Vitamin D and Hormone D values for 2006-2010 for a female patient with autoimmune thyroid disease, born in 1966.Low levels of the vitamin can occur with even more elevated levels of the active hormone but I (the patient) experienced muscle cramps and headaches and irritability and other symptoms at levels such as 56 pg/ml in 2006 and 71 pg/ml in 2010. 71 pg/ml would have been considered elevated in 2006-2009 but then the Reference Range changed from 22-67 pg/ml to 18-78 pg/ml:
In 2006 I was taking a one-a-day supplement that contained vitamin D and had been tan that summer – and irritable. During 2007 and 2008 I was following the Marshall Protocol in the hopes that it would help my migraine problem. Which it did. I was taking Benicar and antibiotics and also avoiding vitamin D and excess sunlight. In 2009 I was no longer taking the medications and was less stringent about sunlight but I was still avoiding vitamin D foods and supplements — I was very irritable in the summer of 2006. Significant stress and poor diet was occurring during the increase in the levels seen in 2010.
From an article I wrote 2/16/2012: “In 2006 the reference range for 1, 25 dihydroxy D was 22-67 pg/mL, in 3/17/2010 it was listed as 18-78 pg/mL, and in 2012 the reference range is listed as 18-72 pg/mL. The patient case study (I’m the patient that I’m referring to) values vary from 51 pg/mL to 71 pg/mL for 1/25 dihydroxy D. The values for 25 D within the same time frame range from 8.0 ng/ml to 46 ng/ml* (*patient was taking supplements at that point in time).” The point I was trying to make is that my active hormone D level was always normal or even towards the elevated end of the normal range and that the range changed. The range for a lab value may just be based on average lab patient data gathered by the lab – average sick people seen by that lab – not average healthy people in a large national study.
2/4/2012, still avoiding vitamin D foods and supplements :
- Vitamin D 25 Hydroxy: serum 11.4 ng/ml *Low Ref. Range: 30.0 – 100.0
- Vitamin D, 1,25-Dihydroxy: serum 69 pg/mL *Normal/high Ref. Range: 18-72 (Vit D3; 1, 25 Dihydroxy: 56 pg/mL and Vit D2; 1, 25 Dihydroxy: 13 pg/mL)
The 6/15/15 lab values:
- Vitamin D, 25 – 10.9 ng/mL — normal is considered: [30.0-100.0]
- Vitamin D 1, 25 – 55 pg/mL — normal is considered: [18-72] (the active hormone D)
The 10/12/2015 lab values, after starting Benicar, 40 mg/day, on 9/23/15:
- Vitamin D, 25 — 18.4 ng/mL — normal range: [30.0-100.0]
- Vitamin D 1, 25 — 36 pg/mL — normal range: [18-72] (the active hormone D)
I have an autoimmune thyroid condition which actually involves a disorder of the bone marrow. Mislabeled bone cells can migrate to the thyroid and elsewhere in the body. The condition is similar to Rheumatoid Arthritis. [ Both conditions may involve intracellular pathogens that block the function of the vitamin D receptor. The low values seen of 25-D can be due to the body’s protective increase in activation of 25-D to the 1, 25-D form. But if a pathogen has the vitamin D receptor blocked even elevated levels of the active hormone aren’t going to help. The medication Benicar is able to bypass the pathogen’s blocking chemicals and can activate the vitamin D receptor. The medication’s typical use is as an angiotensin receptor blocker for helping reduce high blood pressure.
More information about the vitamin D receptor and Benicar is available in the following articles:
- Meg Mangin, Rebecca Sinha, and Kelly Fincher, Inflammation and vitamin D: the infection connection, Inflamm Res. 2014; 63(10): 803–819., Published online 2014 Jul 22. doi: 10.1007/s00011-014-0755-z, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160567/
- Marshall Protocol Knowledge Base: Science behind olmesartan (Benicar). http://mpkb.org/home/protocol/olmesartan
Magnesium deficiency can be a cause of irritability and it can be more of a risk with elevated hormone D levels. The active 1, 25-D at levels above 42 pg/ml signals the bones to release calcium and phosphorus from storage and signals the intestines to preferentially absorb more calcium rather than magnesium.
Epsom salt is a brand name for the alkaline salt magnesium sulfate. Soaking in mineral water has been a traditional remedy for muscle aches and other maladies. I have found it helpful for muscle cramps and restoring a good mood. Being internally irritable for no reason is unpleasant to experience and can be difficult to control — even scratchy clothing can be very annoying — at times. Soaking in an Epsom salt bath has left me feeling like singing after soaking just ten or twenty minutes after I had been feeling more like growling — or worse.
I add about a cup of Epsom salt and one teaspoon of apple cider vinegar to adjust the alkaline pH to a half tub of water and soak for twenty to thirty minutes — forty or more minutes could lead to a slowing of the heart rate and extreme relaxing of the smooth muscles (which can lead eventually to diarrhea or even coma or death — don’t fall asleep in a tub of Epsom salt bath). Epsom salt bath. Risks.
/Disclosure: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes./