Happy Independence Day! “Let freedom ring!”

Let freedom ring! – Martin Luther King, Jr. reminds us in his I Have a Dream speech to sing out for each other’s freedom.

Martin Luther King, Jr. reminds us in his I Have a Dream speech to sing out for each other’s freedom. His words still ring true today.

“I have a dream today”

  • August 28, 1963 – ‘We have come to this hallowed spot to remind America of the fierce urgency of now’
This will be the day when all of God’s children will be able to sing with a new meaning, “My country, ’tis of thee, sweet land of liberty, of thee I sing. Land where my fathers died, land of the pilgrim’s pride, from every mountainside, let freedom ring.
“And if America is to be a great nation this must become true.

So let freedom ring from the prodigious hilltops of New Hampshire. Let freedom ring from the mighty mountains of New York. Let freedom ring from the heightening Alleghenies of Pennsylvania!

Let freedom ring from the snowcapped Rockies of Colorado!

Let freedom ring from the curvaceous slopes of California!

But not only that; let freedom ring from Stone Mountain of Georgia!

Let freedom ring from Lookout Mountain of Tennessee!

Let freedom ring from every hill and molehill of Mississippi. From every mountainside, let freedom ring.

And when this happens, when we allow freedom to ring, when we let it ring from every village and every hamlet, from every state and every city, we will be able to speed up that day when all of God’s children, black men and white men, Jews and Gentiles, Protestants and Catholics, will be able to join hands and sing in the words of the old Negro spiritual, “Free at last! free at last! thank God Almighty, we are free at last!

-An excerpt from Martin Luther King, Jr’s I Have a Dream speech was included in a commemorative article in The Guardian Aug 28, 2008, which was published on the 45th anniversary of the speech.

-The line “Let freedom ring” is from the song “My Country, Tis of Thee,” also known as “America,” which was written by Samuel Francis Smith, Wikipedia.

-The lyrics to the “old Negro spiritual” referred to in the speech are thought to be from a song called “Free at Last” according to a reeply on a public Q/A forum. The lyrics are included along with the full text of Martin Luther King Jr’s speech on the forum.quoteland.com webpage.

 

“Free at last! free at last! thank God Almighty, we are free at last!”

Such a beautiful reminder to value each other and our freedom on this Independence Day, two hundred and forty one years since the first fourth of July celebration.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. 

Pre-eclampsia, oxidative stress, and Celiac sprue

Pre-eclampsia is a serious complication of pregnancy which can become life threatening to the mother and baby. High blood pressure and severe swelling of the lower legs and face are symptoms of pre-eclampsia. If the condition worsens it is called eclampsia and seizures may be the life threatening risk. The swelling can become severe enough that toxin removal by the kidneys is reduced.

What causes pre-eclampsia is not yet well understood. Providing IV solutions of magnesium sulfate just prior to delivery helps reduce risk of seizures and usually delivery of the baby causes the rest of the symptoms to resolve. However people who’ve experienced IVs of magnesium sulfate shared with me that it feels like fire running through their veins. Background information — magnesium is an electrically active mineral that during normal health is kept in a very narrow range within the blood and is largely found within the interior of cells and within the bones. Calcium is also electrically active and it is in higher concentration within the blood than within the interior of cells.

Skipping ahead, oxidative stress prenatally has been shown to be involved in pre-eclampsia and it causes an increase in calcium flow in the placenta. [1]

While looking for more information about pre-eclampsia I found a Celiac Sprue forum [2] that included questions and comments about whether anyone else with celiac gluten intolerance had also experienced pre-eclampsia or HELLP complications of pregnancy and if so any ideas why they might co-occur. HELLP is a blood coagulation problem which I didn’t look into but Celiac sprue and pre-eclampsia may be likely to co-occur because both involve oxidative stress:

Hi, I’m a dietitian with an autoimmune condition and previous work experience with prenatal health. I’ve been researching why the advice I gave when I was working helped so many women at the time worked – but isn’t in the mainstream medical treatment yet. Increasing magnesium rich foods such as beans, nuts, and seeds helped women that had a history of preeclampsia or high blood pressure to have a normal pregnancy.

In a nut shell – oxidative stress causes the placenta to increase flow of calcium. Too much calcium can cause other cellular reactions and fluid changes. And oxidative stress can be caused by gluten exposure when there is an underlying celiac autoimmune condition or probably other autoimmune conditions.

Re oxidative stress, and calcium channels in the placenta: Reactive Oxygen Species Inhibit Polycystin-2 (TRPP2) Cation Channel Activity In Term Human Syncytiotrophoblast [1]

Re Celiac Sprue and oxidative stress, “long chain omega 3 fatty acids, plant flavonoids and carotenoids” were suggested as antioxidants that may help reduce the “oxidative stress, gene expression & production of inflammatory mediators”:  Celiac disease, inflammation and oxidative damage: a nutrigenetic approach.   Carotenoids include beta-carotene from carrots. Orange, red and dark green fruits and vegetables are generally good sources of carotenoids and plant flavonoids are also found in a variety of colorful fruits and vegetables. Omega 3 fatty acids are found in fish oil supplements or salmon, tuna, sardines – limit as a mercury source however during pregnancy or child bearing years. Vegetarian sources of a precursor omega 3 fat include flax seed meal (ground is digestible, whole flax seeds aren’t really), walnuts, and hemp seed kernels.

Sesame seeds, or tahini, sesame paste, has been shown in sports research to help reduce oxidative stress. The trial subjects ate 2 tablespoons per day of the seeds. Effects of Sesame (Sesamum indicum L.) Supplementation on Creatine Kinase, Lactate Dehydrogenase, Oxidative Stress Markers, and Aerobic Capacity in Semi-Professional Soccer Players.

Dark chocolate has also been shown to be beneficial antioxidant source.

Best wishes to any Celiac sufferers – I avoid gluten due to intolerance, initially for fibromyalgia like symptoms, and later autoimmune thyroid  antibodies were found but not antibodies for Celiac Sprue.

A dietitian can help work out more balanced diets when major food items have to be excluded for health purposes. A professional organization offers a search feature for helping to find a Registered Dietitian eatright.org/find-an-expert

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One more link that didn’t make it into the comment, magnesium deficiency in combination with elevated calcium levels may be involved in increasing oxidative stress: Magnesium deficiency and oxidative stress: an update, 2016,  [3]

Who am I? What is my purpose? I am a sick person, with professional health experience, who reads and writes about sickness for my own health and for other sick people — they are the ones who realize just how valuable health is and who may appreciate information whether it has a large price tag & an expensive office — or is shared freely out of love and concern. Pain hurts.

One more link because they’re so informative, the inflammatory system seems to be connected to both pain receptors and other nerve receptors so inflammation, (which leads to oxidative stress) activates pain receptors (nociceptors) – /speculation/ which could be part of the reason fibromyalgia and other inflammatory conditions cause pain – they may simply be causing pain receptors to be over-active due to inflammation: Neurogenic Inflammation – The Peripheral Nervous System’s Role in Host Defense and Immunopathology [4]

The inflammatory process causes oxidative stress: Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. [5]

Adequate oxygen intake and flow to all the cells throughout the body is also necessary to prevent oxidative stress. Obesity can make it more difficult for oxygenated blood to reach all cells. [6]

Moderate exercise and deep breathing relaxation exercises may be helpful for improving oxygen intake and blood flow.

A previous article I wrote regarding magnesium and pre-eclampsia also includes information from a research hypothesis suggesting that intrauterine pressure itself may also be a trigger for worsening pre-eclampsia symptoms. [7] Not included in the hypothesis was why — which is likely to be due to the fact that physical (osmotic) pressure can cause TRP ion channels to open. TRP channels are a large group of specialized proteins which control flow of minerals such as calcium into the interior of cells. TRP channels include the ones that were shown to be dysregulated by oxidative stess in the placenta which allowed an increase of calcium to enter, which is described in the research article: Reactive Oxygen Species Inhibit Polycystin-2 (TRPP2) Cation Channel Activity In Term Human Syncytiotrophoblast [1]

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

  1.  https://www.researchgate.net/publication/5435874_Reactive_Oxygen_Species_Inhibit_Polycystin-2_TRPP2_Cation_Channel_Activity_In_Term_Human_Syncytiotrophoblast
  2. https://www.celiac.com/gluten-free/topic/55927-pre-eclampsia-celiac/
  3. A.A. Zheltova, et al., Magnesium deficiency and oxidative stress: an update, Biomedicine (Taipei). 2016 Dec; 6(4): 20.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112180/
  4. Isaac M. Chiu, et al., Neurogenic Inflammation – The Peripheral Nervous System’s Role in Host Defense and Immunopathology,  Nat Neurosci. 2012 Jul 26; 15(8): 1063–1067.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520068/
  5. Khansari N, Shakiba Y, Mahmoudi M., Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. Recent Pat Inflamm Allergy Drug Discov. 2009 Jan;3(1):73-80. https://www.ncbi.nlm.nih.gov/pubmed/19149749
  6. N. Netzer, Hypoxia, Oxidative Stress and Fat., Biomolecules. 2015 Jun; 5(2): 1143–1150.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496714/
  7. http://transcendingsquare.com/2011/02/19/preeclampsia-magnesium-deficiency-or-grass-staggers/

GPI anchors are cell membrane glycoproteins

Glycosylphosphatidylinositol (GPI)-anchored proteins are long and firmly embed within the membrane and leave an extension out over the surface of the membrane. One end of the protein stays embedded firmly within the cell membrane and the other end can attach to a variety of important molecules such as enzymes and antigens. The enzyme or antigen is held above the cell membrane in a position that makes it available to be activated on the cell surface.

The phosphatidylinositol end is lipid (oil or fat) based and dissolves well in the fatty acid rich environment found within the membrane. The glyco- or sugar part of the molecule is able to dissolve in water or form bonds with other proteins or carbohydrates and is found on the end of the molecule that sticks out over the surface of the membrane.

GPI anchor proteins are essential for life. Mice that were experimentally made to lack the gene thought to encode for GPI anchor proteins did not survive. Experimental “knockout” mice are usually observed to see what types of function the knocked out gene might have performed. The experiment showed that GPI anchors were necessary for basic survival of baby mice. (Ref. 1, Brooks, Dwek, Schumacher, 2002, p 225) When a protein is found to be so essential that a “knockout” mouse doesn’t survive than more minor differences are attempted to be made in order to try to find out what types of functions are changed or are missing from the more slightly modified “knockout” mice.

Background information: GPI anchors are found in some types of G-protein couple receptors and may have importance within the cannabinoid receptor system which has been found to play early and essential roles in implantation of the newly fertilized egg within the mother’s uterus.

/Disclosure: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes./

  1. Brooks SA, Dwek MV, Schumacher U., Functional and Molecular Glycobiology, (Bios, 2002, Oxford, UK)
  2. Landry Y, Niederhoffer N, Sick E, Gies JP., Heptahelical and other G-protein-coupled receptors (GPCRs) signaling., Curr Med Chem. 2006;13(1):51-63. [ncbi.nlm.nih.gov/pubmed/16457639]
  3. Maccarrone M, Bernardi G, […], and Centonze D., Cannabinoid receptor signalling in neurodegenerative diseases: a potential role for membrane fluidity disturbance., Br J Pharmacol. 2011 August; 163(7): 1379-1390 [ncbi.nlm.nih.gov/pmc/articles/PMC3165948/]

Additional note on GPI anchors:

  1. Fujita M, Kinoshita T. “GPI-anchor remodeling: potential functions of GPI-anchors in intracellular trafficking and membrane dynamics.” Biochim Biophys Acta. 2012 Aug;1821(8):1050-8. doi: 10.1016/j.bbalip.2012.01.004. Epub 2012 Jan 11.  Abstract: [http://www.ncbi.nlm.nih.gov/pubmed/22265715] “and discuss how GPI-anchors regulate protein sorting, trafficking, and dynamics.”

/Disclosure: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes./