Fennel Cookies – lightly licorice; and a Lime variation

Onward to new cookie horizons- 

Fennel Seed is served raw or toasted as crunchy after dinner snacks in India based cuisine. They are digestive aids and have a breath freshening effect. The flavor is similar to licorice with a hint of mint lingering after the initial stronger flavor. I eat a small pinch or two equal to a half teaspoon or a teaspoon after meals as I have found it good for my digestion. Health benefits may also include bone strengthening protection against osteoporosis.

I’ve found that some people have a problem with foods that are too crunchy. The raw or toasted seeds are very crunchy. They are also available at speciality spice shops as a ground powder so when shopping for more Gumbo File Powder I also bought ground Fennel Powder – and the results are delicious. I returned to the original cookie variation that uses Golden Flaxmeal and Coconut Oil because I wanted the Fennel flavor to be the main flavor. The pomegranate adds a tangy distinct fruit background flavor which works with the stronger chocolate or molasses but might overpower the licorice mint flavor of Fennel seeds.

Several of the ingredients in addition to the Fennel Seed Powder may help promote our own production of Nrf2 which helps us make our own anti-inflammatory and possibly anti-cancer chemicals in addition to containing other beneficial phytonutrients.

Fennel Cookies:

Wet ingredients:

  • 3 Tablespoons Golden Flaxmeal
  • 10 Tablespoons boiling Water
  • Stir the Flaxmeal into the boiling water in a small bowl for a couple minutes until it thickens and turns opaque slightly. Then add the melted Coconut Oil and stir until it turns creamy white and opaque. Then add the Brown Sugar, Vanilla, and Apple Cider Vinegar.
  • 3/4 cup Coconut Oil, melted
  • 1 cup Brown Sugar
  • 1/2 teaspoon Vanilla
  • 2 1/2 teaspoons Apple Cider Vinegar

Dry ingredients, mix together in a large bowl:

  • 1 cup Brown Rice Flour
  • 3/4 cup Coconut Flour
  • 1/2 cup Tapioca Flour/Starch
  • 1/2 cup ground Fennel Seed Powder
  • 1/2 teaspoon Salt
  • 3/4 teaspoon Baking Soda

Add the wet ingredients from the small bowl to the dry ingredients and stir gently until well mixed. The dough will be soft and sticky, moist enough to easily roll or spoon into small rounds. The batch makes two trays of 24 cookies about one inch around.

Coat the pans with a small amount of coconut oil or pan spray to prevent sticking. Bake at 350’F for 25-30 minutes. Rotate the pans from the top and bottom racks at 15 minutes. Let cool on a wire rack and then store in an airtight container in the refrigerator, freezer or at room temperature. Chilling in the refrigerator or freezer will convert the Tapioca starch into a form that can become a healthier form in the digestive system (called resistant starch).

Fennel Cookies – these are so good, words are inadequate.

Lime Cookies

*I tried a variation of this recipe and decided I liked the first batch best but after a couple days the flavor blended better and was also pretty good. Dried lime powder or dried lemon powder are available in Middle Eastern grocery stores. I used two tablespoons of dried lime powder instead of the half teaspoon of vanilla. The flavir blended into the cookie better after a couple days so it might work better if it were added to the melted coconut oil in advance of mixing the cookie dough – melt the oil, mix in the dried lime powder, stir and let it sit for ten or twenty minutes while measuring the other ingredients and then add it to the emulsified Flaxmeal.

The fennel powder could be replaced with more of one of the other flours or the flavor blended well after couple days and both the lime and fennel have anti-inflammatory phytonutrients content – so give it a try eithet way and maybe both would be enjoyable.

Disclosure: This information is being provided for educational purposes within the guidelines of Fair Use. While I am a Registered Dietitian it is not intended to provide individualized health  care guidance.. Please seek an individual health care professional  individualized health care guidance.

 

 

 

Cheerful Chocolate Cookies

Having chocolate cookies is likely going to be more cheerful than not having chocolate cookies, however these cookies may contain an extra helping of cheerfulness. I made another batch of the Gumbo File/Choctaw Spice/Sassafras Leaf powder Spicy Molasses Cookies http://transcendingsquare.com/2018/03/29/spicy-molasses-cookies-revisited/ with cocoa powder as the main flavoring in place of the Blackstrap Molasses. This time however I wrote out a recipe based on the latest experiment and my latest version of Chocolate Cookies. The calculations revealed that inadvertantly in doubling the batch I had forgotten to double the Baking Soda which is the actual leavening- agent in the recipe, as well as not doubling the emulsifier- the egg replacer, which was the Gumbo File Powder in the experiment and Golden Flaxmeal in my typical egg free versions.

For allergy or digestive intolerant patients it can be nice to have a few substitutions available in case they can’t have one they might still be able to have a different one. The Gumbo File seems to be a more potent emulsifier than the Golden Flaxmeal. The recipe worked with double the amount but still didn’t rise much even with the correct amount of leavening-. The lack of oil or butter and substitution of liquid instead makes the cookies more Brownie or Fudge like, very moist and dense- Energy Bites.

The pomegranate extract and pomegranate juice are likely giving the cookies their increased helping of cheerfulness mood boosting power, beyond the normal yum, it’s chocolate effects. If you want to try the recipe and don’t have Pomegranate Extract on hand then just substitute Pomegranate Juice; 100 percent, unsweetened organic, is what I used and it isn’t low cost – $12/32 ounces. The recipe as I made it this time used 2 1/2 cups juice – 20 ounces, and 1 1/2 cups Pomegranate Extract – 12 ounces; so the double batch, 92 cookies contain 32 ounces of juice/pomegranate peel extract. *Sweetened pomegranate juice would be fine to use, this is a reduced sugar recipe compared to typical cookie recipes. Cherry juice would probably also taste good in this recipe and also has medicinal/functional food benefits. 100 percent juice also means no water is added which could make a tart cherry juice too strong, I typically dilute 100 percent tart cherry juice with some water when I drink it as a beverage, and sometimes the 100percent pomegranate juice but it isn’t quite as tart as the cherry, consider either as somewhat of a concentated juice compared to the milder blends that are available which frequently are based on apple. white grape, or pear juice. Pure fructose can be more difficult for people with digestive sensitivities than a blend of fructose and glucose/table sugar, as the fructose can promote more gassiness occasionally. Smaller portions also can help, a fruit or fruit juice serving is typically four to six ounces and yet bottles sold as individual portions are frequently twelve to twenty ounces-recap it and save some for later.

The Baking Cocoa I used is the  “Dutched” type that is pre-treated with an alkali, similar to the Native American method of treating corn with alkali wood ash (Nixtamil flour) which increases the B vitamin content and helps protect against deficiency of Niacin and pellagra, Niacin deficiency. The process also may help preserve B1, Thiamin content and B2, Riboflavin content (Thiamin content of three sources of corn and arepas…. )(Beriberi- is caused by thiamin/thiamine – B1 deficiency,, the processing of brown rice into a polished low fiber white rice led to large numbers of people developing BeriBeri in early history of Asian food processing.  Thiamin). The “Dutched” cocoa powder is smoother in flavor and a little darker in color then cocoa powder that is not pte-treated with alkali. I don’t know if the B vitamin content is modified in the same way as with Nixtamil  corn flour — but somehow the combination of ingredients made a very dark chocolate cookie:

Cheerful Chocolate Cookies, baked and raw dough – no they are not overbaked.
The raw Cheerful Chocolate Cookie dough.
The baked Cheerful Chocolate Cookies are not overbaked but you have to flip one over in the oven to check the crust in order to tell if is is close to being baked enough – is it crisp with some increased darkness of color.

Dry ingredients, stir together in a large bowl:

  • 1 1/4 cup Brown Rice Flour
  • 3/4 cup Cocoa Powder (Regular or “Dutched” would work similarly)
  • 2 cups Coconut Flour
  • 1 cup Almond Meal
  • 1/2 cup Tapioca Flour/Starch
  • 1 teaspoon Salt
  • 1 teaspoon Cardamom Powder
  • 1 1/4 teaspoon Baking Soda

Emulsifier step- gently heat Pomegranate Extract or Juice to a simmer in a saucepan then remove from heat and stir in the Gumbo File Powder.

  • 1 1/2 cups Pomegranate Extract
  • 6 Tablespoons Gumbo File Powder

Wet ingredients – in a another large bowl combine the thickened warm emulsifier liquid with the Brown Sugar and then stir in half of the remaining juice. Reserve part of the juice to add to the dry ingredients after first mixing in the emulsifier/sugar mixture. (This method is more like making a cake than a cookie, you combine small amounts of the liquid at a time for a smooth cake batter that is not over-stirred.)

  • 2 cups Brown Sugar
  • 2 teaspoons Vanilla
  • 2 1/2 cups Pomegranate Juice, (100 percent, unsweetened organic is what I used – with the goal of a functional/healing food in mind)

The dough should be moist and able to be rolled or spoonef into a sticky round shape that doesn’t crumble – a soft playdough-like consistency.

The Baking time is longer than for a cookie dough made with butter or coconut oil – 20-25 minutes for those became 30-35 minutes for these Brownie or Fudge like Energy Bites. I bake two pans of 24 cookies at a time and rotate the pans from top shelf to bottom shelf and turned around front to back at 20 minutes to get a more even baking. These low fat juice containing cookies then take an additional 10-15 minutes. My typical coconut oil/ butter cookies are rotated at 15 minutes and then left for another 10-15 minutes. If baking only one tray use the top shelf and rotating the pan is less important as the oven heat is directed at the top and bottom of the pan more evenly.

Most of the ingredients in this recipe may be providing beneficial phytonutrients that might help promote our own production of NRF2 which then helps promote our own anti-inflammatory and anti-cancer abilities. Health may never have tasted so good – enjoy!

Disclosure: This information is provided for educational purposes within the guidelines of Fair Use. While I am a Registered Dietitian it is not intended to provide individualized health care guidance. Please seek an individual health care professional for the purpose of individualized health care guidance.

 

 

Nrf2 – helps activate beneficial genes, protective against inflammatory conditions

Nrf2 is an acronym for a substance that helps activate genes that protect against oxidative stress and the resulting inflammation from excess oxidative chemicals. Nrf2 is a lot easier to remember then: nuclear factor erythroid-2-related factor 2 (Nrf2). 

The list of chronic illnesses and genetic conditions that it may help prevent or treat is also quite long. The protective benefits against electromagnetic field radiation that was discussed in the last post may be due to the genes activation and resulting increased protection against oxidative stress chemicals – and this mechanism may be the same pathway for its beneficial role in preventing or treating the long list chronic illnesses.

It has been studied by a number of different groups in the prevention or treatment of: 

  • Cardiovascular diseases including atherosclerosis, ischemic cardiovascular disease, vascular
    endothelial dysfunction, and heart failure;
  • Neurodegenerative diseases including Alzheimer’s, Parkinson’s, ALS, Huntington’s diseases;
  • Cancer (prevention);
  • Chronic kidney diseases;
  • Metabolic diseases: Type 2 diabetes; metabolic syndrome; obesity;
  • Several types of toxic liver disease; (not from the pdf article (1) – Nrf2 helps the liver to better utilize free fatty acids and triglycerides as an alternate energy source during times of starvation/malnutrition, which speculatively then, a deficiency of Nrf2 might be a factor in fatty liver disease (8))
  • Chronic lung diseases including emphysema, asthma, and pulmonary fibrosis;
  • Sepsis;  — (sepsis is a serious type of infection that spreads throughout the blood system.)
  • Autoimmune diseases;
  • Inflammatory bowel disease;
  • HIV/AIDS;
  • Multiple sclerosis;
  • Epilepsy;
  • See Table 1 for the list of studies regarding Nrf2 and the above conditions: (1).

Other diseases or conditions that may also be helped by adequate levels of Nrf2 have been less well studied but the same mechanism of reducing oxidative stress might also benefit in the prevention or treatment of:

  • “hemoglobinopathies including sickle cell
    disease and β-thalassemia [35], malaria [36],
  • spinal cord injury [37], traumatic brain injury [38,39],
  • altitude sickness [40,41], the
    three classic psychiatric diseases, major depression,
    schizophrenia and bipolar disorder [42–45],
  • gastric ulcers [46,47],
    glaucoma [48], age-related macular degeneration [49],
    cataract [50,51],
  • pathophysiological responses to herpes
    activation [52] and
  • benign prostatic hyperplasia [53,54].”
  • Nrf2 was reported to lower skin sensitization produced by sensitizing chemicals [57,58].” — (“skin sensitization..” – this likely refers to chronic itch type of conditions that are exacerbated by chemicals that activate TRP channels, which I discuss in more detail in a series of posts. TRP channels are also a big topic that could use more discussion time: (2, 3, 4, 5,))
  • See page 3, for the quotes and see the citation list of the pdf for the [__] references: (1).

Those are some common and severe conditions – so why aren’t we all aware of Nrf2? I don’t know. Possibly because the suggested treatment by the research discoveries are simple dietary changes which are not high profit margin treatments. However the list of foods that may help happens to overlap with those that I’ve been finding helpful for my own autoimmune and undiagnosed digestive problems. (There is a website with guidance about products that may be falsely claiming to have peer-reviewed studies showing that they are effective as Nrf2 activating compounds 2300 articles are mentioned as having been published on the topic of Nrf2, so I have some reading to catch up on. See: (9).)

So skipping the medical jargon, I’ll share some recipes and menu ideas that incorporate some of these foods and phytonutrients (list from the last post, the phytonutrients were quoted from this pdf: (1)

Specific foods or phytochemicals mentioned to help increase Nrf2 include:

  • sulforaphane from cruciferous vegetables, (such as broccoli and cauliflower);
  • foods high in phenolic antioxidants, (This is a large group including bright yellow and red fruits and vegetables, and deep purple produce. The group includes the subgroup flavonoids which include anthocyanins, flavonols, and it also includes the less familiar subgroup chalcones which are found in the commonly used fruits apples, pears and strawberries. The group also includes aldehydes which are found in vanilla and cinnamon, phenolic acids which include salicyclic acid, and tannins which are found in tea, coffee and wine. Baking cocoa and cherries, beans and whole grains are also mentioned, the summary point would be eat more fruits and vegetables; see: (11))
  • the long-chained omega-3 fats DHA and EPA, (salmon, tuna, sardines, krill oil, ground flax meal, walnuts, hemp seed kernels);
  • carotenoids (especially lycopene), (such as carrots, winter squash, sweet potatoes, cantaloupe, apricots, and lycopene is in tomato, watermelon, pink grapefruit, guava); 
  • sulfur compounds from allum vegetables, (such as onions, garlic, shallots, green onions); 
  • isothiocyanates from the cabbage group and
  • terpenoid-rich foods. (Terpenes are found in real lemon and lime oil, rosemary, oregano, basil and other aromatic green herbs).
  • The Mediterranean and the traditional Okinawan Diets are also mentioned as being Nrf2 promoting diets. See: (wakeup-world.1)

Menu ideas, a start –

  • Add more fruits and vegetables to any meal or snack.
  • Add a dash of real lemon or lime juice to salads or soups. A large spoonful can help aid digestion as we reach middle age. The digestive system tends to produce less natural acidity and it is needed for better absorption of B vitamins. Or sprinkle fresh lemon or lime zest grated from the peel or add a teaspoon of Ground Dried Lemons / Citron Seche Moulu / Limon Seco Molido which may be available at an India foods market. A spoonful of apple cider vinegar or other food grade vinegar could also aid digestion but would not provide the terpenoids found in lemon or lime oil. High quality apple cider vinegar or wine vinegar may contain other beneficial phytonutrients from the phenolic group from the above list as apples and wine are sources of some types.
  • Add a teaspoonful or more or less or any, to taste, of dried green leafy herbs to your salad or soup for aromatic terpenoids and likely phenolic phytonutrients as well; such as Basil, Cilantro, Italian Seasoning, Tarragon, Thyme. Basil and Cilantro are mild and are also used fresh in larger amounts as part of the salad greens. Basil is used fresh or dried in larger amounts in Pesto sauces. Parsley is also used fresh in larger amounts in Tabouli salads.
  • The herb Rosemary is also a good source of terpenoids but is slightly like pine needles and needs to be added to a dish that will be cooked about 20 minutes for better texture. I enjoy Rosemary with beta carotene rich orange flesh Sweet Potatoes which I cook as a skillet scalloped potato. I first saute an Onion sliced in thin rings (allium group) and then add thinly sliced triangles of Sweet Potato so they cook fairly quickly and a teaspoon to a tablespoon of Rosemary. Rosemary is strongly flavored and accidentally spilling too much in the pan can leave the dish inedible, scoop out the excess.
  • Rosemary is a medicinal herb which may help with pain and in traditional folk medicine has been used as a strong tea for pain and inflammation conditions but several cups can have a diuretic effect similar to too much coffee.
  • While discussing hot beverages, Herbal Teas, Green Teas and Black Teas, and Coffee provide phenolic phytonutrients and other antioxidants.
  • Chamomile is a medicinal herb that is frequently used as an Herbal Tea. It has been studied in animal based cell research to increase Nrpf2. (10) The amount used in a cell based study is not something that I could calculate a human recommended serving size for but the traditional medicinal information is available here: (12), caution against its use for asthma, and some seasonal allergy sufferers is mentioned and it is not recommended for use in pregnancy due to a possible risk of miscarriage. Chamomile is a tiny daisy like flower with white petals and a yellow center. The bright yellow center may be a source of phenolic nutrients. (11) Medicinal uses mention digestive and skin complaints, inflammation, relief from muscle contractions, particularly in the intestines, and relief from anxiety. (12)
  • Baking Cocoa is also a source of some phenolic and antioxidant nutrients and can quickly be made into a cup of Hot Cocoa by boiling  a cup of water and adding one or two large spoonfuls of the baking cocoa powder, to taste, along with a spoonful of sweetener. If richness is desired a half teaspoon of Coconut Oil can be stirred in for a hint of creaminess. Less processed/cold pressed Coconut Oil is also a source of phenolic nutrients. (6)
  • Sugar itself can be a source of inflammation so limiting sugar in beverages or other foods is generally a good idea for a health promoting menu plan.
  • Wine can be a source of phenolic nutrients, however it can also be a migraine trigger for some migraine sufferers (like me). Some of the benefits of wine are provided by the free (not-bound-within-a-larger-protein) amino acid content and other free amino acids in wine may be part of the migraine cause. Due to a genetic difference I found a bulk supplier of powdered free amino acids and tried Methionine and Glycine in water. A half teaspoon of each provides a cheerful mood boost without causing excess energy boosting effects – I tried a teaspoon of each initially and it could cause sleeplessness if taken late in the evening and almost too much of a energy boost to the point of increased heart rate. The free amino acids are acidic and cause a puckery tart wine effect. Adding an ounce or two, 2-4 Tablespoons of a 100% purple grape juice or cherry juice or black currant juice could add a hint of sweetness and makes the beverage slightly more juice or wine like. A deficiency of Methionine whether due to a genetic difficulty in metabolism such as I have or due to a dietary lack can increase the body’s need for Nrf2. (7) A deficiency of Nrf2 could negatively effect the body’s supply of the amino acids glycine and serine and it is involved in their biosynthesis pathways. (13) The pathway, called the pentose phosphate pathway, is shown in Figure 2: (14). So speculatively glycine wouldn’t be helping make Nrf2 but if there was a problem with supply of Nrf2 then there might be a shortage of glycine or serine, and they do have biological roles throughout the body.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

  1. Martin L Pall, Nrf2, a master regulator of detoxification and also antioxidant, antiinflammatory and other cytoprotective mechanisms, is raised by health
    promoting factors., Stephen Levine, Acta Physiologica Sinica, February 25, 2015, 67(1): 1–18  http://www.actaps.com.cn/qikan/manage/wenzhang/2015-1-01.pdf (1)  // quoted in: Joseph Mercola, The Harmful Effects of Electromagnetic Fields Explained, wakeup-world.com, Dec. 22, 2017, https://wakeup-world.com/2017/12/22/the-harmful-effects-of-electromagnetic-fields-explained/ (1)
  2. https://effectiveselfcare.info/2017/10/15/g3-5-negative-stress-chemicals-may-cause-symptoms-like-itching-migraines-pain-or-ibs/ (2)
  3. https://effectiveselfcare.info/2017/10/15/antihistamines-may-help-if-genetic-tendency-overproduce-histamine/ (3)
  4. https://effectiveselfcare.info/2017/10/15/g3-6-1-calcium-sparklets-and-oxidative-stress/ (4)
  5. https://effectiveselfcare.info/2017/10/15/trpv-channels-comfort-vanilla-heat-capsaicin/ (5)
  6. Marina AM, Man YB, Nazimah SA, Amin I.,  Antioxidant capacity and phenolic acids of virgin coconut oil. Int J Food Sci Nutr. 2009;60 Suppl 2:114-23. https://www.ncbi.nlm.nih.gov/pubmed/19115123 (6)
  7. Lin AH, Chen HW, Liu CT, Tsai CW, Lii CK., Activation of Nrf2 is required for up-regulation of the π class of glutathione S-transferase in rat primary hepatocytes with L-methionine starvation., J Agric Food Chem. 2012 Jul 4;60(26):6537-45. https://www.ncbi.nlm.nih.gov/pubmed/22676582 (7)
  8. Yu-Kun Jennifer Zhang, Kai Connie Wu, Curtis D. Klaassen, Genetic Activation of Nrf2 Protects against Fasting-Induced Oxidative Stress in Livers of Mice., March 18, 2013http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059122 (8)
  9. Which Nrf2 Products have Peer-Reviewed Studies – Beware of Phony Science, nrf2.comhttp://www.nrf2.com/?page_id=38 (9) Stuff to read later list: */Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity. */Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice. */Effects of a Water-Soluble Curcumin Protein Conjugate vs. Pure Curcumin in a Diabetic Model of Erectile Dysfunction. */Curcumin enhances non-opsonic phagocytosis of Plasmodium falciparum through up-regulation of CD36 surface expression on monocytes/macrophages. */Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.– Curcumin is a vitamin/hormone D analog and is an extract of the root vegetable Turmeric which provides the bright yellow color to Indian curry spice mixes. CYP enzymes are actively involved in vitamin/hormone D metabolism.  /Yes, Vitamin D is needed to produce Nrf2: (15)/ */Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. – so yes, speculatively, a deficiency might increase risk of fatty liver disease. */Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria. */Extremely low-frequency electromagnetic fields activate the antioxidant pathway Nrf2 in a Huntington’s disease-like rat model. */Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats. */Chamomile Confers Protection against Hydrogen Peroxide-Induced Toxicity through Activation of Nrf2 -Mediated Defense Response.
  10. Bhaskaran, Natarajan & Shukla, Sanjeev & Gupta, Sanjay. (2012). Abstract 2594: Chamomile (Matricaria chamomilla L.) upregulates heme oxygenase-1 through activation of ERK-Nrf2 signaling: Cytoprotective mechanism against oxidative damage. Cancer Research. 72. 2594-2594. 10.1158/1538-7445.AM2012-2594. https://www.researchgate.net/publication/275442168_Abstract_2594_Chamomile_Matricaria_chamomilla_L_upregulates_heme_oxygenase-1_through_activation_of_ERK-Nrf2_signaling_Cytoprotective_mechanism_against_oxidative_damage (10)
  11. Maria de Lourdes Reis Giada, Chapter 4: Food Phenolic Compounds: Main Classes, Sources and Their Antioxidant Power, Biochemistry, Genetics and Molecular Biology » “Oxidative Stress and Chronic Degenerative Diseases – A Role for Antioxidants”, book edited by José A. Morales-González, ISBN 978-953-51-1123-8, Published: May 22, 2013    https://www.intechopen.com/books/oxidative-stress-and-chronic-degenerative-diseases-a-role-for-antioxidants/food-phenolic-compounds-main-classes-sources-and-their-antioxidant-power (11)
  12. Roman Chamomile, Penn State Hershey Medical Center, http://pennstatehershey.adam.com/content.aspx?productId=107&pid=33&gid=000233 (12)
  13. Gina M. DeNicola, Pei-Hsuan Chen, Edouard Mullarky, Jessica A. Sudderth, Zeping Hu, David Wu, Hao Tang, Yang Xie, John M. Asara, Kenneth E. Huffman, Ignacio I. Wistuba, John D. Minna, Ralph J. DeBerardinis, and Lewis C. Cantley., NRF2 regulates serine biosynthesis in non-small cell lung cancer., Nat Genet. 2015 Dec; 47(12): 1475–1481.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721512/ (13)
  14. Albena T.Dinkova-KostovaAndrey Y.AbramovThe emerging role of Nrf2 in mitochondrial function., Free Radical Biology and Medicine, Vol 88, Part B, Nov 2015, Pages 179-188, Part of special issueNrf2 Regulated Redox Signaling and Metabolism in Physiology and Medicine Edited by 
    G E Mann, H J Forman, M Yamamoto, T Kensler, J D Hayes,

    https://www.sciencedirect.com/science/article/pii/S0891584915002129 (14)

  15. K Nakai, H Fujii, K Kono, S goto, R Kitazawa, S Kitazawa, M Hirata, M Shinohara, M Fukagawa, S Nishi, Vitamin D Activates the Nrf2-Keap1 Antioxidant Pathway and Ameliorates Nephropathy in Diabetic Rats., American Journal of Hypertension, Volume 27, Issue 4, 1 April 2014, Pages 586–595, https://academic.oup.com/ajh/article/27/4/586/2743232 (15)