Tag Archives: ALS

Mitochondria, P53, cancer and magnesium deficiency

Addition, 7/21/16, there is more information about mitochondria and chronic illness at this link: https://www.sott.net/article/321987-Thanks-Big-Pharma-for-the-Mitochondrial-collateral-damage, the site also has a few other articles on the topic which I haven’t read yet and the topic of magnesium doesn’t come up until you reach the comment that I added. I will have to read more about this topic. Medications that cause an imbalance in calcium and magnesium could be causing stress to the mitochondria and lead to their death and to chronic illness.

  • This article is short introducing a long video. A quote from the short text does mention nutrient deficiencies can be involved, “Nutrient deficiencies are a contributing factor to mitochondrial dysfunction. ” https://www.sott.net/article/308212-Mitochondrial-dysfunction-GMOs-Glyphosate Glyphosate  Inhibition of vitamin D metabolism could lead to magnesium and  calcium imbalance which could be stressing mitochhondria and lead to chronic illness.
  • An abstract with a link to the full text: https://www.sott.net/article/264786-Oxidative-stress-mitochondrial-damage-and-neurodegenerative-diseases
  • https://www.sott.net/article/294075-Fibromyalgia-as-a-mitochondrial-disorder
  • I haven’t watched the video or read all of the articles yet but fibromyalgia is what I had symptoms of that were bad enough to lead to my giving up wheat and gluten products initially. It simply hurt too much when I ate them. And I got better without gluten. Maybe it was the gluten or maybe my genetics with errors in the vitamin D metabolism. I will have to get back to this topic but I share the information now because pain hurts and if even one person is helped then I would be glad. *And I was a professional gourmet baker, I know how to make from scratch croissant, and French baguettes and loaf breads of many types as well as cookies and quick breads. I love wheat products but they didn’t love my body.

A comment of mine that is awaiting moderation posted on another site:

Mitochondria need lots of magnesium (and magnesium is also necessary for white blood cells to be able to perform apoptosis.) “Additionally, exposure to low Mg upregulated plasminogen activator inhibitor-1 (PAI-1) [24]. PAI-1 is considered not merely a marker of senescence, since it is both necessary and sufficient for the induction of replicative senescence downstream of p53 [27].” by D. Killilea and J. Maier, “A connection between magnesium deficiency and aging: new insights from cellular studies” Magnes Res. 2008 Jun; 21(2): 77–82. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790427/ Please U. of Penn. researchers, look into preventing cancer by providing mitochondria with a healthy diet instead of by providing them with some sort of pharmaceutical designed to manipulate P53 — just prevent P53 from being induced by providing adequate magnesium to the cells. Thanks.

The comment is in response to this article which is about recent animal based research that suggests that a cell’s mitochondria when under stress may produce a chemical (P53) that may lead to cancer: http://scienmag.com/penn-team-finds-mitochondrial-stress-induces-cancer-related-metabolic-shifts/#comment-7188

Now I know mitochondria need a lot of magnesium so one search led to the link in the comment and ~391,000 other links, https://www.google.com/webhp?sourceid=chrome-instant&ion=1&espv=2&ie=UTF-8#q=mitochondrial+stress+P53+calcium+magnesium, including this one:

by Giorgi C., et. al., “p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner” PNAS, Feb. 10, 2015, vol. 112, no. 6, pp 1779–1784. http://www.pnas.org/content/112/6/1779.full.pdf

Apoptosis is the method by which white blood cells are able to kill infected or malfunctioning or old cells. Calcium and magnesium are both electrically active and can both act as signals to promote different types of cellular actions. Magnesium is most active within cellular fluid and calcium entry into cells is limited in part by ion channels that are powered by magnesium. So a magnesium deficient cell can allow too much calcium to enter the cell and within the cell calcium can cause a variety of actions and can even over activate the cell to the point of cell death. (155,000 search results for “excess calcium overworks mitochondria” :   https://www.google.com/webhp?sourceid=chrome-instant&ion=1&espv=2&ie=UTF-8#q=excess%20calcium%20overworks%20mitochondria  and which includes a link about the nerve degeneration disease ALS: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933290/  so it looks like if I want to protect myself from cancer or ALS I should not stress out my mitochondria by maintaining a good intake and internal balance of both magnesium and calcium.)

Another addition to look into more at some point – P53 and apoptosis has been found to be affeected by treatment with a homeopathic preparation (which would be a completely non-toxic energy based treatment. http://www.jcimjournal.com/articles/publishArticles/pdf/S2095-4964(16)60230-3.pdf

/Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes./

Actually we do know quite a bit about ALS

The Life Extension Foundation is a non-profit organization focused on research into preventative health strategies. The company does sell supplements, books, and a few other products but it also helps fund research in preventative health care. The foundation publishes an academic type journal and an article from the journal is available on their website which provides a review of the current theories and research available regarding Amyotrophic Lateral Sclerosis (ALS). [1]

The article ends with a quote or two about the limited effectiveness and negative side effects associated with the medication that is currently prescribed for ALS patients. The sad point is that at least then the doctor can feel like they provided a service by writing a prescription but if it doesn’t really help slow progress of the disease and adds negative side effects then is that prescribing doctor really “Doing no harm.”?

The article doesn’t provide vitamin or supplement recommendations or provide other preventative guidance. It is a review of current research which did provide enough information to suggest to me several strategies that might help me reduce my risk of developing ALS. I’m motivated because I fall into one of the ‘you may be at more risk for ALS if you also have this condition’ categories.

Studies suggest that ALS is more associated with some autoimmune and chronic infectious diseases and with some nutrient deficiencies or imbalances and with exposure to some environmental toxins.

A few points gleaned from the article that might help me reduce my risk of developing ALS:

  1. Avoid mercury, lead, aluminum, manganese and other heavy metal toxins.
  2. Be careful if working with herbicides and pesticides to reduce exposure.
  3. Have adequate intake of calcium and magnesium – in balance. Excess calcium and too little magnesium may increase degenerative calcification of the central nervous system.
  4. Avoid excess intake of free glutamates. There are many sources of free glutamates in the diet as they are used as flavoring agents. MSG is one better known example. *The article doesn’t recommend avoiding glutamates, it mentions that ALS is associated with glutamate toxicity. One study found plasma levels of glutamate to be significantly elevated in ALS patients compared to controls (Plaitakis et al, 1993). One theory suggests that there may be a glutamate transport problem that allows the elevated levels to accumulate. [1] *Having adequate zinc and magnesium levels helps the cells control intracellular glutamate levels. [3], magnesium also helps control transmembrane movement of the other electrolytes: calcium, sodium and potassium. [4]
    ALS is highly linked with glutamate. One proposed mechanism is a defective glutamate transport system that permits neurotoxic levels to build up (Onion 1998). A study showed significant elevations (by about 70%) of plasma levels of glutamate in ALS patients as compared to controls (Plaitakis et al. 1993). – See more at: http://www.lifeextensionvitamins.com/amlatscleral.html#sthash.ErWUopES.d
    ALS is highly linked with glutamate. One proposed mechanism is a defective glutamate transport system that permits neurotoxic levels to build up (Onion 1998). A study showed significant elevations (by about 70%) of plasma levels of glutamate in ALS patients as compared to controls (Plaitakis et al. 1993). – See more at: http://www.lifeextensionvitamins.com/amlatscleral.html#sthash.ErWUopES.dpuf
  5. Have adequate but not excessive intake of selenium as it helps the body remove mercury. Two Brazil nuts per day provide about 200 micrograms of selenium which is the recommended daily goal. Excess selenium can cause toxicity symptoms so be careful not to take supplemental one-a-day or other mixtures that contain selenium in addition to taking selenium as an individual supplement or in addition to eating Brazil nuts regularly. Toxicity wouldn’t occur in a few days but might develop if multiple sources were eaten over a longer time period.
  6. Growth factor deficiency may be involved in development of ALS. Touch is important for stimulating human growth factor. Therapy pets and massage may also help stimulate internal production of human growth factor. *The article doesn’t mention the therapeutic benefits of touch. It only mentions that reduced growth factors are an underlying problem associated with ALS and pharmaceutical sources have been found helpful for slowing progress of the disease in some (but not all) studies. However touch can also help stimulate innate production of growth factors without needing a pharmaceutical company. [2]
  7. Spinal compression may increase risks of a similar nerve degeneration problem that can resemble ALS so /speculative/ regular exercise such as swimming might help or regular use of an inversion board at a gentle 10 degree slope might help relieve spinal pressure. /Disclosure, I do use an inversion board and find it helpful for headache and back problems but they can be dangerous so please seek individual guidance regarding their use./
  8. Some infections with long term chronic phases are associated with ALS type symptoms including Lyme’s disease, poliomyelitis, HIV/AIDs, and tertiary syphilis.
  9. Some endocrine and autoimmune diseases such as the hyperthyroid condition Grave’s disease and  Diabetic Amyotrophy are associated with ALS risk. Maintaining lower thyroid levels and avoiding thyrotoxicosis may help reduce risk of developing ALS.
  10. Some other conditions associated with ALS like problems include the neurological diseases: Pick’s Disease and Kennedy’s Syndrome; and the genetic enzyme disorders: Superoxide Dismutase, Hexosaminidase A, and Alpha-Glucosidase.
  11. /Disclosure: This information is provided for educational purposes and is not intended to provide individual health guidance. Please see an health professional for individual health care purposes./
  1. Lyme disease and poliomyelitis
Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Scleros

Amyotrophic Lateral Sclerosis (ALS) and CBD receptors

The cannabinoid receptor system is involved in the control of calcium movement across the cell membrane. Calcium has an electrically active ionic form which can initiate changes within the cell fluid. During normal health a similarly electrically active ionic form of magnesium is found in greater concentration within the cell fluid and greater concentrations of the calcium ion are found within the blood plasma. The energy available from the magnesium ions is used within the cell membrane protein channels. The protein transport channels act as gates that can be opened or closed to allow calcium or other types of chemicals to flow through the channel.

The US federal listing of the cannabis herb as a schedule one drug has limited research into the role of the cannabinoid receptor system to studies about the toxic or addictive properties of cannabinoids. A schedule one drug is considered as having no medicinal value so no research would be necessary. When the cannabis plant was classified as a schedule one substance less was known about the extensive role of cannabinoids in the health of humans and many other species. Suppressing research about the cannabinoid group of chemicals and the cannabinoid receptors may have left us in the dark about the cause and cure of many mystery diseases and conditions.

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects a small percentage of the population yet it has no known cause or cure — except —  cannabinoids may help:

However, there is increasing evidence that cannabinoids and manipulation of the endocannabinoid system may have therapeutic value in ALS, in addition to other neurodegenerative conditions. Cannabinoids exert anti-glutamatergic and anti-inflammatory actions through activation of the CB(1) and CB(2) receptors, respectively. Activation of CB(1) receptors may therefore inhibit glutamate release from presynaptic nerve terminals and reduce the postsynaptic calcium influx in response to glutamate receptor stimulation. [1]