Ellagitannins and red raspberries

Prior to the research on pomegranates and ellagitannins research was being performed on the use of red raspberries for their health and anticancer benefits. The summary points are that the whole fruit, the mixture of a variety of phytonutrients provides the benefits and that an isolated singe phytonutrient may be less bioavailable and less bioactive – less chemically likely to provide benefits as the mixture of phytonutrients that the whole food provides. An article from 2001 discusses this in more detail and mentions that early work on pomegranates suggested they would be an even better source of the group of ellagitannins and other polyphenols.

The compounds when working together within the body seem to help make cancer cells stop dividing and start dying by apoptosis like normal cells would – and without having any toxic effects on other normal healthy cells. The ellagitannins and other phytonutrients in red raspberries also seemed to prevent precancerous cells from becoming cancerous – dividing at above average rate of growth.

Other health benefits of the whole fruit used as a fruit puree equivalent to eating one cup of red raspberries per day, providing 40 mg of ellagitannins, included:

“European medical studies also demonstrate that red raspberry ellagitannins lower the incidence of birth defects, promote wound healing, reduce heart disease, and may reduce or reverse chemically induced liver fibrosis. In addition, the ellagic acid produced from the ellagitannins has anti-bacterial and anti-viral properties.”

Read more: The Truth About Ellagic Acid and Red Raspberries,    https://jonbarron.org/article/truth-about-ellagic-acid-and-red-raspberries

Ellagitannins and pomegranates was a discussion begun in a previous post: Pomegranate polyphenols and Microglia M2 Activation. I didn’t include the information in my summary but one of the links mentions that whole pomegranate juice / juice made with the peel / provides about 2 grams per liter of ellagitannins which would be many times more than 40 milligrams. Two grams would be 2000 milligrams and a liter is slightly less than a quart which is four cups, so roughly the whole pomegranate juice/extract is providing 500 milligrams per cup. A cup of juice would be more concentrated, being a liquid, compared to a cup of loosely packed whole red raspberries with seeds and air space, so a cup of raspberry puree or red raspberry juice would likely provide more than 40 milligrams.

Black raspberries are a dark purple color were not mentioned in the 2001 article but a more recent study on cancer therapy from 2016 mentions them as a source of ellagic acid so they may have an equivalent amount of the beneficial phytonutrients.

Read more: Black raspberries in cancer clinical trials: Past, present and future.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008867/

Blueberries and blackberries and other berries are good sources of a variety of beneficial phytonutrients. Many types have the most prevalent phytonutrients listed and extraction methods that are typically used for commercial products are discussed in this research review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384171/

A shorter article discussing phytonutrients found in blueberries, blackberries and raspberries in a more general way:   http://berryhealth.fst.oregonstate.edu/symposium/lukehowardabstract.htm

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Why care about thyroid cancer? It’s about iodine.

Or more importantly about the lack of iodine and the excess availability of bromide, fluoride and perchlorate – all halides – all chemically similar enough so that the body may build thyroid hormone with them if there is a deficiency of iodine. Bromide replaced iodine in baked goods some point in time around the 1950s as an anti-caking agent in flour. Fluoride was added to water supplies and to toothpaste around the same time. Both fluoride and bromide may be used in medicines to help make a natural product able to be patented as chemically unique. They also may increase the active life of a medicine if the combination can be made to be able to enter cells with a molecule of bromide or fluoride attached then it tends to stay there longer because the molecule of the halide is so big that it is difficult for the cell to excrete  – which may make accumulation to toxic levels more of a long-term risk.

Iodine deficiency makes the risk of radioactive iodine more of a risk but it makes the use of X-ray machines with radioactive iodine more effective. Or the radioactive iodine to kill the thyroid cancer treatment more effective (https://www.ncbi.nlm.nih.gov/pubmed/27856930). I prefer health. Iodine deficiency can make hypothyroid symptoms more likely which may include depression, easy weight gain and a reduced sex drive.

Will we ever be allowed to discuss underlying natural causes of chronic illness and cancer or do we have to simply trust that prescription pads can cure everything no matter how high the cost to individuals or society – and the problem with that plan is they can’t cure everything and the side effects of cancer treatments can be severe and may include cognitive deficits – loss of thinking ability.

Do we as a people have to be ashamed of a desire for health or for a healthy sex drive or is it now the norm to expect looking good to not be associated with feeling good? Shaming women over wanting to feel better or to wonder why they’ve lost interest in life, let alone sexual relations, is something I’ve experienced as a patient. If the standard lab test for hypothyroidism shows the presence of thyroid hormone then any symptoms are ‘crazy’ – ask for an autoimmune antibody lab test to be done. Hypothyroid symptoms may occur during autoimmune hypothyroidism while the thyroid hormone lab test shows the presence of thyroid hormone. It may be present but if it is loaded with bromide, chloride or fluoride atoms then it may simply be adding to long term cancer risk instead of performing the normal functions of regulating metabolism. Feeling cold and having easily thinning hair are also symptoms of hypothyroidism. Constipation and being sensitive to gluten containing foods may also be associated problems with hypothyroidism.

Shaming patients has not been found to be effective at helping them in the area of drug or alcohol problems:

“The results add to a body of literature suggesting that widely used shaming and humiliating methods of treating alcohol and other drug problems — such as those seen on shows like Celebrity Rehab — are not only ineffective but also may be counterproductive.” (9.156)

Patients with problems with chronic obesity or overweight issues that are actually due to hypothyroidism may try very hard to lose weight and may exercise a lot and eat very little and still not lose weight or even gain it. A severe hypothyroid problem can make a person’s metabolic needs drop far below average. An average diet for a person is recommended to not go below 1200 calories per day. Someone with hypothyroidism may be eating 800 calories per day and still not be losing weight – are they shameful over-eaters? or are they starving for iodine? I vote the latter. But society tends to look at anyone who is overweight as someone who eats too much – no it might be someone whose body gains weight too easily.

It has been made clear to me that sexual health is not to be discussed unless it is regarding men’s sexual health. Women don’t sweat, they just glow, or something like that. If men want sexual health it seems like they would want healthy partners too. We really aren’t talking about men’s sexual health either though, just take a pill and don’t worry about potential underlying cardiovascular risks that may be associated with ED (Erectile Dysfunction – yes, actually we don’t talk about that much either.)

Babies come from under cabbage leaves still I guess. Unfortunately they need iodine too. Rhubarb is a good source of iodine so maybe start looking for babies under rhubarb leaves. Or maybe just eat more rhubarb because it would not only be providing iodine, it also has a phytonutrient, parietin, that has been shown to be effective against cancer cells. A concentrated amount of the parietin was used however: https://www.express.co.uk/life-style/health/613194/Cancer-killing-drug-rhubarb-ready-within-years

Parietin is an orange pigment found in the rhubarb and in many types of lichen. I don’t happen to have an image of rhubarb handy but here’s some pretty lichen on a rock in a desert area:

Colorful lichen on a rock in the desert during early winter, with colored pieces of glass, found nearby.

The chemical left healthy cells unharmed which is unlike typical chemotherapy treatments. The parietin may be stopping cancer cell growth by blocking anaerobic metabolism – the burning of energy without oxygen. Our bodies preferentially use metabolic pathways that use oxygen (and cause oxidative stress as a byproduct). This article is longer and contains a list of many other beneficial phytonutrients and vitamins found in whole rhubarb. It contains antioxidants and a variety of beneficial things in addition to iodine:  https://www.naturalhealth365.com/rhubarb-cancer-enzyme-1820.html

While I don’t have a picture I do have a recipe for Blueberry Rhubarb Jam – the two fruits work well together in a sauce, cobbler, or jam because rhubarb is fairly tart – acidic, and blueberries are fairly mild – more alkaline. They balance each other nicely in this low sugar recipe: http://transcendingsquare.com/2012/07/21/blueberry-rhubarb-jam/

If you happen to have a patch of rhubarb or know someone who does you’ll know that when it is season there is lots and then it is out of season, the leaves get large and the usuable part – the celery like stalks become too large, less tender, less colorful and the parietin at least is in the colorful pinkish pigments on the exterior of the rhubarb leaf stalks.

A simpler recipe that I made to use up a lot of rhubarb all at once was a Rhubarb Ginger Sauce which I would freeze in batches which turned into a sorbet like frozen treat. I also would use the sauce thawed in baked goods as a substitution for part of the liquid in a recipe similar to substituting applesauce.

The recipe was roughly 12 cups of washed and chopped rhubarb stalks, about 1/2 inch long sections, simmered with 3 cups of sugar and an inch or two section of ginger root, peeled and minced fine. Some might prefer less ginger or no ginger, that amount made a fairly zingy sauce. The stalks make their own sauce as they simmer and the chunks become soft and lose their form. Simmer for about 20 minutes. I would need to try it again to check the recipe but that is the way I remember making it. Once frozen the sugary treat was easy to eat like a fruit sorbet rather than freezing into a more solid ice cube. The sugar content would be necessary for that effect, I think a sugar free sauce would freeze more solid.

So plan ahead, eat healthy now and prevent precancerous cells the natural way – with a healthy immune system and active metabolic rate. It is difficult to have a normal lifestyle let alone exercise regularly when the body is coasting on 800 calories a day due to hypothyroidism.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Why care about health? It’s about statistics.

The rate of cancer incidence has increased greatly in many countries and is expected to continue to increase, particularly in association with the aging of the population. Cancer is more often a diagnosis after age 65.  The rate of thyroid cancer in particular has increased greatly in women. The rate of developing some type of cancer during one’s lifetime is expected to reach 1 in 2 men and 1 in 3 women by the yea 2050, (MedScape) – or a more general 1 in 2 people, (medicalnewstoday) – those are not good odds.

It is common during youth to feel secure about health but our bodies tend to run out of stored nutrients as we age and metabolic pathways that we depend on to rebuild muscle and remove toxins or defective cells can become less effective. A healthy immune system also protects us from our own body’s normal rebuilding/regrowth of new cells. Defective ones are typically removed from growth areas in bone marrow before they enter circulation. Cancer cells are also removed on a regular basis when our immune systems are healthy.

Magnesium deficiency is a topic I keep stressing because the immune cells require magnesium in order to perform the apoptosis, killing, of defective or precancerous cells. The body’s defense systems are well developed but need fuel on a daily basis in order to be able to function as nature designed. While immune cells need magnesium in order to purposefully kill defective cells by apoptosis ( an enzyme is inserted into the cell which causes it to die and then the immune cell engulfs the debris and removes it for detoxification and excretion from the body), a cell that is deficient in magnesium or calcium may also undergo apoptosis due to the deficiency. (magnesium and apoptosis)

Too little Nrf2 may reduce immune system and antioxidant health but too much can be a problem in cancer cells that grow too rapidly. (Nrf2 overproduction and cancer)

Another person writing about the recent research in the area of Nrf2 shares more information about foods that help promote Nrf2 and how nature may have built in a mechanism within some foods that help prevent an over production of the important protein (Nrf2). See: “Activate Nrf2, then optimize: Brussel Sprouts.” – Bill Lagokos (patreon) /Spoiler, if not a fan of Brussel Sprouts the healthy phytonutrient that is discussed is also found in cruciferous vegetables including cabbage, cauliflower, broccoli, kohlrabi, and kale.

I personally am more sensitive to the group, especially if served raw or in larger quantities, but find steamed kale everyday tolerable to my digestive system. The bloating effect may be due to our good guy bacteria enjoying the fiber rich vegetables so much they produce the excess gas – but it can be a sign of healthy bacteria in our digestive tract. Irritable Bowel Syndrome can be affected by any food that causes bloating effects possibly due to TRP channel’s being activated by increased pressure. People with a history of IBS and other chronic pain syndromes may be suffereing from an underlying issue with overactive TRP ion channels. IBS and TRP channels are discussed on this site in a previous post. TRP channels are discussed in more detail with links on another website: Chronic Itch, migraines, IBS and stress; – that is one part frm a longer series: Relaxation and Stress, which is continued in:  Preeclampsia & TRP Channels.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.