Links on heart disease, calcium and iodine

Whether nutrient deficiencies or other metabolic imbalance is the cause is not clear or it may be a response to oxidative stress, however levels of the trace nutrients magnesium, selenium, zinc, and vitamin D3 were found to be low and the level of calcium elevated in myocardium, a type of muscle tissue in the heart. (1)

The short story – adequate nutrition is needed to support pregnancy and lactation (breast feeding) – longer duration breast feeding (6-12 months or more) is associated with less heart disease (2) and breast cancer (3risk. Increased amounts of iodine is needed for pregnancy and lactation (4) and low iodine and low selenium may be involved in breast cancer risk. (5)

A high protein diet, especially one high in dairy products is associated with more heart disease risk. (6) Background information – a high protein diet creates more work for the kidneys in order to excrete the extra nitrogen from protein that was converted into energy (ketones) (7) instead of being used to build muscle or other proteins.

Magnesium may help protect against calcification in heart disease in two important ways. It is needed for the kidneys to be able to excrete excess calcium. It also acts as a calcium channel blocker by providing electrical power from inside of cells or organ tissue in order to help keep excess calcium from entering the soft tissue and blood vessels through the membrane calcium channels. Medications used for hypertension include several calcium channel blockers.

Cholesterol plaque formation (atherosclerotic plaques) along vessel membrane walls may be simply acting as a coating to prevent the electrically active calcium ions from entering cells or doing other damage by plastering it in place, like plaster or spackle on dry wall. Calcium and magnesium levels in normal health are very carefully controlled by the kidneys. Lack of potassium and excess sodium may also affect the kidneys ability to excrete excess calcium.

The current understanding of atherosclerosis does not describe the role of magnesium in this way – current description: (8) and (9).

The role of potassium, magnesium and calcium in hypertension is available here: (10).

Magnesium has been found to help reduce vascular calcification (atherosclerotic plaques in blood vessels) in animal based research, (11) {and I believe in a few human research studies too but I have to find the links again. See Table 7 for a list of symptoms common to magnesium deficiency, hypertension and myocardial infarction are included: (14)} Magnesium may also help reduce prostate cancer risk or progression, (15), and low magnesium levels may be an underlying factor in the formation of cancer tumors, (18); and depression (16) can be a symptom of magnesium deficiency (14) and frequently co-occurs with other diagnoses. (17)

The short story – excess calcium may increase heart disease risk while adequate iodine, selenium, magnesium, potassium and vitamin D are all important for a healthy pregnancy, ability to lactate for a longer duration and reduce the risk of heart disease and breast cancer.

Addition, miscarriage history and history of having more than four pregnancies/four children has been associated with increased risk of heart disease for the mothers. (12) Increased losses of iodine and magnesium stores from the bones may be an underlying factor.  Premature infants born to multiparous women (women who had previous pregnancies) are more likely to have low Thyroid Stimulating Factor – which is associated with hypothyroidism which can simply be due to low iodine levels during the pregnancy. (13)

The long story is in the links below;

except for references about magnesium, potassium and vitamin D for pregnancy and breast feeding but they are also important for pregnancy and lactation. The baby may not thrive or may be fussier if the breast milk is low in essential nutrients or it may be difficult to maintain an adequate supply if the woman is malnourished.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes. Thanks.

  1. Karl T. Weber, William B. Weglicki, Robert U. Simpson, Macro- and micronutrient dyshomeostasis in the adverse structural remodelling of myocardium, Cardiovasc Res. 2009 Feb 15; 81(3): 500–508. https://www.ncbi.nlm.nih.gov/pubmed/18835843 (1)
  2. Katherine Lindemann, Mothers who breastfeed may be less likely to suffer from heart disease and stroke later in life, an interview with Sanne A. E. Peters, University of Oxford, Research Fellow in Epidemiology, June 21, 2017, researchgate.net blog post,   https://www.researchgate.net/blog/post/breastfeeding-may-have-long-term-health-benefits-for-mothers-too  Benefits were seen/measured with six months increments in breastfeeding duration, with a large group of Chinese mothers, “Mothers who had breastfed their babies had a nine percent lower risk of heart disease and an eight percent lower risk of stroke.” (2)
  3. Loren Lipworth, L. Reness Bailey, Dimitrios Trichopoulos,

    History of Breast-Feeding in Relation to Breast Cancer Risk: a Review of the Epidemiologic Literature, JNCI: Journal of the National Cancer Institute, Volume 92, Issue 4, 16 February 2000, Pages 302–312, https://academic.oup.com/jnci/article/92/4/302/2624708 “Overall, the evidence with respect to “ever” breast-feeding remains inconclusive, with results indicating either no association or a rather weak protective effect against breast cancer. […] It appears that the protective effect, if any, of long-term breast-feeding is stronger among, or confined to, premenopausal women. It has been hypothesized that an apparently protective effect of breast-feeding may be due to elevated breast cancer risk among women who discontinue breast-feeding or who take medication to suppress lactation; however, the evidence is limited and should be interpreted with caution” (3)

  4. Angela M. Leung, MD, MSc, Elizabeth N. Pearce, MD, MSc,* and Lewis E. Braverman, MD, Iodine Nutrition in Pregnancy an Lactation, Endocrinol Metab Clin North Am. 2011 Dec; 40(4): 765–777. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266621/  Iodine needs are increased during pregnancy and lactation and in iodine replete geographic areas breast milk levels seemed adequate for the infant’s needs. 250-290 micrograms is estimated to be needed compared to the RDA of 150 micrograms. That level did not seem adequate in geographically low area of New Zealand: ” In a recent study, the iodine needs for breastfed infants in iodine-deficient New Zealand remained inadequate even when their mothers were supplemented with 150 μg/d of iodine during the first 6 postpartum months.” (4)
  5. Peter PA Smyth, The Thyroid, Iodine and Breast CancerBreast Cancer Res. 2003; 5(5): 235–238.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC314438/ Autoimmune thyroid disease and goiter is more common in patients with breast cancer. Iodine and selenium may be protective against both conditions, a review of literature rather than a study. (5)
  6. Heart Risk of High Protein Diets, June 4, 2018, The Hippocrtic Post,  https://www.hippocraticpost.com/ageing/heart-risk-of-high-protein-diets/?utm_source=website&utm_medium=webpush&utm_campaign=notifications The group of men with the highest intake of protein in percentage of total calories had increased risk of heart disease, except for protein from fish or eggs. “When they compared men who ate the most protein to those who ate the least, they found their risk of heart failure was:33 percent higher for all sources of protein;
    43 percent higher for animal protein;
    49 percent higher for dairy protein;
    17 percent higher for plant protein.” (6)
  7. Sherwin RS, Hendler RG, Felig P.,  Effect of Ketone Infusions on Amino Acid and Nitrogen Metabolism in ManJ Clin Invest. 1975 Jun;55(6):1382-90.
       https://www.ncbi.nlm.nih.gov/pubmed/1133179 (7)
  8. Isabella AlbaneseKashif KhanBianca BarrattHamood Al‐KindiAdel Schwertani, Atherosclerotic Calcification: Wnt is the Hint, Basic Science for Clinicians, February 8, 2018 Journal of the American Heart Association,  http://jaha.ahajournals.org/content/7/4/e007356 (8)
  9. The Cardiovascular System in Disease, Diseases of the Vessels, Chapter 6, Ch006-M3430.indd 4/19/2007, http://booksite.elsevier.com/samplechapters/9780723434306/9780723434306.pdf (9)
  10. Mark C. Houston MD, MS, Karen J. Harper MS, PharmD,  Potassium, Magnesium, and Calcium: Their Role in Both the Cause and Treatment of Hypertension, JCH, Vol 10, Issue 7, pp 3-11, July 2008,  https://onlinelibrary.wiley.com/doi/full/10.1111/j.1751-7176.2008.08575.x (10)
  11. Fatih Kircelli, Mirjam E. Peter, Ebru Sevinc Ok, Fatma Gul Celenk, Mumtaz Yilmaz, Sonja Steppan, Gulay Asci, Ercan Ok, Jutta Passlick-Deetjen, Magnesium reduces calcification in bovine vascular smooth muscle cells
    in a dose-dependent manner, Nephrol Dial Transplant (2012) 27: 514–521, https://watermark.silverchair.com/gfr321.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAZ0wggGZBgkqhkiG9w0BBwagggGKMIIBhgIBADCCAX8GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMbSRHWigPf17i-jCnAgEQgIIBUIkKsm3S-WvD5qd-tNiIBBwsoiqBg-FrbTXdm2oS2q2AdX0wuviR-rsM-hi6IMVKWwMEinUYTbh7DopBg7SWLxBIi4bHXaQft3IHdQqhDKr_RiB69uxkVRwW_2aHFGYjR0FzhUSfhDrmVLweVHZRTIYDVbrSkgaVgLnFq4YHvxohG08oMbAeF4C26XL026jpA7J1xbOodHz_o5MUvoQgVcxwhrIFuu7ysxD_B7bjJehfrw6SLjkrm3Q43jrsS3vS37v_hIig_lTQyFCPe5L6UhFwlQvH1mwPIKPNituSvoob5OxY5odMFjtcXNg0Wz2tqLajbKP_Cg4Rt1X0c67CLvTGMkos_d7QLKbxwiFibtfpcrPJlIfbPPEIjd4jKRI2MWFePBaQTQLnUOoC934JHOp4abLCC5jRaOAgHykzJhZPOpvgmvrgj-jJmZBtfdgW9g (11)
  12. Kashmira Gander, Having More Kids Linked to Heart Disease Risk in Mothers, According to New Study, June 4, 2018, newsweek.com, http://www.newsweek.com/kids-linked-heart-disease-risk-mothers-according-new-study-956066 (12)
  13. Kelli K Ryckman, M.S., PhD, Cassandra N Spracklen, M.S., John M Dagle, M.D., PhD., Jeffrey C Murray, M.D.Maternal Factors and Complications of Preterm Birth Associated with Neonatal Thyroid Stimulating Hormone, J Pediatr Endocrinol Metab. 2014 Sep; 27(0): 929–938. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260397/ “Maternal and neonatal thyroid levels are tightly correlated and hypothyroidism …. Multiparous women had infants with lower TSH levels (P=8×10−4) compared to …” (13)

  14. R. Swaminathan, Magnesium Metabolism and Its Disorders, Clin Biochem Rev. 2003 May; 24(2): 47–66.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855626/ (14)
  15. Oseni, Saheed & Quiroz, Elsa & Kumi-Diaka, Jim. (2016). Chemopreventive Effects of Magnesium Chloride Supplementation on Hormone Independent Prostate Cancer Cells. Functional Foods in Health and Disease. 6. 1-15.  https://www.researchgate.net/publication/291164181_Chemopreventive_Effects_of_Magnesium_Chloride_Supplementation_on_Hormone_Independent_Prostate_Cancer_Cells (15)

  16. Eby GA, Eby KL, Rapid recovery from major depression using magnesium treatment.Med Hypotheses. 2006;67(2):362-70. Epub 2006 Mar 20. https://www.ncbi.nlm.nih.gov/pubmed/16542786 (16

  17. Hee-Ju Kang, Seon-Young Kim, Kyung-Yeol Bae, Sung-Wan Kim, Il-Seon Shin, Jin-Sang Yoon, and Jae-Min Kim, Comorbidity of Depression with Physical Disorders: Research ad Clinical ImplicationsChonnam Med J. 2015 Apr; 51(1): 8–18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406996/ (17)
  18. : Castiglioni S, Maier JAM. Magnesium and cancer: a dangerous liason. Magnes Res 2011; 24(3): S92-S100 doi:10.1684/mrh.2011.0285   http://www.mgwater.com/Magnesium%20and%20Cancer.pdf (18)

Oxidative stress and aging; trace minerals and antioxidants

For a more detailed review of the current understanding of how oxidative stress and inflammation are involved in the aging process see this chapter from a longer book: Oxidative Stress and the Aging Brain: From Theory to Prevention, [1]

Mitochondria are the main energy producers in cells. They are involved in breaking down each molecule of glucose (one half of the larger molecule that is commonly known as sugar). During the process of breaking the chemical bonds found in the glucose molecule the free radicals that can cause oxidative damage are produced. When adequate antioxidants are available the free radicals are stabilized before they can cause damage. The body’s internally produced antioxidant enzymes also require the trace minerals copper, zinc and manganese. /Separate topic: An imbalance in copper and zinc can cause health problems./

“Free radicals are chemical species with a single unpaired electron. The unpaired electron is highly reactive as it seeks to pair with another free electron; this results in the production of another free radical. The newly produced free radical is unstable in most cases and, as a result, it can also react with another molecule to produce yet another free radical. Thus, a chain reaction of free radicals can occur, leading to more and more damaging reactions.” [1]

“Several antioxidant defense mechanisms have evolved to protect cell components from the attack of oxidative stress and associated oxidative damage. These mechanisms include antioxidant enzymes, such as SOD, superoxide reductases, catalase, glutathione peroxidases (Gpx), and many heat-shock proteins.” “SOD exists in two forms: Cu/ZnSOD is present primarily in the cytoplasm while MnSOD is present primarily in the mitochondria.” [1]

More information about manganese superoxide dismutase (MnSOD) and how mitochondria function is available here: MnSOD in Oxidative Stress Response-Potential Regulation viaMitochondrial Protein Influx [2]

Supplementing the diet with a manganese and other trace minerals may be helpful as manganese and other trace minerals may be chelated by glyphosate, the active ingredient of the herbicide RoundUp. Chelation is a chemical term for the tendency for one chemical to bind with another – take hold and make the other one less freely available in the environment. The process can be helpful in some situations as it can act as a carrier, a taxi cab so to speak, but at other times it is simply removing the other chemical from being available for other uses.

Plant scientists are aware of the problem and there are agricultural suggestions for reducing the negative effects of manganese chelation by glyphosate in the following article: What About Glyphosate-Induced Manganese Deficiency? The effects of glyphosate’s chelation of iron, copper and zinc is also included in addition to the discussion of manganese. [3] The summary of plant yield research found that improved crop yields were produced when manganese, copper and zinc were applied as a supplemental fertilizer a certain amount of time after the glyphosate containing herbicide was applied to the fields:

“The greatest soybean yield response on high organic soils
was with both Mn and Cu applied 8 to 12 days after the glyphosate.
The highest yields for corn were obtained by foliar-applying Zn 15
days after glyphosate was applied in northwestern Indiana,” [3]

So if plant health scientists recommend supplementing with manganese, copper and zinc for best plant health do human health scientists? Some do, but the topic is still considered alternative medicine rather than being a mainstream medical recommendation. [4] Risks of increased toxicity from trace metals that have negative health effects such as aluminum. [4]

Antioxidant rich foods or supplements that were discussed in the chapter on Oxidative Stress and Aging include vitamin E, which had positive results when used as a supplement in animal studies and mixed results in studies with humans, addition of whole foods such as nuts which are a good source of vitamin E and other nutrients had more consistent positive results in human clinical research studies; Green Tea and its active metabolite EGCG; blueberries, spinach and spirulina, a blue-green algae. [1]

  • Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
  1. Carmelina Gemma, Jennifer Vila, Adam Bachstetter, and Paula C. Bickford, Chapter 15: Oxidative Stress and the Aging Brain: From Theory to Prevention, from Brain Aging: Models, Methods, and Mechanisms. Riddle DR, editor. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. https://www.ncbi.nlm.nih.gov/books/NBK3869/
  2. Demet Candas and Jian Jian Li, MnSOD in Oxidative Stress Response-Potential Regulation viaMitochondrial Protein Influx, Antioxid Redox Signal. 2014 Apr 1; 20(10): 1599–1617. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942709/
  3. Don M. Huber, What About Glyphosate-Induced Manganese Deficiency?, Fluid Journal, Fall 2007, http://www.agweb.com/assets/import/files/58p20-22.pdf
  4. Anthony Samsel and Stephanie Seneff, Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies, Surg Neurol Int. 2015; 6: 45. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392553/

All are equal in Equal Opportunity Programs

“Some are more equal than others” in the book Animal Farm by George Orwell. (paraphrased)

“All animals are equal, but some animals are more equal than others.”

In the 60’s and 70’s women’s liberation and sexual liberation were somewhat connected. Being a single unwed mother was rare and was disapproved of.  That has changed for the better, women and children are accepted no matter the marital history. However the poverty support programs as they are currently written promote unwed mothers by penalizing couples -giving less support or no support help to married couples or unwed couples where the father is named.

A support net that promotes single parenting and not naming a child’s father is discriminating against the child’s right to know their father and their medical and cultural heritage. Welfare programs in larger areas even inspect for evidence of an unnamed father figure and women can lose their benefits even if the large size jeans were their own. Supporting children is a goal that benefits society and stressful situations make parenting more difficult. Rewriting policies that are more open to two parent households whether it is mom and dad, or mom and mom, or dad and dad, would be a positive goal for the sake of raising healthy and secure children who have adequate caregiving available.

Raising children is a challenge with two parents and raising them with one parent may be less stressful and the wiser choice if one parent is unreliable or abusive, so flexibility in any welfare type support net program is the wisest choice for the children’s sake. And for the future’s sake raising secure well adjusted children is most likely to lead to more well adjusted  prosocial tax paying self sufficient adults. (link elsewhere on this site.: From a previous post: Regarding potential underlying reasons for a person to resort to mass violence – typically it isn’t due to “mentally ill” people unless they were already prone to violence. An increased risk for violence is not associated with depression, anxiety or ADHD. Increased risk for mass violence is significantly associated though with being a male who had experienced child trauma and who is a binge drinker.  (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318286/ ))

Sexual liberation was openly discussed by some in the past, 60s/70s, but it wasn’t common for the average woman or household (some women were free/open to casual encounters but most others were not; and swinging/key parties were an experiment of the 70s). Now we have fifty percent (roughly) of children growing up in poverty and many of them living in poverty have single parent households. The inequality of women’s pay to men’s pay when broken down into more precise detail is actually more of a difference in mother’s pay to other’s pay. nytimes The salaries of women without children are more comparable to men’s wages.

So who is liberated now – father’s from their previous role as a head of household? Or are they liberated from being anywhere in the household? Maybe but liberated maybe not. Some are in prison as the number of prisoners has increased with the for-profit prison industry. Since 1974 the amount of prisoners has increased from a steady 100/100,000 to 500/100,000 by 2004. nap.edu

Is sexual liberation still around – or just single parenthood? It seems to be the latter, based on my experience it went away with the increase in sexually transmitted disease and the increase in AIDS/HIV that occurred in the 80s and 90s.

What about equality? Are some animals more equal than others? Yes, some do seem to have different rules than others regarding taxation and legal protection and even in television show games we have many that focus on voting who to keep and who to remove from the lineup of contenders. Some animals are more equal it seems, in our modern times.

In my world we are all equal and the animals count too. We need offshore microbes to modify the form of trace minerals found in ocean water into a form that is available in the atmosphere.

Some animals may think they are more equal than other animals but in the long run we may all be looking to microbes for help that they won’t be able to provide in an ocean that is more acidic and warmer. It is hard to predict who will be more equal than who in a greatly changed world, planning ahead now might make the transition go smoother. Stopping change is already too late, it is happening at the more severe rates that have been used in calculations of predicted events.

In the world I grew up as a child in the 70s we cared about climate and cleaning up air and water and women’s liberation included freedom to touch and be touched not just be seen in more exposed and expensive fashions. Fathers were part of the household, not just on visitation days. Was it perfect then? probably not, but is it perfect now? not really. Lack of jobs for many and lack of time for those who do have jobs is a problem in our modern society that isn’t going to change without the creation of new industries. Globalization has decreased poverty around the world but has led to fewer jobs in the U.S. that are as well paying in proportion to the type of pay that a father as head of household might have had in the 50s or 60s. It will require planned change in priorities to create a new job or basic income society. The advantage could be more stable parenting by two parent households.

Men, on average, are still expected to be a good earner in order to win a woman’s partnership as a spouse and parent. cnn.com/american-men-less-marriageable-partner Expectations may be involved in the suicide rate by males which is a problem of our modern society that was also a problem in the 50s and 60s. More men commit suicide than women on average (males ~18-21/100,000, females ~ 4-6/100,000) and both rates have been fairly consistent since the 1950s. statista.com  Social roles being demanding in different ways seems unlikely to explain that consistent of a difference, speculatively, testosterone levels are not directly associated with violence but in individuals whether male or female if prone to violence increased testosterone can increase tendency towards violence and suicide is a violent reaction against the self. (Sapolosky, Behave)

So are women liberated yet? are men? are children? Prisoners certainly aren’t. /https://mic.com/articles/86519/19-actual-statistics-about-america-s-prison-system#.RB8uGOHzW/ And are we sexually liberated yet? I read one study showed an average of less than two encounters per week for couples – we were supposed to be shocked that the use of medical marijuana was associated with a 20% increase in the rate, bumping up close to 1/week to closer to 2/week metro.co.uk/2017/10/27/weed-smokers-have-more-sex-apparently – I was shocked by both rates. It was not a large study, so maybe there’s more healthy fun going on in the world of consensual couples. Although for the busy pace of a full-time job and commute and helping with children’s homework or doing other household chores it can be difficult to find energy let alone time for extraneous activities no matter how fun. For me fun, solo, helps with better mental health and it can have pain killing benefits for a woman. Migraine relief was sometimes only a few minutes of concentration away if I had some privacy. Good and good for you.

Asexuality seems to be the new liberation. Zinc and omega 3 fatty acids and iodine and selenium may all be helpful for boosting that average for men or women. Food sources of iodine and selenium are available here: effectivecare.info/g9-iodine-&-thyroid

Some animals do seem to be more equal than others. George Orwell was right about that part.

The new site that I still need to work on is meant as ideas, not to be considered better or worse than anyone, the point of Equal Opportunity Programs is that all are treated equally, equal service offered in a variety of languages. The site has ideas, just ideas to consider and online translation services can give a rough translation, but currently the site is in English and written from the perspective of someone who worked in the U.S. in a field that was largely staffed by women, so my ideas may not convert well to a modern mixed gender working world, however the goal of Equal Opportunity Employment is that gender ratios in all of the businesses participating would be similar or not matter if they weren’t in similar ratios. Pay and benefits would be equivalent. Goals are a starting point to consider and work towards, ideas are a place to start.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.