Autism rate is increasing at a rate faster than evolution can explain

The rate of autism in the 1970s was around 1 child in 10000. Prior to  the 1930s the disease was barely heard of and only a few children, fewer than ten, had even been documented in psychiatric medical records as having any symptoms similar to the autism spectrum symptoms. (Denial/Blaxill, Olmsted)

Around 1999 to 2000 there was a sharp increase in the rate of autism diagnosed. Changes in awareness and/or diagnosis criteria may have some impact on short term changes but the increase in rate from the 1970s is significant. Extrapolating into the future following the recent rate of change in the rate of children diagnosed with autism takes us to an estimated rate of 1 in 34 children in the year 2042. We all need to ask ourselves if now is a better time to try to prevent autism from occurring in our nation’s children or if we should wait until 2042. There are multiple risk factors including specific timing during the infant’s prenatal development, exposure to certain toxins, and nutrient deficiency and/or genetic susceptibility – complex, yes, but complex just takes a little more work to handle.

Autism Rate, U.S., Actual : 1970s-2018, Extrapolated from 2018 to 2042
U.S. Autism Rate Soars to 1 in 59 Children,

Improved screening for risk factors of mothers during perinatal and prenatal care and screening of infants and toddlers before symptoms occur could help provide individualized guidance to help reduce known risk factors associated with increased risk of developing autism.

On another website I have a start on self care steps for preventing autism and other chronic illnesses for different stages of life:

This series of pages titled as Step 1, Step 2, etc. is a draft of steps for how to prevent autism or other chronic illnesses:

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Revisiting superstition from the perspective of economics

What do imaginary goods, virtual cats and superstition have to do with each other? – Economics. ‘Imaginary goods’ is a term used by an Austrian economic theorist from the 1800’s, Carl Menger, to describe goods that might be sold but which did not meet all the criteria of a ‘goods‘ – a thing of value which could be sold or purchased. Imaginary goods could also be sold but they did not meet all of his criteria for ‘goods‘ because their value was more transient – in the imagination of the buyer and/or seller rather than clearly apparent to any normal consumer of goods.  (Principles of Economics, by Carl Menger, a translation in English)

As I’ve been working on devising ways to make pomegranate peel edible I’ve been thinking about the idea of a market or demand for a good versus the actual value of the good. You can’t sell something of value if no one considers it valuable even if it fits the criteria of being ‘goods‘ – fulfilling human needs; while it recently was brought to my attention, a refresher course having grown up in era of ‘Pet Rocks,” that some people will pay for anything if it is popular – if other people are bidding on the item too. I was astonished as a child that anyone would pay real money for a rock in a box just because it was called a ‘Pet Rock‘ – just go outside, find a rock, stick it in a box – there you go, your very own ‘pet rock’ captured from its wilderness and tamed for your own enjoyment. The current trend that was brought to my attention is less solid but requires an imagination – virtual cats, bred to have unique characteristics, the bidding is based on the uniqueness of the characteristics ( – my thought, too much time or too much money, and too little space for a real pet cat.

People need love and affection as it promotes oxytocin and dopamine which are hormones that promote positive feelings.

For those with limited room in their lives for an expensive virtual cat, consider going outside and looking for a wild rock to tame instead.

Bringing this back around to the New Year’s Day topic of good luck black-eyed peas and the following day’s topic of superstition – Carl Menger includes in his examples of imaginary goods items that might be considered good luck charms and also medications that aren’t effective.

Pomegranate peel might be effective but until there is proof that it is effective there might not be a market of consumers willing to pay for it let alone even try it. So Master Chef Challenge – Pomegranate Peel -> make it appetizing and if people also feel good after eating it then they will return for seconds -> thus creating a market that hadn’t previously been known.

Carl Menger’s four criteria for what makes something a consumer ‘good’:

“If a thing is to become a good, or in other words, if it is to
acquire goods-character, all four of the following prerequisites
must be simultaneously present:

  1. A human need.
  2. Such properties as render the thing capable of being brought
    into a causal connection with the satisfaction of this need.
  3. Human knowledge of this causal connection.
  4. Command of the thing sufficient to direct it to the satisfaction
    of the need.” page 52 (Principles of Economics, by Carl Menger, a translation in English)

According to his theory something can lose its value as a consumer good if it stops fulfilling any one of those four criteria, to paraphrase – if we 1: stop needing it because the problem it solved no longer exists, 2: the thing no longer works to solve the original problem  3: we forget that the thing is useful for fulfilling the need, 4: the thing is no longer something humans have access to (the WiFi goes out and the virtual cat breeding stops functioning) :

“Hence a thing loses its goods-character: (1) if, owing to a
change in human needs, the particular needs disappear that the thing is capable of satisfying, (2) whenever the capacity of the
thing to be placed in a causal connection with the satisfaction of
human needs is lost as the result of a change in its own properties,
(3) if knowledge of the causal connection between the thing and
the satisfaction of human needs disappears, or (4) if men lose
command of it so completely that they can no longer apply it
directly to the satisfaction of their needs and have no means of
reestablishing their power to do so.” -pages 52-53 (Principles of Economics, by Carl Menger, a translation in English)

So for those who may have forgotten (reason #3), – caring for living people or pets can help one’s own health through increased oxytocin, dopamine and reduced oxidative stress. If owning a real pet is not possible due to housing issues visiting a local Humane Society type agency and volunteering to help care for the shelter animals is generally possible and appreciated. If money isn’t a problem hiring a human for a service that involves touch such as a manicure is helping others by providing money for jobs and providing oxidative stress reducing touch from the hands-on service. If owning a real pet or hiring human hands-on service isn’t possible than oxytocin, dopamine and possibly even reduction in oxidative stress may be provided by a caring relationship with a houseplant that cleans the air of toxins (ferns and other types), or by enjoying looking at art objects that have to do with nature or possible the touch of a smooth natural object such as a rock or crystal or wooden object.

While my search of oxidative stress and art didn’t turn up the link I was looking for it did find a review of research on male infertility, oxidative stress, antioxidants (vitamin E, C and CoQ10) and ART, assisted reproductive techniques, while it doesn’t mention iodine it’s worth saving for reference and smoking is mentioned as risk:

Smoking increases intake of formaldehyde as well as other toxins. There are also other common sources of formaldehyde in modern living environments. Tips for reducing risk of formaldehyde exposure and links for the houseplants that help detoxify indoor air from formaldehyde and other common volatile chemicals are included in an older post, Formaldehyde (volatile – chemicals that might be easily released from plastics or carpets into the air – ie “new car smell”).

The topic on nature and art and oxidative stress is discussed with links in the section Art – Food for the Eyes on another website,, 10. food Helps Too.

Returning to the Master Chef Challenge – Pomegranate Peel,  – it is helping my mood and health more consistently than the 1/2 cup of pomegranate seeds did but it is quite acidic. I’ve taken to using a couple spoonfuls in my bean soup instead of the lime juice or apple cider vinegar that I had been adding as a digestive aid. I’ve also tried it on salads in place of lime juice.

As a beverage I occasionally have the original blend of approximately 3 ounces of the pomegranate extract/soup stock with about 3 ounces of water and 1 ounce of cherry juice with four pinches of Baking Soda (sodium bicarbonate) to make it less acidic. Sugar is inflammatory in itself so I’v stopped using much of it. After the review of the blueberry/rhubarb jam recipe I bought some blueberries and will try a combination of the pomegranate extract with the less acidic fruit. Cherry juice is also acidic. Blueberry juice concentrate is available in specialty stores but I wasn’t at one.  The Baking Soda may be too much sodium or something in the pomegranate extract or the level of acidity it adds to the diet may have a diuretic effect like coffee – so like many things in life – it’s not perfect. But being sick isn’t either.

When you start thinking about food as fuel and as your body’s natural medicine cabinet then taste is something that can be acquired and adapted to suit the needs of health – but first the mind has to overpower the habit of “I always eat what my family ate, or what I got used to at college, or whatever my friends are eating.” Social settings and food are very strongly linked and it can be viewed as rude to refuse an offer of food that is being offered – sometimes life isn’t perfect either.

Good luck and best wishes all you Master Chefs out in virtual reader land – I know you can take on whatever culinary challenges you choose.

If at the beginning of 2017 someone predicted that I would successfully be using pomegranate peel, baker’s cocoa, cardamom, and leafy green herbs and vegetables instead of medical marijuana for my autoimmune health condition I might have thought they were imagining things – but Carl Menger was right we have to know the causal connection between a good and a problem it might solve before we go to the effort to purchase, prepare, and use the good for solving that problem/need (health care improvement in my case). pages 51-58, (Principles of Economics, by Carl Menger, a translation in English).

A tastes better than it looks salad – Blueberry Pomegranate Avocado Quinoa Salad.

Bring two and a half cups of water to a boil and add one cup quinoa (or amaranth or cracked wheat for a more traditional tabouli like salad). Cook for twenty minutes at a simmer. Stir occasionally to keep it from sticking to the saucepan. Once the water is fully absorbed remove the pan from the heat and add about (all of the following ingredients are estimates except for the avocado- this is a first try) one tablespoon coconut oil and stir into the hot cooked cereal. Add about one cup of frozen or fresh blueberries, 1/2 cup frozen or fresh pomegranate seeds, 1/4 cup pomegranate peel extract, one chopped ripe avocado, one tablespoon dried tarragon and one tablespoon dried basil (or more if fresh is available), and 1/4 cup chopped walnuts. Stir the mixture thoroughly. The cereal will turn purplish color from the blueberries. Serve a cup or so of the mixture over a plate of chopped salad greens and top with a pretty 1/8th cup of fresh or frozen pomegranate seeds.

I always add salt to taste at the table. We taste only the salt on the surface of food, not what has been cooked into a food or stirred into a mixture as much.

The flavors and textures work well together, sweet and tanginess from the fruit, creaminess from the avocado, quinoa and coconut oil. Tarragon adds flavor, the basil is milder and wasn’t noticeable in the amount I added here. Tarragon has a slightly minty flavor. The walnut is a stronger flavor and the crunch and flavor balance with the flavor of the blueberries and crunch of the pomegranate seeds. This was a success flavor and texture-wise no matter what it looks like and it would be nutritionally balanced with protein, essential fats and carbohydrates and plenty of fiber and trace nutrients and antioxidants. Walnuts and blueberries have both been found effective for cardiovascular health and male health issues.

Blueberry Pomegranate Avocado Quinoa Salad
Blueberry Pomegranate Avocado Quinoa Salad.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Autism may be able to be prevented prenatally with individualized perinatal education and nutrition therapy

This got long and complicated and I need to buy a couple of the articles and work on this more but in the meantime, I’m sorry for suggesting the food supply might have something to do with the increased rate of autism or that the health insurance companies don’t want a clear diagnostic procedure etc. but without a lab test that says someone is sick they can save money on paying claims — however costs in the long run may end up being a lot more than they might have been with an earlier diagnosis and preventative treatment. I’m sure the health insurance companies and government and FDA love us all and that autism must be a complete mystery – but leaving something a complete mystery still leaves it a worry for expectant parents and grandparents throughout the pregnancy and even into the early childhood years. The symptoms aren’t usually diagnosed until age two or older. But earlier diagnosis might help prevent more severe loss of function. The condition can cause a sudden or more gradual loss of social skills and development progress.  

Autism can leave a child unable to take care of themselves independently for the rest of their lives. At a rate of 1 child in 45, [Nov. 2015, CDC,], there were 3,932,181 births in the USA in 2013, so roughly that would suggest that 87,381 of those children will go on to develop some symptoms of autism or pre-primary developmental delay — and that possibly 87,381 parents will no longer be able to work at their normal jobs because they will be needed as full time caregivers for their child with autism, possibly for the rest of their lives. So if that rate held steady for the decade then in ten years there could be 1,747,620 children with autism and parents who may not be able to work at a normal job. When will it be enough children and parents to do something about?

I closed with the following paragraph but I’m going to paste it here at the beginning too, as the best of the good news: a lab test has been developed that consistently predicted which infants would later go on to develop autism. This helps clear up the mystery of whether autism is a condition that a toddler can suddenly “get” like an infection or have suddenly develop as an acute reaction to something or whether it develops prentally — it develops prenatally and can get worse — which suggests that it might not also have to get worse if appropriate interventions can be provided. Autoimmune disease frequently can flair up, go into remission, flair up again, and go back into remission. Autism appears to be related to autoimmune conditions of the brain so dietary and lifestyle changes might be able to help keep the overactive white blood cells more in ‘remission’ and less busy doing brain damaging things — that would be my hope at least.

A method has been developed using samples of umbilical cord blood to identify which infants are likely to develop autism later in childhood. The method checks fifteen “biomarkers,’ — (various lab values or other physical signs, I haven’t read the full article yet, need to buy it) — infants whose values were more elevated or reduced compared to normal in a certain pattern were found to be predictive of which infants went on to develop autism. [6 ] This is early research but it would help identify which infants were at risk for autistic changes in a year or two, but at birth instead of having to wait — and worry — for a year or two.

I have some good news and some bad news. It looks plausible that autism could be caused prenatally by a combination of low vitamin D (or possibly a vitamin D system that is blocked by pathogens), and low folate availability (possibly due to a genetic methylation defect, [4], defects that may make the supplemental form, folic acid, not as helpful prenatally and possibly even harmful because the folic acid may inhibit the activity of whatever folate is available, [29] ), and increased formaldehyde either from dietary sources like Nutrasweet or from smoking or living in small enclosed rooms with poor ventilation. Other toxins might also be involved that add to an increased risk for there to be production of autoimmune antibodies in the vitamin D deficient mother and fetus. Malfunction in the vitamin D receptor immune functions could lead to malfunctions in the dendritic cell’s ability to inhibit autoimmune overactivity in the immune system. Autoimmune antibodies might cause problems during fetal brain development or later in the child’s life.

Low vitamin D in infants has been associated with autism – but not for all siblings with low vitamin D — so other factors must be involved. And not taking a prenatal vitamin during the three months prior to pregnancy and the first month of pregnancy has been associated with more risk for having a child with autism and certain genetic defects in the methylation cycle that helps make the B vitamin folate more bioactive have been associated with autism risk [4] – but not every mother who doesn’t take prenatal vitamins during the months prior to becoming pregnant has a child with autism — so other factors must be involved.

Not much information is available about Nutrasweet but during digestion the methanol portion of the larger molecule is released which then is broken down into formaldehyde – which is a known cause of birth defects and a known neurotoxin.

Formaldehyde is produced when something is burned so it could be a concern for any people who are around cigarette smoke or inhale other types of smoke regularly. Formaldehyde can also collect in the air in small enclosed spaces, and increased warmth may also increase volatility of the gas so warmer areas or overheated apartments may allow for more accumulation of the gas in poorly ventilated rooms.

Formaldehyde is also found in prepackaged juice products, particularly in older packages, as formaldehyde is produced as the fruit or vegetable juice ages. Formaldehyde is also produced during digestion from the methanol portion of the alternative sweetener Nutrasweet. Studies on the potential risk of the formaldehyde content that might be available to adults from dietary Nutrasweet found that it was a less significant risk than the amount an adult might receive as a cigarette smoker or from environmental exposures. However an adult has a fully mature liver while a fetus does not. Babies and children also have less mature livers and may be more at risk of having chemicals accumulate to toxic levels because they are not being broken down and excreted quickly enough. (Folate, a B vitamin, is necessary to break down formaldehyde, more on that later.)

Formaldehyde can cross the placenta to the fetus where it accumulates to a larger concentration than within the mother’s bloodstream. The fetal liver tissue is less able to detoxify formaldehyde than the mother’s.

Industrial exposure to formaldehyde is associated with an increased risk of the presence of cancer causing human alpha fetoprotein antigens. Occupational exposure to formaldehyde has also been associated with increased levels of alpha fetoprotein in adult male and female subjects. The study subjects with occupational exposure to formaldehyde were also found to have significantly reduced levels of Total Protein, Albumin, and White blood cell count. Subjects with workplace exposure to formaldehyde reported allergic type symptoms including: “sneezing/airways-related symptoms, itching and watery eyes.” [3] Formaldehyde exposure may also be a cause of systemic allergic contact dermatitis, [15, 16] possibly even on the eyelids. [13] A diet designed to avoid formaldehyde intake may be helpful for alleviating the eczema like rash. [14]

Levels of alpha fetoprotein are normally only elevated in pregnant women and the expected infant.

Levels of maternal serum alpha fetoprotein are already being checked regularly as a prenatal screening test because low levels are associated with having a baby with the genetic condition Down’s Syndrome. Levels of maternal serum alpha fetoprotein have been found to be more elevated for the mothers of children with autism than in mothers whose child did not have autism. [1] Alpha fetoprotein (AFP) has immunomodulatory effects and a recombinant human alpha fetoprotein (rhAFP) version has been found to help alleviate autoimmune symptoms in clinical trials that used mice with “experimental autoimmune encephalomyelitis (EAE), the animal model used for the study of MS.” [2] Alpha fetoprotein is normally produced by the fetus and it does cross into the fetal brain where it seems to be involved with controlling estrogen and helping baby girls to be more feminine and less masculine.

/Speculation: So if alpha fetoprotein antigens are involved in causing autism maybe boys are more at risk for the condition because the estrogen connection somehow is protecting baby girls from developing the antigens. However if the basic problem is a malfunctioning dendritic cell system which is making it more difficult for the mother’s body and fetus’ body to accept the presence of each other’s foreign DNA then other proteins might also have antigen/autoimmune antibodies develop. Male infants may simply be more susceptible to autism because their Y chromosome is more foreign to the mother’s body than a female infant’s X chromosomes. / — Someone already figured this part out and explains it better than me, in a Medical Hypotheses journal – if you have the money for the journal article ($31.50, now added to my shopping list). An excerpt from the Abstract: “Prenatal/maternal factors linked to increased autism risk include valproic acid, thalidomide, alcohol, rubella, cytomegalovirus, depression, schizophrenia, obsessive-compulsive disorder, autoimmune disease, stress, allergic reaction, and hypothyroidism. It will be shown how each of these risk factors may initiate expression of genes which are sensitive to retinoic acid and/or estradiol – whether by direct promotion or by reducing production of alpha-fetoprotein. It is thus hypothesized here that autism is not a genetic disorder, but is rather an epigenetic disruption in brain development caused by gestational exposure to chemicals and/or conditions which either inhibit alpha-fetoprotein production or directly promote retinoic acid-sensitive or estradiol-sensitive gene expression. This causation model leads to potential chemical explanations for autistic brain morphology, the distinct symptomology of Asperger’s syndrome, and the differences between high-functioning and low-functioning autism with regard to mental retardation, physical malformation, and sex ratio.” – CR King [29]

So speculatively,

  • if formaldehyde can make it more likely for someone to make alpha fetoprotein antigens,
  • and maternal serum alpha fetoprotein levels are more elevated in the mother’s of children with autism,
  • and low vitamin D is more common in babies who have autism,
  • and vitamin D helps the dendritic cells of the mother and infant accept each other’s foreign DNA instead of making autoimmune antibodies against each other’s foreign proteins,
  • then low vitamin D might leave the dendritic cells unable to prevent autoimmune antibodies from developing
  • which then may cause changes in the developing fetal brain and may leave the child with autoimmune antibodies that may continue to cause changes in the child’s developing brain later in life.
  • The formaldehyde could be from Nutrasweet and bottled juice products and/or from cigarette smoke or other environmental sources or the combined total of all of the sources. The timing of the introduction of aspartame/Nutrasweet to the U.S. food supply in 1981 and the increase in rate of children with autism is very closely correlated. [5] Nutrasweet and Neotame were both inventions of the Monsanto Company and limited research about them is available. Neotame was invented as the patent for Nutrasweet was expiring and Monsanto was able to get FDA approval for it by 2002. The patent for Neotame was sold to a private equity firm, the J.W. Childs Equity Partners II. L.P.. []

So in summary the good news is autism may be preventable – but the bad news is that it will be difficult to prove and preventative education and treatment will likely need to be individualized as so many factors are involved.

A summary of the factors that may interact during the prenatal and/or perinatal  (three months prior to conception) time period in a way that may lead to the development of autism within the fetal brain.

Possible Vitamin D Issues – it might not just be a lack of vitamin D or sunshine:

  • Simple vitamin D deficiency
  • An underlying genetic defect in the Vitamin D Binding Protein causes a tendency to become vitamin D deficient more easily than normal. [10, 11, 12] (Might a simple protein deficiency then also add a risk to a simple deficiency of all important proteins?)
  • An underlying infection is present with a pathogen that is suppressing the vitamin D receptor system.

Possible Folate Issues:

  • Simple folate/folic acid deficiency/lack of prenatal vitamin during the perinatal time period. [4]
  • Genetic defect in mother affecting the methylation cycle makes her more susceptible for folate deficiency. [4]
  • Genetic defect in the fetus affecting the methylation cycle makes it more at risk for autism. [4]
  • A methylated form of the vitamin may be more effective for reducing risk of developing autism. The natural food form, folate, is more bioactive than the supplemental form, folic acid, that is used in prenatal vitamins. [29]

Formaldehyde might be accumulating from several sources [3, 5]:

  • Aseptically packaged juices
  • Nutrasweet
  • Neotame
  • Smoking
  • Badly ventilated air.
  • Workplace exposure

Other, other factors that may be involved in development of autism may include a variety of chemicals known to be toxic for brain development and which may be common in our modern environment.  From the Abstract of a review article by Dr. Philippe Grandjean, MD and Philip J. Landrigan, MD, Neurobehavioural effects of developmental toxicity., (The Lancet Neurology, 2014):  “In 2006, we did a systematic review and identified five industrial chemicals as developmental neurotoxicants: lead, methylmercury, polychlorinated biphenyls, arsenic, and toluene. Since 2006, epidemiological studies have documented six additional developmental neurotoxicants—manganese, fluoride, chlorpyrifos, dichlorodiphenyltrichloroethane, tetrachloroethylene, and the polybrominated diphenyl ethers. We postulate that even more neurotoxicants remain undiscovered. To control the pandemic of developmental neurotoxicity, we propose a global prevention strategy.” [30]

And other factors associated with autism that were mentioned in the other hypothesis about autism and folic acid included: “valproic acid, thalidomide, alcohol, rubella, cytomegalovirus, depression, schizophrenia, obsessive-compulsive disorder, autoimmune disease, stress, allergic reaction, and hypothyroidism.”  – CR King [29]

  1. valproic acid, a medication commonly used to prevent seizures in epilepsy, may also be prescribed for bipolar disorder or to prevent migraine headaches. (Valporate (VPA), sodium valproate, and divalproex sodium, Depakote). It has been known to cause serious abnormalities in babies when used by pregnant women and is no longer typically prescribed to women of childbearing years. [Wikipedia]
  2. thalidomide,a medication that was prescribed to pregnant women for preventing nausea in the 1960s but it was discovered to cause serious birth defects. It is still used for the treatment of leprosy and still has been known to cause birth defects in the babies of women with leprosy who become pregnant. []
  3. alcohol, – alcohol use by the mother during pregnancy or by the father during the days prior to conception can be a cause of Fetal Alcohol Syndrome in the infant. A zinc deficiency in the pregnant woman may increase the risk of the expected infant developing FAS. [search term alcohol FAS zinc deficiency]
  4. rubella, – also known as German measles, it is the R part of the MMR vaccine. It is rare in the U.S. now with less than ten cases per year but can cause defects in an expected infant if a pregnant woman gets sick with the infection prior to 20 weeks gestation. []
  5. cytomegalovirus, a viral disease that may affect vitamin D levels: “However, when outliers were removed, the association was not apparent. The effect of outliers could not be assessed when vitamin D was dichotomized because no patients with CMV antibodies had sufficient vitamin D levels after outliers were dropped.” []
  6. depression, – can be a symptom of hypothyroidism and has been associated with vitamin D deficiency [] and with folate deficiency. And the methylated form was given as a supplemental treatment, L-Methylfolate, rather than the unmethylated form, folic acid, which is the form used in prenatal vitamins.   [] Depressive disorders have been associated with impaired methylation: [] And with zinc deficiency: []
  7. schizophrenia, vitamin D deficiency is more common in people diagnosed with schizophrenia. [] And folate and B12 have both been found to help treat schizophrenia symptoms (or help treat those patient’s whose symptoms are actually due to an underlying deficiency of folate or B12 which may cause symptoms that resemble schizophrenia and providing the nutrients simply is helping the brain to function normally again.) [] And a zinc deficiency/copper excess is more common in schizophrenia: [] And a zinc deficiency prenatally may be involved in the causing schizophrenia later in life: [] []
  8. obsessive-compulsive disorder, – can be early symptoms of a B12 deficiency. [] Has been associated with folate deficiency, elevated homocysteine levels and impaired methylation function: []
  9. autoimmune disease, – associated with vitamin D deficiency and malfunction of the dendritic cells ability to promote self tolerance of the immune system. The dry cleaning chemical and degreaser tetrachloroethylene has been shown to cause autoimmune disease in lab animal studies on toxicity: []
  10. stress, – increases cortisol and inflammatory stress chemicals, a lack of antioxidant nutrients may make it more difficult for the body to recover from the stress response. [] And may use up stores of folate and cause elevated levels of homocysteine. [] Elevated levels of cortisol during pregnancy has been shown to cause reduced growth rate in the babies in animal studies. []
  11. allergic reaction, and the vitamin D receptor and the Dendritic cells are what control the immune system’s allergic reaction. Excerpt: “1α,25-dihydroxyvitamin D(3) (calcitriol), the biologically active form of vitamin D, is an immunomodulatory hormone, e.g. it inhibits IgE synthesis in B cells. As its clinical application is limited by hypercalcemia, synthetic vitamin D receptor (VDR) agonists that mediate immunomodulatory activities without adverse hypercalcemic effects are of great interest.“- []
  12. hypothyroidism. – may be associated with iodine deficiency which prenatally can cause mental retardation and thyroid defects in the expected infant. Hypothyroidism in female workers has been associated with the flame retardant, polybrominated diphenyl ethers,  [], and the insecticide chlorpyrifos,  [], and the pesticide known as DDT dichlorodiphenyltrichloroethane also  [], [], and polychlorinated biphenyls [ fluoride are also associated with risk of hypothyroidism.

To help prevent autism from occurring prenatally we may need to work together to show that a combination of nutritional deficiencies or metabolic defects and environmental toxins may be causing autism to develop in infants prenatally. And we may need to work together as a group of concerned individuals rather than waiting for the government or a medical corporation to look further into a problem that might leave them at some risk of legal repercussions. Historically there have been several examples of government and corporate interests blocking the lawsuits of factory workers or townspeople whose health was damaged by industrial chemicals. The lawyers were able to show expert testimony demonstrating that the supposedly ‘harmful’ toxin really had some beneficial use and was really a safe and helpful ‘treatment.’ If we could make this about helping the babies stay healthier and more on track developmentally then insurance companies and governments would probably save a lot of money in the long run actually.

Pretending things are a mystery makes it harder to work on solving the underlying problems and preventing more cases from developing into future years or future decades. Thalidomide was a mystery that got solved. Only a few pregnant women with leprosy have to worry about whether their baby might be born with thalidomide birth defects. Before the cause was known every pregnant woman of that generation probably was scared. Now we do have a variety of information about autism and putting together the puzzle is a little complicated but the good news is that it is not a complete mystery and may be preventable with individualized health guidance that begins at least one to three months prior to conception – the prenatal vitamin research suggests that the pre-conception diet is important.

Fetal Alcohol Syndrome has been shown to be related to the father’s alcohol intake around the time of conception as well as the mother’s alcohol intake during the pregnancy so the father’s diet on the days before conception may also be involved in autism development — zinc is very important for male fertility. A longevity type study could include information about both the mother and the father’s health prior to conception and then follow the pregnancy and infancy and hopefully the preventative diet and lifestyle changes would have prevented autism from occurring. 

Part of the bad news that didn’t make it into the earlier discussion of the digestion of menthol and formaldehyde is that humans have a genetic defect that makes menthol extremely more toxic to us than to all other animals — so lab research would demonstrate that menthol isn’t really that bad after all –(to lab animals, that is, but let’s keep that part a secret between corporate research scientist’s and their consciences). So in a global corporate NAFTA/TPP type world where a corporation can sue nations over lost profits, feasibly corporate research scientists and lawyers could force nations to either accept the products made with aspartame and Neotame whether it is a risk to their citizen’s health or not, or else pay the corporation for their estimated lost profits.

Aspartame and Neotame are so much sweeter than sugar that they are simply cheaper to use in food products than sugar, and since its introduction in 2002 Neotame has never even had to be listed with the ingredients, so sweet, delicious, calorie free and guilt free, no alternative sweetener was used in that product according to the label. Aspartame is the number one food additive for consumer complaints to the FDA about adverse side effects. With Neotame not ever being listed on the food label consumers have no idea if they consumed it or not even if they do have an adverse effect and we have no idea if the FDA would have received consumer complaints about the food additive because it was never required to be added to the ingredient label. People who avoid aspartame due to it causing migraines can’t look for Neotame on the ingredient list.

Avoiding all processed foods and all restaurant meals seems like a lot to ask of pregnant women but that might be necessary in order to avoid Neotame. And with Neotame as a possible source of formaldehyde for the developing fetus then as a prenatal nutrition counselor that would be the most cautious advice given the research that is already known about menthol and formaldehyde’s risks to fetal development. Avoiding all toxins and reducing stress and risk of infection would be the ideal goal for all pregnant women.

Working towards removing aspartame/Nutrasweet and Neotame from the food supply may be an impossible goal given the deep pockets of corporations but trying to get Neotame added to the ingredient list seems like a necessary compromise or first step if we are really going to be able to help prenatal and perinatal women avoid all sources of formaldehyde in the hopes of helping prevent autism from developing in the child later in life.

*This got long and complicated and there’s more: The other, other factors would include undiagnosed cases of hypothyroidism and undiagnosed iodine deficiency and BPA/pthalate exposure. Each individual mother/child with autism probably have a slightly different combination of genetic and nutritional susceptibilities and negative load of various environmental toxins and maybe even a sensitivity to the supplemental folic acid (supposedly helping prevent spina bifida but may be adding to autism risk for the babies of moms who have certain genetic defects in the methylation cycle).

So this is a preliminary draft of a preventative health education strategy for trying to prevent autism. A longevity study that started with women at least three months prior to conception and followed them and their children for years would be able to try a multi-factored prevention plan and wait and see if fewer of the children developed autism than compared to the rate of children developing autism in the average population. [rate at 1 in 45 births, Nov. 2015, CDC,] Imprecise diagnostic criteria makes it easier for insurance companies to deny coverage.

A method has been developed using samples of umbilical cord blood to identify which infants are likely to develop autism later in childhood. The method checks fifteen “biomarkers,’ — various lab values — infants whose values were more elevated or reduced compared to normal in a certain pattern were found to be predictive of which infants went on to develop autism. [6 ] This is early research but it would help identify which infants were at risk for autistic changes in a year or two, but at birth instead of having to wait — and worry — for a year or two.

/Disclosure: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes./


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