chitin of insects. The use of insects in the diet may have helped prevent kwashiokor in young children in tropical regions. The intestinal lining in some individuals, possibly those who had a recent infection, seems to malfunction in the ability to convert other sugars into glucosamine. The use of a rich broth from a bone stock might suit more people’s taste than insects. Although there are chefs presenting some appetizing dishes. . . . citations to follow when I am more awake.
Moderate use of dairy products like cheese, milk, yogurt and other calcium rich foods would benefit bone health without sacrificing magnsium absorption. Two to three dairy servings per day would provide adequate calcium. Supplements are not generally needed.
The food pyramid and http://www.mypyramid.gov is a nice start but I tend to recommend:
    • a bit less grains – swap some starchy root vegetables for the carbohydrate calories,
    • and a bit more vegetables -AICR – recommends 5-9 veg and fruit per day as anticancer medicine.
    • Juice is concentrated and limiting to 4-6 oz/day is healthy – especially for small bodies.
    • A bit less meat and dairy groups and use the calories for nuts, beans, and seeds.

/Disclosure: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes./

*2015, edit, I’m not sure why I included this chart in 2011 but I’m leaving it here for now.

http://www.nal.usda.gov/fnic/foodcomp/search/             nutrient data base

NBD #
Food
Unit
kcal
protein
fat
Calcium
Magns.
Vit D IU
Vit A IU
01211
Whole milk no added A or D
1 cup
149
7.67 gr
7.98 gr
276 mg
24 mg
5 IU
395 IU
01107
Human milk, mature
1 cup
172
2.53 gr
10.77 gr
79 mg
7 mg
7 IU
522 IU
03850
Infant Formula, similac
100 gr x 2.43 = 1 cup
158
3.3 gr
8.62 gr
124 mg
10 mg
95 IU
479 IU

**Note that the example infant formula is fortified with vitamin D at 13.6 times the amount of human milk and 19 times the amount in cow’s milk. There are more nutrients but the blog is narrow.

1.      http://online.wsj.com/article/SB10001424052748703293204576106072340020728.html  Marcel Dicke, Arnold Van Huis are professors of entomology at Wageningen University in the Netherlands.  (2-19-11, The Wall Street Journal, pC3)  The Six-Legged Meat of the Future, Insects are nutritious and easy to raise without harming the environment. They also have a nice nutty taste

2. http://www.cnpp.usda.gov/publications/foodsupply/foodsupply1909-2000.pdf Gerrior, S., Bente, L., & Hiza, H. (2004). Nutrient Content of the U.S. Food
Supply, 1909-2000. (Home Economics Research Report No. 56). U.S. Department of Agriculture,
Center for Nutrition Policy and Promotion.
http://onlinelibrary.wiley.com/doi/10.1111/j.1525-139X.2010.00705.x/abstract
 Effect of Diabetes Mellitus on Protein–Energy Wasting and Protein Wasting in End-Stage Renal Disease, Nazanin Noori1, Joel D. Kopple1,2Article first  published online:13 APR 2010DOI: 10.1111/j.1525-139X.2010.00705.x

http://www.ncbi.nlm.nih.gov/pubmed/19121473  Semin Nephrol. 2009 Jan;29(1):39-49. Causes and prevention of protein-energy wasting in chronic kidney failure. Dukkipati R, Kopple JD. Division of Nephrology and Hypertension, Los Angeles Biomedical  Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90509, USA.
 http://www.ncbi.nlm.nih.gov/pubmed/19121477 Semin Nephrol. 2009 Jan;29(1):75-84. Nutrition support for the chronically wasted or acutely catabolic chronic kidney disease patient.
Ikizler  TA.Department of Medicine, Division of Nephrology, Vanderbilt University School of  Medicine,Nashville, TN 37232-2372, USA.

http://www.ncbi.nlm.nih.gov/pubmed/16129200Am J Kidney Dis. 2005 Sep;46(3):387-405. Multinutrient oral  supplements and tube feeding in maintenance dialysis: a systematic review and meta-  analysis. StrattonRJ, Bircher G, Fouque D, Stenvinkel P, de Mutsert R, Engfer M, Elia  M.Instituteof Human Nutrition, University of Southampton, UK.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891019/?tool=pubmed New Insights into the Role of Anabolic Interventions in Dialysis Patients with Protein Energy Wasting Jie Dong and T. Alp Ikizler1 Curr Opin Nephrol Hypertens. Curr Opin Nephrol Hypertens. 2009 November; 18(6): 469–475.doi: 10.1097/MNH.0b013e3283 31489d.
 “Economic Implications of Nutritional interventions It is also important to assess the impact of nutritional supplements not only in terms of changes in nutritional parameters, but to extrapolate these observations to potential improvements in hospitalization, mortality, and cost-effectiveness. In a recent study, Lacson et al showed that a hypothetical increase in serum albumin concentration in the order of 2 g/L in 50%  of the United States dialysis population would be associated with  projections of approximately 1400 lives saved, approximately 6000 hospitalizations  averted, and approximately $36 million in Medicare cost savings resulting  from a reduction of approximately 20,000 hospital days over one year[68]. This is a reasonable estimation since 2 g/L increase in serum albumin is the average improvement reported in most nutritional intervention studies.”

***The above paper is suggesting that giving them growth hormones  and other anabolic steroids along with protein will help them to stop catabolizing. They have had success with the strategy, but wouldn’t magnesium plus protein (ideally magnesium foods) be cheaper than hormones and protein.

Dietitian Recommends less Vitamin D and Calcium

We can cure the epidemic of ill health and obesity that has seized our nation and the world. The food supply is low on some important nutrients and has too much focus on calcium. Calcium is important but health is built on a variety of essential nutrients, and clean air and water of course.
We can have health if we seek to rebuild instead of hunt for a disease to name and for a magic bullet cure. There will always be a need for acute care but we are overloading the medical system with chronic degenerative disease. Chemotherapy kills and so do corticosteroids. They are powerful drugs that are aimed at the disease but our bodies get in the way. Food that nourishes with a full range of essential nutrients in forms that can be absorbed and used can help us heal ourselves from within.
We are designed to fight cancer and to rebuild organs using our own stem cells and white blood cells but we can only do that if they are working right. White blood cells protect us by patrolling for old, pre-cancerous or infected cells. The bad cells can be mercy-killed in a process called apoptosis. We grow new skin cells every day and new intestinal cells weekly. New cells of whatever type we need can be rebuilt from our own stem cells. Any organ can be ours for the making – if we have the essential nutrients in our food supply in a mixture that we can absorb.
Our food supply isn’t providing us with the variety of nutrients that we need, in ratios that we can absorb well. Our nutrient guidelines were developed in the 1940’s to help make K-rations that could keep our soldiers strong and healthy under conditions of war.  The original work has been reviewed and modified by the Institute of Medicine. The calcium guidelines were increased in 1997 and while they have been reviewed they haven’t been changed since. The increase was based on an estimation of how much calcium might be needed for better bone absorption.
Do we have stronger bones now as a nation then we did in 1996? That is a simple question with a simple answer – no.Our nation’s diet was changed in 1997 and since then chronic illness, obesity and osteoporosis rates have been expanding quicker than our budgets or belts.
We can’t grow strong bones out of excessive calcium and vitamin D supplements. Bones do require some vitamin D and calcium but we also need magnesium, strontium, vitamin K, and water to name a few essential nutrients.
Calcium is being consumed at levels that our bodies are not able to excrete. The kidneys actively save calcium and use magnesium to remove acidic wastes and some of the excess calcium. Diuretics and alcohol use also increase magnesium losses. Magnesium is lost in sweat but many brands of electrolyte beverages don’t contain it. Our food supply is low in magnesium and high in calcium from dairy products, fortified foods, and supplements.
The dairy products available in our U.S. food supply in the year 2007 provided 716 milligrams of calcium in just 351 calories of cheese and milk per day. Many people eat more than 351 calories of dairy products daily. On average we are consuming more cheese and less milk than we did prior to 1970. Cheese is a more concentrated source of fat and calcium than liquid milk.
Toddlers (n=925) usual intakes from food, beverages, and supplements as reported in FITS 2008 provided on average 892 mg/day of calcium and 160 mg/day of magnesium.
The abnormal vitamin D levels have been misunderstood. Low lab values are linked to ill health and obesity but more of the vitamin won’t fix the underlying problem. The mega-dose is a short term fix but not a long term cure for chronic illness and cancer. It is considered safe for everyone but it is only safe for those with healthy kidney control over the activation of vitamin D to hormone D. High levels of the active hormone D can cause health problems to worsen over time, adding to chronic degeneration.
Vitamin D has two forms and two lab tests of interest, and one test is more expensive. The cheap lab test for 25 hydroxy D (Dᴣ), is what most of the research is based on. It is the inactive form of the vitamin and is available as a supplement. It is considered safe at higher doses because it is assumed that all people, not just healthy people, have very good kidney control over the activation of the vitamin to the hormone. The enzyme needed for activation to 1,25 dihydroxy D is being produced uncontrollably by inflammatory white blood cells and it has been shown to be produced by some cancer cell strains as well.
We are not deficient in vitamin D and haven’t been since milk fortification was begun. The average American’s serum 25-D levels were normal, above 20 ng/ml and Canadian’s had average levels around 24 ng/ml, also normal, from a 2009 Institute of Medicine report. An increased risk of fractures has not been observed at these levels. [4]
Lack of sunlight is not a problem either, according to the research by Dr. James Norman. He has put together a database of over 10,000 patients with hyper-para-thyroidism from around the world who live under a wide range of sunlight conditions. Their vitamin 25-D levels average 19.4 ng/ml, but their active hormone, 1-25 D levels and calcium levels are very high no matter where they live. As soon as their para-thyroid tumor is removed their bodies’ 25-D and 1-25 D balance normalize, no matter where they live.
Dr. Norman, does not recommend supplementing with vitamin D. The supplements push the patient’s lab values for 1-25 D and calcium even higher. He has multiple case examples where stroke or sudden illness occurred after vitamin D supplementation was begun by the patient’s endocrinologist. His seminar about it is on Youtube, listed under ParaThyroid TV, and is posted on my webpage.
I recently started working at an assisted living facility and many of the residents were started on high doses of vitamin D by their individual doctors about a year ago when this research was first getting popular. I read charts cover to cover – and I saw their quality of life deteriorate, their pain levels increase, and worsening of their weakness, cardiac symptoms and dementia, and one death. High doses of vitamin D may not be safe for unhealthy people.
Our public health initiatives have been successful at preventing rickets in the majority; we already won the battle against vitamin D deficiency. Many foods are now fortified with vitamin D not just milk. I met about 4000 babies in fifteen years as a WIC dietitian and only one showed early symptoms of rickets. He was exclusively breast fed and he and his mother both had severe milk protein allergies. They both took to sardines which are an excellent natural source of vitamin D, and supplements were never even needed for the little boy.
We are not vitamin D deficient but we do have a sub-population of chronically ill and obese people with depressed levels of the inactive form of the vitamin. The inactive vitamin Dᴣ is being activated at an unlimited rate in some cancer cells and by white blood cells in wound and inflammatory conditions, resulting in elevated levels of the active hormone form.
Increased levels of the active hormone cause movement of calcium and magnesium out of the bone which eventually leads to osteoporosis of the bone and calcification of everything else. It increases intestinal absorption of calcium and it can increase levels of cortisol, the stress hormone. [39] Too much cortisol can increase abdominal weight gain but it also acts like corticosteroid drugs on the immune system.
Activated hormone D leads to increased cortisol and a short term reduction in inflammatory symptoms because it kills off the overactive white blood cells. However it also kills off the healthy ones. Mega doses of vitamin D are being used in a way similar to corticosteroids. Ultimately the immune system is functioning even worse. The current increase in allergic sensitivities to foods like gluten and peanut butter is due to the over active white blood cells. If we kill off the white blood cells then we won’t get the allergic symptoms as bad but we may get more colds, skin infections, and other illnesses.
Mega-dosing with vitamin D is like paying for Prednisone, if we’re sick and for an expensive cholesterol supplement if we’re healthy. 
Vitamin D is actually a very powerful steroidal hormone based on cholesterol. The average American is making enough vitamin D from their stored cholesterol. Vitamin D is an expensive cholesterol supplement if you don’t need it.[1]  If you are worried about whether you need a supplement or currently are supplementing with vitamin D, then ask your medical provider for both lab tests, cheap and expensive, 25 hydroxy D and 1, 25 dihydroxy D.  The good news is that the combined test result comparison will serve as a biomarker to show who does have chronic inflammatory conditions – proving that fibromyalgia isn’t all in our heads.
Low levels of 25-D combined with high levels of 1,25 D is an abnormal balance that is not seen in the healthy person with good kidney control.It occurs due to the increased production of the activating enzyme in the cancer cells or infected cells. Autoimmune disease may be due to a variety of chronic infections that are not readily identifiable by today’s standard lab tests.
Excessive levels of the active vitamin D cause the bone to lose calcium and magnesium. Too much calcium can cause muscle cramps, increase pain, and can cause anxiety, irritability and headaches.
We need less calcium then we are getting on average and more magnesium. If we limit our intake to 800 mg calcium we should absorb magnesium better, but we still need about twice as much magnesium as we are currently getting. Nuts, beans, seeds and greens are all excellent sources of magnesium and so is chocolate. Just two and a half dairy servings per day, about what is recommended already, would provide adequate calcium for strong bones without overloading our intestines. Too much calcium is causing magnesium to be poorly absorbed in the intestines and to be wasted in urinary losses.
Magnesium blocks calcium channels in cell membranes and would protect the brain cells from being over-flooded with calcium and being overworked to the point of cell death. The over-excitation of the brain cells causes anxiety and irritability and may be underlying the increase in rates of bullying and violence. PMS is another name for magnesium deficiency that is associated with excessive irritiability and chocolate cravings (a good source of magnesium).
Magnesium provides power inside of the cell – fatigue is a common symptom of magnesium deficiency. Anemia and edema are early symptoms of magnesium deficiency. It is essential for the growth of mature red and white blood cells in bone marrow. It is used by over 300 enzymes and it is essential for apoptosis – the mercy killing of infected and precancerous cells. Hypertension and increased serum cholesterol and insulin are also symptoms. If I were writing the books, then Metabolic Syndrome would be called magnesium deficiency and so would pre-eclampsia.
We can heal ourselves, if we learn how to feed ourselves better and repair the food supply and nutrient guidelines.I recommend stopping the push to supplement with vitamin D and calcium and instead I would encourage trying the DASH diet plan. It was a primary education tool that I used successfully to prevent pre-eclampsia reoccurrence in high risk women. The DASH diet provides a good supply of magnesium from the Bean, Nut and Seed food group. The plan has been found helpful for weight loss as well as reducing hypertension.
I propose ten steps for turning around our epidemic of chronic illness and obesity
  1.  Look for health in Food First, treating symptoms does not restore function.
  2. Increase Magnesium in water and other electrolyte beverages. Softened water adds salt to our daily intake and sucks magnesium from our bones.
  3.  Increase magnesium rich foods. They also give us fiber that builds a healthy glycocalyx lining and stronger immune system. Beans, nuts, seeds, greens, whole grains and chocolate are good sources and there is a little in everything else.
  4. Sub-populations need to be identified and informed about their individual nutrient needs, whether increased or decreased from the average person’s to promote optimal health and quality of life.
  5. Poor intestinal absorption of magnesium is part of the problem. We can deliver nutrients from other directions. Skin lotions and Epsom salt (MgSO4) baths are low budget, low risk and very effective methods. [35, 36, 37]
  6.  Nutrients can be delivered by inhalation in an aerosolized  form that would be safer than intravenous magnesium use. [30, 31]
  7.  Limit calcium intake – more is not better. We will retain more when we consume less. The research on strong bones and calcium supplements were for people whose native diet averaged 300 mg calcium per day – not our current RDA of 1000 mg.
  8. Don’t worry about D deficiency and if you are worried then ask for both tests, the inactive and active form of the most powerful hormone in our body.
  9. Ask your government representatives to support food labeling reform. Neotame and free amino acids may be causing migraines, seizures and lead to dementia.
  10. We need our Nutrient Guidelines – the math – checked by a multi-disciplinary team of scientists who use the numbers – food scientists, dietitians, and biochemists should be involved. The math makes our infant formulas and cafeteria menus and when it is wrong then we all suffer.
All nutrients are equally essential. Currently our food supply and health care messages are over-loaded with calcium and vitamin D and it is hurting us. Draining the magnesium from our bones is draining the energy and fluid from our cells and leaves us puffy and pale from anemia. Without magnesium we can’t grow proper blood cells and without healthy white blood cells we can’t protect ourselves from infections and we can’t breakdown decaying, pre-cancerous cells for normal recycling.
Cancer occurs from old cells mutating. Healthy white blood cells can kill the active cancer too. The Linus Pauling Institute successfully treats tumors with high doses of vitamin C. The Gerson Clinic successfully uses a raw foods approach and detoxification with coffee enemas Not too pretty sounding but chemotherapy isn’t pretty either. Why do we continue to hurt people with harsh chemicals when nature gave us what we need in whole foods and the potent herbs and spices. Cinnamon, oregano and rosemary have shown promise in chronic illness. Spice up your lives and enjoy.
Our bodies can do it, we just have to feed ourselves an absorbable balance of a wide variety of essential nutrients.

See Bibliography on the page with this title. I will continue to add to it as I get it organized .

Disclaimer: This information is provided for educational purposes within the guidelines of fair use. Please see an individual health care professional for individualized health care services. If you have questions or comments please contact me at: jenniferdepew@jenniferdepew.com