Average Autism and Alzheimer’s Rates Differ by Gender

Autism is more of a risk for boys than girls by a factor of four boys for every one girl or three boys for every one girl diagnosed with autism depending on the type of study and diagnostic criteria. There is some speculation that autism in girls presents with less obvious symptoms than in boys. Girls with autism may have less repetitive behavior and be able to fit in socially better than boys with autism and may have less obvious focus on one main topic of interest. (1)

At the other end of the age spectrum females have a greater rate of Alzheimer’s Disease than males. (13)

The difference has been shown to be significant, not just a difference in diagnostic criteria. Estrogen is a female hormone that may be protecting girls from the risk of developing autism but then in menopause is no longer protecting older females from the risk of developing Alzheimer’s Disease. Patients with Autism and Alzheimer’s have been shown to have a tendency to have increased amounts of protein clusters (amyloid beta) in the brain which in normal health would be cleared away. An animal based study found a genetic strain of mice with a clear gender and age difference. Young male mice developed autism like symptoms and older female mice developed Alzheimer’s like symptoms.

A different study found a gender difference in the amount of a protective protein (ADNP) in young male mice with autism like symptoms and older female mice with Alzheimer’s like symptoms. (6) Complete lack of the protective protein leads to very early death with neural tube defects in animal studies.  (7) The neuroprotective protein (ADNP) seems to promote autophagy (our body’s recycling method, it makes us more energy efficient and helps detoxify/remove old cells or material such as the beta-amyloid protein for reuse, read more:  14) and the deficit of it may also be involved in schizophrenia. (8) The protein is involved with control of the dendritic branching of brain cells which is typically found to be  different in children with autism. The protein also plays a role in regulating over 400 genes involved in embryo development including ApoE and the tau protein which is found to collect in the brains of patients with Alzheimer’s Disease in addition to beta-amyloid protein. (9)

The role of apoE involves membranes, cholesterol, cannabinoid receptors and lipid rafts – chemistry geeks have fun, three dimensional drawings and a discussion of cholesterol within the brain and its role in several neurodegenerative diseases is available online in full text, the brain includes 25% of the body’s cholesterol even though the brain only accounts for 2% of the total body weight, on average. (10).  A briefer description of the role apoE plays in the brain and with estrogen and Alzheimer’s risk is available with a discussion of the gene differences that are known to increase but not guarantee risk of developing Alzheimer’s Disease. (11)

Disclosure: a genetic screening suggests I do have one of the higher risk differences in the ApoE gene. (rs2254958)

Strategies to help increase autophagy may help reverse some of the risk factors associated with reduced ApoE/reduced ADNP levels –

  1. vigorous exercise,
  2. a ketosis promoting, low carbohydrate diet, regularly or occasionally,
  3. fasting for a day or a partial day occasionally. (14)

The activity of the apoE protein on other genes can be affected by cannabinoids, too little cannabinoids may be a problem or too much.

The take home point – magnesium and adequate cannabinoids seem to be involved in helping clear the protein clusters during normal health.

  • Nutritional strategies recommended to help prevent Alzheimer’s disease include increasing intake of magnesium. Research has found that low levels of magnesium promoted build up of  beta amyloid protein while high levels of magnesium promoted breakdown of the misshapen proteins.

“Lab studies show that magnesium modulates enzymes involved in amyloid beta production; at low levels, magnesium favors amyloid beta buildup, while at higher levels it favors amyloid beta breakdown.101,102″ [2]  (from a  2014 post)

Certain genetic conditions and chronic health conditions or older age can make the body less able to make cannabinoids endogenously/internally. External sources of cannabinoids have been shown to be helpful for clearing the protein clusters involved in Alzheimer’s Disease. (https://www.sciencedaily.com/releases/2016/06/160629095609.htm)

An underlying infection with bacteria or yeast may be involved in the buildup of the protein clusters as they have a protective effect against some types of infection, so addressing low grade chronic infection may be needed to help stop the over production of the amyloid beta protein clusters in addition to providing adequate magnesium and cannabinoids. Note that there are non-euphoric cannabinoids and legal food sources in addition to medical marijuana. Pumpkin seeds are a good source, $200 billion per year is estimated to be spent on Alzheimer’s care annually at our current rate of the disease prevalence – that would buy a lot of pumpkin seeds. (15 )

That article also mentions that 192 pharmaceutical chemicals have been anticipated and tested in hope of a cure or effective treatment for Alzheimer’s Disease but which have ultimately not been found to be successful. One hundred and ninety two chemicals tested, one hundred and ninety two chemicals found ineffective – magnesium and cannabinoids however have been found effective at helping the body to naturally break down the tau and  beta-amyloid protein clumps that lead to brain damage and later symptoms of dementia in Alzheimer’s Disease and a few other neurological conditions including traumatic brain injuries and autism. (15 ) (links re tau/amyloid in autism & Alzheimers) (links re tau/amyloid protein in traumatic brain injury)

Ibuprofen is a pharmaceutical that is no longer covered by a patent and it has been found to be beneficial in protecting against Alzheimer’s Disease (link: 16) and the underlying reason is likely that ibuprofen prevents the break down of cannabinoids (17)(Search term: “ibuprofen prevents break down of cannabinoids”) – but you need cannabinoids first and some people might no longer be able to make them after a certain age or state of health or may never have been able to make them as well due to genetic differences.

So celebrate protecting your brain today by eating pumpkin seeds, cardamom spice, the herb rosemary, chocolate, or leafy green vegetables. – and the brightly colored tiny inner part of a piece of corn that you can see when eating corn on the cob is also a good source.

  • The misshapen tau/amyloid-beta proteins have a protective effect against bacteria and the yeast Candida albicans so a chronic lowgrade infection may be an underlying cause of the accumulation of beta amyloid placques. [3] [4] (from a  2014 post)

There are many more legal food sources of cannabinoids or a precursor available, a longer list is included below. The progression of Alzheimer’s Disease can take twenty years before symptoms are obvious, so getting an early start on protecting against the tau/beta-amyloid protein build-up makes sense to me (Disclosure, I have a direct family history of the disease in older relatives and a genetic screening suggests that I am more at risk, so I am biased towards preventing the disease in my own brain or other family members.)

Phospholipids are part of cannabinoids and other phosphorus containing nutrients are important in energy production. The phospholipids and cannabinoids are important for the health and function of skin and other membranes lining cells and organs, and/or if you care more about having a good hair day than whether you might get Alzheimer’s Disease in several decades, then the phospholipids are also important for hair growth: *The phospholipid mixture in this animal-based study was applied on the skin surface for hair loss associated with inflammatory skin dermatitis: (18)

(Additional Discloure: I am also genetically at risk for Male Pattern Baldness which became visibly apparent when my autoimmune disease was more severe, however with my switch to phospholipid rich foods my hair has since grown back and my autoimmune condition is in remission as long as I continue with my new health habits).

Other nutrients including the B vitamins, vitamin E, and zinc are also important for healthy hair growth (read more) but many of the following list would also be good sources of B vitamins, vitamin E, zinc and other trace minerals and essential omega 3 and omega 6 fatty acids. Pumpkin seeds are a good vegetarian source of zinc, otherwise the mineral is more commonly available in meats.

  • Food Sources of Phospholipids and other phospho-nutrients: Hemp seed kernels and oil; Artemisia turanica/wormwood leaf; amaranth seed; asparagus; avocado fruit or the inner kernel, dried and powdered; beans/legumes; cardamom seeds and powder; carrots; celery stalks and leaves; cocoa beans and cocoa powder, baker’s chocolate, dark chocolate and to a lesser amount milk chocolate and chocolate syrup; coconut; cumin seed/powder; fennel seed, flax seed, pine nuts; sesame seeds, pumpkin seed kernels, squash seeds; butternut squash and pumpkin; gingko leaf; grapefruit and orange juice with the pulp; Jerusalem artichoke (this is a root vegetable rather than a green artichoke); lettuce, spinach and mustard leaves and other leafy green vegetables and herbs; nuts/peanuts, cashews, walnuts; oats; okra seeds; onion root, leek leaves, garlic;  parsnip root; pomegranate seeds and pomegranate peel extract;rice, white or brown but the bran is the best source; rosemary; sorghum;  sweet potato or yam; buckwheat (a seed botanically that is not wheat and is gluten free); wheat. (G.26)

That topic took a walk around the block and picked some daisies along the way but the important message might be that eating well and exercising regularly may promote healthy hair, a fit body right now while helping maintain healthy brain function into the future. Genetic susceptibility may be involved in the rate of young males with autism and older females with autism and prevention might include more magnesium and phospholipid rich foods in the diet with a diet that is moderate in carbohydrates and regular vigorous exercise to promote autophagy to help promote the natural recycling of tau and beta-amyloid protein that tends to accumulate in the brains of people with autism and Alzheimer’s Disease. Lack of ADNP protein may lead to lack of ApoE or a genetic difference may cause reduced ApoE and the deficiency may lead to a reduced level of autophagy.

Fasting for a day or partial day occasionally or a low carbohydrate diet, even just a diet balance as low as 30% of calories, and vigorous exercise are three natural ways that may help promote autophagy – our body’s natural method for removing and reusing old cellular material. (14) Those strategies might help a woman with Alzheimer’s risk but for an infant or toddler may need to be adapted to simply allowing vigorous, safe play, and a diet that with a greater percentage of healthy fats than average. The list of phosphonutrient rich foods are generally healthy and safe for prenatal diets or other stages of life and would likely promote a fit body and healthy hair for a person of any age and gender – and what is good for the hair is good for other membranes throughout the body and is also good for the brain. The hair is a protein that is a modified form of skin tissue and so is fingernail protein – beauty is more than skin deep.

Some daisies.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes. Thanks.

  1. Sarah Deweerdt,  Estimate of autism’s sex ratio reaches new low, April 27, 2017,  spectrumnews.org https://www.spectrumnews.org/news/estimate-autisms-sex-ratio-reaches-new-low/ 
  2. Liam Hawkins, Nutritional Strategies and Alzheimers, March 2013 lifeextension.com, http://www.lifeextension.com/magazine/2013/3/Nutritional-Strategies-to-Combat-Alzheimers/Page-02
  3. Lisa Conrick, What is Causing Beta-Amyloid Production in Alzheimer’s and Autism?, Oct. 23, 2012, ageofautism.com, http://www.ageofautism.com/2012/10/what-is-causing-beta-amyloid-production-in-alzheimers-and-autism.html
  4. Molnar Mark, Alzheimer’s Disease Emerging Role of Infection,  http://miklossy.ch/
  5. Why women have more Alzheimer’s disease than men: gender and mitochondrial toxicity of amyloid-beta peptide. J Alzheimers Dis. 2010;20 Suppl 2:S527-33. https://www.ncbi.nlm.nih.gov/pubmed/20442496
  6. Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer’s pathologies. Transl Psychiatry. 2015 Feb 3;5:e501. https://www.ncbi.nlm.nih.gov/pubmed/25646590
  7. Shmuel Mandel, Gideon RechaviIllana Gozes, Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis. Developmental Biology, Volume 303, Issue 2, 15 March 2007, Pages 814-824. https://www.sciencedirect.com/science/article/pii/S0012160606013960

  8. Shlomo Sragovich, Avia Merenlender‐Wagner, Illana Gozes, ADNP Plays a Key Role in Autophagy: From Autism to Schizophrenia and Alzheimer’s Disease. BioassaysVolume39, Issue 11, November 2017, Pages 1700054 https://onlinelibrary.wiley.com/doi/pdf/10.1002/bies.201700054

  9. Gozes Illana, (2015) Activity-dependent neuroprotective protein (ADNP): from autism to Alzheimer’s disease. SpringerPlus. 4. L37. 10.1186/2193-1801-4-S1-L37.  https://www.researchgate.net/publication/282802744_Activity-dependent_neuroprotective_protein_ADNP_from_autism_to_Alzheimer’s_disease
  10. M Maccarrone, G Bernardi, A Finazzi Agrò, and D Centonze, Review: Cannabinoid receptor signalling in neurodegenerative diseases: a potential role for membrane fluidity disturbance. British Journal of
    Pharmacology, Themed Issue: Cannabinoids in Biology and Medicine, Part I, Nov. 16, 2010. http://files.iowamedicalmarijuana.org/petition/2012/bjp-aug-2011-1379-1390.pdf
  11. Hilary Lampers, ND, 5 Reasons to Know Your APOE:  Understanding Your Alzheimer’s Disease Risk. June 13, 2016 thenatpath.com
  12. http://thenatpath.com/body/5-reasons-to-know-your-apoe/
  13. Maxwell A. Ruby, Daniel K. Nomura, Carolyn S. S. Hudak, Lara M. Mangravite, Sally Chiu, John E. Casida, and Ronald M. Krauss, Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38): 14561–14566. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567196/

  14. Nick English, Autophagy: The Science-Backed Way to Cleanse Your Body, July 4, 2016, greatist.com, https://greatist.com/live/autophagy-fasting-exercise
  15. Stuart W Titus, PhD, Dr. Titus’ Insights: Alzheimer’s Research and the Work of Dr. Schubert, Aug. 5, 2016, medicalmarijuanainc.com,  https://www.medicalmarijuanainc.com/dr-titus-insights-alzheimers-research-work-dr-schubert/
  16.  Neuroscientists say daily ibuprofen can prevent Alzheimer’s disease., March 26, 2018, sciencedaily.com,   https://www.sciencedaily.com/releases/2018/03/180326140239.htm

  17. K. D. Rainsford, IbuprofenDiscovery, Development and Therapeutics. 
    John Wiley & Sons, June 25, 2015, page 134, https://books.google.com/books?id=CAcLCgAAQBAJ&pg=PA134&lpg=PA134&dq=ibuprofen+prevents+break+down+of+cannabinoids&source=bl&ots=oJ_cjSrWXr&sig=yQgwSrdZOkA1MNDkbf7EF7waItY&hl=en&sa=X&ved=0ahUKEwjf7ZKPrcnaAhVlneAKHeDyAuAQ6AEIlQEwCA#v=onepage&q=ibuprofen%20prevents%20break%20down%20of%20cannabinoids&f=false
  18. Seong-Hyun Choi, Jeong-Su Moon, Byung-Suk Jeon, Yeon-Jeong Jeon, Byung-Il Yoon, and Chang-Jin Lim, Hair Growth Promoting Potential of Phospholipids Purified from Porcine Lung Tissues. Biomol Ther (Seoul). 2015 Mar; 23(2): 174–179. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354319/
  19. ADNP related syndrome FTNW, *lack of ADNP genetically leads to reduced muscle tone and can cause eating problems in children. https://www.rarechromo.org/media/information/Chromosome%2020/ADNP%20related%20syndrome%20FTNW.pdf

Cannabinoids and Alzheimer’s Disease

I woke up to an odd dream and it left me thinking, huh? I haven’t t dreamed much in years because of nutrient deficiencies but I increased my use of some supplements I need due to genetics and have had a few dreams again. They are fun even if they don’t mean anything but it may be a way for the subconscious to put together bits of information that the conscious mind hadn’t noticed.

Dreaming is diminished when B vitamin deficiencies are a problem particularly vitamin B6 which can be a problem with some genetic conditions. I’ve been taking my vitamins regularly though and it is always fun to dream after having many years without any memory of dreams. Wondering what the mind was thinking can be fun even if just a guessing game.

It was just a fragment, chatting with another nutrition professional as we were waiting for a nutrition conference to begin – but first a calvacade of 200 different car companies showing their latest and greatest or most classic, I don’t know, we hadn’t seen them yet – the feeling or comment from the other nutritionist was why is this happening here? My answer as I awoke besides, odd, was that we all need fuel to keep going, and a variety of types of fuel.  This was an educational metaphor that worked well with adults or children – you need fuel to keep your body going just like your car needs gasoline.

Background, I’m driving a loaner car which is brand new, full of brand new volatile chemical car smell, while my car’s rusty transmission is being replaced. Turns out cars not only need gasoline and windshield wiper fluid and radiator fluid they also need transmission fluid that isn’t full of rust – good to know.

The body needs carbohydrates, proteins, fats, vitamins, trace minerals, and phospholipids and many other chemicals that can be made within the body if it is well-nourished and has average genetic and youthful abilities. That is a lot to expect from a body and a nutritionist can be a helpful expert to have on your team in addition to your automechanic experts.

It is 420 day – a typical day in some circles to discuss or celebrate cannabinoids – so some celebratory news – cannabinoids have been shown to help breakdown the clumps of protein that lead to Alzheimer’s Disease – and the good news from my research for everyone who prefers to keep their distance from cannabis/marijuana itself is that cannabinoids are part of cell membranes and can be found in many foods in small quantities and in a few foods in larger quantities. https://www.medicalmarijuanainc.com/dr-titus-insights-alzheimers-research-work-dr-schubert/ – search term 200 found this article which includes the number $200 billion is spent on Alzheimer’s Disease care every year. That would buy a lot of pumpkin seeds.

The article includes the number 192 – the number of pharmaceutical chemicals that have been anticipated and tested in hope of a cure or effective treatment for Alzheimer’s Disease that have ultimately not been successful. One hundred and ninety two chemicals tested, one hundred and ninety two chemicals found ineffective – cannabinoids however have been found effective at helping the body to naturally break down the tau and  beta-amyloid protein clumps that lead to brain damage and later symptoms of dementia in Alzheimer’s Disease and a few other neurological conditions including traumatic brain injuries and autism. (links re tau/amyloid in autism & Alzheimers) (links re tau/amyloid protein in traumatic brain injury)

So I personally don’t want to wait for number 193, 194, 195, 196, 197, 199 and 200 in hopes that a patent protected chemical treatment can be found to substitute for our body’s natural abilities – I would rather eat pumpkin seeds and other phospholipid rich foods today. Ibuprofen is a pharmaceutical that is no longer covered by a patent and it has been found to be beneficial in protecting against Alzheimer’s Disease (link: https://www.sciencedaily.com/releases/2018/03/180326140239.htm) and the underlying reason is likely that ibuprofen prevents the break down of cannabinoids (book excerpt)(a variety of links) – but you need cannabinoids first and some people might no longer be able to make them after a certain age or state of health or may never have been able to make them as well due to genetic differences.

So celebrate protecting your brain today by eating pumpkin seeds, cardamom spice, Rosemary, chocolate, or leafy green vegetables. – the brightly colored tiny inner part of a piece of corn that you can see when eating corn on the cob is also a good source.

Another source of a variety of beneficial phytonutrients that we tend to discard instead of eating is the white part around oranges and grapefruit – don’t worry about trimming it all away because it is good for us and mild in flavor. The tougher peel also has beneficial nutrients but it is strongly flavored and can be used in tiny amounts to add a lemony flavor to foods, either freshly grated as lemon or orange zest, or it can be purchased in Middle Eastern grocery markets as powdered dried lemon or lime (Citron vert Seche moulu or Limon seco molido, or Arabic, see example). For maximal flavor add the dried lemon or lime after cooking at the table. The flavor rich terpenes that give the lemony flavor can be effected by long cooking times. The boiling point of limonene is 348.8°F.

Disclosure: This information is being provided for educational purposes within the guidelines of Fair Use. While I am a Registered Dietitian is is not intended to provide individualized health care guidance. Please seek an individual health care professional for the purpose of individualized health care guidance. Thanks.

Distractions from nutrition – a timeline

Goals for the chronically ill often are different than for those who enjoy typical health – avoiding a cold is less difficult than avoiding increased inflammation that can lead to an inability to digest food, or to heal small wounds, or to grow skin in areas where skin cells are replaced on a weekly basis such as in mucous membranes of the nose or mouth or in the ear canal. Those rapidly growing areas represent all of the lining of the intestinal tract. If your skin isn’t healing well from minor scrapes and you have frequent nose bleeds then likely your entire digestive tract isn’t in good shape either. Cells are replaced throughout the body on a regular basis but some areas have a longer life cycle for the replacement than other areas.

(Non-healing sores may be more common in autoimmune condition Lupus, patient forum, may also occur with vasculitis – migraines may involve vasculitis. Patient forums for people with odd diseases can be comforting if only to let them know they aren’t alone. Sunlight exposure can make Lupus worse or be a trigger for some types of vasculitis sores.  The patient forum tips also included a warning not to use petroleum jelly (Vasoline TM) within the nasal passages as it can increase risk for a type of lung infection. Coconut oil was recommended by another forum comment and is the active ingredient in a product that I’ve found helpful for moistening the dry scabby tissue – pain is the common complaint along with bleeding or seeping plasma from the sore tissue. Applying tiny amount within the nasal passage or ear area is not easy but pain is unpleasant. /(After reading the patient forum tips I’ve switched to plain coconut oil as was suggested and it does seem more healing than the thicker chapstick which likely contains some waxes in addition to coconut oil. While a humid, moist air quality is helpful I’ve also found that clean air is important, smoke or smog like air made the skin condition worse whether there was a humidifier or not.)/

I’ve also found relief after a magnesium sulfate/Epsom salt bath and the dryness is reduced with adequate humidity in the air. A damp towel hung near a heating vent can help add humidity to a closed small room if a commercial humidifier isn’t available or seems inadequate. Commercial humidifiers should be cleaned with bleach water or another sanitizing agent occasionally or they may be adding mold or other infectious pathogens to the air – the damp towel dries each night and needs to be remoistened and simply washed occasionally as it doesn’t really get dirty or mold because it doesn’t stay damp. Mold and pathogens can grow on the commercial humidifiers because they tend to always retain some moisture in portions of the machinery. )

Not having a severe headache, migraine pain, and being able to breathe through both nostrils at the same time due to frequent congestion problems are also part of my good days versus bad days. Severe exhaustion and just having the energy to get dressed can be a limiting factor for a day’s goals to get anything else accomplished. Chronic illness is becoming more common rather than less common and how to help prevent or manage it is something that nutrition can help in ways that a bottle of medication can’t because the cell repair throughout the body needs many trace nutrients, vitamins and minerals, and an adequate amount and variety of protein and essential fats and carbohydrates – every day, throughout the day.

Strolling through the distractions used to suggest my concerns about nutrition are unfounded simply reveal the accuracy. (More on the “Weaponization of Social Media” by the U.S. and others) My providing free information is simply in the hope that it might be helpful to someone. I will be fine because I’ve found the research and am using it for my own benefit. Living in a desert is not something that my health can handle however and has never been my goal. The advantage of a virtual world is that if twenty readers find my information valuable then they can benefit from it wherever they are sitting and don’t need me to be present or to be living in a desert area.

Do your own research or find a health care practitioner that is trained in nutrition to help guide you if you are interested in taking better care of yourself now rather than waiting for worse chronic illness or brain degeneration. You could be one of the twenty readers who are interested or not, life is full of choice but consider whether you are choosing for yourself or whether you are accepting society’s Darwin Award of chronic illness via modern lifestyle. The United States is becoming one of the most unhealthy countries on average. Qatar is leading the group too but only since the decades since switching to a modern lifestyle and dietary habits.  (20% diabetes rate in Qatar)(Magnesium deficiency causes insulin resistance)

Supporting big business profit goals is noble but so is survival of the ecosystem over the next thousand years – if we make it through the next one hundred I have hope that we will have figured out more sustainable ways to produce energy and use renewable agricultural methods and that we will survive the next thousand – we are at a turning point where pretending the status quo is working is no longer helpful and is harmful even over the short term.

  1. Obsessive about vitamin D, must be crazy – no my recommendation to not take excessive vitamin D and calcium supplements as it is not a sure way to protect against bone fracture risk and may be harmful, has been since supported by research and is now the standard recommendation. My initial recommendation was in February 2011, this update is December 2017:  https://www.acsh.org/news/2017/12/27/calcium-and-vitamin-d-supplements-still-do-not-prevent-fractures-12329
  2. Some people may truly have low vitamin and hormone D levels while others may have a condition that causes the inactive vitamin D level to be low while the active hormone D level is elevated and likely causing an elevation or tendency to elevation of the body’s calcium levels through increased absorption and decreased excretion and which also leads decreased magnesium absorption and increased magnesium excretion as the minerals are kind of a team. In ancient times magnesium was very plentiful in the water and food supply while calcium is rare so our evolutionary physiology tipped towards conserving calcium and wasting magnesium. Ideally simply ask to have both your inactive vitamin D level (25-D) and your active (1-25-D) hormone D levels to be tested but the current treatment and research recommendations generally just test the less expensive measurement of 25-D. Sarcoidosis, HIV, tuberculosis, Rheumatoid Arthritis are some examples of diseases that may have altered balances of 25-D and 1-25-D. The metabolism of vitamin D is complicated and the commonly used herbicide Roundup which contains glyphosate may be inhibiting the CYP enzymes that are needed to make the active form of hormone D from the inactive form or to make the inactive form with sunshine. This is not a widely accepted theory yet (more on the topic in a previous post) but my own health is better for having reduced my intake of foods that may contain glyphosate and by adding a powdered form of the amino acid glycine to my daily routine. I added the supplemental powder when I had a genetic screening performed that revealed a double gene difference in my ability to digest larger proteins down to the individual glycine. It has active roles within the brain which can help reduce anxiety as well as performing other functions and my health has been much improved. Glyphosate is only one methyl group (-OH, one atom of oxygen and one of hydrogen) different from glycine. (more on glycine & glyphosate in this previous post) Inhibition of CYP enzymes might also increase risk of pancreas problems and diabetes and may play a role in risk of developing autism but it isn’t the only chemical that is likely involved and deficiency of vitamin D is likely not the only nutrient deficiency involved – (more on that in this post.)  By the way, I’m looking for a particular link and just haven’t found it yet – please be patient. Still looking but here is a post with some dietary guidance for prenatal or other people interested in reducing intake of foods that may contain glyphosate: (Self care for prenatal care, part one) Okay I found it, see link [page 19, 1] “Other pathogens that have been shown to reduce the activity of the Vitamin D Receptor, in addition to the pathogen that causes Tuberculosis, include the mold Aspergillus, the viruses that cause Epstein-Barr chronic fatigue syndrome and HIV/AIDS, and the autoimmune diseases sarcoidosis, Crohn’s Disease, and Rheumatoid Arthritis. Elevated levels of 1, 25(OH)2D are seen with the bacterial infections: “Elevated 1,25(OH)2D appears to be evidence of a disabled immune system’s attempt to activate the VDR to combat infection.” [page 19, 1]”  an excerpt from post: [http://transcendingsquare.com/2015/08/11/whether-to-be-compliant-or-to-be-healthy-seems-like-an-easy-question-to-answer/]” which I included in (Preventing autism perinatally – before conception) Newborn umbilical cord samples which are already collected could be tested for more chemicals in order to help identify which infants are likely to be more at risk for developing autism – I would be because of my genetic difference in my ability to digest protein down to the individual amino acid glycine. A researcher found 15 lab test biomarkers/chemicals in common and to save money organized them into three groups – if an infant has the first five, then pay for the screening of the second set of five and if the infant also has those differences then screen for the last set of three chemicals. If all fifteen or most of the fifteen are different than average than the infant may need dietary modifications to help with special methyl forms of B vitamins or supplements of glycine or methionine or help with detoxifying heavy metals for example. See (Newborn Sceening for Autism – 3 sets of 5 potential biomarkers) As an overview and update I will add a link to an article about a recent review of research on the finding that low vitamin D levels are associated with increased risk for many types of cancer – but – excess levels of vitamin D don’t help protect even more than adequate or good levels. Some nutrients and chemicals are safe at elevated levels because they are excreted easily while others are safe and helpful in a -U- shape, too little or too much can be unsafe to health. Vitamin D when activated to the hormone can help control our own immune system’s ability to make antibiotic type chemicals of our own – all day, everyday as long as the nutrient building blocks are available. Too much or too little vitamin/hormone D can increase risk of cancer or of autoimmune disease.
  3. This isn’t about “I told you so” it is about our government or some other agent actively preventing helpful information from being shared. I will keep sharing information that can be helpful because I know how much pain hurts and some chronic degeneration of body and brain function can not be reversed it can only be prevented – seeing your loved ones and having them not remember basic facts about themselves or their family members hurts emotionally – having them forget how to be able to swallow food hurts them physically unless caregivers to spoon feed them can be afforded or are available within the family. You may have to physically massage their throat to help stimulate a swallow reflex, simply putting the spoon in the mouth may not be enough to stimulate a swallow reflex in end stage Alzheimer’s Disease.
  4. Magnesium matters – and Epsom salt baths or foot-soaks (about one cup magnseium sulfate salt to a half bath for 20 minutes every 3 to 4 days or half cup in a tub of water for a 20-40 minute footsoak) can be a better absorbed method – this is now supported by research. It may also help protect against and reverse early stages of Alzheimer’s  Disease. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182554/
  5. Symptoms of magnesium deficiency can include mood changes such as depression, anxiety, or anger and irritability and physical symptoms such as muscle cramps, eye twitches, or dry eye. https://www.healingtheeye.com/dry_eye.html
  6. Magnesium is nature’s method for blocking calcium channels – and it doesn’t cause the potential side effects that pharmaceuticals may cause (PPIs such as Pprilosec, Nexium and Prevacid.) http://transcendingsquare.com/2015/10/18/magnesium-deficiency-can-cause-irritability-anxiety-and-chronic-degeneration/
  7. Iodine is an essential nutrient for a healthy weight and appetite for adults and infants and moderate deficiency during pregnancy may be an under lying cause of later development of autism. For some reason I can’t imagine the U.S. nutrient database for iodine content was deleted some point in time between when I first started writing about it in 2010/2011 and now. I keep checking in the hope that the information has been restored – but that day isn’t today: https://ndb.nal.usda.gov/ndb/nutrients/index
  8. Zinc, B12 and vitamin D deficiency can mimic symptoms of schizophrenia which is a mental disorder where the brain isn’t recognizing the person’s own subvocal thoughts and mutterings. Treating with psychiatric drugs or only one of the missing nutrients wouldn’t cure the person of the symptoms if multiple nutrient deficiencies were the cause.  Low thyroid levels may also be a risk factor and elevated C-reactive protein or an elevated copper to zinc ratio may also be a factor. http://transcendingsquare.com/2016/03/19/the-voices-that-people-with-schizophrenia-are-hearing-are-probably-their-own-inner-thoughts/
  9. Calcium or vitamin D deficiency can cause hyperparathyroidism which can cause disoriented thinking and may cause self injury or suicidal urges. http://transcendingsquare.com/2016/04/23/self-injurious-behavior-in-autism-patients-with-low-calcium-levels/

That’s the short list.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.