Links on heart disease, calcium and iodine

Whether nutrient deficiencies or other metabolic imbalance is the cause is not clear or it may be a response to oxidative stress, however levels of the trace nutrients magnesium, selenium, zinc, and vitamin D3 were found to be low and the level of calcium elevated in myocardium, a type of muscle tissue in the heart. (1)

The short story – adequate nutrition is needed to support pregnancy and lactation (breast feeding) – longer duration breast feeding (6-12 months or more) is associated with less heart disease (2) and breast cancer (3risk. Increased amounts of iodine is needed for pregnancy and lactation (4) and low iodine and low selenium may be involved in breast cancer risk. (5)

A high protein diet, especially one high in dairy products is associated with more heart disease risk. (6) Background information – a high protein diet creates more work for the kidneys in order to excrete the extra nitrogen from protein that was converted into energy (ketones) (7(29) instead of being used to build muscle or other proteins.

Magnesium may help protect against calcification in heart disease in two important ways. It is needed for the kidneys to be able to excrete excess calcium. It also acts as a calcium channel blocker by providing electrical power from inside of cells or organ tissue in order to help keep excess calcium from entering the soft tissue and blood vessels through the membrane calcium channels. Medications used for hypertension include several calcium channel blockers.

Potassium is also important to protect against calcification of blood vessels by preventing increased calcium entry into the cell. The mineral is also important for preventing high blood pressure/hypertension – in addition to excess sodium/salt, too little potassium can be a problem. See excerpt with the link. (29)

Five to nine servings of vegetables or fruits per day is the recommendation for a healthy balanced diet (five) or potentially cancer preventing diet (nine). They are a good source of potassium and magnesium in addition to other trace nutrients.

Cholesterol plaque formation (atherosclerotic plaques) along vessel membrane walls may be simply acting as a coating to prevent the electrically active calcium ions from entering cells or doing other damage by plastering it in place, like plaster or spackle on dry wall. Calcium and magnesium levels in normal health are very carefully controlled by the kidneys. Lack of potassium and excess sodium may also affect the kidneys ability to excrete excess calcium.

The current understanding of atherosclerosis does not describe the role of magnesium in this way – current description: (8) and (9).

The role of potassium, magnesium and calcium in hypertension is available here: (10) and (29).

Magnesium has been found to help reduce vascular calcification (atherosclerotic plaques in blood vessels) in animal based research, (11) {and I believe in a few human research studies too but I have to find the links again. See Table 7 for a list of symptoms common to magnesium deficiency, hypertension and myocardial infarction are included: (14)} Magnesium may also help reduce prostate cancer risk or progression, (15), and low magnesium levels may be an underlying factor in the formation of cancer tumors, (18); and depression (16) can be a symptom of magnesium deficiency (14) and frequently co-occurs with other diagnoses. (17)

The short story – excess calcium may increase heart disease risk while adequate iodine, selenium, magnesium, potassium and vitamin D are all important for a healthy pregnancy, ability to lactate for a longer duration and reduce the risk of heart disease and breast cancer.

Addition, miscarriage history and history of having more than four pregnancies/four children has been associated with increased risk of heart disease for the mothers. (12) Increased losses of iodine and magnesium stores from the bones may be an underlying factor.  Premature infants born to multiparous women (women who had previous pregnancies) are more likely to have low Thyroid Stimulating Factor – which is associated with hypothyroidism which can simply be due to low iodine levels during the pregnancy. (13)

The long story is in the links below;

except for references about magnesium, potassium and vitamin D for pregnancy and breast feeding but they are also important for pregnancy and lactation. The baby may not thrive or may be fussier if the breast milk is low in essential nutrients or it may be difficult to maintain an adequate supply if the woman is malnourished.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes. Thanks.

  1. Karl T. Weber, William B. Weglicki, Robert U. Simpson, Macro- and micronutrient dyshomeostasis in the adverse structural remodelling of myocardium, Cardiovasc Res. 2009 Feb 15; 81(3): 500–508. https://www.ncbi.nlm.nih.gov/pubmed/18835843 (1)
  2. Katherine Lindemann, Mothers who breastfeed may be less likely to suffer from heart disease and stroke later in life, an interview with Sanne A. E. Peters, University of Oxford, Research Fellow in Epidemiology, June 21, 2017, researchgate.net blog post,   https://www.researchgate.net/blog/post/breastfeeding-may-have-long-term-health-benefits-for-mothers-too  Benefits were seen/measured with six months increments in breastfeeding duration, with a large group of Chinese mothers, “Mothers who had breastfed their babies had a nine percent lower risk of heart disease and an eight percent lower risk of stroke.” (2)
  3. Loren Lipworth, L. Reness Bailey, Dimitrios Trichopoulos,

    History of Breast-Feeding in Relation to Breast Cancer Risk: a Review of the Epidemiologic Literature, JNCI: Journal of the National Cancer Institute, Volume 92, Issue 4, 16 February 2000, Pages 302–312, https://academic.oup.com/jnci/article/92/4/302/2624708 “Overall, the evidence with respect to “ever” breast-feeding remains inconclusive, with results indicating either no association or a rather weak protective effect against breast cancer. […] It appears that the protective effect, if any, of long-term breast-feeding is stronger among, or confined to, premenopausal women. It has been hypothesized that an apparently protective effect of breast-feeding may be due to elevated breast cancer risk among women who discontinue breast-feeding or who take medication to suppress lactation; however, the evidence is limited and should be interpreted with caution” (3)

  4. Angela M. Leung, MD, MSc, Elizabeth N. Pearce, MD, MSc,* and Lewis E. Braverman, MD, Iodine Nutrition in Pregnancy an Lactation, Endocrinol Metab Clin North Am. 2011 Dec; 40(4): 765–777. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266621/  Iodine needs are increased during pregnancy and lactation and in iodine replete geographic areas breast milk levels seemed adequate for the infant’s needs. 250-290 micrograms is estimated to be needed compared to the RDA of 150 micrograms. That level did not seem adequate in geographically low area of New Zealand: ” In a recent study, the iodine needs for breastfed infants in iodine-deficient New Zealand remained inadequate even when their mothers were supplemented with 150 μg/d of iodine during the first 6 postpartum months.” (4)
  5. Peter PA Smyth, The Thyroid, Iodine and Breast CancerBreast Cancer Res. 2003; 5(5): 235–238.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC314438/ Autoimmune thyroid disease and goiter is more common in patients with breast cancer. Iodine and selenium may be protective against both conditions, a review of literature rather than a study. (5)
  6. Heart Risk of High Protein Diets, June 4, 2018, The Hippocrtic Post,  https://www.hippocraticpost.com/ageing/heart-risk-of-high-protein-diets/?utm_source=website&utm_medium=webpush&utm_campaign=notifications The group of men with the highest intake of protein in percentage of total calories had increased risk of heart disease, except for protein from fish or eggs. “When they compared men who ate the most protein to those who ate the least, they found their risk of heart failure was:33 percent higher for all sources of protein;
    43 percent higher for animal protein;
    49 percent higher for dairy protein;
    17 percent higher for plant protein.” (6)
  7. Sherwin RS, Hendler RG, Felig P.,  Effect of Ketone Infusions on Amino Acid and Nitrogen Metabolism in ManJ Clin Invest. 1975 Jun;55(6):1382-90.
       https://www.ncbi.nlm.nih.gov/pubmed/1133179 (7)
  8. Isabella AlbaneseKashif KhanBianca BarrattHamood Al‐KindiAdel Schwertani, Atherosclerotic Calcification: Wnt is the Hint, Basic Science for Clinicians, February 8, 2018 Journal of the American Heart Association,  http://jaha.ahajournals.org/content/7/4/e007356 (8)
  9. The Cardiovascular System in Disease, Diseases of the Vessels, Chapter 6, Ch006-M3430.indd 4/19/2007, http://booksite.elsevier.com/samplechapters/9780723434306/9780723434306.pdf (9)
  10. Mark C. Houston MD, MS, Karen J. Harper MS, PharmD,  Potassium, Magnesium, and Calcium: Their Role in Both the Cause and Treatment of Hypertension, JCH, Vol 10, Issue 7, pp 3-11, July 2008,  https://onlinelibrary.wiley.com/doi/full/10.1111/j.1751-7176.2008.08575.x (10)
  11. Fatih Kircelli, Mirjam E. Peter, Ebru Sevinc Ok, Fatma Gul Celenk, Mumtaz Yilmaz, Sonja Steppan, Gulay Asci, Ercan Ok, Jutta Passlick-Deetjen, Magnesium reduces calcification in bovine vascular smooth muscle cells
    in a dose-dependent manner, Nephrol Dial Transplant (2012) 27: 514–521, https://watermark.silverchair.com/gfr321.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAZ0wggGZBgkqhkiG9w0BBwagggGKMIIBhgIBADCCAX8GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMbSRHWigPf17i-jCnAgEQgIIBUIkKsm3S-WvD5qd-tNiIBBwsoiqBg-FrbTXdm2oS2q2AdX0wuviR-rsM-hi6IMVKWwMEinUYTbh7DopBg7SWLxBIi4bHXaQft3IHdQqhDKr_RiB69uxkVRwW_2aHFGYjR0FzhUSfhDrmVLweVHZRTIYDVbrSkgaVgLnFq4YHvxohG08oMbAeF4C26XL026jpA7J1xbOodHz_o5MUvoQgVcxwhrIFuu7ysxD_B7bjJehfrw6SLjkrm3Q43jrsS3vS37v_hIig_lTQyFCPe5L6UhFwlQvH1mwPIKPNituSvoob5OxY5odMFjtcXNg0Wz2tqLajbKP_Cg4Rt1X0c67CLvTGMkos_d7QLKbxwiFibtfpcrPJlIfbPPEIjd4jKRI2MWFePBaQTQLnUOoC934JHOp4abLCC5jRaOAgHykzJhZPOpvgmvrgj-jJmZBtfdgW9g (11)
  12. Kashmira Gander, Having More Kids Linked to Heart Disease Risk in Mothers, According to New Study, June 4, 2018, newsweek.com, http://www.newsweek.com/kids-linked-heart-disease-risk-mothers-according-new-study-956066 (12)
  13. Kelli K Ryckman, M.S., PhD, Cassandra N Spracklen, M.S., John M Dagle, M.D., PhD., Jeffrey C Murray, M.D.Maternal Factors and Complications of Preterm Birth Associated with Neonatal Thyroid Stimulating Hormone, J Pediatr Endocrinol Metab. 2014 Sep; 27(0): 929–938. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260397/ “Maternal and neonatal thyroid levels are tightly correlated and hypothyroidism …. Multiparous women had infants with lower TSH levels (P=8×10−4) compared to …” (13)

  14. R. Swaminathan, Magnesium Metabolism and Its Disorders, Clin Biochem Rev. 2003 May; 24(2): 47–66.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855626/ (14)
  15. Oseni, Saheed & Quiroz, Elsa & Kumi-Diaka, Jim. (2016). Chemopreventive Effects of Magnesium Chloride Supplementation on Hormone Independent Prostate Cancer Cells. Functional Foods in Health and Disease. 6. 1-15.  https://www.researchgate.net/publication/291164181_Chemopreventive_Effects_of_Magnesium_Chloride_Supplementation_on_Hormone_Independent_Prostate_Cancer_Cells (15)

  16. Eby GA, Eby KL, Rapid recovery from major depression using magnesium treatment.Med Hypotheses. 2006;67(2):362-70. Epub 2006 Mar 20. https://www.ncbi.nlm.nih.gov/pubmed/16542786 (16

  17. Hee-Ju Kang, Seon-Young Kim, Kyung-Yeol Bae, Sung-Wan Kim, Il-Seon Shin, Jin-Sang Yoon, and Jae-Min Kim, Comorbidity of Depression with Physical Disorders: Research ad Clinical ImplicationsChonnam Med J. 2015 Apr; 51(1): 8–18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406996/ (17)
  18. : Castiglioni S, Maier JAM. Magnesium and cancer: a dangerous liason. Magnes Res 2011; 24(3): S92-S100 doi:10.1684/mrh.2011.0285   http://www.mgwater.com/Magnesium%20and%20Cancer.pdf (18)
  19.  Pharmacology of Cardiac Potassium Channels, Cardiovascular Research, Volume 62, Issue 1, 1 April 2004, Pages 9–33, Oxford Academic – see Table 4, https://academic.oup.com/cardiovascres/article/62/1/9/373105 (19)
  20. Lakshman Goonetilleke, John Quayle, TREK-1 K+ Channels in the Cardiovascular System: Their Significance and Potential as a Therapeutic Target, Cardiovascular Therapeutics 30 (2012) e23–e29  https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1755-5922.2010.00227.x (20)
  21. University of Pittsburgh: Cardiovascular system during the postpartum state in women with a history of preeclampsia, Chapter 2: Cardiovascular System,  pp 190-191, Advances in Physiology Research and Application: 2012 Edition, Scholarly EditionsDec 26, 2012, ebook, https://books.google.com/books?id=3SyvNMZLBU0C&pg=PA190&lpg=PA190&dq=TREK+1+preeclampsia&source=bl&ots=2SzKQHcFJ0&sig=fGwDeK6cMIkUXhtwPDNKqio1zIQ&hl=en&sa=X&ved=0ahUKEwirhN_h6-XbAhUSbq0KHWDZCS0Q6AEIUjAF#v=onepage&q=TREK%201%20preeclampsia&f=false (21)
  22. Ma R, Seifi M, Papanikolaou M, Brown JF, Swinny JD, Lewis A.TREK-1 Channel Expression in Smooth Muscle as a Target for Regulating Murine Intestinal Contractility: Therapeutic Implications for Motility Disorders.  Front Physiol. 2018 Mar 6;9:157, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845753/ (22)
  23. Antidepressant Drugs Suppress Activity of Potassium Channels, Lawrence Berkeley National Laboratory, Feb. 8, 2011, psypost.org,  https://www.psypost.org/2011/02/antidepressant-ssri-potassium-channel-4068 (23)
  24. Nicholas J. Talley, SSRIs in IBS: Sensing a dash of disappointment. Clinical Gastroenterology and Hepatology, May 2003, Volume 1, Issue 3, Pages 155–159.  https://www.cghjournal.org/article/S1542-3565(03)70030-5/fulltext (24)
  25. Tülay Özkan Seyhan, Olgaç Bezen, Mukadder Orhan Sungur, İbrahim Kalelioğlu, Meltem Karadeniz, and Kemalettin Koltka,

    Magnesium Therapy in Pre-eclampsia Prolongs Analgesia Following Spinal Anaesthesia with Fentanyl and Bupivacaine: An Observational Study., Balkan Med J. 2014 Jun; 31(2): 143–148.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115934/ Exerimental group needed less fluid replacement and waited longer before requesting additional pain killing medication than the women with normal (no preeclampsia) deliveries. (25)

  26. Ramanathan J, Vaddadi AK, Arheart KL. Combined spinal and epidural anesthesia with low doses of intrathecal bupivacaine in women with severe preeclampsia: a preliminary report. Reg Anesth Pain Med. 2001 Jan-Feb;26(1):46-51. https://www.ncbi.nlm.nih.gov/pubmed/11172511 (26)
  27. KCNK2 potassium two pore domain channel subfamily K member 2 [ Homo sapiens (human) ], Gene ID: 3776, updated on 23-May-2018,   https://www.ncbi.nlm.nih.gov/gene/3776 (27)

     

  28. Tayyba Y Ali, Fiona Broughton Pipkin, and Raheela N Khan, The Effect of pH and Ion Channel Modulators on Human Placental Arteries. PLoS One. 2014; 9(12): e114405. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260857/  “In vessels isolated from placentae of women with pre-eclampsia (n = 6), pH responses were attenuated.” (28) *attenuated means a weakened response, less responsive to the stimulus.
  29. Qi Qian, Dietary Influence on Body Fluid Acid-Base and Volume Balance: The Deleterious “Norm” Furthers and Cloaks Subclinical Pathophysiology, Nutrients 2018, 10(6), 778; Open Access, http://www.mdpi.com/2072-6643/10/6/778/htm “Recently, Sun et al. [53] demonstrated a causal role for dietary K+ in the regulation of osteogenic differentiation and calcification of vascular smooth muscle cells, both in vitro and in atherosclerotic animal models. Specifically, lower levels of extracellular fluid K+ induce vascular smooth muscle cell osteogenic transformation by elevating intracellular calcium. The latter activates CREB (cyclic AMP response element-binding protein) leading to an enhanced expression of osteogenic markers, e.g., RUNX-2, and simultaneously reduced smooth muscle cell markers, e.g., α-actin. Remarkably, even a slight serum K+ reduction (mean K+ level, 3.70 ± 0.21 mEq/L) in mice can trigger significant vessel calcification associated with elevated pulse-wave velocity, a reliable indicator of aortic stiffness. On the contrary, when K+ levels are raised to ~4.73 mEq/L by dietary modification, signs of osteogenic differentiation were abrogated, and vascular calcification prevented. Consistent with the notion of K+ being protective to vasculature, a high ratio of urine Na+/K+ excretion (indicative of high Na and low K+ intake) has recently been linked to the genesis of HTN [54].?” (29)
  30.  Robert Vink, Mihai Nechifor, editors, Magnesium in the Central Nervous System, University of Adelaide Press, 2011, adelaide.edu.au, free ebook pdf, https://www.adelaide.edu.au/press/titles/magnesium/magnesium-ebook.pdf  See page 20 re TRPM7 channels and different effects of oxidative stress on calcium versus magnesium being allowed through the ion channel. Magnesium helps survival while calcium can increase risk to the cell.  other notes about the book:   https://twitter.com/deNutrients/status/1012685811001806849?s=19

Conscientious, helpful people tend to live longer; and other longevity tips

The worldest most recent, oldest living person lived to the age of 117 and passed away last year, in April 2017. Emma Morano was from Italy and was born in the late 1800’s. She lived a simple life and was unconventional in many ways however remained interested in life and busy with taking care of her own daily needs until very late in her life. Religious faith was important to her and kept few possessions beyond family photos and a few other momentos.

An article about her includes more details about her life and health habits and reviews research on trends in the habits of long lived people from around the world. Being conscientious and helpful are among the trends in common among people with long lifespans. See this article for more details on nutrients such as magnesium that may help promote longevity: https://articles.mercola.com/sites/articles/archive/2017/06/10/amp/remembering-worlds-oldest-person.aspx?__twitter_impression=true

DDisclosure: This information is being provided for educational purposes within the guidelines of Fair Use. While I am a Registered Dietitian this information is not intended to provide individualized health care guidance. Please seek an individual health care professional for the purpose of individualized health care guidance. Thanks.

 

Distractions from nutrition – a timeline

Goals for the chronically ill often are different than for those who enjoy typical health – avoiding a cold is less difficult than avoiding increased inflammation that can lead to an inability to digest food, or to heal small wounds, or to grow skin in areas where skin cells are replaced on a weekly basis such as in mucous membranes of the nose or mouth or in the ear canal. Those rapidly growing areas represent all of the lining of the intestinal tract. If your skin isn’t healing well from minor scrapes and you have frequent nose bleeds then likely your entire digestive tract isn’t in good shape either. Cells are replaced throughout the body on a regular basis but some areas have a longer life cycle for the replacement than other areas.

(Non-healing sores may be more common in autoimmune condition Lupus, patient forum, may also occur with vasculitis – migraines may involve vasculitis. Patient forums for people with odd diseases can be comforting if only to let them know they aren’t alone. Sunlight exposure can make Lupus worse or be a trigger for some types of vasculitis sores.  The patient forum tips also included a warning not to use petroleum jelly (Vasoline TM) within the nasal passages as it can increase risk for a type of lung infection. Coconut oil was recommended by another forum comment and is the active ingredient in a product that I’ve found helpful for moistening the dry scabby tissue – pain is the common complaint along with bleeding or seeping plasma from the sore tissue. Applying tiny amount within the nasal passage or ear area is not easy but pain is unpleasant. /(After reading the patient forum tips I’ve switched to plain coconut oil as was suggested and it does seem more healing than the thicker chapstick which likely contains some waxes in addition to coconut oil. While a humid, moist air quality is helpful I’ve also found that clean air is important, smoke or smog like air made the skin condition worse whether there was a humidifier or not.)/

I’ve also found relief after a magnesium sulfate/Epsom salt bath and the dryness is reduced with adequate humidity in the air. A damp towel hung near a heating vent can help add humidity to a closed small room if a commercial humidifier isn’t available or seems inadequate. Commercial humidifiers should be cleaned with bleach water or another sanitizing agent occasionally or they may be adding mold or other infectious pathogens to the air – the damp towel dries each night and needs to be remoistened and simply washed occasionally as it doesn’t really get dirty or mold because it doesn’t stay damp. Mold and pathogens can grow on the commercial humidifiers because they tend to always retain some moisture in portions of the machinery. )

Not having a severe headache, migraine pain, and being able to breathe through both nostrils at the same time due to frequent congestion problems are also part of my good days versus bad days. Severe exhaustion and just having the energy to get dressed can be a limiting factor for a day’s goals to get anything else accomplished. Chronic illness is becoming more common rather than less common and how to help prevent or manage it is something that nutrition can help in ways that a bottle of medication can’t because the cell repair throughout the body needs many trace nutrients, vitamins and minerals, and an adequate amount and variety of protein and essential fats and carbohydrates – every day, throughout the day.

Strolling through the distractions used to suggest my concerns about nutrition are unfounded simply reveal the accuracy. (More on the “Weaponization of Social Media” by the U.S. and others) My providing free information is simply in the hope that it might be helpful to someone. I will be fine because I’ve found the research and am using it for my own benefit. Living in a desert is not something that my health can handle however and has never been my goal. The advantage of a virtual world is that if twenty readers find my information valuable then they can benefit from it wherever they are sitting and don’t need me to be present or to be living in a desert area.

Do your own research or find a health care practitioner that is trained in nutrition to help guide you if you are interested in taking better care of yourself now rather than waiting for worse chronic illness or brain degeneration. You could be one of the twenty readers who are interested or not, life is full of choice but consider whether you are choosing for yourself or whether you are accepting society’s Darwin Award of chronic illness via modern lifestyle. The United States is becoming one of the most unhealthy countries on average. Qatar is leading the group too but only since the decades since switching to a modern lifestyle and dietary habits.  (20% diabetes rate in Qatar)(Magnesium deficiency causes insulin resistance)

Supporting big business profit goals is noble but so is survival of the ecosystem over the next thousand years – if we make it through the next one hundred I have hope that we will have figured out more sustainable ways to produce energy and use renewable agricultural methods and that we will survive the next thousand – we are at a turning point where pretending the status quo is working is no longer helpful and is harmful even over the short term.

  1. Obsessive about vitamin D, must be crazy – no my recommendation to not take excessive vitamin D and calcium supplements as it is not a sure way to protect against bone fracture risk and may be harmful, has been since supported by research and is now the standard recommendation. My initial recommendation was in February 2011, this update is December 2017:  https://www.acsh.org/news/2017/12/27/calcium-and-vitamin-d-supplements-still-do-not-prevent-fractures-12329
  2. Some people may truly have low vitamin and hormone D levels while others may have a condition that causes the inactive vitamin D level to be low while the active hormone D level is elevated and likely causing an elevation or tendency to elevation of the body’s calcium levels through increased absorption and decreased excretion and which also leads decreased magnesium absorption and increased magnesium excretion as the minerals are kind of a team. In ancient times magnesium was very plentiful in the water and food supply while calcium is rare so our evolutionary physiology tipped towards conserving calcium and wasting magnesium. Ideally simply ask to have both your inactive vitamin D level (25-D) and your active (1-25-D) hormone D levels to be tested but the current treatment and research recommendations generally just test the less expensive measurement of 25-D. Sarcoidosis, HIV, tuberculosis, Rheumatoid Arthritis are some examples of diseases that may have altered balances of 25-D and 1-25-D. The metabolism of vitamin D is complicated and the commonly used herbicide Roundup which contains glyphosate may be inhibiting the CYP enzymes that are needed to make the active form of hormone D from the inactive form or to make the inactive form with sunshine. This is not a widely accepted theory yet (more on the topic in a previous post) but my own health is better for having reduced my intake of foods that may contain glyphosate and by adding a powdered form of the amino acid glycine to my daily routine. I added the supplemental powder when I had a genetic screening performed that revealed a double gene difference in my ability to digest larger proteins down to the individual glycine. It has active roles within the brain which can help reduce anxiety as well as performing other functions and my health has been much improved. Glyphosate is only one methyl group (-OH, one atom of oxygen and one of hydrogen) different from glycine. (more on glycine & glyphosate in this previous post) Inhibition of CYP enzymes might also increase risk of pancreas problems and diabetes and may play a role in risk of developing autism but it isn’t the only chemical that is likely involved and deficiency of vitamin D is likely not the only nutrient deficiency involved – (more on that in this post.)  By the way, I’m looking for a particular link and just haven’t found it yet – please be patient. Still looking but here is a post with some dietary guidance for prenatal or other people interested in reducing intake of foods that may contain glyphosate: (Self care for prenatal care, part one) Okay I found it, see link [page 19, 1] “Other pathogens that have been shown to reduce the activity of the Vitamin D Receptor, in addition to the pathogen that causes Tuberculosis, include the mold Aspergillus, the viruses that cause Epstein-Barr chronic fatigue syndrome and HIV/AIDS, and the autoimmune diseases sarcoidosis, Crohn’s Disease, and Rheumatoid Arthritis. Elevated levels of 1, 25(OH)2D are seen with the bacterial infections: “Elevated 1,25(OH)2D appears to be evidence of a disabled immune system’s attempt to activate the VDR to combat infection.” [page 19, 1]”  an excerpt from post: [http://transcendingsquare.com/2015/08/11/whether-to-be-compliant-or-to-be-healthy-seems-like-an-easy-question-to-answer/]” which I included in (Preventing autism perinatally – before conception) Newborn umbilical cord samples which are already collected could be tested for more chemicals in order to help identify which infants are likely to be more at risk for developing autism – I would be because of my genetic difference in my ability to digest protein down to the individual amino acid glycine. A researcher found 15 lab test biomarkers/chemicals in common and to save money organized them into three groups – if an infant has the first five, then pay for the screening of the second set of five and if the infant also has those differences then screen for the last set of three chemicals. If all fifteen or most of the fifteen are different than average than the infant may need dietary modifications to help with special methyl forms of B vitamins or supplements of glycine or methionine or help with detoxifying heavy metals for example. See (Newborn Sceening for Autism – 3 sets of 5 potential biomarkers) As an overview and update I will add a link to an article about a recent review of research on the finding that low vitamin D levels are associated with increased risk for many types of cancer – but – excess levels of vitamin D don’t help protect even more than adequate or good levels. Some nutrients and chemicals are safe at elevated levels because they are excreted easily while others are safe and helpful in a -U- shape, too little or too much can be unsafe to health. Vitamin D when activated to the hormone can help control our own immune system’s ability to make antibiotic type chemicals of our own – all day, everyday as long as the nutrient building blocks are available. Too much or too little vitamin/hormone D can increase risk of cancer or of autoimmune disease.
  3. This isn’t about “I told you so” it is about our government or some other agent actively preventing helpful information from being shared. I will keep sharing information that can be helpful because I know how much pain hurts and some chronic degeneration of body and brain function can not be reversed it can only be prevented – seeing your loved ones and having them not remember basic facts about themselves or their family members hurts emotionally – having them forget how to be able to swallow food hurts them physically unless caregivers to spoon feed them can be afforded or are available within the family. You may have to physically massage their throat to help stimulate a swallow reflex, simply putting the spoon in the mouth may not be enough to stimulate a swallow reflex in end stage Alzheimer’s Disease.
  4. Magnesium matters – and Epsom salt baths or foot-soaks (about one cup magnseium sulfate salt to a half bath for 20 minutes every 3 to 4 days or half cup in a tub of water for a 20-40 minute footsoak) can be a better absorbed method – this is now supported by research. It may also help protect against and reverse early stages of Alzheimer’s  Disease. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182554/
  5. Symptoms of magnesium deficiency can include mood changes such as depression, anxiety, or anger and irritability and physical symptoms such as muscle cramps, eye twitches, or dry eye. https://www.healingtheeye.com/dry_eye.html
  6. Magnesium is nature’s method for blocking calcium channels – and it doesn’t cause the potential side effects that pharmaceuticals may cause (PPIs such as Pprilosec, Nexium and Prevacid.) http://transcendingsquare.com/2015/10/18/magnesium-deficiency-can-cause-irritability-anxiety-and-chronic-degeneration/
  7. Iodine is an essential nutrient for a healthy weight and appetite for adults and infants and moderate deficiency during pregnancy may be an under lying cause of later development of autism. For some reason I can’t imagine the U.S. nutrient database for iodine content was deleted some point in time between when I first started writing about it in 2010/2011 and now. I keep checking in the hope that the information has been restored – but that day isn’t today: https://ndb.nal.usda.gov/ndb/nutrients/index
  8. Zinc, B12 and vitamin D deficiency can mimic symptoms of schizophrenia which is a mental disorder where the brain isn’t recognizing the person’s own subvocal thoughts and mutterings. Treating with psychiatric drugs or only one of the missing nutrients wouldn’t cure the person of the symptoms if multiple nutrient deficiencies were the cause.  Low thyroid levels may also be a risk factor and elevated C-reactive protein or an elevated copper to zinc ratio may also be a factor. http://transcendingsquare.com/2016/03/19/the-voices-that-people-with-schizophrenia-are-hearing-are-probably-their-own-inner-thoughts/
  9. Calcium or vitamin D deficiency can cause hyperparathyroidism which can cause disoriented thinking and may cause self injury or suicidal urges. http://transcendingsquare.com/2016/04/23/self-injurious-behavior-in-autism-patients-with-low-calcium-levels/

That’s the short list.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.