Excerpt – glyphosate entering the ocean may chelate manganese and leave coral unable to form their protective layer of mucus containing sulfated glycoproteins: “A protective layer of mucopolysaccharides called mucus is secreted by corals, and it has been characterized as containing sulfated glycoproteins similar to chondroitin sulfate, [44] which play an important role in controlling pH and the transepithelial movement of electrolytes and water, just as is the case in vertebrate mucosa. Mucus pathology is implicated in coral disease leading to mortality, particularly in the Caribbean.[219] Thus, an interesting hypothesis that should be considered is that glyphosate chelation of Mn is a crucial factor in the worldwide coral die-off.” (Samsel, Seneff, 2015)
Manganese is important:
“Vitamin D deficiency has reached epidemic proportions in the US and increasingly around the world in recent years. [124] In a large population study in the US, Bodnar et al. [34] found deficient levels of vitamin D in 83% of Black women and 92% of their newborns, as well as in 47% of White women and 66% of their newborns, despite the fact that over 90% of the women were on prenatal vitamins. This deficiency is associated with an increased risk to bone fractures, likely due to impaired calcium homeostasis. [145] It is even likely that care-takers are being falsely accused (“Shaken Baby Syndrome”) of abusing children in their care who suffer from bone fractures. [255] These children are highly vulnerable to bone fractures due to impaired bone development. Bone fractures in the elderly due to osteoporosis have also risen sharply recently in the industrialized world. [139] The cause of a surging incidence of hip fractures across multiple age groups remains a mystery to medical personnel. [140]
Samsel and Seneff [248,249] proposed that the current vitamin D deficiency epidemic is caused by glyphosate, due to glyphosate’s interference with CYP enzymes. The metabolite that is usually measured, 25-hydroxy vitamin D, is the product of activation in the liver by a CYP enzyme that is also critical in bile acid formation. However, there is a larger problem with bone development due to impaired Mn homeostasis.” (Samsel, Seneff, 2015)
Selenium is also important (selenoproteins):
“Dopamine suppresses thyroid stimulating hormone, and therefore dopamine insufficiency can lead to overactive thyroid and potential burnout of the thyroid gland. [270] This problem is compounded by the fact that thyroid hormone itself is derived from tyrosine, one of the three aromatic amino acids that are negatively impacted by glyphosate through disruption of the shikimate pathway. The thyroid gland also depends critically on selenoproteins as antioxidants. [249] Glyphosate’s depletion of both selenium and methionine will lead to reduced bioavailability of selenoproteins. It is conceivable that all of these factors working together can explain the strong correlation of glyphosate application to corn and soy with thyroid cancer [Figure 7], as well as the association between maternal thyroid disease and autism. [238]” (Samsel, Seneff, 2015)
Glutathione is depleted, Manganese is needed for its production, along with other nutrients and Nrf2 promotion and/or a healthy circadian cycle:
“Experiments exposing immature rats to Roundup®, whether via exposure to the dam during pregnancy and lactation or via acute exposure to the pup for 30 min, demonstrated lipid peroxidation and NMDA receptor activation in the hippocampus, indicative of oxidative stress and glutamate excitotoxicity. [59] Acute exposure increased the release of glutamate into the synaptic cleft, and depleted GSH.
Glutamine synthase depends upon Mn as a cofactor, so depleted Mn supplies would lead to a build-up of glutamate that cannot be returned to the neurons using normal channels. Multiple sclerosis is associated with both depleted Mn in the cerebrospinal fluid [185] and depleted GSH synthase in the white matter lesions. [309]” (Samsel, Seneff, 2015)
Why should we care about coral? Because we and coral have similar biological pathways. Nature loves a good design and sticks with it across the plant and animal and microbial kingdoms. Also it would be better to be good stewards of the planet, instead of being an invasive parasite that destroys everything in its path.
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
Reference List
(Samsel, Seneff, 2015) Samsel A, Seneff S. Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies. Surg Neurol Int. 2015 Mar 24;6:45. doi: 10.4103/2152-7806.153876. PMID: 25883837; PMCID: PMC4392553. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392553/
I have been very busy with the pomegranate paper, and sadly, or not surprising, it was not accepted for further review – non-standard, which is true. It was too long and I learned more while researching for it and needed to rewrite the main article. A book or website with guided pages and some screening questions to help guide people to material that may be helpful is my plan.
My goal is to make a more concise site with a dropdown menu of some sort to help guide people to the info that they want or need – and some screening question sections to help pinpoint which information may be needed. I have started a very preliminary workflowy.com (https://workflowy.com/s/hyperinflammation-pr/NA9NrJpva8lyi1nH) but got hung up on how to add images. It says just “drag and drop” and I have no idea why that doesn’t seem to work. Is that an Apple thing? ** I figured out how to drag and drop an image but then I couldn’t move it to any other sections. WorkFlowy may not be for me.
I have been posting on SubStack and need to post here more. I have posted a few new things to peace-is-happy.org, but an older post was most read in November so that may have been Oct or even longer ago. The images in this post are some of my travel pics. Peace is mental and physical. (peace-is-happy.org) It is not a long post but has some good starting points. Build mindfulness, peaceful brain pathways and try to forget stressful worry pathways by not thinking about them. One anxiety tip I like – make a Worry Jar and write down your worry, stick it in the jar, schedule 15 minutes to go through your Worry Jar once a week. Saves mental strain to not have an overload on your mind. Writing lists or goals can help put them someplace else where you know you can find it again, and have a little more peace of mind.
“Great design should be ‘intuitive.’ Translation: feel natural.” — Tom Peters
Nature repeats chemical structures and pathways across the chain of life. The essential omega 3 fatty acid DHA is ancient, unchanged from simple life forms to complex.
This post is the first of a series, in which I will share my Genes Table.
It has the solution for the health problems that gene alleles may cause – plant polyphenols. Polyphenols may be able to correct the up or down regulation in important pathways that the dysfunctional allele caused by affecting microRNA.
“microRNA are the real regulators of gene transcription”. – Substack.
“microRNA, elevated homocysteine and is there a role for excess Retinoic Acid?” (substack.com) *The hyperhomocysteinemia/homocystinuria section of my Genes Table.
“Pollutants in Human Plasma Found via Double-Filtration Plasmapheresis Plasma Exchange”, James Lyons-Weiler. (substack.com) *This is a cross post. Heavy metal toxins and thread like objects and aluminum-silicon combinations were found in a filtration of plasma procedure. This is related to pomegranate because the peel is effective at clumping nanoparticles into larger clumps that are big enough for white blood cells to sense as something needing to be removed.
“POTS – Postural Orthostatic Tachycardia Syndrome, can be epigenetic & therefore may be reversible”. (substack.com) *The Dystonia section of my Genes Table.
Before moving on to more sections, or exploring other conditions and yet more links…
This one is excellent and has a video abstract/overview: (Hayden, Tyagi, 2022) Hayden, M.R., Tyagi, S.C., (2022). Impaired Folate-Mediated One-Carbon Metabolism in Type 2 Diabetes, Late-Onset Alzheimer’s Disease and Long COVID. Medicina. 58(1):16. https://doi.org/10.3390/medicina58010016 Available at https://www.mdpi.com/1648-9144/58/1/16 (Accessed: 4 Dec 2022) Figure 1: Folate-Mediated One-Carbon Metabolism (FOCM).
In it we learn that the one-carbon methylation cycles are used within cell’s cytoplasm, within the mitochondria, and within the cell’s nucleus – and if the nucleus version is impaired, then … methylation of DNA will be impaired – it will not occur. Epigenetic changes will be very likely if there is dysfunction in the one-carbon methylation cycle within the nucleus.
Nature loves a good design and will repeat it.
“Figure 2. Compartmentalization of FOCM. Note the presence of the folate-methionine one carbon cycle metabolism in the cytoplasm (cytosol), mitochondria and nucleus.Additionally, note the importance of formate being transferred from the mitochondria to the nucleus, as well as S-adenosylmethionine (SAM) via nuclear pores. Importantly, deoxythymidine monophosphate (dTMP) synthesis occurs in the cytosol, nucleus and mitochondria, whereas purine synthesis and methionine synthesis take place within the cytosol. Mitochondrial FOCM generates formate for cytosolic and nuclear FOCM and biosynthetic precursors for mtDNA synthesis and mitochondrial protein translation. Thymidylate synthase (TYMS) converts deoxyuridine monophosphate (dUMP) to dTMP in a 5,10-methylene-THF-dependent reaction (not shown). It is important to note that mitochondrial SAM (Mt SAM) is derived from cytosolic SAM (cSAM). Additionally, the Krebs cycle also resides within the mitochondria and provides NADH and FADH2 to the electron transport chain for ATP production. ATP = adenosine triphosphate; c = cytosol; ETC = electron transport chain; FAD = flavin adenine dinucleotide; FADH = reduced flavin adenine dinucleotide; FFA = free fatty acids; HHcy = hyperhomocysteinemia; MS = methionine synthase; Mt = mitochondria; NADH = reduced nicotinamide adenine dinucleotide; T = thymidylate-thymine; U = uracil.” (Hayden, Tyagi, 2022)
I had a reply recently saying nobody understands this (roughly) and my response would be: We learn by studying things that we don’t understand and looking up whatever words we need to look up in order to better understand it.
Here, in this complex graphic (above) – even a First Grader might guess that “Formate” is important. It appears that the nucleus version of the one-carbon cycles will not occur without formate to get it started. SAM is also important – the one-carbon cycle taking place in the cell’s cytoplasm creates the methyl donor cSAM which is converted into mitochondrial mSAM. The nucleus needs the (I don’t know what it is either) “Formate” and cSAM to enter through nuclear pores in order for the one-carbon cycle to be able to take place within the nucleus for DNA methylation needs. Meaning mitochondrial dysfunction of the one-carbon cycle leads to epigenetic changes and lack of DNA methylation in the nucleus of the cell, and dysfunction of the one-carbon cycle in the cytoplasm might precede the mitochondrial dysfunction as the cSAM is needed by the mitochondria and the nucleus. (Hayden, Tyagi, 2022) *They recommend that physicians screen homocysteine levels more often – it is not standardly measured with basic labs.
Formate, heat stress and SMYD3.
Internet answers: Formate is a result of the breakdown of Carbon dioxide, CO2,— and various engineering research approaches have been used to try to reduce CO2 from the air by promoting formate production (in microbes or chemical reactions) – but that is tangentially related and simply was the immediate search results. More to the physiological point – if we want to be able to make formate, we need the gene SMYD3 to be functional and active as it promotes synthesis of formate.
“Conclusions: Our study demonstrates that SMYD3 regulates the activity of the mitochondrial metabolic enzyme MTHFD1L through H3K4me3 histone methylation modification, promotes formate synthesis and induces mitophagy, which inhibits M1 polarization in macrophages.” (Zhu, et al., 2022)
SMYD3 is important in histone methylation, and growth of embryos and cancer tumors, in order to localize it to the nucleus, where we need it for the one carbon cycle and methylation of DNA, Heat Shock Protein 90 (HSP 90) is needed as a nuclear chaperone (~transport protein). “[12, 23, 31]” (Bernard, et al, 2021)
“In summary, SMYD3 is critical for the activation of MAP3K2, a key kinase in the Ras-activated MAP signaling pathway, in both lung and pancreatic cancers. Furthermore, SMYD3 is associated with advanced stage and poor survival in NSCLC, and promotes cell proliferation, invasion, and chemotherapy resistance phenotypes.” (Bernard, et al, 2021)
… ‘miR-3613-3p/MAP3K2/p38/caspase-3 pathway regulates the heat-stress-induced apoptosis of endothelial cells’ (Liu, Liu, Chen, 2021)
“The results revealed that miR-3613-3p expression was reduced in human umbilical vein endothelial cells (HUVECs) following [heat stress] HS, which led to apoptosis. Mechanistically, following HS, a decrease in miR-3613-3p binding to the 3′-untranslated region of MAP3K2 directly upregulated its expression, and the downstream p38 and caspase-3 pathways, thereby leading to apoptosis. Taken together, the results of the present study demonstrated that HS suppressed miR-3613-3p expression, which activated the MAP3K2/p38/caspase-3 pathway, leading to the apoptosis of HUVECs.” (Liu, Liu, Chen, 2021)
Our goal – to not get overheated – avoid heat stress.
Not the same miRNA exactly, but from an interesting paper. “Chen et al. identified two miRNAs (hsa-miR-1307-3p and hsa-miR-3613-5p) that could prevent viral replication by targeting the 3′-UTRs of replication-related SARS-CoV-2 RNA 67.” (Yang, et al., 2022)
Pomegranate and heat stress – nature designed the plant to tolerate heat.
Pomegranate is a sustainable crop because it can tolerate heat, and salty soil and doesn’t need much water. The MAPK pathway is inhibited by pomegranate peel extract, and also by the 9 polyphenols discussed in the post: 1. “microRNA are the real regulators of gene transcription”. – Substack. I am not sure if the MAP3K2 is similarly inhibited but it seems likely.
Postural Orthostatic Tachycardia Syndrome can have an epigenetic cause.
Why is this important? Postural Orthostatic Tachycardia Syndrome is no fun and kind of scary. If you stand up too fast, your blood pressure can no longer shift quickly enough, however that works, and you get dizzy and need to grab something and rest a minute to get the accompanying tachycardia (very rapid heart rate, like it is trying to leap out of your chest almost). Laying down and lifting the knees and feet up helps slow the heart rate. Sitting or at least pausing is necessary or fainting may occur. I did faint once or twice and that is an odd feeling to find yourself on the floor after you come around. See: POTS – Postural Orthostatic Tachycardia Syndrome, can be epigenetic & therefore may be reversible. (substack.com) *Includes the Dystonia section of my Genes Table with more info and a link to my book chapter on the topic (but in computer lingo, the links don’t work).
Many chronic conditions involve epigenetic changes. Sometimes it can be reversed but not always and less likely the longer the condition has lasted. I had POTS-like symptoms for a few months twice and I figured out how to get better. It is not a fun condition and standard treatment usually does not help enough. People become physically disabled as it worsens. You can’t over-exert or stand up too fast or the symptoms of dizziness and racing heart occur.
When you have an open mind, you can learn new things.
Epigenetics – the basics.
Epigenetics – an overview/the opening of an Abstract about a review paper focused on cancer treatment and epigenetics:
“Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but play an important role in the control of gene expression.
In mammals, epigenetic mechanisms include changes in
DNA methylation,
histone modifications and
non-coding RNAs.
[microRNA are non-coding RNAs (19-23 nucleotides) and there are also longer ones (up to ~100, or a few >/= 200 nucleotides) that are still shorter than an mRNA which is used to transcribe a protein, so it is the full length of the matching DNA from the gene sequence, but only half of the zipper/ladder shape of the double helix.]
Although epigenetic changes are heritable in somatic cells, these modifications are also potentially reversible, which makes them attractive and promising avenues for tailoring cancer preventive and therapeutic strategies. Burgeoning evidence in the last decade has provided unprecedented clues that diet and environmental factors directly influence epigenetic mechanisms in humans. Dietary polyphenols from green tea, turmeric, soybeans, broccoli and others have shown to possess multiple cell-regulatory activities within cancer cells. More recently, we have begun to understand that some of the dietary polyphenols may exert their chemopreventive effects in part by modulating various components of the epigenetic machinery in humans.” (Link, Balaguer, Goel, 2010)
*Bullet points and note added by me. See: Non-coding RNAs: Classification, Biology and Functioning. (Hombach, Kretz, 2010)
Cancer is mitochondrial dysfunction related to cytoplasm dysfunction of the One-Carbon Methylation cycles.
As it turns out, nature really likes the one-carbon methylation cycle and mitochondria seem to be a control center of our cells rather than the nucleus. Cancer is dysfunction of mitochondria which leads to aberrant signaling to the cell nucleus which leads to cancerous like changes in their growth. Experiments have shown though, that when the nucleus of a cancer cell, with the gene changes in place, is transplanted into a healthy cell with healthy mitochondria and cytoplasm, the cell does not become cancerous. However, when a nucleus from a healthy cell is transplanted into a cancer cell that had its nucleus removed, the cell remains cancerous. When cancer cell mitochondria are transplanted into a healthy cell with a normal nucleus – it changes into a cancer cell with cancerous gene changes and out of control growth. The increased growth may be part of more normal pathways used during embryology and child growth. This indicates that cancer is NOT a GENETIC disease. The disease pathology was connected to the diseased cell’s mitochondria, not the diseased cell’s nucleus.
It turns out that mitochondria direct events within the cell and are the controller for signaling the need for apoptosis – put this cell to a merciful death, it is done. But with dysfunctional mitochondria there is no signal presented to kill the cell and it grows out of control or remains dysfunctional but alive – a senescent cell – alive and consuming, but no longer producing functional benefits for the organism or organ.
Cancer is a mitochondrial dysfunction. The one flaw in Dr Seyfried’s treatment plan though, is that such a high fat diet will still promote mitochondrial dysfunction. I would recommend a less stringent ketone diet, at least after some short-term initial phase that is moderate carb and >/= 50% of calories from fats. Use more ketones and some protein, but a diet above 60% fat may in itself cause mitochondrial dysfunction.
His depressing but helpful message is that also, the chemotherapy, radiation and some of surgical approaches are likely just adding to mitochondrial dysfunction and making the cancer worse. Carbohydrates and glutamates need to be restricted – and that equals sugar, bread, potatoes, pasta, pizza, tomato products, cheese, soy sauce, Worcestershire sauce, barbecue sauce or barbecue, artificial seasonings, ice cream, sweetened beverages, etc – much of the modern diet in other words.
Resources
/Housekeeping – I noticed an older comment suggesting that I provide checklists or more guidance for what to do, regarding my Table 5 – Nutrients depleted by psychiatric medications, which also are nutrients needed by mitochondria, and are risk factors for schizophrenia, Alzheimer’s dementia, or COVID19. I shortened the name of that Table to ‘Nutrients of Concern’.
See:
Downloadable Tools in my toolbox – by Jennifer Depew, R.D. (substack.com)
My first Substack post is still pertinent – Nrf2 & NF-kB – 2 proteins to know. (substack.com)
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
(Liu, Liu, Chen, 2021) Liu J, Xu S, Liu S, Chen B. (2021). miR‑3613‑3p/MAP3K2/p38/caspase‑3 pathway regulates the heat‑stress‑induced apoptosis of endothelial cells. Mol Med Rep. Sep;24(3):633. doi: 10.3892/mmr.2021.12272. Epub 2021 Jul 19. PMID: 34278472; PMCID: PMC8280962. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280962/ (Accessed: 5 Dec 2022)
(Yang, et al., 2022) Yang, C.Y., Chen, Y.H., Liu, P.J., Hu, W.C., Lu, K.C., Tsai, K.W., (2022). The emerging role of miRNAs in the pathogenesis of COVID-19: Protective effects of nutraceutical polyphenolic compounds against SARS-CoV-2 infection. Int J Med Sci. Jul 18;19(8):1340-1356. doi: 10.7150/ijms.76168. PMID: 35928726; PMCID: PMC9346380. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346380/ (Accessed: 5 Dec 2022)
(Zhu, et al., 2022) Zhu, W., Wang, S., Xue, L., Liu, L., Yang, X., Liu, Z., et al., (2022). The SMYD3-MTHFD1L-formate metabolic regulatory axis mediates mitophagy to inhibit M1 polarization in macrophages, International Immunopharmacology, 113(Part A), 2022, 109352, ISSN 1567-5769, https://doi.org/10.1016/j.intimp.2022.109352. https://www.sciencedirect.com/science/article/pii/S1567576922008360
Excerpt from The Epoch Times gives another warning to be cautious of psychiatric referrals. Autoimmune patients are used to being called hypochondriacs & sent to talk therapy. Now more are at risk.
Via COVID-19 Vaccine Injury, Syndrome Not a Disease: FLCCC Conference Shares How to Treat It, by Marina Zhang, Oct 17, 2022, The Epoch Times, (Zhang/theepochtimes):
[Dr. Ryan Cole] “Cole presented biopsies that showed spike protein presence and inflammation in small blood vessels, muscles, heart muscles, brain tissue, lungs, spleen, and many more.
Most of the biopsies presented damaged cells that expressed only spike protein, rather than other SARS-CoV-2 proteins. This suggests spike injuries are caused by vaccination and not natural infection, because in infection other SARS-CoV-2 proteins including nucleocapsid proteins [the base subunit S2 is connected to Nucleocapsid subunits] are present in addition to the spike protein.
[Dr. Paul Marik, co-founder and Chief Science Officer of the Frontline COVID-19 Critical Care Alliance (FLCCC),]
Cole’s findings fed into Marik’s lecture on symptoms and treatment options for long COVID and post-vaccine injury syndrome.” (Zhang/theepochtimes)
React19 is a science-based non-profit offering financial, physical, and emotional support for those suffering from longterm Covid-19 vaccine adverse events globally. (react19.org/about
“Evaluating React19 survey data from people suspecting vaccine injuries, Marik found the most common symptoms of spike protein-induced diseases.” (Zhang/theepochtimes)
Ten most commonly reported symptoms of people surveyed about suspected CoV vaccine injury.
Dr. Paul Marik’s slides presented at the FLCCC Conference in Orlando Florida (Courtesy of the FLCCC) (Zhang/theepochtimes)
““Believe it or not … the average number of symptoms reported is 23,” said Marik.
However, because most patients complain of an extensive list of symptoms not found in any disease, “[patients] will go to the doctor with all these complaints … and the doctor will say it’s all in your head,” said Marik.
Marik said that many patients are thus referred to psychiatric specialties rather than physicians who understand and can treat their disease.
“The vaccine-injured are vast,” said Kory, “the numbers are massive … they are underserved and their needs are not being met.”” (Zhang/theepochtimes)
Brain fog experienced by 71.5% of people who suspect they were CoV vak injured. (Zhang/theepochtimes)
Wormwood and artemisinin have also been part of my self-care arsenal. The pomegranate peel helps a lot but when I had post CoV infection fatigue and any flair ups since, artemisinin and then Wormwood tea more recently has helped fairly quickly. The artemisinin got more expensive, so I switched when I ran out of the 6 bottles I had bought online in 2020 when my symptoms felt like anemia of chronic inflammation/infection. It worked, I used it am and pm, 200 mg, for a few months and then once a day for the next year. The Wormwood tea is harsh on the gut, and I use it for flair-ups, any worsening of cold symptoms, swollen lymph nodes, achy body pain, or night sweats (a sign of worse autoimmune/inflammation/cancer).
Addition: Sweet Wormwood leaves is what I should have bought. Wormwood has thujone and is used in absinthe. Too much is a GABA disruptor and can cause seizures. Neither is recommended during pregnancy or child-bearing years. Artemisia afra is used I believe as an anti-malarial preventive in endemic regions of Africa. Artemisia afra does not have the same phytonutrients as the other Artemisia/wormwoods (and mugworts), but trials have had positive results. (du Toit and van der Kooy, 2019)
I used an old browser url to open my transcendingsquare.site and it was synchronicity – pertinent: Neuropathy can be a cause of extreme tiredness, 8/Dec/2016, with a helpful list of possible things to try. (transcendingsquare.com)
What I wanted was this post, I wrote about it more and of my use for my extreme fatigue: Artemisinin, arteannuin-B, sgp130Fc and COVID-19, 25/June/2020. The extreme fatigue needs an iron chelator to help the body recover balance after an infection causes a shift of iron from hemoglobin into storage as free iron or ferritin. If too much is free the storage becomes an issue and if it leaks to extracellular tissue, it causes oxidative damage and more inflammation.
The protein sgp130Fc may also be helpful but I have not seen much followed up on that topic.
SARS-CoV-2 and COVID-19: Is interleukin-6 (IL-6) the ‘culprit lesion’ of ARDS onset? What is there besides Tocilizumab? SGP130Fc. (Magro, 2020)
This article is mostly about the medications but mentions the sgp130Fc, a normal protein that would be protective, but during inflammation/infection we would need five times more. My post includes more description in a later section. Artemisinin, arteannuin-B, sgp130Fc and COVID-19
“There has been increased interest in employing the inhibitory agents tocilizumab, siltuximab and sarilumab in COVID-19 patients, with a series of clinical trials being registered and launched in different countries. In addition, the use of anti-IL-6 drugs is associated with an increased risk of some adverse reactions [8]. The use of metalloproteinase 17 (ADAM17) or soluble glycoprotein 130 fused chimera (sgp130Fc) to specifically inhibit pathological IL-6 trans-signaling in patients with severe COVID-19 promises to be a more effective and safer strategy to ameliorate disease states.” (Du, et al, 2021)
When I talk about membrane damage, realize that also means nerve membranes – myelination which makes our nerve signaling more rapid and accurate. (effectivecare.info/G12. Demyelination) I never got back to finish that page – a very revealing trend that I meant to move onto next was general malnutrition seems to be a big risk for demyelination. If the body gets hungry enough it starts using muscle tissue for protein and likely breaks down myelin for fatty acids.
My fingers get more pins and needles numb when I forget my methyl B12 too often or go too long between Epsom salt soaks. CoQ10 is on my Don’t forget list, and I have been.
Seeking help from people that dismiss your long list of aches and pains as hypochondria or psychosomatic is a bad idea. Complaining about it/their treatment, to them, may be a worse idea, as it may lead to a psychiatric commitment against your will and psychiatric medications that are likely to speed up the chronic degeneration and worsen the neurological damage.
This is serious. The powers in charge are forcing this through (CoV vak and other mRNA vak-to-be or other treatments) and ignoring all evidence of the harm of the mRNA process and the LNPs. Banging your head against a locked door (metaphorically) is not sensible . . . asking or demanding help from the people who are harming and denying harm and threatening mental illness diagnosis for people talking negatively about the causal substance . . . is not sensible.
A social media acquaintance literally escaped from a lock facility after their family had them committed for apparent craziness about Covid and posting too much online (late 2021). The person was put on medications that made the escape more difficult and surreal – a family member got a doctor to prescribe something and then swapped it for an antibiotic that was needed (so combined surreal issues from pain and an untreated infection). Psychiatric medications are dangerous, to many people at least, and we aren’t supposed to talk about that. Family members who are all “concerned” about you can also be very dangerous as they have sway with medical or legal officials.
Seek help from more reliable sources like the FLCCC or the World Health Council, or people who have lived it and survived to tell the tale (of life as an autoimmune patient), like me, and try to find a functional practitioner for local/individual support which is also a need.
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
Reference List
(Du, et al, 2021) Du P, Geng J, Wang F, Chen X, Huang Z, Wang Y. Role of IL-6 inhibitor in treatment of COVID-19-related cytokine release syndrome. Int J Med Sci 2021; 18(6):1356-1362. doi:10.7150/ijms.53564. https://www.medsci.org/v18p1356.htm
(du Toit and van der Kooy, 2019) du Toit A, van der Kooy F. Artemisia afra, a controversial herbal remedy or a treasure trove of new drugs? J Ethnopharmacol. 2019 Nov 15;244:112127. doi: 10.1016/j.jep.2019.112127. Epub 2019 Jul 31. PMID: 31376515. https://pubmed.ncbi.nlm.nih.gov/31376515/
(Magro, 2020) Magro G. SARS-CoV-2 and COVID-19: Is interleukin-6 (IL-6) the ‘culprit lesion’ of ARDS onset? What is there besides Tocilizumab? SGP130Fc. Cytokine X. 2020 Jun;2(2):100029. doi: 10.1016/j.cytox.2020.100029. Epub 2020 May 14. PMID: 32421092; PMCID: PMC7224649. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224649/
Includes chimeric spike gene sequences involved in fusion entry of cells, and Ehden Biber’s latest post with FOIA information from Pfizer including the Omicron BA.1 (“Riltozinameran”) genetic sequence.
Hard to understand info for non-geneticists from Ehden – thanks for sharing maybe some geneticists will translate for us: The Sequence; We now have Pfizer’s Omicron BA.1 (“Riltozinameran”) genetic sequence, alongside other important information, thanks to a FOI request to the UK’s regulatory body, the MHRA. – by Ehden Biber – Sense of Awareness (substack.com)
I had just added a gene sequence image to something I had written, and was searching posts and not finding it (and getting frustrated ;-) when I remembered where it was – Gp41 in SARS-CoV-2 spike, so here we are back with the delicious and royal fruit.
Pomegranate is so awesome it can take on a multi-fanged genetic chimera:
1) Blocks entry at the ACE2 receptors and preserves ACE2 function.
Pomegranate peel extract blocks entry at the ACE2 receptor which also helps protect the function of ACE2 receptors, and pomegranate extract also inhibited “the activity of thevirus 3CL protease.” (Tito, et al, 2020) Lung edema and other symptoms of severe Covid19 are also symptoms of lack of ACE2 function. As the infection spreads to cells with ACE2, the spike blocked receptor is dysfunctional. The juice/fruit likely helps but the peel is more potent, more concentrated in phytonutrients and has additional hydrolyzable tannins.
2) Inhibits NET formation, and inflammasome creation.
Inhibits NET formation (Kirchner, et al, 2013) which would promote inflammasome production – which kills good cells when it is an over-reaction. The SARS-CoV-2 virus spike protein, the E protein section, causes activation of NLRP3 Inflammasome creation, and the resulting increase in inflammation can also signal further creation of them. (Wong and Saier, 2021) An allergy like sensitization seems to occur. Macrophages from people who had been sick with COVID-19 reacted to exposure to the SARS-CoV-2 spike protein and inflammasome production occurred. Cells from people who had not been pre-exposed to SARS-CoV-2 did not react to cause inflammasome creation. (Theobald, et al, 2021)
3) Inhibits fusion of HIV-1 and entry into cells by membrane fusion. It may do the same for SARS-CoV-2.
*I am not sure if “HIV-1 entry inhibitor” is the same as fusion inhibitor for preventing the splitting of S1 from the S2 portion of spike. (Neurath, et al, 2004)
“Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide.” (Neurath, et al, 2004)
If it is, pomegranate phytonutrients could inhibit the fusion cleavage site from opening and freeing the S1 subunit which then can block nAChR function and has prion like domains and a galectin-3 like sequence. So, preventing S1 release would protect cholinergic function, reduce misfolded protein risks, and reduce risk of galectin-3 over-stimulating excess angiogenesis (blood vessel formation or doubling/splitting).
It was noted by (Wu Zhang and Leng Yap, 2004) that HIV-1 gp41 and SARS-CoV(1) S2 proteins are similar in structure. The gp41 protein helps HIV-1 fuse directly with cells in order to infect them, (Chen, 2019), which SARS-CoV-2 can also do. The S2 portion of spike forms a wedge like shape and directly invades a cell’s bilipid membrane layer for the purpose of membrane-to-membrane fusion with the viral particle. The sequence “GB1” is discussed and a Spike SARS-CoV-2 Fusion peptide, see Fig. S1. (Koppisetti, Fulcher, Van Doren, 2021) If pomegranate can prevent HIV-1 membrane fusion than maybe it is preventing separation of the S1 from the S2 subunit – more research is needed.
Background info by (Wu Zhang and Leng Yap, 2004) on the roles of the two parts of a coronavirus species’ spike protein – S1 (“cellular reception recognition”) and S2 (fusion of the viral and host cell membranes for entry):
“Coronavirus spike protein plays a very important role in virus entry, virus–receptor interaction, variations in host range and tissue tropism. The S proteins of majority of coronaviruses are cleaved into two functional subunits, S1 and S2. Liu et al. [1] indicated that the S protein of SARS-associated coronavirus (SARS-CoV) also forms S1 and S2 domains. The peripheral S1 portion is responsible for cellular receptor recognition, while the membrane-spanning S2 portion mediates the fusion of viral and cellular membrane, hence S protein determines the specificity of host and virulence of coronavirus [2]. Similarly, there are two non-valently associated subunits in the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein, gp120 and gp41, gp120 directs target-cell recognition and viral tropism through interaction with the cell-surface receptor CD4, while the membrane-spanning gp41 promotes fusion of the viral and cellular membranes so that viral contents are released into the host cell [3].” (Wu Zhang and Leng Yap, 2004)
The chimeric S1 subunit can be free and effect receptors elsewhere in the body or be released in exosomes in exhaled breath or sweat, and body fluids. It has the snake venom toxin-like nAChR cholinergic blocking effect and has a galectin-3 look alike sequence. Preventing S1 separation would reduce harm.
4) Acts as a modulator for inflammation & immune function,, promoting or inhibiting as needed for the situation.
Acts as a modulator and can increase Nitric oxide production if low or reduce Nitric oxide production if it excessive. Modulatory benefits for oxidative stress – pomegranate peel can help increase Nitric oxide by promoting eNOS (Delgado, et al, 2017), (de Nigris, et al, 2007a), (Wang D, et al, 2018), or reduce excess by promoting iNOS. (Kandeil, et al, 2019)
5) Protects against misfolded protein conditions.
Protects against misfolded protein conditions – the delphinidin (Noda, et al, 2002) and other anthocyanidins (Masci, et al, 2016), (Qu, et al, 2015) that give pomegranate its purple red hue, may help stabilize proteins as allosteric modulators and many phytonutrients or nutrients can act on receptors as agonists or reverse agonist (less often). (Silva, et al, 2019)
6) Promotes Nrf2 which helps promote DNA damage repair, glutathione production, and immune function.
Promotes Nrf2 which helps promote glutathione production, immune function, and DNA damage repair and inhibits inflammatory cytokines including IL-6 (Karwasra, et al, 2019) and NFkB. (Rasheed, et al, 2009). Nrf2 and pomegranate peel inhibit mast cell degranulation which would reduce inflammation, cytokines, and histamine. (Parisio, et al, 2020) Antihistamines tend to help in CoV treatment. Nrf2 inhibits mast cell degranulation by promoting SIRT4. (Hu B et al, 2020)
7) Contains potent antioxidants in addition to promoting Nrf2 and our own glutathione production.
Pomegranate peel contains potent antioxidants and diuretics (the tannins/EGCG/catechins) which help with detox – have several servings earlier in the day if ill and drink plenty of water, or once a day as a preventive.
The fruit juice and seeds provide some of the benefits for reducing inflammation and protecting the brain, but the peel contains more of the phytonutrients with potent antiviral and antioxidant function. Antioxidant power so strong, pomegranate peel extract can be used as an anti-corrosive for steel. (Rashid, et al, 2017) Too much is a pro-oxidant, use in moderate amounts. The diuretic effect is a clue when you may be getting too much, or just a good amount if puffiness is a problem.
8) Protects against liver, kidney, and brain damage risks from hyperinflammation.
Protects against liver, kidney, (Middha, et al, 2013) and brain damage risks from (spike) hyperinflammation. (Ahmed, et al, 2014) (Morzelle, et al, 2016) With a healthy microbiome, metabolites urolithin A and B can cross the blood brain barrier and reduce neuroinflammation. (Kujawska, et al, 2019) EGCG helps promote new growth of hippocampal cells. (Itika, et al, 2020) Urolithin A may be helpful against aging, metabolic dysfunction, IBD, and neurodegenerative disorders by promoting mitophagy and removal of defective mitochondria leading to improved health of mitochondria. (Singh, et al, 2022)
Species that help produce urolithin A and B may include Firmicutes, Clostridiales and Ruminococcaceae family and Akkermansia muciniphlia. Having more Bacteroides in ratio to Firmicutes was associated with non-production of urolithin A in response to 8 oz of pomegranate juice. A 500 mg supplement product, MitoPure, led to much greater increases in plasma levels of urolithin than the juice, in a crossover self-controlled clinical study. (Singh, et al, 2022)
Firmicutes are the main butyrate producing species, Ruminococcaceae also produce it, and Akkermansia muciniphlia produce other short-chain fatty acids. They are anaerobes fermenting undigested starches within the colon and the short chain fatty acids help feed the colon cells. (Parada Venegas, et al, 2019) *Probiotics provide species that populate the small intestines. We need to eat adequate resistant starches and zinc to support the anaerobe of the colon.
9) Improves gut health, membrane and cardiovascular health and promotes a beneficial microbiome balance of butyrate producing species.
Tip – think of skin health, gut health and blood vessel/cardiovascular health as all connected – similar tissue, slightly different issues.
Promotes balance between Firmicutes and Bacteroides species, butyrate producing microbial species in the gut. Excess Firmicutes is associated with obesity and excess Bacteroides with Inflammatory Bowel Disease. Pomegranate led to a decrease in Firmicutes in an animal-based study about a gut pathogen. (George, et al, 2019)
“These results suggest that consumption of pomegranate polyphenols altered the microbiome, making it more resistant to displacement by infection with Cr, indicating that pomegranate polyphenols may mitigate the pathogenic effects of food‐borne bacterial pathogens.” (George, et al, 2019)
When we protect our gut, we are also protecting our brain, because they are connected via the large vagus nerve. It can act as a superhighway and allow chemicals to enter the brain from the gut or enter the gut from the brain. Parkinson’s Disease seems to involve this connection. Pomegranate peel extract helped a brain inflammation condition by modulation of the species in the gut. (Lu, et al, 2020)
“Pomegranate peel extract ameliorates the severity of experimental autoimmune encephalomyelitis via modulation of gut microbiota.” (Lu XY, et al, 2020)
Promotes the microbiome. Sepsis – did not help in one animal model. Pretreatment for a month with pomegranate may have increased gut microbiome leaving the animals at increased risk of sepsis effects when surgery was performed. (Tavasoli, et al, 2014)
Summary: The juice/fruit provide many of these benefits but not all, the peel is more potent in the anti-viral & other benefits.
Pomegranate peel extract blocks entry at the ACE2 receptors and preserves ACE2 function.
Inhibits NET formation which leads to (killer) inflammasome creation.
Inhibits fusion of HIV-1 and entry into cells by membrane fusion. It may do the same for SARS-CoV-2.
Acts as a modulator for inflammation and immune function, promoting or inhibiting as needed for the situation – restoring balance.
Protects against misfolded protein conditions (prions).
Promotes Nrf2 which helps promote DNA damage repair, glutathione production, and immune function.
Pomegranate contains potent antioxidants in addition to promoting Nrf2 and our own glutathione production.
Protects against liver, kidney, and brain damage risks from hyperinflammation.
Improves gut health, membrane and cardiovascular health; and promotes a beneficial microbiome balance of butyrate producing species.
The juice/fruit provide many of these benefits but not all, the peel is more potent in the anti-viral benefits.
Ellagic acid/EGCG alternatives:
If pomegranate/peel is not available to you, then sumac/Zataar contains similar phytonutrients and so do Goji berries, and red raspberries a smaller amount and maybe black raspberries too: “The seeds of raspberries contained 87.8% of the ellagic acid,” (Daniel, et al, 1989), strawberries had more in the pulp than the seeds. Green tea also contains some of the catechin benefits ~ 3 cups per day provides about 200 mg of EGCG which is a typical amount found in supplements of EGCG. If gut issues are also an issue though, green tea may cause discomfort due to the oxalate content.
We should listen to Geert Vanden Bossche, PhD, DVM:
Geert says we need to treat everyone prophylactically to stop breakthrough infections & slow the mutation rate. (substack.com) a post on my SubCtack links to his audio/post.
Early treatment works – we need to prophylactically treat everyone with the basic Z-Stack or preferred equivalent. Preventively taking supplements means you are treating somewhat at the first exposure. Then if signs of a cold occur, increase the vitamin C and anti-viral/iron chelators like quercetin, pomegranate peel product/tea and/or black seed oil.
I also include intranasal rinse or spray, and negative ionizers for air quality control in addition. Stop the exposure in the nose where the body has IgA antibodies that react against any coronavirus. Once the RNA species reach the lung, they have mutated somewhat and are harder for the body to fight.
Negative ionizers are something that should be in public places.
Anyone in power over a facility – please see what you can do to add it. CoV spike is positively charged and will clump and fall from the air. Sweep and mop more often. Part of the risk is the air above big crowds – think of it as a circulating swamp of everyone’s mutation variants, which then all can rapidly mingle and the whole swarm can quantumly it seems, all mutate to a new (worse) variant and make the whole crowd sick. Karl Sirotkin, PhD’s work.
Golden Silkworms in Pandora’s Box – by Harvard2TheBigHouse (substack.com)
Pomegranate peel and fruit is an “antidote” for many diabolical features of the patented computer-generated sequence that is causing harm. It happens to be pomegranate season in the Northern Hemisphere. Are we collectively going to start using the fruit and peel for its full benefits? Or continue waiting for a rich person to suggest it? Or wait for Tedros and the WHO to use a little money to research pomegranate peel extract against SARS-CoV-2?
If you want medical doctor/researcher recommendations about the benefits of pomegranate, read this open access peer-reviewed book: Pomegranate, (IntechOpen), 2021. In a chapter on the antimicrobial benefits, Celiksoy and Heard did a phenomenal job creating extensive Tables of research trials showing antimicrobial potential of pomegranate peel extract or whole fruit extract. The Tables include which species were targeted using pomegranate extract of what dose, standardized to 13% ellagic acid, or other extraction method details are listed. (Celiksoy and Heard, 2021) It is just one Chapter in an open access peer-reviewed (long) book: Pomegranate, (IntechOpen), 2021.
Pomegranate and early treatment can work – if you use it.
It can’t work if you don’t use it.
Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
