Glutathione, Nrf2, Autism and glyphosate

Glyphosate use has escalated (1) at a similar rate and overlapping time frame to the increase in autism in children. The rate of autism in Japanese children is even greater than in U.S. children. The Japanese children may be consuming a larger percent of GMO soy from the U.S. as the country is a significant importer of the crop. (4)Testing has shown that basically all GMO soy, Roundup Ready, has residue of glyphosate. (1) Glyphosate residue has been found in all foods tested by the FDA except for broccoli. (6)

The herbicide Roundup has been shown to induce oxidative stress in animal studies (5), and children with autism have been shown to have an increase in oxidative stress and reduced levels of an antioxidant, glutathione, (2), that is made within our bodies during normal health.

Use of Nrf2 promoting foods might help increase our own production of glutathione. (3) Broccoli is one food that may help promote our own supply of Nrf2 which then helps us make the antioxidant glutathione.

Glyphosate may be metabolized into other chemicals within the body and it or the metabolites may inhibit enzymes important for a variety of functions throughout the body. (7)

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

  1. John Peterson Myers, Michael N. Antoniou, Bruce Blumberg, Lynn Carroll, Theo Colborn, Lorne G. Everett,Michael Hansen, Philip J. Landrigan, Bruce P. Lanphear, Robin Mesnage, Laura N. Vandenberg, Frederick S. vom Saal,Wade V. Welshons, and Charles M. Benbrook,

    Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement.  Environ Health. 2016; 15: 19. Pub. online 2016 Feb 17,  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756530/?utm_content=buffere016d&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

  2. S. Rose, S MelnykO PavlivS BaiT G NickR E Frye,  S J James, Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain, Translational Psychiatry Vol. 2, page 134 (2012), nature.com, https://www.nature.com/articles/tp201261
  3. Megan L. Steele, Stacey Fuller, Mili Patel, Cindy Kersaitis, Lezanne Ooi, and Gerald Münch, Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cellsRedox Biol. 2013; 1(1): 441–445. Published online 2013 Sep 12, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814960/

  4. Zen Honeycutt, Shockingly Higher Rates of Autism and Developmental Delays in Asia, Report from Japan speaking tour, March 1-10, March 21, 2017, MomsAcrossAmerica.com, https://www.momsacrossamerica.com/shockingly_higher_rates_of_autism_and_developmental_delays_in_asia
  5.  Low toxic herbicide Roundup induces mild oxidative stress in goldfish tissuesChemosphere, Vol. 76, Issue 7, Aug 2009, pp 932-937
    ScienceDirect,  https://www.sciencedirect.com/science/article/pii/S0045653509005256
  6. Toxic Weed Killer Glyphosate Found in Most Foods Sold in the U.S., wakeup-world.com, https://wakeup-world.com/2018/05/24/toxic-weed-killer-glyphosate-found-in-most-foods-sold-in-the-u-s/
  7. Ford et al., Mapping Proteome-wide Targets of Glyphosate in Mice, Cell Chemical Biology (2016), http://dx.doi.org/10.1016/
    j.chembiol.2016.12.013 https://www.cell.com/cell-chemical-biology/pdf/S2451-9456(16)30474-3.pdf

Tamarind Powder, Nrf2, and Soup flavoring notes

Really good flavor in today’s batch of soup – notes for the virtual record:

I didn’t measure anything in measuring cups or spoons, so roughly, to one basic batch of soup which includes onion, garlic, celery, carrot, sweet potato and today, pinto beans green beans – written in the order that they are added to the cooking time process:

  • I also used several large bay leaves,
  • approximately 1 tablespoon of Rosemary,
  • 2 tablespoons of ground Cumin,
  • 2 tablespoons of ground Coriander,
  • 1-2 Tablespoons of Tamarind Powder dissolved in some cold water in a small bowl – it tends to clump
  • 1 generous teaspoon Oregano
  • 1 generous teaspoon Sage

All of the ingredients would likely have health benefits and contain beneficial phytonutrients and other vitamins and minerals.

I’ve mentioned a few in the past but haven’t mentioned Tamarind Powder/fruit paste. It has been shown to have medicinal benefits and adds a slightly sweet tartness to foods. It also contains some beneficial fibers which is likely why it tends to clump when I add it directly to a batch of hot soup. It can be purchased as a paste or a dry powder. If purchased in a more whole form the small seeds need to be removed before use. It is a common ingredient in India and can be found in Indian food grocery stores. The paste dissolves better in the hot liquid or sometimes is used to make a sweetened beverage. While the powder may be easier to dissolve in a small bowl where you can continue stir more vigorously until no lumps remain. Tamarind Seed Powder: (1)

Polyphenols in Tamarind Seed Powder have been found beneficial for promoting Nrf2 and reducing oxidative stress. The seeds are edible and are dried and used similarly to lentils/beans. (2) The powder I used is called Tamarind Powder and may just contain the dried fruit. The fruit pulp, leftover from processing, was analyzed and found to contain yellow flavonoids and  polyphenols, (3), both of which are in a group of phytonutrients that may promote our own production of Nrf2 – which can help a variety of chronic health conditions. See this previous post for more information about the potential health benefits and phytonutrients that may promote Nrf2: Nrf2 helps activate beneficial genes that are protective against inflammatory conditions.

The basic bean soup recipe is described in this previous post:   New Year, new recipes.

or at the end of this webpage: G8: Cookies and Bean Soup.

Search result somewhat unrelated to cooking soup – tamarind and pomegranate have low residue tolerance limits for glyphosate (0.2 ppm) compared to wheat, milling fractions other than flour (20 ppm) : https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/galangal – scroll down to the article in the lower right corner – Richard P. Pohanish, in Sittig’s Handbook of Pesticides and Agricultural Chemicals (Second Edition), 2015

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

  1. adachigroup, Medicinal Benefits of Tamarind Seed Powder, Sept. 26, 2013, https://adachigroup.wordpress.com/2013/09/26/tamarind-seed-powder/
  2. Nurhanani Razali, Sarni Mat Junit, Azhar Ariffin, Nur Siti Fatimah Ramli and Azlina Abdul Aziz, Polyphenols from the extract and fraction of T. indica seeds protected HepG2 cells against oxidative stress, BMC Complementary and Alternative Medicine (2015) 15:438. https://bmccomplementalternmed.biomedcentral.com/track/pdf/10.1186/s12906-015-0963-2
  3. Larissa Morais Ribeiro da Silva, Evania Altina Teixeira de Figueiredo, Nagila Maria Pontes Silva Ricardo, Icaro Gusmao Pinto Vieira, Raimundo Wilane de Figueiredo, Isabella Montenegro Brasil, Carmen L. Gomes., Quantification of bioactive compounds in pulps and by-products
    of tropical fruits from Brazil., Food Chemistry 143 (2014) 398–404. https://core.ac.uk/download/pdf/82174064.pdf

 

I work for the children and the planet

“Don’t work harder than the client,” was something social workers in public health recommended – for sensible reasons. There was always more clients and more need and sad, sad stories in public health that couldn’t be helped with our limited number of staff and budget. It was also about common sense, you can encourage change and provide guidance but you can’t make people change when they aren’t interested or ready. The strategy helped with preventing work burnout too, not getting too emotionally involved in the difficulties instead focus on compassion for their difficulties.

However I did have difficulty with the recommendation because I also saw the children as my clients. In the book Timequake the author, Kurt Vonnegut, wrote as a repeated statement in different ways the theme that children don’t ask to be born – – – so underlying theme- – – we shouldn’t blame them for the circumstances of their birth or parents or whatever the example included in the section pertained to.

Currently in the U.S. also adults are facing grim odds – one in two men are statistically likely to develop cancer in their lifetimes and one in every three women — what odds will the next generation likely have? Currently almost two percent of children in the U.S. have autism and roughly twenty percent of the young adult generation have mental health diagnoses and roughly twenty percent identify as something other than heterosexual/customer gender. What will the numbers be for the next generation?  (for those interested in self care information the Nrf2 promoting foods and recipes (Nrf2 posts) are likely helpful for prevention and/or treatment for cancer – unless it is a form of cancer that has developed ways to use Nrf2  to resist chemotherapy – some types of leukemia  cancer strains may have that capability – mentioned at the end of this post: http://transcendingsquare.com/2018/04/05/age-is-a-state-of-mind-and-health/

If tobacco use is preferred but concern for health is also a preference then having a little extra attention to diet may help provide the nutrients that are depleted and that may include a depletion of Nrf2 (research article with animal based study: https://www.ncbi.nlm.nih.gov/pubmed/28641491) so the Nrf2 promoting diet tips may help protect the body when use of tobacco products is a choice – the nicotine itself can provide some benefits to some people. )

I personally am being helped by the health information that I’ve learned and if only twenty people read and use it then I will be glad for them or their children- even if only one child or individual is helped then it will have been worth sharing the information. Kurt Vonnegut cared and likely still cares in some form, in my opinion at least – I will work in his memory – because no child asked to be born and therefore they all deserve e our compassion and help

Disclosure: This information is being provided for the purpose of education within the guidelines of Fair Use. While I am a Registered Dietitian this information is not intended to provide individualized health care guidance. Please seek an individual health care professional for the purpose of individualized health care guidance. Thanks