When my dog was a puppy she was very sick from Parvo virus. It causes severe vomiting and dehydration can be deadly. Intravenous fluids were given by a vet and she slowly recovered but had no appetite. Home cooked meats were accepted though but then she would relapse as I tried to ease her back onto regular dog food.
After months she was more stable and able to ease back onto the commercial dog food but prior to that it seemed that any fortified foods would make her sick again. Phosphorus and calcium from milk-bone type dog biscuits also made her sick. I had already been reading about the nutrient’s role in human infectious disease and so I stuck with the months of chopping home cooked meats for her.
I wrote about the story and included photos in this post:
I hoped that sharing the story would help other canines to survive parvo virus — just withhold extra vitamin D and excess phophorus and calcium while fighting the sickness. The virus must be/ may be one of the type of pathogens that have learned how to modify the vitamin D receptor metabolism. It is involved closely with the immune system and protecting against infection.
From a different old post: “Canada is farther north than most of the United States and yet their population’s average vitamin D level is normal (50 nmol/L). [5, 6] The number of Americans with vitamin D levels below 30 nmol/L increased between a study performed from 1988-1994 (45% > 30nmol/L, n=18,883) and one performed in 2004 (23% > 30nmol/L, n= 13,369) but there is some controversy over whether differences in how the lab test was processed might have skewed the results. ”
— I had been concerned in the past that this odd difference in population averages might be due to increased infection with pathogens that affect vitamin D in the US population compared to the Canadian population but after learning about the inhibition of CYP enzymes by glyphosate that makes more sense as an explanation for a populationwide difference. Some people have infections that affect vitamin D metabolism (see next paragraph for more info), but many many many more people eat food every day, and glyphosate is used on crops that are used as ingredients in most prepared foods.
From a different old post: Tuberculosis, I learned recently, is also a type of infection that interferes with normal vitamin/hormone D metabolic pathways. The vitamin D receptor (VDR) plays a role in the ability of white blood cells to kill infected cells and cancerous cells. Some pathogens have developed ways to suppress the Vitamin D Receptor’s activity so white blood cells aren’t able to effectively resist the infection process. Other pathogens that have been shown to reduce the activity of the Vitamin D Receptor, in addition to the pathogen that causes Tuberculosis, include the mold Aspergillus, the viruses that cause Epstein-Barr chronic fatigue syndrome and HIV/AIDS, and the autoimmune diseases sarcoidosis, Crohn’s Disease, and Rheumatoid Arthritis. Elevated levels of 1, 25(OH)2D are seen with the bacterial infections: “Elevated 1,25(OH)2D appears to be evidence of a disabled immune system’s attempt to activate the VDR to combat infection.” [page 19, 1]
I’m glad my puppy survived Parvo virus. It would be nice if more could survive deadly diseases, especially when it is as easy as not fortifying food – not adding something. All we would need is some dog food that isn’t fortified – but you can’t buy it because it doesn’t meet the dog food regulations.
Benicar and curcumin, an extract of turmeric, are both analogues – similar shaped – to hormone D. They can activate the vitamin D receptor and might help patients fight some of the diseases that affect the vitamin D receptor – depending on the type of infection. Receptors and hormones or their analogues act like puzzle pieces or a lock and key that fit together. The analogues might be similar to a master key/skeleton key that can fit in the lock and bump out any ligand/blocking chemical that the infection produced to inhibit the body’s immune system. The vitamin D receptor when activated can then activate aspects of the immune system.
/Disclosure: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes./