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Fullscript Cyber sale through Nov 28.

Dandelions in close up with a mountain in the distance.

Fullscript is a wholesale supplement dispensary which carries a lot of reputable brands. Individuals can order through an affiliated healthcare professional. People ordering through my account will receive a 30% discount. Happy Health to you!

If interested sign up here and browse the various protocols that I have posted for anyone’s use. (Welcome/Sign up page) Product examples included in one of my protocols are intended for you to browse through rather than a recommendation to get all of it. (Any time I edit a protocol the system requires that I add another product to be able to save the edits.) People signed up under my account are allowed to browse the entire catalog or select from the examples I put in some protocols.

In order to participate in Fullscript’s promotion I had to change my settings – so the holiday discount should be active as of now through November 28th. Feel free to ask me questions in the comments or you can reply to email posts directly rather than making a public comment.

Thanks for the support and feedback about leg lymphedema. (Yesterday’s post: Lymphedema, movement, and structured water. (open.substack.com/pub/denutrients) – subscribe to my Substack for emails of my latest posts) I was trying to be light-hearted about it but it is worse than it used to be and I don’t really know why/what to do different besides try to return to my good health habits that I have been slacking on too long.

I ordered some compression stockings to try in the meantime.

The infrared space heater structured water experiment in yesterday’s post seems to have worked. I tried some this morning and it also has the slightly thicker/slipperier mouth feel that is different than tap water. I haven’t read much about health benefits of diatomaceous earth but it does add a slight cloudiness/whiteness to the water.

It is a source of silica and is good for skin, hair, teeth and bones.

“When taken by mouth, diatomaceous earth is used as a source of silica, for treating high cholesterol levels, for treating constipation, and for improving the health of skin, nails, teeth, bones, and hair.” (WebMD.com)

Brain fatigue post – happy midweek to you!

What’s on the menu? Some time in nature. And blogs on preventing or treating chronic inflammation. I will try to copy my planned series here in addition to Substack.

Dandelion mountain?

Food first! Many very nutrient packed plants and foods are available in the grocery store or foraged from wild areas that haven’t been treated with lawn chemicals.

Disclaimer: This information is being provided for educational purposes within the guidelines of Fair Use and is not intended to provide individual health care guidance.

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Link to Niacin/wild hamster cannibalism/glyphosate and a list of Glyphosate posts, with a CoV theme.

Expanded last post: Niacin deficiency linked to glyphosate and cannibalism (in wild hamsters). (substack.com) I posted that link before I was done watching the video, and slept a little more after watching it. So now the post has the hamster story in more detail and some other info from the video webinar. Each of the four speakers had significant info that added to the bigger picture.

What I didn’t include in my rewrite was that action individually is being encouraged – informing the government isn’t working or what they claim to be doing is on a too long-time scale – status quo to continue until some future date.

We are in a corporatocracy, an oligarchy, and corporate profit is protected over individual consumers. Our buying power collectively may be our biggest voice. If the consumers stop buying the poisonous products more producers might switch to organic foods. However – with the government complicit – they buy a lot of food and provide a lot of school children on Free or Reduced-price meals with two and sometimes three meals a day. Our individually stopping the purchase of RoundUp ready crops or meats raised with them – will not stop the big bucks that agribusiness gets from government purchase for schools, VA hospitals or facilities, or the military. Anyone on a cafeteria meal-plan will likely be getting glyphosate foods.

brown mouse on brown wooden table
“Teddy, my Syrian Hamster.” Photo by Andy Holmes on Unsplash

Glyphosate disrupts actin which is like a scaffolding with a crane that can direct activity and line up vital chemical parts within the cell. Glyphosate disrupts the crane’s ‘hook’.

Series – glyphosate is a big deal and has been since around 1965, use greatly increased sometime between 1985 and 1995:

  • Glycine & glyphosate & misfolded proteins – Seneff article. (June 13, 2021)
  • Covid-19 “broken glass lung” and glyphosate, draft (March 4, 2021), posted (Dec 17, 2022) *This is/was a follow-up to Glyphosate & COVID19, (Oct 25, 2020)
  • Glyphosate increases histamine, both may be a factor in COVID19 (Nov 10, 2020)
  • Glyphosate & COVID19, (Oct 25, 2020) *Biofuel made with RoundUp biomass is producing increased glyphosate residue in the air of communities near the biofuel production facility and in areas that now use a lot of biofuel in their gasoline mix. This post has a link to a company where you can self-order a screening test for glyphosate residue (in a urine sample I think).
  • Glutathione, Nrf2, Autism & Glyphosate, (May 26, 2018)
  • A US Congressman [Ted Lieu] is concerned about safety of glyphosate, (March, 19, 2017) Excerpt from the brief post: “An employee of the EPA may have colluded with Monsanto to suppress investigation of the safety of glyphosate and the herbicide Roundup.” (My words, link to a sustainablepulse.com article in the post).
  • Glycine, Cheerful Juice, and testing for glyphosate, (Oct 26, 2016) *One of my solutions is to take powdered Dimethylglycine in water with a little sweetener, smidge of baking soda to offset the acidity, and a little juice for flavor. It can taste a little like red wine. Acidic citrus juices are not as helpful as a little blueberry, pomegranate or cherry juice. This post has links to previous posts I had written about DMG and my ‘Cheerful Juice’ – it makes me more cheerful but can taste kind of bad without the extra additions.
  • Glyphosate and disruption of the protective mucus layer made by coral species. *an old draft post that I just posted, (Oct 19, 2016) (Dec 17, 2022)
  • The herbicide Round-Up found more dangerous than glyphosate alone, (Oct 17, 2016)
  • Glyphosate, a consensus statement; a link, (Sept 21, 2016)
  • Updates regarding glycine, health, and glyphosate, (Sept. 20, 2016)
  • Glyphosate was found in vaccines; and tips for reducing dietary exposure, (Sept 16, 2016)
    • *Gelatin from commercial sources is likely also a source of glyphosate residue as collagen is a protein made with a lot of glycine – leaving a lot of opportunity for glyphosate to be substituted instead in an animal fed RoundUp crops as feed. This would make gelatin capsule supplements a negative and any collagen joint support products that use commercially sourced collagen instead of organically raised sources.
  • Glyphosate was created as an antibiotic and mineral chelator but is being used as an herbicide, (Aug 2, 2016)
  • CYP enzymes are needed to produce both 25 vitamin D and 1, 25 hormone D; and more on glyphosate, (June 29, 2016)
  • There is never going to be a good time to say that glyphosate is unhealthy, (June 17, 2016). This post is more about how society ignores some people, the second in command in the airplane, and that can lead to big crashes. I bring up the infertility aspect of glyphosate in this post, and that it is likely part of the increase in gender dysphoria.
  • Vitamin D activating enzyme and Glyphosate, the herbicide Roundup, (June 14, 2016)
  • Vitamin D, Cholesterol sulfate, concussions, and glyphosate (Round-up), (June 11, 2016)

Glyphosate would be causing a DNA female fetus to develop male pattern instinctual behaviors – rougher active play as a child and mounting dominance behavior when sexuality is developing rather than bending over and wanting to submit. Gender dysphoria is very real and occurs in the prenatal hormone environment of an infant when there is a mismatch between the uterine hormones that are predominant and the fetal DNA sex.

Historically, male DNA with female gender behavior was more common, though rare still. A pregnant woman is female and has female hormones, so it makes sense. Endocrine mimetic pesticides and BPA are likely increasing the incidence of male DNA babies that grow up with female gender behavior instincts. The glyphosate is newer to human history and now there is a big increase in female DNA babies that grow up with male gender behavior instincts. There is also social pressure on young girls and woman to be very overtly sexual, or maybe skip it by transitioning to male. Join the fun LGBTQIA+ marginalized group and give up your ‘white privilege’ – along with your healthy body, normal function sexual parts, and ability to have a baby or breast feed it…. This is not a solution to reducing glyphosate or estrogen mimetics in our food supply and environment.

We, humans, are causing trans or homosexuality in other species too. It makes me embarrassed for humans and sad for other species and the planet as a whole. We are a blight on this planet.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

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Covid-19 “broken glass lung” and glyphosate

The HO-1 enzyme that may be being made wrong, with glyphosate in place of glycine, promotes another chemical (granulocyte macrophage-colony stimulating factor (GM-CSF) that is seen to be elevated in Covid-19 (1) and the receptor for the chemical may be involved in a lung condition (2) that also has “broken glass” like lung images. The unusual lung images are due to the alveolar areas to be fluid filled and dysfunctional, opaque white areas in the images instead of black/air filled cavities that would normally be visible. (2)

PAP – Pulmonary alveolar proteinosis – “broken glass” lung, or “paving tile”.

The “broken glass” lung issue is also called pulmonary alveolar proteinosis (PAP). (2, 3)

Medical opinion: “Clinical data, analytical findings and the few pathological references we have so far suggest SARS-CoV-2 lung disease could be a secondary interferonopathy with pulmonary alveolar proteinosis (PAP)-like features and sometimes thrombotic microangiopathy.” (3)

Treatment with Interferon inhibitors might provide “IFN-γ blockage” and medication trials were recommended.

“The presence of PAP suggests alveolar macrophage dysfunction in clearing surfactant from the alveoli. Whether IL-18 or IFNγ blockage and/or treatments aimed at increasing surfactant phagocytosis/processing by alveolar macrophages are viable treatment strategies, needs further exploration.” (3)

Take home point from clinical trial information and an Abstract-less paper: the PPAR-gamma activator Pioglitazone helped reduce the size of alveolar macrophages in autoimmune pulmonary alveolar proteinosis (PAP). (Vis, Kelly, De Heuvel, MacEachern, 2020) (CTG Labs/NCTO3231033)

GM-CSF promotes growth of alveolar macrophages.

“COVID-19 is a clinical syndrome ranging from mild symptoms to severe pneumonia that often leads to respiratory failure, need for mechanical ventilation, and death. Most of the lung damage is driven by a surge in inflammatory cytokines [interleukin-6, interferon-γ, and granulocyte-monocyte stimulating factor (GM-CSF)]. Blunting this hyperinflammation with immunomodulation may lead to clinical improvement. GM-CSF is produced by many cells, including macrophages and T-cells. GM-CSF-derived signals are involved in differentiation of macrophages, including alveolar macrophages (AMs).” (1)

The authors go on to explain that some GM-CSF can be helpful and promote growth of alveolar macrophages while too much of the GM-CSF stimulation is not. Trials are underway with medication to either block the receptors or antibody medication that combines with the free floating GM-CSF in the blood stream so it is no longer available. (1)

“This blockade can be achieved through antagonism of the GM-CSF receptor or the direct binding of circulating GM-CSF. Initial findings from patients with COVID-19 treated with a single intravenous dose of mavrilimumab, a monoclonal antibody binding GM-CSF receptor α, showed oxygenation improvement and shorter hospitalization. “

Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies https://ncbi.nlm.nih.gov/pmc/articles/PMC7348297/… “HO-1-dependent heme catabolism, regulates GM-CSF synthesis in human airway..”

PPAR-gamma activation helped autoimmune PAP. (Vis, Kelly, De Heuvel, MacEachern, 2020) (CTG Labs/NCTO3231033) See Figure 3, the PPAR alpha, beta/delta, and gamma activate different functions in normal health. Figure 5 shows natural and synthetic ligands of the PPAR receptors, (Grygiel-Gorniak, 2014), but fails to include 9-cis-Retinoic Acid. It was found that both a synthetic and a natural agonist of PPAR gamma only had the desired anti-inflammatory effect when 9-cis-Retinoic acid was also present. (Worley, et al., 2003)

Use of a retinoid medication for a type of leukemia can cause an adverse reaction syndrome that include “ground glass lung” scans.  (Weerakkody, et al, 2012)  See this post for more info and the full citation: microRNA, elevated homocysteine and is there a role for excess Retinoic Acid? (substack.com) I think there is a role for excess active retinoids in COVID19 and hyperinflammation that seems to be related to the “ground glass lung” scans – fluid filled alveoli – patients drowning in their own body fluids.

We would need to find out if there is an aberrant form of the HO-1 enzyme containing glyphosate in its amino acid construction, that is functional in some new aberrant way, possibly promoting too much GM-CSF – causing a change in the function rather than just making it dysfunctional.

Regulation of IL-1 beta-induced GM-CSF production in human airway smooth muscle cells by CO [Carbon monoxide] — retracted article – need to rethink/read more, https://journals.physiology.org/doi/pdf/10.1152/ajplung.00212.2002 * “The American Physiological Society is retracting this article due to inclusion of data in Figure 4A that were published previously in Figures 5 and 6 of the article “Carbon Monoxide Inhibits Human Airway Smooth Muscle Cell Proliferation via Mitogen-Activated Protein Kinase Pathway” (https:// doi.org/10.1165/rcmb.4851) and represent different results. Due to the length of time since initial publication, the authors were unable to provide original captures for these experiments to resolve the concerns.” (Retraction statement) **So, ignore Figure 4A.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Reference List

  1. Bonaventura A, Vecchié A, Wang TS, et al. Targeting GM-CSF in COVID-19 Pneumonia: Rationale and Strategies. Front Immunol. 2020;11:1625. Published 2020 Jul 3. doi:10.3389/fimmu.2020.01625 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348297/
  2. Borie R, Danel C, Debray M-P, et al., Pulmonary alveolar proteinosis. European Respiratory Review 2011 20: 98-107; DOI: 10.1183/09059180.00001311 https://err.ersjournals.com/content/20/120/98
  3. Julián Fernández-Martín, Pérez-Álvarez Roberto and Lamas-Barreiro José María, COVID-19: An Acute Secondary Interferonophaty? The Mirror of Autoinflammatory Syndromes. Arch of Immunology, Vol 2, Issue 1, DOI: 10.36959/885/368 https://scholars.direct/Articles/immunology/aim-2-005.php?jid=immunology
  4. Mair, K.M., Robinson, E., Kane, K.A., Pyne, S., Brett, R.R., Pyne, N.J. and Kennedy, S. (2010) Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. British Journal of Pharmacology, 161 (1). pp. 176-192. ISSN 1476-5381 https://core.ac.uk/download/pdf/80831.pdf
  5. Giacoppo S, Mazzon E. Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?. Neural Regen Res. 2016;11(12):1896-1899. doi:10.4103/1673-5374.197125 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270417/
  6. ARN14988 (aCDase Inhibitor), https://echelon-inc.com/product/arn14988-acdase-inhibitor/
  7. Xiao Mei Wang, Hong Pyo Kim, Kiichi Nakahira, Stefan W. Ryter and Augustine M. K. Choi, The Heme Oxygenase-1/Carbon Monoxide Pathway Suppresses TLR4 Signaling by Regulating the Interaction of TLR4 with Caveolin-1. J Immunol March 15, 2009, 182 (6) 3809-3818; DOI: https://doi.org/10.4049/jimmunol.0712437 https://www.jimmunol.org/content/182/6/3809
  8. Rebecca Gilbert, Update on COVID-19 and Parkinson’s Disease. Oct. 27, 2020, apdaparkinson.org, https://www.apdaparkinson.org/article/newly-published-studies-on-covid-and-pd/
  9. Fukushima T. Niacin metabolism and Parkinson’s disease. Environ Health Prev Med. 2005;10(1):3-8. doi:10.1265/ehpm.10.3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723628/
  10. Francisco Navarrete, María Salud García-Gutiérrez, Rosa Jurado-Barba, et al., Endocannabinoid System Components as Potential Biomarkers in Psychiatry. Front. Psychiatry, 27 April 2020 | https://doi.org/10.3389/fpsyt.2020.00315 https://www.frontiersin.org/articles/10.3389/fpsyt.2020.00315/full
  11. Erukainure OL, Matsabisa MG, Salau VF, Islam MS. Tetrahydrocannabinol-Rich Extracts From Cannabis Sativa L. Improve Glucose Consumption and Modulate Metabolic Complications Linked to Neurodegenerative Diseases in Isolated Rat Brains. Front Pharmacol. 2020;11:592981. Published 2020 Nov 24. doi:10.3389/fphar.2020.592981 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774498/
  12. CK Eternity, Melatonin: the master antioxidant. August 9, 2020, multiflora-herbs.com, https://www.multiflora-herbs.com/blogs/news/melatonin-the-master-antioxidant
  13. Yingying Lu,Baixia Hao,Richard Graeff &Jianbo Yue, NAADP/TPC2/Ca2+ Signaling Inhibits Autophagy.
  14. Article: e27595, Published online: 08 Jan 2014, https://doi.org/10.4161/cib.27595, https://www.tandfonline.com/doi/full/10.4161/cib.27595
  15. Li R, Li Y, Liang X, Yang L, Su M, Lai KP. Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets [published online ahead of print, 2020 Nov 10]. Brief Bioinform. 2020;bbaa300. doi:10.1093/bib/bbaa300 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717147/
  16. Tweet Thread https://twitter.com/Parsifaler/status/1367148395278856193?s=20
  17. https://ncbi.nlm.nih.gov/pmc/articles/PMC6399501/… https://medlineplus.gov/genetics/condition/spinal-muscular-atrophy-with-progressive-myoclonic-epilepsy/… https://ncbi.nlm.nih.gov/pmc/articles/PMC3779446/… https://ncbi.nlm.nih.gov/pmc/articles/PMC7382416/… https://ncbi.nlm.nih.gov/pmc/articles/PMC3779446/… https://sciencedaily.com/releases/2016/11/161103122227.htm
  18. https://www.cedclinic.com/blog/tetrahydrocannabinol-rich-extracts-from-cannabis-sativa-l-improve-glucose-consumption-and-modulate-metabolic-complications-linked-to-neurodegenerative-diseases-in-isolated-rat-brains / pdf https://drive.google.com/file/d/14x6YFb_SoL_2FETSRMrcjfrKga0oNlO_/view
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Glyphosate and disruption of the protective mucus layer made by coral species.

Excerpt – glyphosate entering the ocean may chelate manganese and leave coral unable to form their protective layer of mucus containing sulfated glycoproteins: “A protective layer of mucopolysaccharides called mucus is secreted by corals, and it has been characterized as containing sulfated glycoproteins similar to chondroitin sulfate, [44] which play an important role in controlling pH and the transepithelial movement of electrolytes and water, just as is the case in vertebrate mucosa. Mucus pathology is implicated in coral disease leading to mortality, particularly in the Caribbean.[219] Thus, an interesting hypothesis that should be considered is that glyphosate chelation of Mn is a crucial factor in the worldwide coral die-off.” (Samsel, Seneff, 2015)

Manganese is important:

“Vitamin D deficiency has reached epidemic proportions in the US and increasingly around the world in recent years. [124] In a large population study in the US, Bodnar et al. [34] found deficient levels of vitamin D in 83% of Black women and 92% of their newborns, as well as in 47% of White women and 66% of their newborns, despite the fact that over 90% of the women were on prenatal vitamins. This deficiency is associated with an increased risk to bone fractures, likely due to impaired calcium homeostasis. [145] It is even likely that care-takers are being falsely accused (“Shaken Baby Syndrome”) of abusing children in their care who suffer from bone fractures. [255] These children are highly vulnerable to bone fractures due to impaired bone development. Bone fractures in the elderly due to osteoporosis have also risen sharply recently in the industrialized world. [139] The cause of a surging incidence of hip fractures across multiple age groups remains a mystery to medical personnel. [140]

Samsel and Seneff [248,249] proposed that the current vitamin D deficiency epidemic is caused by glyphosate, due to glyphosate’s interference with CYP enzymes. The metabolite that is usually measured, 25-hydroxy vitamin D, is the product of activation in the liver by a CYP enzyme that is also critical in bile acid formation. However, there is a larger problem with bone development due to impaired Mn homeostasis.” (Samsel, Seneff, 2015)

Selenium is also important (selenoproteins):

“Dopamine suppresses thyroid stimulating hormone, and therefore dopamine insufficiency can lead to overactive thyroid and potential burnout of the thyroid gland. [270] This problem is compounded by the fact that thyroid hormone itself is derived from tyrosine, one of the three aromatic amino acids that are negatively impacted by glyphosate through disruption of the shikimate pathway. The thyroid gland also depends critically on selenoproteins as antioxidants. [249] Glyphosate’s depletion of both selenium and methionine will lead to reduced bioavailability of selenoproteins. It is conceivable that all of these factors working together can explain the strong correlation of glyphosate application to corn and soy with thyroid cancer [Figure 7], as well as the association between maternal thyroid disease and autism. [238]” (Samsel, Seneff, 2015)

Glutathione is depleted, Manganese is needed for its production, along with other nutrients and Nrf2 promotion and/or a healthy circadian cycle:

“Experiments exposing immature rats to Roundup®, whether via exposure to the dam during pregnancy and lactation or via acute exposure to the pup for 30 min, demonstrated lipid peroxidation and NMDA receptor activation in the hippocampus, indicative of oxidative stress and glutamate excitotoxicity. [59] Acute exposure increased the release of glutamate into the synaptic cleft, and depleted GSH.

Glutamine synthase depends upon Mn as a cofactor, so depleted Mn supplies would lead to a build-up of glutamate that cannot be returned to the neurons using normal channels. Multiple sclerosis is associated with both depleted Mn in the cerebrospinal fluid [185] and depleted GSH synthase in the white matter lesions. [309]” (Samsel, Seneff, 2015)

Why should we care about coral? Because we and coral have similar biological pathways. Nature loves a good design and sticks with it across the plant and animal and microbial kingdoms. Also it would be better to be good stewards of the planet, instead of being an invasive parasite that destroys everything in its path.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Reference List

(Samsel, Seneff, 2015) Samsel A, Seneff S. Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies. Surg Neurol Int. 2015 Mar 24;6:45. doi: 10.4103/2152-7806.153876. PMID: 25883837; PMCID: PMC4392553. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392553/