Carrots, spices and baby aspirin help prevent cancer and inflammation

 Aspirin has two active parts that help reduce pain and swelling. The salicylate was first isolated from myrtle and willow tree bark but it has since been identified in many plants and is particularly rich in herbs and spices including turmeric and mint. A compound similar to curcumin found in the spice turmeric has been found to have similar bioactivity and structure to salicylic acid. Benefits may include reduced breast, colon and prostate cancer risks:

“Dibenzoylmethane (DBM) has been reported to exhibit chemopreventive activities in several animal models, including mammary, colon and prostate tumorigenesis during the past few years.2,12–16” [2]

Production of the isolated phytochemicals are being studied but in the meantime spicing up the diet with plenty of fruits, vegetables, herbs and spices seems like a good bet and it looks like a baby Aspirin might help protect against breast and prostate cancer as well as cardiovascular disease. Eating more fiber rich produce and spices would help protect against ulcer risks associated with regular use of Aspirin or ibuprofen (I think if I looked that ibuprofen would have similar protective effects because it also reduces the breakdown of endogenous cannabinoids which would reduce free arachidonic acid availability for breast or prostate cancer cells).

From the research article: Table 1: Examples of total salicylate content of food items. [1]
Fruits
Vegetables
Food Item
Salicylate/ mg/kg
Food Item
Salicylate / mg/kg
Blackberries
0.81
Asparagus
1.29
Blueberries
0.57
Carrots
0.16
Gala melon
0.62
Celery
0.04
Grapefruit
0.44
Green beans
0.07
Green apple
0.55
Mange tout
0.20
Kiwi fruit
0.31
Mushroom (button)
0.13
Nectarine
3.29
Onion (white)
0.80
Strawberry
0.61
Tomato
0.13
Drinks
Spices and Herbs
Apple juice
0.83
Black cumin
25.05
Cranberry juice
0.99
Cumin
29.76
Grapefruit juice
0.10
Chat masala
  5.74
Orange juice
0.68
Garam masala
12.85
Pineapple juice
4.06
Paprika
28.25
Tomato juice
1.32
Turmeric
20.88
White wine
0.44
Thyme
28.60
Red wine
0.50
Mint
54.20
Tea
1.06
Fennel
14.00

1. [pubs.rsc.org] Garry G. Duthie and Adrian D. Wood, Natural salicylates: foods, functions and disease prevention, Food Funct, 2011, 2, 515-520, DOI: 10.1039/C1F010128E (full text free with login registration)

“Rodent models using ‘‘nutritional’’ rather than ‘‘pharmaceutical’’ dietary intakes indicate that salicylic acid modulates a range of proteins involved in protein folding, transport, energy metabolism and cytoskeletal regulation.40,41 The biological significance of these changes is unclear. However, several of the identified proteins are known to be involved in two major redox pathways (thioredoxin and glutathione). This strongly suggests that salicylic acid modulates interactive components of the cellular redox system, such as glutathione S-transferase yb-2, p53 and AP-1.42 Oxidative stress is implicated in the pathogenesis of many diseases, including heart disease, diabetes and several cancers.43 Consequently, cellular exposure to low concentrations of salicylic acid may benefit health by regulating the activity or expression of transcription factors involved in modulating oxidative stress, such as the antioxidant response element.44 This potential effect is not, however, unique to salicylic acid as other dietary-derived phenolic compounds, such as flavonoids, also activate this enhancer sequence, thus mediating the transcriptional activation of genes in cells exposed to oxidative stress.45”

“The bioactivity of Aspirin is unique in that it is characterised by two compounds within the same molecule. In addition to salicylic acid, the acetyl moiety is released within minutes of Aspirin consumption by enzymatic hydrolytic cleavage by esterases in the intestine, blood and liver.68 The binding of the acetyl group to serine530 in platelets inactivates the active site of cycloxygenase-1, thus preventing the access of arachidonic acid and irreversibly inhibiting prostaglandin synthesis. (*** also preventing access by prostate and breast cancer cells to the arachidonic acid breakdown metabolite 5-HETE) The resultant prevention of platelet aggregation is a major reason for the widespread use of Aspirin in the prevention and treatment of cardiovascular disease.69 However, the other primary metabolite of Aspirin , salicylic acid, has a much longer half-life of several hours.70 It is likely that its broad spectrum of cellular targets, already discussed, contributes to disease prevention through, for example, its anti-inflammatory, antiproliferative and antioxidant activity. This view is supported by meta-analyses,71–73 which strongly corroborate the hypothesis that the regular consumption of Aspirin -derived salicylic acid can inhibit the incidence and progression of several diseases where platelet function is not a major consideration. However, the doses employed in such trials (30–1300 mg day 1) exceed that which can be obtained from diet alone. Current clinical data are most supportive of a 75 mg daily dose of Aspirin 74 (equivalent to 66 mg salicylic acid), which is readily available from pharmacies and retail outlets in the UK. Larger doses may be required to obtain significant anticancer effects, although a recent population study75 showed for the first time that doses of around 100 mg day 1 may confer some protection. This does not preclude the possibility that the sustained lower intakes achievable by the regular consumption of salicylate-rich diets may also have a disease-preventative activity. However, to date, no double-blind randomised controlled trials using doses of 5–10mg salicylic acid have been conducted in support of the hypothesis that dietary salicylates have long term health benefits. It should also be pointed out that even with therapeutic doses of acetylated salicylic acid of 75mg day 1, there is a peptic ulcer incidence of 5–10% over 3–6 months of usage, a bleeding complication rate of 0.5–2.0 per 100 patient years and a mortality rate of ulcer complications of about 5% of those who have been admitted to hospital due to ulcer bleeding.76 It is likely that the risk of GI toxicity from salicylate levels in food is low, but as a note of caution, Aspirin intakes as low as 10mg day 1 are reported to produce demonstrable gastric damage in humans.77”

Future perspectives

“Interest in the potential beneficial effects of dietary salicylates has arisen, in part, because of the extensive literature on the disease preventative effects of Aspirin . However, it should not be forgotten that plant products found to contain salicylic acid are generally rich sources of other phenolic acids. For example, rich sources of hydroxycinnamic acids such as ferulic, synapic and caffeic acids include legumes, cocoa, fruit, herbs, nuts and cereals. In addition to salicylic acid, other hydroxybenzoic acids such as protocatechuic, vanillic and syringic acids are present in wine, berries, herbs, fruit juices and tea.78 Daily intakes of many may markedly exceed that of salicylic acid. Estimated intakes of caffeic and ferulic acid in a Finnish population are 417 and 129 mg, respectively.79 Many of these compounds also have a marked anti-inflammatory and redox-related bioactivity in mammalian cells.80 Their potential protective effects should not be overlooked. In this context, the importance of dietary salicylic acid should not perhaps be over emphasised. “

***This research team is encouraging the use of whole foods and the intake of a variety of active phytochemicals in the same dose. Earlier within the article the anti-cancer benefits of the dose available from food intake are compared with the dose from a baby aspirin or regular dose aspirin. Within the discussion section, excerpted above, the authors point out that many other active phytochemicals contained within a food would boost the active dose from eating more produce, herbs and tea (and moderate amounts of wine).

2. [pubs.rsc.org] Chuan-Chuan Lin, Yue Liu, Chi-Tang Ho and Mou-Tuan Huang, Inhibitory effects of 1,3-bis-(2-substituted-phenyl)-propane-1,3-dione, β-diketone structural analogues of curcumin, on chemical-induced tumor promotion and inflammation in mouse skin, Food Funct., 2011, 2, 78-83 DOI: 10.1039/C0FO00098A
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Ginger slows prostate cancer growth

In a study at Georgia State University whole ginger extract was found to slow growth rate and to cause the death of pancreas cancer cells (PC-3 line) in petri dish type studies and in live mice. [1]

Two grams of ginger per day for one month time periods was found successful at reducing inflammation of the intestinal lining in human studies. [5,6] Free arachidonic acid levels were reduced. Arachidonic acid levels are typically increased in inflammation and it has been found to be a precursor for 5-HETE, a main energy source for stimulating prostate cancer cell growth. [8-12] The prostate cancer cells seem to have the ability to increase production of  an enzyme that converts arachidonic acid (half of the endogenous cannabinoid, anandamide) into 5-HETE which is a form needed by the cancer cells.

Conjugated linolenic acid (CLA) was used successfully to reduce breast tumor growth in a study regarding the same enzyme from the prostate cancer cells, 5-lipoxygenase (5-LO). The CLA, an essential fatty acid, was not found to be inhibiting the 5-LO enzyme but instead it was reducing the enzyme’s activating protein and possibly competing with arachidonic acid (also an essential fatty acid). It might be able to stand in for the 5-LO enzyme but less 5-HETE was being produced and breast tumor cell growth was “attenuated” (sounds like a good thing).

Attenuation can be defined as the process by which a virus, bacterium, etc., changes under laboratory conditions to become harmless or less virulent.

So I think this research shows:

  1. Prostate and breast cancer cells have learned how to make the 5-LO enzyme or more likely how to make 5-LO’s activating protein
  2. In humans, mice, and in petri dish studies, ginger has been found to inhibit the action of 5-LO from converting as much arachidonic acid into 5-HETE and slowing prostate cancer cell growth.
  3. Conjugated linolenic acid may also help slow the conversion by taking the place of the arachidonic acid and/or by inhibiting the activating protein.
  4. If a patient has breast or prostate cancer currently then do eat at least two grams of ginger extract per day. I aim for a 5 gram per day arthritis research-pain killing intake – which is about a teaspoon of the powder. I sprinkle on a variety of foods or beverages throughout the day or I eat the crystallized ginger or cook with the raw root as well. Easy bruising, blood thinning properties, are the only side effect that I’ve noticed and only when I’m eating the candied ginger as well as the powder.
  5. Avoiding excess amounts of foods rich in arachidonic acid [livestrong.com AA food sources], while fighting prostate or breast cancer and increasing CLA and omega 3 fatty acids might help reduce the 5-HETE availability to cancer cells.
  6. Increasing intake of the other endogenous cannabinoid building blocks, the essential phospholipids could help rebuild stronger membranes. Loss of the arachidonic acid as a membrane building block leaves weakened defenses against other infections. Anandamide, the endogenous cannabinoid that contains arachidonic acid, isn’t the only one, so medical marijuana – an external source of cannabinoids,  might not be the only solution to rebuilding strong membranes without also feeding the cancer cells. – Flaw in that plan is that the foods high in arachidonic acid also tend to be good sources of phospholipids – not really a surprise –  half the brain weight is made up of phospholipids.

________________________________________________________________________
Addition Dec. 15, 2011:  [drdavidbrownstein.blogspot.com]  has info about iodine levels in association with breast and prostate cancer rates.

*This list of articles was tacked on the eicosanoid article but it became apparent that more discoveries had been made regarding ginger itself.

1. [ncbi.nlm.nih.gov/pubmed/21849094] 2011 Aug 18:1-12. [Epub ahead of print] Benefits of whole ginger extract in prostate cancer. Karna P, Chagani S, Gundala SR, Rida PC, Asif G, Sharma V, Gupta MV, Aneja R. Source: Dept. of Biology, Georgia State U., Atlanta, GA 30303, USA.

*These articles were tacked on the bottom of the eicosanoid article but it became apparent that more discoveries had been made regarding ginger itself.

4. “Nutritional Sources of Arachidonic Acid, Livestrong.com [livestrong.com]

5. [mdnews.com]
Colon Inflammation Markers Lower With Ginger Extract

*** Two grams of ginger was given daily for 30 days and intestinal lining inflammation seemed improved based on reduced free arachidonic acid (which is released from breakdown of the endogenous cannabinoids after they are released from their membrane storage in response to elevated intracellular calcium or glutamate levels – just to review from a few blogs ago).

6. [ncbi.nlm.nih.gov/] 
Zick SM, Turgeon DK, Vareed SK, Ruffin MT, Litzinger AJ, Wright BD, Alrawi S, Normolle DP, Djuric Z, Brenner DE. Phase II Study of the Effects of Ginger Root Extract on Eicosanoids in Colon Mucosa in People at Normal Risk for Colorectal Cancer.Cancer Prev Res (Phila). 2011 Oct 11.

7. [ncbi.nlm.nih.gov/]

Prostaglandins Leukot Med. 1986 Dec;25(2-3):187-98. Isolation and effects of some ginger components of platelet aggregation and eicosanoid biosynthesis. Srivastava KC.

“Interestingly the incorporation of AA into platelet phospholipids increased in platelets treated with aqueous ginger extract.”

***** Swish and score – ginger helped the body to rebuild endogenous cannabinoids – AA plus phospholipid = healthy rebuilt membranes and endogenous cannabinoids reloaded ready for the next stress signal to fire them off where they can be messengers or be transformed into eicosanoids or other metabolites.

8.  [/i4cmwo.com.au/ginger.html]

** I should have just read this one first. It seems that prostate cancer eats only a metabolite of arachidonic acid – which itself is a building block of endogenous cannabinoids and strong membranes. It would be to the cancer cell’s advantage to have learned how to use the body’s own system to mobilize resources as a way to get nutrients for themselves. The cancer cell can make the enzyme that activates vitamin 25-D to hormone 1,25-D; hormone 1,25-D signals the bones to release calcium; increased intracellular levels of calcium signal the release of endogenous cannabinoids from membrane storage – arachidonic acid and free phospholipids – cancer food. In the placenta they would have become nutrients for the fetus.

9. [ncbi.nlm.nih.gov]
Jagadananda Ghosh and Charles E. Myers, Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells Proc Natl Acad Sci U S A. 1998 October 27; 95(22): 13182–13187.    ***I think this might be the research mentioned in the previous link.

10. [ncbi.nlm.nih.gov]
Cancer. 2001 Feb 15;91(4):737-43. Lipoxygenase-5 is overexpressed in prostate adenocarcinoma. Gupta S, Srivastava M, Ahmad N, Sakamoto K, Bostwick DG, Mukhtar H.

***Aha, the problem – the prostate cancer cells have learned how to signal the body to make the 5-Lipoxygenase so more ginger for men as a preventative and if prostate cancer is already present then excess intake of arachidonic acid foods may not be good.

11.  [ncbi.nlm.nih.gov] Myers CE, Ghosh J Lipoxygenase inhibition in prostate cancer.. Eur Urol. 1999;35(5-6):395-8.
12. [ncbi.nlm.nih] Carcinogenesis. 2011 Jun;32(6):822-8. Epub 2011 Mar 10. Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid. Grant GE, Rubino S, Gravel S, Wang X, Patel P, Rokach J, Powell WS.

***Did anyone besides me notice that they stimulated those cancer cells with calcium? Might simply not over stimulating cancer with excess calcium be an attractive target for cancer therapy? and cheap? – less calcium intake – more health output? /speculation/

13. [ncbi.nlm.nih.gov] Biochim Biophys Acta. 2005 Oct 1;1736(3):244-50. Attenuation of breast tumor cell growth by conjugated linoleic acid via inhibition of 5-lipoxygenase activating protein. Kim JH, Hubbard NE, Ziboh V, Erickson KL.

***Take home point – if you already have breast cancer (and probably similar for prostate cancer) then consuming more CLA type of good fats may help reduce the over-conversion of arachidonic acid into the cancer friendly type, 5-HETE.
Disclaimer: This is provided for informational purposes. Please see a health professional for the purposes of individual health care.

What to say when you’re talking to yourself

What To Say When You Talk To Yourself, is a book about a cognitive therapy strategy that I found very helpful for my overeating problem. I never attended an Overeater’s Anonymous group. I didn’t think my dietitian self could stay anonymous or keep from trying to counsel others. The OA 12 Step group I believe recommends no snacks and controlling your meals carefully. I believe that deprivation and over-controlling eating can make the binge eating problem worse in my experience and based on review of other research in the field of eating disorders.

My individual therapy with a child trauma counselor helped guide me to my suppressed feelings of unworthiness. Deep down I felt bad, naughty, undeserving of comfort or touch. Not at any fault of my parents. I did get hugs and kisses and loving guidance through life but we didn’t talk about our feelings much. I grew up eager to please or eager to avoid attention so I could continue reading my latest book in peace.

Negative messages that you heard your entire life can be hard to change. Reading new statements can help retrain the old negative message into a healthier one. Daily review of the new self talk statements can be done while brushing your teeth if the statement is on an index card by your mirror, or if it’s posted in your car, or by your phone. I wrote them all in a spiral notebook of index cards and would flip through the whole set  a few times a day. I haven’t read them in a while and I think I should start again – they are helpful.

I am posting my modified statements about health and eating based on the recommendations for rewriting your internal self talk,

What to Say When You Talk To Yourself:  Amazon Link .

The book did have eating related examples but some of them were deprivation oriented. Retraining disordered eating habits requires focus on relearning hunger and fullness signals. Deprivation and controlled eating tend to backfire and lead to worse binges in my experience and based on my review of research in the field of disordered eating. The body has to have sustenance and just stop all use, “cold turkey” type strategies do not work the same for substances that are essential to life. We have to eat food for daily fuel and rebuilding purposes and can’t just stop eating “cold turkey” in the same way and some other addictions may be given up 100% rather than be used in moderation or withdrawn from use slowly.

Cravings have to do with real physical needs of the body. Our instincts and taste buds help guide us to the foods that have the nutrients that we need. Trying to fight cravings with a set menu and controlled portions of foods chosen by someone else or even by yourself but at a different time may not be what your body needs at the moment and may leave the appetite unsatisfied and still seeking something.

Allowing yourself to nibble a variety of things by the bite or two can help to retrain the appetite and taste-buds to recognize the flavors and smells associated with the food that ultimately satisfies – when the bite or two leads to the “aha that is what I want” food, then eat more of that and the appetite memory for that taste and satisfied feeling will be stronger the next time that you have that sort of hunger.

Foods deliver nutrients and the body can learn which foods satisfy certain types of needs – salty snacks deliver sodium which is needed after a sweaty day or may be needed in increased amounts after drinking a lot of diuretic beverages such as coffee, black tea, or alcoholic beverages.

Salt and potassium delivery units are essential after a sweaty workout or a long night. The piece of fruit in the morning with a handful of lightly salted almonds would quench a thirst for electrolytes with more variety of nutrients then the glass of juice and salty piece of bacon found in a common American breakfast would deliver. Both meal examples are only part of a typical breakfast – I’m trying to highlight the potassium and sodium cravings. We need a little every few hours all day long. Meals and snacks help with good hydration and that helps with energy level and regular removal of toxins. Lactic acid build up in muscle tissue can slow down the  worker/athlete. Drinking plenty of water and having a salty food with a fruit or juicy vegetable will give the body the replacements that were sweated out or used up by the working muscles. Bonus if the salty food is magnesium rich because the muscles waste that as well. (like nuts )

I know how to eat well and it is still a daily challenge, more due to laziness however and less due to emotional reasons  now (I slowly realized that I was stuffing my anger – eating my words with the emotional over eating problem.)

Positive self talk statements

I live actively. My body is strong and healthy.

I have the lung and heart power to do what I need to do every day.

I move fluidly through space.

I have the power to leap joyfully.

I breathe deeply. I enjoy ginger, spicy food, hot soup and tea and saunas because they help my sinuses.

I protect my inner ear from congestion, by avoiding foods that are mucous producing and environments that are dusty, musty and smokey.

I avoid toxic food and environments that make me feel sicker.

I protect myself from sickness.

I rest when I need to rest.

I respect my body’s limits and I don’t push myself past my limits.

I move my body regularly and avoid sitting still for hours.

(I need to start rereading this list – actually I’m going to set my computer up where I can stand in front of it. If the system has problems, then change the system.)

I avoid extremes by planning my time and setting steps towards my ultimate goals.

I plan my day and calmly do what I can towards fulfilling the goals.

I prioritize my goals so that important things are not put off.

I am in control of myself in every way — at all times and in all situations.

Each time that I sit down to eat I remember my goal for health. By eating right, and never giving in I am reaching the weight that I want.

Whether eating in or eating out, I really enjoy not over eating; being overstuffed is uncomfortable.

I never feel the need to finish the food in front of me. I eat only until my hunger is satisfied — and never one bite more.

*I have purposely started a practice of actually spitting out food (into a napkin), if I do notice myself eating from emotional reasons. I stop chewing and spit the food out – just because I made the mistake of starting the angry or sad or anxious eating reaction doesn’t mean that I have to swallow – to continue the emotional over-reaction – and to continue reinforcing the negative habit. Better to break the pattern, even if a napkin is involve.

I eat healthy food for energy and sustenance, not for comfort or boredom.

Starving children on the other side of the world are not going to benefit by my emptying my dinner plate.

Leftovers are for saving for later, not for finishing up even if I’m full.

I put away leftovers and make the meal useful the next day for lunch, dinner, or a healthy snack.

I help starving children by buying less junk food and donating the money.

One way to weight loss that’s easy and works, is less food on my plate, and less on my fork!”   *This and the next statement are from the book, What to Say When You Talk To Yourself,  by Shad Helmstetter, PhD. I kept the two statements but am not a proponent of the “eat less” theory of weight loss. Fiber rich foods are bulky and we eat healthier when we eat more bulky fiber rich whole foods. So less chocolate bars or dessert on my plate – yes – but less food altogether is not necessarily a healthier choice.

Less on my plate means less on my waist.” *** author, Shad Helmstetter’s example – that statement is both true and not true, see above.

When I sit down to eat, at no time do I allow anyone else to influence, tempt, or discourage me in any negative way.

What I eat and the goals I reach, are up to me. And I give no one else the right to hinder or control my success.

I am never, at any time, tempted to take one bite more than I need. I am strong, I am capable of reaching my goal, and I am doing it!

Although others may benefit from my success, I am achieving my weight-loss goals for my own personal reasons — for myself, my life, my future, and my own personal well-being.

I feed my inner child love and nurturing and prepare healthy meals and snacks. Sedating myself with carbohydrates is harmful and not helpful.

I comfort myself with meditation, a warm bath, a hot cup of tea, or music and movement.

***I found the movie “The Celestine Prophecy”[thecelestineprophecymovie.com/] so helpful that I added a few statements from it to my flip-book of cognitive therapy statements. The movie was based on the book, The Celestine Prophecy, by author, James Redfield, Amazon: [amazon.com]

I let go and Let be.”

“I find energy within and avoid battling others for it.”

“I open up and receive energy.”

“I accept energy from others and the energy is amplified for both of us.”

“Instead of taking energy from others I give it.”

“I follow my instincts and listen to my heart and gut.”

“The guidance within us, leads us towards the heaven within us.
To know this . . . is our destiny.”

Our instincts try to guide us towards what we need but it is up to us to pause and listen.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Cantaloupe, Listeria, and sea squirts, oh my

Grab your umbrella if you’re on the Pacific coast in a rainstorm, it might be raining Listeria monoctyogenes. Warming trends in the Pacific ocean are due to the change in the cold ocean currents. The deep current that brings cold water down from the Arctic and circulates warmer water north has been getting smaller. With a smaller current flowing, there is less heat exchange and the warmer ocean results in the harsh El Nino’ weather patterns every few years [6]. Listeria is the bacteria that has been in the news from cantaloupe related food poisonings.[16, 17] It can grow at refrigerator temperatures, so older leftovers should be reheated to steaming before eating. Cold lunch meat sandwiches can be a risk, especially to people with weakened immune systems or during pregnancy. The pregnant woman may not feel sick but the baby may be effected. [12 food safety info]Warming of the water in the Pacific ocean due to the change in the deep, cold currants has allowed the bacteria, Listeria, to flourish. While Listeria probably isn’t able to be carried by raindrops and an umbrella might not be necessary to protect yourself from that staying out of rain may become a better idea as our pollutants continue to add up. Toxic chemicals can evaporate and be in “acid rain” or “smog” and have been shown to damage plants and property. After the Japanese nuclear reactor incident this year, it was recommended to avoid skin contact with rain during times when radioactivity levels were detectable in the air.Smog levels, pollen count, and now ocean bacterial count might be needed. Listeria can be in the fish, algae, seaweed and the ocean water itself. Bird droppings from birds that ate the sickened fish may have dropped on a few cantaloupe or it might have gotten in the irrigation system. Listeria was a problem with air conditioning systems during their early introduction. Poorly maintained air conditioners could support the growth of Listeria. it likes a very watery environment that can be cool or warm – versatile bacteria. Dirty air conditioner (or humidifier) could be blowing microscopic droplets containing Listeria bacteria throughout a building. There isn’t a vaccination. The best way to stay healthy is to not have a weakened immune system. One in five people may die from it but they aren’t the younger, stronger, healthier individuals. Pregnant women are at risk for their baby’s sake more than their own risk of a severe case if infected.Why Cantaloupes – why are they the canary in this story?Imagine a nice warm, juicy, fragrant cantaloupe. Smell it in your mind, sweet and floral. Their rinds are so thin you could practically eat it whole. Membranes – weakened membranes, in a fruit so juicy, would leave it at risk to disease. It is a hungry world and so much juicy goodness is begging to be eaten. The orange color is a sign of vitamin A and the nutrient content is similar to sweet potatoes, carrots and other dark orange, red and green fruits and vegetables. Endless variety in nature may run out sooner then we realize, if the building blocks aren’t in the soil and toxins are found there instead.

Mitar Tarabic (1829-1899) predicted that the last great war would be fought with “cannonballs that do not kill, but that cast a spell over the land, the livestock and the people.” (Aftermath, 2010, L.E. Joseph) The cannonballs whizzing around may not be Listeria or radioactivity in rain. We have many chemical pollutants to choose from as our killing cannonballs.

The Food and Drug Administration regulates the safe use of chemicals in foods and products but the standards used have not addressed toxic effects that can be caused overtime at tiny doses. Drugs are evaluated for cancer risks, total toxic load (how much of the drug would kill a mouse for example) and for teratogenicity – whether it causes birth defects or not. What is not addressed is the research on excitoxins – the free amino acids that act as brain neurotransmitters  and messengers throughout the body – and estrogen like chemicals that have been linked to infertility and feminization of animals.

Today’s googling led me from three chemicals found to cause immunotoxicity in sea squirts to marine boat paint and creosote soaked boat dock pilings and lobster cages. Turns out that one of the three, TBTO, was widely used in marine boat poaint in a form that was very unstable. The current paint in less unstable but the TBTO is still allowed for use in the US in ships greater than 25 meters long. Do you think using it on a longer ship makes it safer for the environment or maybe just cheaper for the big boat owners, like say, the Navy, Army, Airforce, and Marines perhaps?

No, I don’t think bigger ships make toxin containing paint any safer than using it on little boats.

Back to sea squirts who live in the sea (with creosote and TBTO and copper sulfate).

I went straight to sea squirts on the long list of animals with research on health effects of chemicals. At the membrane level sea squirts are one of the most basic multi-celled organisms that also have cannabinoid receptors.

The endogenous cannabinoids (eCBs) are not just messenger chemicals but are also membrane building blocks and precursors for other important messengers like the eicosanoids. The eCBs building blocks are actually part of the cellular membrane wall and they can be quickly released in response to changes in calcium or glutamate levels in the cell fluid. Phospholipid and arachidonic acid are released from the membrane and combined into anandamide, an eCB, which might go on to signal changed activity as itself or it might be converted into an eicosanoid with a different message or it might be used to assemble membranes in a different cell (wound healing, baby building, normal breakdown and repair of individual’s cells, or growth of infection/parasitic use). However, if there are constant signals to help, heal, or flee (stress response) then the membranes get more and more “used up”. If the messengers are also the bricks and there are no more bricks coming in on the fertilizer truck the membrane can not be rebuilt. Agribusiness mainly fertilizes with a few nutrients – the basics to achieve growth but with little replacement of trace minerals or compost.

It turns out that compost is important for humic acid and other complex soil compounds that traditional farm dirt has in abundance. Crumbly and black and sweet smelling, farm soil is a good childhood memory. My recent month in a wetland mitigation project reminded me of the difference in soil quality and the impact that has on plants, insects, and small wildlife. The wetland project had five main sections and only one of them had really good dirt and it was the one with the most diverse flowers, insects and even had frogs (seeds were planted in all of them fairly equally but they didn’t all grow the same). There was growth in all of the sections but the creation of “wetland” vs sandy meadow was affected by the soil quality. Fertilizing is not allowed in the regulations – sounds too much like modern medicine – grow a wetland with sand and little water. We’ll see, but I think the buckthorn is winning.

Humic acid is a mixture of complex chemicals and contains amino acids, oils and aromatic chemicals. Another phrase of Mirat Tibarak’s prophecy states “when wildflowers have lost their smell”. Invasive plant control this summer taught me that problem is rampant. Herbs and flowers are fragrant from chemicals called terpenes that are commonly found along with the eCBs. The terpenes also have medicinal properties. Pine oil and lemon oil are examples of aromatic oil compounds.

Our climate may be warmer or colder or both and what exactly is the cause is not as important as recognizing and admitting that change is here. Doing nothing is choosing to do something – more of the same that got us in the mess in the first place.

Creosote is leftover from making oil – it is tarry black goo that is painted or soaked into wood. Railroad ties are the most obvious example. The TBTO made cheap boat paint the protected against bacterial rot of the ship. Copper sulfate is used as an pesticide in Dutch Elm disease (I didn’t look into that one as much). All three caused reduced Natural Killer Cell activity and reduced phagocytosis in sea squirts. – The sea squirts weren’t able to protect themselves from infection or decayed/precancerous cells.

In investigating health I found mass die-offs in birds, bats, fish, insects, tress and sickened cantaloupe. Fish meals in Hawaii ahve also been recalled this summer due to Listeria.

Bento box meal recalled in Hawaii from 7-11 chain stores.

Quantum mechanics might suggest that we can make matter out of energy – something out of nothing – but I think it is more like making something slightly different out of something slightly similar but in a different form.

We can not make strong membranes and vitamin A out of potassium, nitrogen and phosphorus and neither can a cantaloupe. A cantaloupe that is also dealing with soil and ground water that is laced with TBTO, copper sulfate, and creosote might end up with a compromised immune system just like the sea squirt. They had less Natural Killer Cell activity and reduced rates of phagocytosis (ability for white blood cells to engulf and dispose of infected or decaying cells). Both effects have to do with apoptosis and the enzyme blast of death.
Yes, Virginia, we have cannabinoid rich membranes just like sea squirts and cantaloupes and if a bunch of toxins are around then the membranes can’t do their job properly and sickness develops. If the building blocks for the membranes aren’t in the fertilizer, then the plant doesn’t make strong membranes and our food supply for animals and humans doesn’t have as much membrane building blocks. Poor soils cause sickly plant growth and sickly insects and sickly animals and sickly humans.Decomposing plant material makes up the complex humic acid and rich soil that plants need to thrive and that insects, birds, and animals also need for survival. Substances found in rich soil that are not as common in sandy soil are aromatic and oil rich compounds – membrane building blocks.
Umbrellas won’t really help us. The invisible cannonballs are in ground water and eagle shells and human breast milk and our government seems to be voting to further reduce environmental standards daily. Is corporate profit worth sinking our planet in toxins and burning up our resources?
Burning up oil reserves for short term energy and short term profit may be adding to our world’s weak membranes because that huge ground oil reservoir of aromatic and oil rich compounds is being siphoned off and burnt up or turned into plastics. In the ground it was probably adding to the richness of soil by some seepage into the ground water but as plastics or burnt atmospheric waste it is no longer available to strengthen membranes in cantaloupe, sea squirts, or humans.Sweet potatoes and carrots can help build strong membranes and give vitamin A – if cantaloupe is leaving you a little leary. Otherwise heat to steaming and Listeria will be cooked – raw is the risk with lettuce and cantaloupe – we don’t heat them to the steaming point.

See my blogs, Membrane Building Foods and Feed your membranes to spell relief,
for more on eating defensively.

Didn't someone once say that a good fence makes good neighbors?
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Disclaimer: This information is provided for educational purposes within the guidelines of Fair Use. It is not intended to provide individual guidance. Please seek a health care provider for individualized health care guidance.

1.http://www.pesticideinfo.org/List_AquireAll.jsp?Species=1446&Effect=%27Immunological%27

PAN Pesticides Database – Chemical Toxicity Studies on Aquatic Organisms

Sea squirt (Styela plicata) Toxicity Studies – Toxicology studies from the primary scientific literature on aquatic organisms

Copper sulfate (anhydrous)       http://www.pesticideinfo.org/images/book16x16.gifShow Copper sulfate (anhydrous) studies for all species

Creosote       http://www.pesticideinfo.org/images/book16x16.gifShow Creosote studies for all species

Tributyltin oxide       http://www.pesticideinfo.org/images/book16x16.gifShow Tributyltin oxide studies for all species

***Effects for all three poisons include:

immunological Natural killer cell activity
Immunological Phagocytosis

Copper sulfate also had info on:
Immunological Antibody titres

2.http://www.inchem.org/documents/cicads/cicads/cicad14.htm

   This report contains the collective views of an international group of
    experts and does not necessarily represent the decisions or the stated
    policy of the United Nations Environment Programme, the International
    Labour Organisation, or the World Health Organization.

Concise International Chemical Assessment Document 14: TRIBUTYLTIN OXIDE (TBTO)


8.7.1  Immunotoxicity
      A large number of well-conducted studies have shown that TBTO
    causes depression of immune functions dependent on the thymus. Results
    from a number of short-term studies are listed in Table 1. Subchronic
    and chronic studies (Vos et al., 1990) are summarized in detail below
    and are listed in Table 1. The chronic study conducted by Vos et al.
    (1990) shows effects on thymus-dependent immune responses at a dose lower than that at which any other toxic effects have been observed.
    The Vos et al. (1990) study also establishes that weanling animals are
    more sensitive than adults to the effects of TBTO. For example,
    following subchronic exposure, the LOAEL in weanling rats was 0.25
    mg/kg body weight per day, whereas the LOAEL in aged rats was 2.5
    mg/kg body weight per day. The NOAELs were 0.025 and 0.25 mg/kg body
    weight per day, respectively. Data from Buckiova et al. (1992) and
    Smialowicz et al. (1989) also show that exposure of mice  in utero
    and exposure of rat pups prior to weaning cause effects at exposures
    lower than those required for the same effects in adult animals.
         In a subchronic immunotoxicity study (Vos et al., 1990; a
    companion to the chronic study summarized below), aged (1-year-old)
    male Wistar rats were exposed for 5 months to the same diets used in
    the principal study. Based on the authors’ statement from the chronic
    study (see below), estimated compound intake was 0, 0.025, 0.25, or
    2.5 mg/kg body weight per day. End-points were the same as some of
    those evaluated in the chronic study.
         Compound-related effects occurred only in the high-dose group and
    consisted of significantly decreased thymus weight (39% lower than
    controls,  P < 0.01), impaired resistance to  Trichinella spiralis
    (indicated by increased recovery of adult worms from the small
    intestine [780% higher than controls;  P < 0.01] and number of
    larvae in muscle [80% higher;  P < 0.001]), and impaired resistance
    to  Listeria monocytogenes (indicated by approximately 300% increased
    splenic bacterial count;  P < 0.05).
*** Immunotoxicity is not addressed in approval of use of this chemical – only carcinogenicity and lethal dose information is given – for mice. It may not be a problem for humans since it hasn’t been tested for that. (sarcasm)
*** didn’t read it word for word but this popped out during my skim:
Food consumption was slightly increased in all dose groups in males throughout the study (p value not reported).  ***subtext to me  – chemical that may increase appetite and weight gain possibly. The previous link mentioned depressed thymus – aka increased hypothyroidism
Statistically significant decreases in survival occurred in treated mice of both sexes. In males, survival after 18 months was 67, 52, 42 and 42% in the control and low-, mid-, and high-dose groups, respectively (p < 0.05, all doses). The overall survival of the low-dose males (52%) was within the range of the controls (45-78%). Because the difference in survival between the low- dose and control males became apparent late in the study (beginning at 15 months) and was marked at termination (54% vs. 71% in controls), the decreased survival in the low-dose males is considered treatment-related. Survival in females at 18 months was 59, 48, 40 and 27% in the control and low-, mid- and high-dose groups, respectively (p < 0.05, except for the low-dose group). No information on causes of death was available. Other treatment-related effects included significantly decreased food consumption and increased absolute and relative liver weights in females at the high dose.
*** High does are assoc with poor weight gain and shorter life. Offspring had poor weight gain at higher doses in the mothers.
“Based on decreased thymus weight, the LOAEL for parental toxicity is 2.95 mg/kg-day in males and 3.43 mg/kg-day in females. The NOAEL for parental toxicity is 0.29 mg/kg-day in males and 0.34 mg/kg-day in females.”
“Actual weight gain was 4.5% higher, 1.8% lower, and 26% lower than controls at the low-, mid- and high-dose, respectively. Adjusted weight gain (excluding uterus) was 5.5, 22.2 and 69.4% lower than controls at the low-, mid- and high-dose, respectively.”
*** – yes lower dose mice gain more weight – these were pregnant but it’s a clue. What is more disturbing  is how hard the pregnancy was on the mice at the higher doses – subtracting the uterus left them 69.4% lighter than the controls and the low dose mice actually lost weight compared to controls as well so the average size of the uterus from that group of mice was 10% larger than the  control group’s.
*** Organic chemistry of earth science – increasing acidity of rain and ground water may be triggering a change in soil conditions towards sequestering minerals.
From chapter 14:
Soil humic substances contain higher amino acid concentrations: roughly 500 nM/mg for soil humic acids and 150 nM/mg for soil fulvic acids. Hydrogen bonding appears to play a role in molecular aggregation.
Soil humic substances have core structures that are highly aromatic (20 to 70% of total C) The shape of humic substances is strongly influenced by pH. At low pH, humic and fulvic molecules are fibrous. At neutral pH, these fibers tend to mesh together to form a sponge-like structure. This mesh structure is capable of trapping smaller molecules. For example, fatty acids and acyclic alkalenes, which are found in most humic and fulvic acids, may be simply trapped rather than bonded to the molecular backbone. Under alkaline conditions the structure becomes plate-like. (pg 612) Aquatic humic substances are primarily aliphatic whereas soil humic substances are primarily aromatic. This observation in itself does not exclude derivation of aquatic humic substances from soil (since leaching may preferentially remove aliphatic-rich molecules), but the difference is consistent with soil humic substances being derived primarily from higher plants (which are rich in aromatic molecules such as lignin and tannins), and aquatic humic substances being derived primarily from algae and zooplankton (which are poor in aromatic molecules). (pg 612)
Dependence on pH
Figure 14.31 shows the effect of pH on the adsorption of humic acid on Al2O3: the extent of adsorption is greatest at a pH of about 3 and is generally greater at low pH than at high pH. This pH dependence arises because the availability of hydrogen ions in solution will affect the charge on a solid
surface in contract with that solution. At pH below the isoelectric point of a mineral, mineral surfaces
will be protonated and will carry a positive charge; at higher pHÕs the mineral surface will bear a negative charge. Furthermore, dissociation and protonation of organic functional groups, which will affect the extent of adsorption through the mechanisms discussed above, is pH dependent (pg 624)
THE WORLD OF ORGANOTIN CHEMICALS: APPLICATIONS, SUBSTITUTES, AND THE ENVIRONMENT
John M. Batt, Director – Product Stewardship, Additives Division, ATOFINA Chemicals, Inc.
In the marine antifoulant (MAF) paint market, tributyltin is used as a biocide in
paint formulations. These paints are then used to protect the underwater surface
area of a ship’s hull against barnacles, algae, etc. in order to avoid increased fuel
consumption and premature dry-docking. Triorganotins were introduced for this
application 30 to 40 years ago. Originally, tributyltin oxide (TBTO) was freely
dispersed in what were called Free Association Paints (FAP). These paints had
uncontrolled, rapid leaching rates of the biocide.
Polar oceans key to temperature in the tropics (6-17-10)

7. http://www.ontariogenomics.ca/outreach/episode-8-brood-14-fact-sheet

CAN CROWS BECOME VIOLENT FROM A DIET OF COPPER SULFATE-LACED CICADAS?

***this was a TV show plot explanation – I don’t think cicadas that ate copper sulfate laced nutrients (from Dutch Elm Disease treatment of tree roots) would hatch well  for the crows to be able to eat them, probably and short term craziness in the crow would be less likely then gradual weakening of the immune system and eventual death from infection.

8. http://www.ontariogenomics.ca/

The Ontario Genomics Institute (OGI) is a private, not-for-profit corporation focused on using world-class research to create strategic genomics resources and accelerate Ontario’s development of a globally-competitive life sciences sector.

9. http://www.whygenomics.ca/

“Genomics is our best weapon in the battle against world hunger, disease, and environmental challenges.”
***If we are only focused on one question – how gene manipulation can save the world – then we may miss out on saving the world.

9.1. http://www.ontariogenomics.ca/outreach/episode-8-brood-14-sceince-society

10. http://geochange.er.usgs.gov/sw/changes/natural/elnino/

 “During an El Niño, the trade winds are too weak to cause upwelling of nutrient-rich waters off the coasts of Ecuador and Peru. Generations of South American fisherman thus have recognized these conditions by the disappearance of their standard catch, commonly during December and January, every three to seven years. Because of the near coincidence in timing between these conditions and Christmas, the fishing communities have called the phenomenon “El Niño”, for the Christ child. The geologic record suggests that El Niño conditions have been a part of earth’s climate for at least several thousand years.”

13. http://mauidish.com/breaking-maui-foodie-news/possible-food-listeria-contamination-7-eleven-bentos-recalled/ Possible Food Listeria Contamination 7-Eleven Hawaii Bentos RECALLED, by Jen Russo on July 7, 2011 – 11:12 am

14. http://www.inchem.org/documents/cicads/cicads/cicad62.htm#1.2

Concise International Chemical Assessment Document 62, Coal Tar Creosote

“Aquatic invertebrates and fish bioaccumulate creosote components, as has been demonstrated mainly for PAHs by field monitoring studies at creosote-contaminated sites, relocation experiments, and laboratory or microcosm studies. Generally, PAH profiles in insects and crayfish were close to that found in sediments, whereas fish had greatly altered ratios for low/high-molecular-weight PAHs. Bioconcentration factors (BCFs) in connection with creosote exposure have rarely been reported. However, BCFs for PAH components from creosote-contaminated sediments have been estimated to range from 0.3 to 73 000.”  *** Creosote has many compounds including benzene, fluorene, and fluoranthene

7.5.3 Endocrine disruption

“A coal tar creosote (partial specification: 15 PAHs) has been examined in vitro for estrogen receptor-mediated activity using competitive ligand binding assays and reporter gene assays (Fielden et al., 2000). Creosote was found to bind to the mouse estrogen receptor, bind to the human sex hormone-binding globulin, and elicit partial agonist activity in reporter gene assays in transiently transfected MCF-7 cells (human mammary carcinoma-derived cells). The mouse competitive ligand binding assay (using uterine cytosol from female ICR mice) resulted in an IC50 value (displacement of the labelled ligand from the estrogen receptor) of 135 mg/litre creosote (compared with 7 µg/litre for 17beta-estradiol). Based on these values, it was estimated that creosote has a relative estrogenic potency of 0.000 165 and contains approximately 165 mg/litre of estradiol-equivalents. In the assay with human cells (human pregnancy serum), creosote displaced approximately 50% of the ligand at a concentration of 220 mg/litre; however, an IC50 value could not be determined, because full displacement curves could not be obtained due to the insolubility of creosote at higher concentrations.”

8.2.2.1 Non-cancer effects

Women (281 cases, 216 controls, USA) occupationally exposed to dusts that were primarily wood- and agriculture-related were found to have an increased risk of infertility (OR = 2.87, CI = 1.05–7.88); however, there were no data available to establish an association with the wood preservatives (PCP, creosote, formaldehyde, chromium, or arsenic) commonly used (Smith et al., 1997).

*** That effect may in part be due to the fluorine and fluoanthene and increased thyroid inhibition.

“An increase in susceptibility to infectious disease has been demonstrated in eastern oysters (Crassostrea virginica) exposed to 0, 15, and 30% dilutions of the WSF generated from Elizabeth River sediments. The mean total PAH concentration in this sediment was 2.4 g/kg dry weight. The mean concentration of aromatic compounds in the WSF (more than 100 compounds) was 4.08 mg/litre, with naphthalene, acenaphthene, 2-methylnaphthalene, phenanthrene, fluorene, dibenzofuran, 1-methylnaphthalene, and carbazole being the predominant compounds (concentrations ranging from 0.15 to 1.51 mg/litre). Exposure to these fractions for 56 or 68 days enhanced pre-existing infections caused by the protozoan parasite Perkinsus marinus (Dermo) and increased the oysters’ susceptibility to experimentally induced infection in a dose-dependent manner (Chu & Hale, 1994).”

 Bad Food, Good Wrap, The Boston Globe, Stephen reucroft and John Swain (4-25-2000)

CDC says 18 deaths tied to listeria in cantaloupe, AP Online, (10-4-2011) BY Mary Clare Jalonick

“FDA Commissioner Margaret Hamburg said Tuesday that the agency is still investigating the cause of the outbreak. Officials have said they are looking at the farm’s water supply and possible animal intrusions among other things in trying to figure out how the cantaloupes became contaminated. Listeria bacteria grow in moist, muddy conditions and are often carried by animals.”

17. http://www.highbeam.com/doc/1G1-268415671.html ADH Reports Case Connected to Multi-State Outbreak of Listeriosis Linked to Whole Cantaloupes from Jensen Farms, Colo.., States News Service  September 29, 2011

18.http://www.ncbi.nlm.nih.gov/pubmed/12043163 Zh Mikrobiol Epidemiol Immunobiol. 2002 Mar-Apr;(2):81-3. [Opportunistic bacteria detected in cultivated mussels].[Article in Russian] Beleneva IA, Maslennikova EF.Institute of Marine Biology, Far East Branch, Russian Academy of Sciences, Vladivostok, Russia.

“As many as 8 Listeria monocytogenes strains, 12 Pseudomonas aeruginosa strains and 5 Staphylococcus aureus strains were isolated from mussels Mytilus edulis, grown on special installations in the Trinity Bay of the Gulf of Peter the Great, the Sea of Japan. The isolated cultures proved to be highly resistant to a number of antibiotics. Many strains displayed DNAase and haemolytic activity. The cultures of L. monocytogenes, S. aureus and P. aeruginosa also had high lipase, protease and lecithinase activity. The organism of the mussels seems to be a confinement for these bacteria under study. “
Mar Pollut Bull. 2011 Feb;62(2):382-7. Epub 2010 Oct 13., Incidence and characteristics of Staphylococcus aureus and Listeria monocytogenes from the Japan and South China seas.,  Beleneva IA, .A.V. Zhirmunsky Institute of Marine Biology, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok 690041, Russia. beleneva.vl@mail.ru

20.  http://news.yahoo.com/scientists-bacteria-spreading-warming-oceans-142213062.html
Scientists: Bacteria spreading in warming oceans By DON MELVIN – Associated Press | AP – Tue, Sep 13, 2011

 21. http://www.highbeam.com/doc/1G1-225623023.html Study data from Technical University of Munich update understanding of Listeria.

Biotech Week May 12, 2010  ***study on laying hens, organically fed vs standard feed groups comparing their amount and types of Listeria and Enterococcus infection. Levels of pathogen infections were similar but the amount of antibiotic resistant strains were fewer in the organically fed chickens.

22. http://www.highbeam.com/doc/1G1-139036416.html  Orca Bay recalls crab legs: USDC detects Listeria contamination.(United States Department of Commerce )

“The risk of listeriosis can be decreased in ruminants by feeding good quality silage with a low pH. Spoiled or mouldy silage should be avoided, as well as silage from the superficial few inches exposed to air.”
Amazon Link – textbook

24. http://books.google.com/books?id=NZsS6tbSAFYC&pg=PA637&lpg=PA637&dq=listeria+wild+animals&source=vrt&ots=3sGFgl_eS2&sig=TEOjD7TVh-EpR4VmFYpfdJWK6rM&hl=en&ei=Dj6NTvePIYS2tweWhfWJDA&sa=X&oi=book_result&ct=result&resnum=11&sqi=2&ved=0CHsQ6AEwCg#v=onepage&q=listeria%20wild%20animals&f=false
Elliot T. Ryser, Elmer H. Marth, Listeria, Listeriosis and Food Safety, (page 637)

“Listeria spp can be recovered from non-plolluted environments and the source of this bacterium may very well be from avian species, especially seagulls.[99]”

25. http://www.highbeam.com/doc/1G1-144294853.html Winter wellness: answering your body’s need for nurturance: pamper yourself with herbalist Karyn Sweet.(DEPT.> herbal healing)

New Life Journal February 1, 2006 | Sweet, Karyn

Essential oil of oregano, active compound carvacrol.

Oregano means “joy of the mountain” in Greek–let it bring some joy into a cold mountain day. It is a warming herb that can add delicious taste to Italian sauces while soothing the digestive tract and preventing free radical damage. A compound of oregano oil called carvacrol is a powerful antiseptic and so can be used as a gargle to soothe sore throats or mouth inflammations. In aromatherapy, the essential oil is used as a treatment for bacterial and fungal infections. Research has found that it is as effective against bacteria such as listeria, staphylococcus, and E. coli as conventional antibiotics. Use of the diluted essential oil may alleviate toothache, gum infections, athlete’s foot, psoriasis, or eczema. Oregano’s antiseptic properties can be enjoyed by grinding it into soap and its anti-inflammatory properties can be released in homemade salves and oils. Furthermore, oregano’s use as an expectorant makes it particularly useful during these winter months. Add a strong infusion to the bath and relax in the warm water while the winds blow cold outside. ”