Excerpt – glyphosate entering the ocean may chelate manganese and leave coral unable to form their protective layer of mucus containing sulfated glycoproteins: “A protective layer of mucopolysaccharides called mucus is secreted by corals, and it has been characterized as containing sulfated glycoproteins similar to chondroitin sulfate, [44] which play an important role in controlling pH and the transepithelial movement of electrolytes and water, just as is the case in vertebrate mucosa. Mucus pathology is implicated in coral disease leading to mortality, particularly in the Caribbean.[219] Thus, an interesting hypothesis that should be considered is that glyphosate chelation of Mn is a crucial factor in the worldwide coral die-off.” (Samsel, Seneff, 2015)
Manganese is important:
“Vitamin D deficiency has reached epidemic proportions in the US and increasingly around the world in recent years. [124] In a large population study in the US, Bodnar et al. [34] found deficient levels of vitamin D in 83% of Black women and 92% of their newborns, as well as in 47% of White women and 66% of their newborns, despite the fact that over 90% of the women were on prenatal vitamins. This deficiency is associated with an increased risk to bone fractures, likely due to impaired calcium homeostasis. [145] It is even likely that care-takers are being falsely accused (“Shaken Baby Syndrome”) of abusing children in their care who suffer from bone fractures. [255] These children are highly vulnerable to bone fractures due to impaired bone development. Bone fractures in the elderly due to osteoporosis have also risen sharply recently in the industrialized world. [139] The cause of a surging incidence of hip fractures across multiple age groups remains a mystery to medical personnel. [140]
Samsel and Seneff [248,249] proposed that the current vitamin D deficiency epidemic is caused by glyphosate, due to glyphosate’s interference with CYP enzymes. The metabolite that is usually measured, 25-hydroxy vitamin D, is the product of activation in the liver by a CYP enzyme that is also critical in bile acid formation. However, there is a larger problem with bone development due to impaired Mn homeostasis.” (Samsel, Seneff, 2015)
Selenium is also important (selenoproteins):
“Dopamine suppresses thyroid stimulating hormone, and therefore dopamine insufficiency can lead to overactive thyroid and potential burnout of the thyroid gland. [270] This problem is compounded by the fact that thyroid hormone itself is derived from tyrosine, one of the three aromatic amino acids that are negatively impacted by glyphosate through disruption of the shikimate pathway. The thyroid gland also depends critically on selenoproteins as antioxidants. [249] Glyphosate’s depletion of both selenium and methionine will lead to reduced bioavailability of selenoproteins. It is conceivable that all of these factors working together can explain the strong correlation of glyphosate application to corn and soy with thyroid cancer [Figure 7], as well as the association between maternal thyroid disease and autism. [238]” (Samsel, Seneff, 2015)
Glutathione is depleted, Manganese is needed for its production, along with other nutrients and Nrf2 promotion and/or a healthy circadian cycle:
“Experiments exposing immature rats to Roundup®, whether via exposure to the dam during pregnancy and lactation or via acute exposure to the pup for 30 min, demonstrated lipid peroxidation and NMDA receptor activation in the hippocampus, indicative of oxidative stress and glutamate excitotoxicity. [59] Acute exposure increased the release of glutamate into the synaptic cleft, and depleted GSH.
Glutamine synthase depends upon Mn as a cofactor, so depleted Mn supplies would lead to a build-up of glutamate that cannot be returned to the neurons using normal channels. Multiple sclerosis is associated with both depleted Mn in the cerebrospinal fluid [185] and depleted GSH synthase in the white matter lesions. [309]” (Samsel, Seneff, 2015)
Why should we care about coral? Because we and coral have similar biological pathways. Nature loves a good design and sticks with it across the plant and animal and microbial kingdoms. Also it would be better to be good stewards of the planet, instead of being an invasive parasite that destroys everything in its path.
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
Reference List
(Samsel, Seneff, 2015) Samsel A, Seneff S. Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies. Surg Neurol Int. 2015 Mar 24;6:45. doi: 10.4103/2152-7806.153876. PMID: 25883837; PMCID: PMC4392553. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392553/
I have been very busy with the pomegranate paper, and sadly, or not surprising, it was not accepted for further review – non-standard, which is true. It was too long and I learned more while researching for it and needed to rewrite the main article. A book or website with guided pages and some screening questions to help guide people to material that may be helpful is my plan.
My goal is to make a more concise site with a dropdown menu of some sort to help guide people to the info that they want or need – and some screening question sections to help pinpoint which information may be needed. I have started a very preliminary workflowy.com (https://workflowy.com/s/hyperinflammation-pr/NA9NrJpva8lyi1nH) but got hung up on how to add images. It says just “drag and drop” and I have no idea why that doesn’t seem to work. Is that an Apple thing? ** I figured out how to drag and drop an image but then I couldn’t move it to any other sections. WorkFlowy may not be for me.
I have been posting on SubStack and need to post here more. I have posted a few new things to peace-is-happy.org, but an older post was most read in November so that may have been Oct or even longer ago. The images in this post are some of my travel pics. Peace is mental and physical. (peace-is-happy.org) It is not a long post but has some good starting points. Build mindfulness, peaceful brain pathways and try to forget stressful worry pathways by not thinking about them. One anxiety tip I like – make a Worry Jar and write down your worry, stick it in the jar, schedule 15 minutes to go through your Worry Jar once a week. Saves mental strain to not have an overload on your mind. Writing lists or goals can help put them someplace else where you know you can find it again, and have a little more peace of mind.
“Great design should be ‘intuitive.’ Translation: feel natural.” — Tom Peters
Nature repeats chemical structures and pathways across the chain of life. The essential omega 3 fatty acid DHA is ancient, unchanged from simple life forms to complex.
This post is the first of a series, in which I will share my Genes Table.
It has the solution for the health problems that gene alleles may cause – plant polyphenols. Polyphenols may be able to correct the up or down regulation in important pathways that the dysfunctional allele caused by affecting microRNA.
“microRNA are the real regulators of gene transcription”. – Substack.
“microRNA, elevated homocysteine and is there a role for excess Retinoic Acid?” (substack.com) *The hyperhomocysteinemia/homocystinuria section of my Genes Table.
“Pollutants in Human Plasma Found via Double-Filtration Plasmapheresis Plasma Exchange”, James Lyons-Weiler. (substack.com) *This is a cross post. Heavy metal toxins and thread like objects and aluminum-silicon combinations were found in a filtration of plasma procedure. This is related to pomegranate because the peel is effective at clumping nanoparticles into larger clumps that are big enough for white blood cells to sense as something needing to be removed.
“POTS – Postural Orthostatic Tachycardia Syndrome, can be epigenetic & therefore may be reversible”. (substack.com) *The Dystonia section of my Genes Table.
Before moving on to more sections, or exploring other conditions and yet more links…
This one is excellent and has a video abstract/overview: (Hayden, Tyagi, 2022) Hayden, M.R., Tyagi, S.C., (2022). Impaired Folate-Mediated One-Carbon Metabolism in Type 2 Diabetes, Late-Onset Alzheimer’s Disease and Long COVID. Medicina. 58(1):16. https://doi.org/10.3390/medicina58010016 Available at https://www.mdpi.com/1648-9144/58/1/16 (Accessed: 4 Dec 2022) Figure 1: Folate-Mediated One-Carbon Metabolism (FOCM).
In it we learn that the one-carbon methylation cycles are used within cell’s cytoplasm, within the mitochondria, and within the cell’s nucleus – and if the nucleus version is impaired, then … methylation of DNA will be impaired – it will not occur. Epigenetic changes will be very likely if there is dysfunction in the one-carbon methylation cycle within the nucleus.
Nature loves a good design and will repeat it.
“Figure 2. Compartmentalization of FOCM. Note the presence of the folate-methionine one carbon cycle metabolism in the cytoplasm (cytosol), mitochondria and nucleus.Additionally, note the importance of formate being transferred from the mitochondria to the nucleus, as well as S-adenosylmethionine (SAM) via nuclear pores. Importantly, deoxythymidine monophosphate (dTMP) synthesis occurs in the cytosol, nucleus and mitochondria, whereas purine synthesis and methionine synthesis take place within the cytosol. Mitochondrial FOCM generates formate for cytosolic and nuclear FOCM and biosynthetic precursors for mtDNA synthesis and mitochondrial protein translation. Thymidylate synthase (TYMS) converts deoxyuridine monophosphate (dUMP) to dTMP in a 5,10-methylene-THF-dependent reaction (not shown). It is important to note that mitochondrial SAM (Mt SAM) is derived from cytosolic SAM (cSAM). Additionally, the Krebs cycle also resides within the mitochondria and provides NADH and FADH2 to the electron transport chain for ATP production. ATP = adenosine triphosphate; c = cytosol; ETC = electron transport chain; FAD = flavin adenine dinucleotide; FADH = reduced flavin adenine dinucleotide; FFA = free fatty acids; HHcy = hyperhomocysteinemia; MS = methionine synthase; Mt = mitochondria; NADH = reduced nicotinamide adenine dinucleotide; T = thymidylate-thymine; U = uracil.” (Hayden, Tyagi, 2022)
I had a reply recently saying nobody understands this (roughly) and my response would be: We learn by studying things that we don’t understand and looking up whatever words we need to look up in order to better understand it.
Here, in this complex graphic (above) – even a First Grader might guess that “Formate” is important. It appears that the nucleus version of the one-carbon cycles will not occur without formate to get it started. SAM is also important – the one-carbon cycle taking place in the cell’s cytoplasm creates the methyl donor cSAM which is converted into mitochondrial mSAM. The nucleus needs the (I don’t know what it is either) “Formate” and cSAM to enter through nuclear pores in order for the one-carbon cycle to be able to take place within the nucleus for DNA methylation needs. Meaning mitochondrial dysfunction of the one-carbon cycle leads to epigenetic changes and lack of DNA methylation in the nucleus of the cell, and dysfunction of the one-carbon cycle in the cytoplasm might precede the mitochondrial dysfunction as the cSAM is needed by the mitochondria and the nucleus. (Hayden, Tyagi, 2022) *They recommend that physicians screen homocysteine levels more often – it is not standardly measured with basic labs.
Formate, heat stress and SMYD3.
Internet answers: Formate is a result of the breakdown of Carbon dioxide, CO2,— and various engineering research approaches have been used to try to reduce CO2 from the air by promoting formate production (in microbes or chemical reactions) – but that is tangentially related and simply was the immediate search results. More to the physiological point – if we want to be able to make formate, we need the gene SMYD3 to be functional and active as it promotes synthesis of formate.
“Conclusions: Our study demonstrates that SMYD3 regulates the activity of the mitochondrial metabolic enzyme MTHFD1L through H3K4me3 histone methylation modification, promotes formate synthesis and induces mitophagy, which inhibits M1 polarization in macrophages.” (Zhu, et al., 2022)
SMYD3 is important in histone methylation, and growth of embryos and cancer tumors, in order to localize it to the nucleus, where we need it for the one carbon cycle and methylation of DNA, Heat Shock Protein 90 (HSP 90) is needed as a nuclear chaperone (~transport protein). “[12, 23, 31]” (Bernard, et al, 2021)
“In summary, SMYD3 is critical for the activation of MAP3K2, a key kinase in the Ras-activated MAP signaling pathway, in both lung and pancreatic cancers. Furthermore, SMYD3 is associated with advanced stage and poor survival in NSCLC, and promotes cell proliferation, invasion, and chemotherapy resistance phenotypes.” (Bernard, et al, 2021)
… ‘miR-3613-3p/MAP3K2/p38/caspase-3 pathway regulates the heat-stress-induced apoptosis of endothelial cells’ (Liu, Liu, Chen, 2021)
“The results revealed that miR-3613-3p expression was reduced in human umbilical vein endothelial cells (HUVECs) following [heat stress] HS, which led to apoptosis. Mechanistically, following HS, a decrease in miR-3613-3p binding to the 3′-untranslated region of MAP3K2 directly upregulated its expression, and the downstream p38 and caspase-3 pathways, thereby leading to apoptosis. Taken together, the results of the present study demonstrated that HS suppressed miR-3613-3p expression, which activated the MAP3K2/p38/caspase-3 pathway, leading to the apoptosis of HUVECs.” (Liu, Liu, Chen, 2021)
Our goal – to not get overheated – avoid heat stress.
Not the same miRNA exactly, but from an interesting paper. “Chen et al. identified two miRNAs (hsa-miR-1307-3p and hsa-miR-3613-5p) that could prevent viral replication by targeting the 3′-UTRs of replication-related SARS-CoV-2 RNA 67.” (Yang, et al., 2022)
Pomegranate and heat stress – nature designed the plant to tolerate heat.
Pomegranate is a sustainable crop because it can tolerate heat, and salty soil and doesn’t need much water. The MAPK pathway is inhibited by pomegranate peel extract, and also by the 9 polyphenols discussed in the post: 1. “microRNA are the real regulators of gene transcription”. – Substack. I am not sure if the MAP3K2 is similarly inhibited but it seems likely.
Postural Orthostatic Tachycardia Syndrome can have an epigenetic cause.
Why is this important? Postural Orthostatic Tachycardia Syndrome is no fun and kind of scary. If you stand up too fast, your blood pressure can no longer shift quickly enough, however that works, and you get dizzy and need to grab something and rest a minute to get the accompanying tachycardia (very rapid heart rate, like it is trying to leap out of your chest almost). Laying down and lifting the knees and feet up helps slow the heart rate. Sitting or at least pausing is necessary or fainting may occur. I did faint once or twice and that is an odd feeling to find yourself on the floor after you come around. See: POTS – Postural Orthostatic Tachycardia Syndrome, can be epigenetic & therefore may be reversible. (substack.com) *Includes the Dystonia section of my Genes Table with more info and a link to my book chapter on the topic (but in computer lingo, the links don’t work).
Many chronic conditions involve epigenetic changes. Sometimes it can be reversed but not always and less likely the longer the condition has lasted. I had POTS-like symptoms for a few months twice and I figured out how to get better. It is not a fun condition and standard treatment usually does not help enough. People become physically disabled as it worsens. You can’t over-exert or stand up too fast or the symptoms of dizziness and racing heart occur.
When you have an open mind, you can learn new things.
Epigenetics – the basics.
Epigenetics – an overview/the opening of an Abstract about a review paper focused on cancer treatment and epigenetics:
“Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but play an important role in the control of gene expression.
In mammals, epigenetic mechanisms include changes in
DNA methylation,
histone modifications and
non-coding RNAs.
[microRNA are non-coding RNAs (19-23 nucleotides) and there are also longer ones (up to ~100, or a few >/= 200 nucleotides) that are still shorter than an mRNA which is used to transcribe a protein, so it is the full length of the matching DNA from the gene sequence, but only half of the zipper/ladder shape of the double helix.]
Although epigenetic changes are heritable in somatic cells, these modifications are also potentially reversible, which makes them attractive and promising avenues for tailoring cancer preventive and therapeutic strategies. Burgeoning evidence in the last decade has provided unprecedented clues that diet and environmental factors directly influence epigenetic mechanisms in humans. Dietary polyphenols from green tea, turmeric, soybeans, broccoli and others have shown to possess multiple cell-regulatory activities within cancer cells. More recently, we have begun to understand that some of the dietary polyphenols may exert their chemopreventive effects in part by modulating various components of the epigenetic machinery in humans.” (Link, Balaguer, Goel, 2010)
*Bullet points and note added by me. See: Non-coding RNAs: Classification, Biology and Functioning. (Hombach, Kretz, 2010)
Cancer is mitochondrial dysfunction related to cytoplasm dysfunction of the One-Carbon Methylation cycles.
As it turns out, nature really likes the one-carbon methylation cycle and mitochondria seem to be a control center of our cells rather than the nucleus. Cancer is dysfunction of mitochondria which leads to aberrant signaling to the cell nucleus which leads to cancerous like changes in their growth. Experiments have shown though, that when the nucleus of a cancer cell, with the gene changes in place, is transplanted into a healthy cell with healthy mitochondria and cytoplasm, the cell does not become cancerous. However, when a nucleus from a healthy cell is transplanted into a cancer cell that had its nucleus removed, the cell remains cancerous. When cancer cell mitochondria are transplanted into a healthy cell with a normal nucleus – it changes into a cancer cell with cancerous gene changes and out of control growth. The increased growth may be part of more normal pathways used during embryology and child growth. This indicates that cancer is NOT a GENETIC disease. The disease pathology was connected to the diseased cell’s mitochondria, not the diseased cell’s nucleus.
It turns out that mitochondria direct events within the cell and are the controller for signaling the need for apoptosis – put this cell to a merciful death, it is done. But with dysfunctional mitochondria there is no signal presented to kill the cell and it grows out of control or remains dysfunctional but alive – a senescent cell – alive and consuming, but no longer producing functional benefits for the organism or organ.
Cancer is a mitochondrial dysfunction. The one flaw in Dr Seyfried’s treatment plan though, is that such a high fat diet will still promote mitochondrial dysfunction. I would recommend a less stringent ketone diet, at least after some short-term initial phase that is moderate carb and >/= 50% of calories from fats. Use more ketones and some protein, but a diet above 60% fat may in itself cause mitochondrial dysfunction.
His depressing but helpful message is that also, the chemotherapy, radiation and some of surgical approaches are likely just adding to mitochondrial dysfunction and making the cancer worse. Carbohydrates and glutamates need to be restricted – and that equals sugar, bread, potatoes, pasta, pizza, tomato products, cheese, soy sauce, Worcestershire sauce, barbecue sauce or barbecue, artificial seasonings, ice cream, sweetened beverages, etc – much of the modern diet in other words.
Resources
/Housekeeping – I noticed an older comment suggesting that I provide checklists or more guidance for what to do, regarding my Table 5 – Nutrients depleted by psychiatric medications, which also are nutrients needed by mitochondria, and are risk factors for schizophrenia, Alzheimer’s dementia, or COVID19. I shortened the name of that Table to ‘Nutrients of Concern’.
See:
Downloadable Tools in my toolbox – by Jennifer Depew, R.D. (substack.com)
My first Substack post is still pertinent – Nrf2 & NF-kB – 2 proteins to know. (substack.com)
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
(Liu, Liu, Chen, 2021) Liu J, Xu S, Liu S, Chen B. (2021). miR‑3613‑3p/MAP3K2/p38/caspase‑3 pathway regulates the heat‑stress‑induced apoptosis of endothelial cells. Mol Med Rep. Sep;24(3):633. doi: 10.3892/mmr.2021.12272. Epub 2021 Jul 19. PMID: 34278472; PMCID: PMC8280962. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280962/ (Accessed: 5 Dec 2022)
(Yang, et al., 2022) Yang, C.Y., Chen, Y.H., Liu, P.J., Hu, W.C., Lu, K.C., Tsai, K.W., (2022). The emerging role of miRNAs in the pathogenesis of COVID-19: Protective effects of nutraceutical polyphenolic compounds against SARS-CoV-2 infection. Int J Med Sci. Jul 18;19(8):1340-1356. doi: 10.7150/ijms.76168. PMID: 35928726; PMCID: PMC9346380. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346380/ (Accessed: 5 Dec 2022)
(Zhu, et al., 2022) Zhu, W., Wang, S., Xue, L., Liu, L., Yang, X., Liu, Z., et al., (2022). The SMYD3-MTHFD1L-formate metabolic regulatory axis mediates mitophagy to inhibit M1 polarization in macrophages, International Immunopharmacology, 113(Part A), 2022, 109352, ISSN 1567-5769, https://doi.org/10.1016/j.intimp.2022.109352. https://www.sciencedirect.com/science/article/pii/S1567576922008360
“Evidence-based” healthcare mushes everyone into one average group who all get the same guidance – that is flawed. It was intended to be general guidance that is individualized further as needed.
A couple quick Substack links and points – “Anything other than N-of-1 medicine is a crime against humanity.” Toby Rogers
“I. The Mass Poisoning of Society For the last 140 years, coal-fired power plants have spewed mercury into the air, water, and soil — and it then makes its way up the food chain into larger and larger animals. American cities first started adding fluoride…” · Toby Rogers
Clinical trials use “n=__” as typical jargon to show how big the study was. Larger studies generally are more reliable – bigger group, may more represent “average”. But what is average? No one person is “average”. It is just a math concept. Evidence-based guidance designed to best help the “average” person may not help everyone or anyone. Individual variables may leave some people harmed by the “average” solution.
It is like the Mom-ism – “But mom…… everyone is doing it” – “But child…you are not everyone…if they all are jumping off a cliff are you going to jump off a cliff too?” – “Oh, no I guess not mom, thanks.” The bungee jumping fad proved that many people would jump off a cliff just because everyone else seems to be doing it.
Human instincts are to flock together – to fit in with the group and mimic each other. That doesn’t mean it is always a good idea or even sensible.
Self-controlled studies are less average focused, and more individual focused. Instead of having an experimental group of people and a control group of people which has the difficulty of trying to randomly match both groups for variables like age, gender, socio-economic and health status, a self-controlled study has time periods as the experimental and control phases and all participants are tracked over time. Like a Before and After phase – what were their health parameters before an experimental event and what happened to their health after the experimental event?
Jessica Rose has a SubStack today that describes the self-controlled study concept when used for a vaccine type trial. The experimental time period is considered 28 days after the vaccine in the example she provides. Other experiments might designate a longer window to watch for health changes to check for a temporal association with an experimental procedure. Other studies might look at anything that happens after an experimental procedure as the follow-up phase. The value in the study design is that there isn’t a need to match for variables – each person is their own control, so their individual variables are an exact match for their own individual variables.
“There was a study done recently related to COVID-19 injection adverse event eventuality by analysts in the State of Florida entitled: “Exploring the relationship between all-cause and cardiac-related mortality following COVID-19 vaccination or infection in Florida residents: a self-controlled case series study…” · Jessica Rose
My Retinoid Toxicity/Histamine Excess research proposal is a self-controlled study design. With conditions that are characterized by being heterogenous – varied – trying to mash everyone together into one average is not helpful – the condition itself doesn’t have an “average”. Many birth issues, congenital differences, seem to have a cluster of varied gene alleles that may have some similarities across the individuals, but it heterogenous – not consistently the same gene alleles.
In order to both understand the problem better, and to help the individuals, then we need to look at them all as individuals with a varied and unknown group of gene alleles that may be negatively impacting their health by causing metabolic dysfunction or increased inflammation or chronic nutrient deficiencies. Their health may be able to be helped a lot, but not with an “average” treatment. Their condition is not “average” – it is genetically heterogenous.
A crime against humanity and all of nature is taking place with mRNA and CRSPR gene technology. Decoding the human genome was supposed to be a huge breakthrough – leading to wonderful new medications – or something. The tone is big disappointment – the genes had more “nonsense” than expected and more variability – one gene doesn’t do one thing – typically. The tone in my opinion should be joyous – we can easily screen and identify individuals for metabolic gene alleles that could be helped by dietary changes – and yet we are not doing that, or rarely. Methylation gene differences may be screened for but it is not done as a first step usually and not for everyone.
Unfortunately, my research paper topic is too vast for me to finish by the deadline this week. I have made a lot of progress and will post an updated draft soon but currently I have two papers written that are complimentary, rather than collated. The first half is posted and focuses on the histamine excess and Retinoid toxicity and the second half is in the works. I posted some of the Tables, but the “That is not a Table!” Table is still an enormous run-on Not-A-Table still.
Tables of data help us see patterns – that is what I do – see patterns in data trends. Organizing it into a neat Table or graph makes it easier for other people to see the patterns too. Mathing it all up in neat statistical graphs, though, is not what I do. Figuring out what is for dinner and how to prepare it, out of all that data, for an individual’s needs, is my focus. And the question is more difficult than picking a favorite restaurant – in our modern times, and for individual people with varied health conditions, what we choose to eat may be very harmful to our health. Processed foods are frequently designed to be somewhat addictive or very addictive and often are seriously depleted in nutrients beyond carbohydrate and fat calories.
Pain means you are doing something wrong – it might have been okay when you were younger, but now it is no longer working for you. Change is needed. Pain means change is needed and the individual needs to figure out what changes are needed in order to restore normal function – which is not supposed to hurt. If something hurts, then you are over-exerting or your body has changed and can no longer keep up with your previous pace – something is wrong, whether it is age, or infection, or stress load – something needs to be changed. And that change is probably not going to be as simple as “Take this pill once a day.” However, the medical model is based on the concept that health can be restored if you just “Take this pill once a day.”
The myth of a single medication “cure” was based on the early success of antibiotics, but also the resounding success of discovering “nutrients”. Early food processing changes left entire populations with nutrient deficiencies. Once the nutrient was discovered and the food processing methods were modified to reduce the lost nutrients, or foods were fortified with the removed nutrient, then the entire population suddenly was “cured” of the deadly or disabling “condition”.
The medical industry has come so far that they have lost their roots – scurvy – vitamin C deficiency – is missed in modern health care – left untreated as a mystery condition until someone hopefully recognizes the old sailor disease – scurvy. We all need vitamin C every day. That is a biological fact. Medical doctors need to take their blinders off – the body is not made out of medicine. Not a single medicine is a “nutrient need”. We have no deficit of aspirin in biology, but we might have a lack in our diet. We can get plenty of salicylates in our herbs and spices – nature provides us aspirin in our foods.
Oldie, but a goldie: Carrots, spices and baby aspirin help prevent cancer and inflammation, Oct. 21, 2011, (transcendingsquare.com).
Newer: Being grateful for our bitter sensing tastebuds, Jan. 3, 2018, (transcendingsquare.com).
My Problem Solving episodes in my How Are You Feeling? podcast series gets into more detail about the genetics of bitter taste perception and how it may conveniently be more sensitive in people like me who need an external source of bitter tasting cannabinoids and phospholipids. The transcripts and audio links to the series are on this webpage: Peace-is-happy.org/How are you feeling?.
Bitter taste receptors turned out to be critically important for COVID19 treatments. Bitter phytonutrients or medications can get mucus thinned and flowing during congestion – but adequate zinc is needed first. In order to make the bitter or other types of taste and odor receptors.
Mother Nature gave us a medicine cabinet and an ability to taste the dose that will be most effective without being excessive (starts to taste bad instead of good) – and “medical doctors” need to get out of the way.
Be an n=1 self care provider and pay attention to your own body and it may help guide you towards less pain and better quality of life. The negative symptoms tend to be later that night or next day after eating inflammatory foods or doing inflammatory activities so the patterns can be easy to miss if there is a lot of variability in a person’s routine habits and diet choices.
The paper and Tables that I have been working on will hopefully make it easier to see what individually is helping or hurting. I will post another update this week but it isn’t quite blog ready, let alone journal submission ready.
“Bitters” have been a medical standard for centuries or longer in Traditional Chinese Medicine. Photo by micheile dot com on Unsplash
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
We can not always choose our attitude – just smile and be happy – nutrient deficiencies can cause mood changes that are not going to change without getting the nutrients. Then the change to a better mood can happen rapidly sometimes, within 20 minutes for magnesium if needed.
Hunger, sleepiness, stress or anger, loneliness, all may interfere with mood or mood control. Patience is a virtue, and practice helps. So does a good night’s sleep. Low blood sugar can lead to irritability or poor concentration, so can poor sleep. Briefly resting can help recharge things towards a better mood, and sometimes a walk may help.
Nature or images of nature cam help sooth stress and walking was found more beneficial in natural surroundings than in urban settings for relieving stress.
Brighter lighting indoors can help mood if sunshine isn’t available. Sunshine helps our circadian cycle and helps make vitamin D, surprise also water soluble forms of vitamin A and D. Full spectrum lighting might be a good health and mood supplement during winter months.
Salt crystal lamps can help improve air quality for mood due to negative ions being released. These may also help improve air quality by helping remove odor particles or mold. When the salt is warmed it releases negative ions and possibly a little ozone, but not much based on sites selling other types of air cleaners. Ozone is safe if it is not in excessive amounts and it can also have a positive effect on mood.
The negative ions or ozone help air quality by clumping with air particles which causes them to drop from the air. Then just sweep it up.
http://www.natural-salt-lamps.com/negative-ions.html * I am unaffiliated with this site but as personal testimonial – I went upstairs to get my lamp because the basement smelled musty and unpleasant. Using the salt lamp several hours a day does give it a fresh feeling and salty ocean aroma instead of musty.
This helps with mold spores or odor particles or secondhand smoke chemicals and odor. Too much ozone can cause headaches, but the salt crystal doesn’t produce much, not compared to ozone producing air cleaners. The negative ions may build up, so leaving the lamp warming all day may be more than you want. I do reach a point where I want to turn off the lamp after it had been on for hours.
The reddish glow may have health benefits as light therapy if other lights are turned off. In the evening having dimmer lighting can help the body adjust to getting ready for sleep. Bright screen blue light is too much like sunny day light and keeps our circadian cycle genes set to active awake mode. Blue light blocking glasses are available to wear for the last 3 hours before sleep time, to help the circadian cycle switch gears.
We need that to happen for growth and repair genes to be activated and the active awake, inflammatory functions are turned off for the night. The two systems share a protein, so they have to take turns. We can’t use both pathways at the same time if they both need the same assembly line machine.
Himalayan Salt Cystal lamp, it has a dial so it can be darker and cooler, less ozone released.
Joy can be practiced. The feeling of gratitude and connection to others or the planet can be a support when things are tough. Pausing to look for beauty, or snap an image, smell a flower, pet a friendly animal, all can be an island of joy in an otherwise busy day.
Tiger lilies and wild goldenrod.
My site peace-is-happy.org is my art escape with posts that are generally shorter than are found on this site. It also has sustainable building information and biodiversity- peace is living within a community of friends, family, and wildlife. Peace is clean air, water, and food. Peace is shelter on a cold day, or a shady canopy on a sunny summer day. Peace is caring for oneself, and the community as an extention of oneself. Peace is lending a hand and accepting one when in need.
Peace is a warm puppy, or a comfortable baby. Hat-tip to Charles Schultz and his book “Love is a Warm Puppy.” The titles on the peace-is-happy.org site are based on his simple and beautiful little book.
Love is a soft blanket,
to surround oneself or others.
Peace is love for oneself and others, even when annoying or annoyed.
The peace-is-happy.org site has a page with links to a podcast series I did last year regarding our feelings or mood and what those feelings might mean. They may not mean anything beyond, you need a nap or a snack. Or they might mean the snack you had was not a great choice for your later mood. But in either case – might not mean that someone else was purposely trying to irritate you. You – might just be feeling irritable.
The podcast is called: How Are You Feeling? The webpage has links to the audio and to transcripts with references and occasionally additional information. https://www.peace-is-happy.org/how-are-you-feeling
Disclaimer: This information is being shared for educational purposes within the guidelines of Fair Use and are not intended to provide individual health care guidance. Please seek an individual health care provider for individualized health care guidance.
