Regarding links and research

The links I collect may include research studies that don’t seem to be directly about the point I made – sometimes research hasn’t been performed yet and I’m referring to background information in the article to which I linked or I’m drawing inferences from the research that the research authors did not include. Frequently research studies are focused on finding ways to make a medication or technique that can be patented. I am trying to figure out how normal and abnormal physiology may be affected by diet or lifestyle.

Read and live at your own risk. Medical doctors practice the provision of medicine – at least so I was informed by one medical doctor. My training was regarding diet for the lifespan in health and sickness, from perinatal/prenatal, through lactation and introduction of solid foods, to childhood and teen growth spurts through adulthood and into the typical changes in metabolism that occur with aging. Chronic disease is not a typical part of aging but a slowing down of metabolism and reduced need for total calories in combination with an increased need for protein and other trace nutrients is normal. Reduced appetite and thirst signals may also be normal so remembering to eat and drink enough can be a problem during aging.

I care a lot but there are only so many reading hours in a day.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes. Thanks.

Links on Alzheimer’s, diabetes, insulin and P38 MAPK

P38 MAPK can be activated by insulin. (1Insulin is also a growth factor; it is not just a hormone involved with sugar metabolism. Blocking Cannabinoid Receptor type 1 was found to inhibit the activation of P38 MAPK by insulin or insulin-like growth factor. (2) Malfunction of insulin’s growth factor function may be involved in Alzheimer’s Disease (3) as almost 200 pharmaceuticals designed to decrease levels of amyloid or tau protein have not been found effective for treatment of the disease in humans. (See previous post.) Mouse models may not be representative of the disease process in humans.

/Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes. Thanks./

  1. Jvotshna Kanungo, DNA-PK and P38 MAPK: A Kinase Collusion in Alzheimer’s Disease?, Brain Disord Ther. 2017; 6(2): 232. Published online 2017 May 1.    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504707/ (1)
  2. Bouaboula M, Perrachon S, Milligan L, Canat X, Rinaldi-Carmona M, Portier M, Barth F, Calandra B, Pecceu F, Lupker J, Maffrand JP, Le Fur G, Casellas P. A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions. J Biol Chem. 1997 Aug 29;272(35):22330-9. https://www.ncbi.nlm.nih.gov/pubmed/9268384 (2)
  3. What is the cause of Alzheimer’s? Scientists think insulin could hold the answer | Opinion, June 6, 2018, newsweek.com,  http://www.newsweek.com/what-cause-alzheimers-scientists-think-insulin-could-hold-answer-960752 (3)

Habits save energy, will power uses energy

In a previous post recently I briefly discussed habits and working towards change. Three weeks to build a habit is an educational message – translational research – that has been shown to be inaccurate. Newer research suggests that two months may be more realistic – an average of 66 days.

I haven’t read the original research for either recommendation however a discussion of how habits can save energy while the use of will power actually seems to deplete our energy, and can lead to less ability to stick to a plan and act impulsively, is available here: Strengthen Your Willpower by Creating New Habits, by Isaiah Hankel, Ph.D. (https://www.isaiahhankel.com/strengthen-your-willpower-by-creating-new-habits)

/Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes. Thanks./