Pomegranate polyphenols and Microglia M2 activation

The short story is that pomegranate polyphenols activate a very strong positive defense mechanism against inflammation that may be less active in autism. Read more:

Pomegranate juice polyphenols induce a phenotypic switch in macrophage polarization favoring a M2 anti-inflammatory state. (1)

“Pomegranate juice given daily for 2 years to 40 prostate cancer patients with increasing PSA levels provides evidence for the possible utilization of a nontoxic option for prevention or delay of prostate carcinogenesis. It is remarkable that 85% of patients responded to pomegranate juice in this study.” Pomegranate Ellagitannins – Herbal Medicine, (4)

(Punicagilanin and other polyphenols from a group called ellagitannins are found in the pomegranate juice and more are available when the entire fruit is used to extract juice. The bioactive phytonutrients seem to start being excreted from the body within 12 hours based on clinical studies, so a daily intake would be required for consistent benefits. Pomegranate Ellagitannins – Herbal Medicine, (4))

The long story is best left to read on a website written by a doctor who is working with research on the role of endocannabinoids in autism, how they may be involved in the risk as well as treatment for patients with the condition.

  • Read more: What Glyphosate Does To Your Brain: (2), which is a continuation of an overview on the topic of the herbicide glyphosate, autism and an endogenous cannabinoid that acts on the CB2 receptors.
  • Read more: The Autism Brain, Glyphosate, and Super-Cannabinoid Production (3)
  • Glyphosate was originally produced as an antibiotic and mineral chelator and may affect many pathways in the body due to changes to enzyme and mineral access and due to its chemical similarity to an important amino acid, glycine, which can act as a brain neurotransmitter.

So the short story is our body needs endogenous cannabinoids to protect our brain and the brains of infants from inflammatory toxins and pomegranate polyphenols may be a substitute as well as the non-euphoric cannabinoid CBD which activates the CB2 receptors.

Other foods that also may provide some natural cannabinoids or polyphenols that affect the system beneficially may include the herb Rosemary, the spice Cardamom, and unrefined cocoa bean products such as dark chocolate and Baker’s Cocoa Powder or Baking Chocolate.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

  1. Saar Aharoni, Yoni Lati, Michael Aviram, Bianca Furhman,  Pomegranate juice polyphenols induce a phenotypic switch in macrophage polarization favoring a M2 anti-inflammatory state. Biofactors, Volume 41, Issue 1, Jan/Feb 2015
    Pages 44–51  http://onlinelibrary.wiley.com/doi/10.1002/biof.1199/full (1)
  2. Christian Bogner, MD, What Glyphosate Does to Your Brain, Jan. 16, 2017, http://drbogner.com/glyphosate-vs-brain/ (2)
  3. Christian Bogner, MD, The Autism Brain, Glyphosate, and Super-Cannabinoid Production, Dec. 10, 2016, http://drbogner.com/glyphosate-autism-2/ (3)
  4. David Heber, Chapter 10: Pomegranate Ellagitannins,Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition., Benzie IFF, Wachtel-Galor S, editors. Boca Raton (FL): CRC Press/Taylor & Francis; 2011., https://www.ncbi.nlm.nih.gov/books/NBK92772/ (4)

Revisiting superstition from the perspective of economics

What do imaginary goods, virtual cats and superstition have to do with each other? – Economics. ‘Imaginary goods’ is a term used by an Austrian economic theorist from the 1800’s, Carl Menger, to describe goods that might be sold but which did not meet all the criteria of a ‘goods‘ – a thing of value which could be sold or purchased. Imaginary goods could also be sold but they did not meet all of his criteria for ‘goods‘ because their value was more transient – in the imagination of the buyer and/or seller rather than clearly apparent to any normal consumer of goods.  (Principles of Economics, by Carl Menger, a translation in English)

As I’ve been working on devising ways to make pomegranate peel edible I’ve been thinking about the idea of a market or demand for a good versus the actual value of the good. You can’t sell something of value if no one considers it valuable even if it fits the criteria of being ‘goods‘ – fulfilling human needs; while it recently was brought to my attention, a refresher course having grown up in era of ‘Pet Rocks,” that some people will pay for anything if it is popular – if other people are bidding on the item too. I was astonished as a child that anyone would pay real money for a rock in a box just because it was called a ‘Pet Rock‘ – just go outside, find a rock, stick it in a box – there you go, your very own ‘pet rock’ captured from its wilderness and tamed for your own enjoyment. The current trend that was brought to my attention is less solid but requires an imagination – virtual cats, bred to have unique characteristics, the bidding is based on the uniqueness of the characteristics (investopedia.com) – my thought, too much time or too much money, and too little space for a real pet cat.

People need love and affection as it promotes oxytocin and dopamine which are hormones that promote positive feelings.

For those with limited room in their lives for an expensive virtual cat, consider going outside and looking for a wild rock to tame instead.

Bringing this back around to the New Year’s Day topic of good luck black-eyed peas and the following day’s topic of superstition – Carl Menger includes in his examples of imaginary goods items that might be considered good luck charms and also medications that aren’t effective.

Pomegranate peel might be effective but until there is proof that it is effective there might not be a market of consumers willing to pay for it let alone even try it. So Master Chef Challenge – Pomegranate Peel -> make it appetizing and if people also feel good after eating it then they will return for seconds -> thus creating a market that hadn’t previously been known.

Carl Menger’s four criteria for what makes something a consumer ‘good’:

“If a thing is to become a good, or in other words, if it is to
acquire goods-character, all four of the following prerequisites
must be simultaneously present:

  1. A human need.
  2. Such properties as render the thing capable of being brought
    into a causal connection with the satisfaction of this need.
  3. Human knowledge of this causal connection.
  4. Command of the thing sufficient to direct it to the satisfaction
    of the need.” page 52 (Principles of Economics, by Carl Menger, a translation in English)

According to his theory something can lose its value as a consumer good if it stops fulfilling any one of those four criteria, to paraphrase – if we 1: stop needing it because the problem it solved no longer exists, 2: the thing no longer works to solve the original problem  3: we forget that the thing is useful for fulfilling the need, 4: the thing is no longer something humans have access to (the WiFi goes out and the virtual cat breeding stops functioning) :

“Hence a thing loses its goods-character: (1) if, owing to a
change in human needs, the particular needs disappear that the thing is capable of satisfying, (2) whenever the capacity of the
thing to be placed in a causal connection with the satisfaction of
human needs is lost as the result of a change in its own properties,
(3) if knowledge of the causal connection between the thing and
the satisfaction of human needs disappears, or (4) if men lose
command of it so completely that they can no longer apply it
directly to the satisfaction of their needs and have no means of
reestablishing their power to do so.” -pages 52-53 (Principles of Economics, by Carl Menger, a translation in English)

So for those who may have forgotten (reason #3), – caring for living people or pets can help one’s own health through increased oxytocin, dopamine and reduced oxidative stress. If owning a real pet is not possible due to housing issues visiting a local Humane Society type agency and volunteering to help care for the shelter animals is generally possible and appreciated. If money isn’t a problem hiring a human for a service that involves touch such as a manicure is helping others by providing money for jobs and providing oxidative stress reducing touch from the hands-on service. If owning a real pet or hiring human hands-on service isn’t possible than oxytocin, dopamine and possibly even reduction in oxidative stress may be provided by a caring relationship with a houseplant that cleans the air of toxins (ferns and other types), or by enjoying looking at art objects that have to do with nature or possible the touch of a smooth natural object such as a rock or crystal or wooden object.

While my search of oxidative stress and art didn’t turn up the link I was looking for it did find a review of research on male infertility, oxidative stress, antioxidants (vitamin E, C and CoQ10) and ART, assisted reproductive techniques, while it doesn’t mention iodine it’s worth saving for reference and smoking is mentioned as risk: http://ccf.org/reproductiveresearchcenter/docs/agradoc261.pdf

Smoking increases intake of formaldehyde as well as other toxins. There are also other common sources of formaldehyde in modern living environments. Tips for reducing risk of formaldehyde exposure and links for the houseplants that help detoxify indoor air from formaldehyde and other common volatile chemicals are included in an older post, Formaldehyde (volatile – chemicals that might be easily released from plastics or carpets into the air – ie “new car smell”).

The topic on nature and art and oxidative stress is discussed with links in the section Art – Food for the Eyes on another website, effectivecare.info, 10. food Helps Too.

Returning to the Master Chef Challenge – Pomegranate Peel,  – it is helping my mood and health more consistently than the 1/2 cup of pomegranate seeds did but it is quite acidic. I’ve taken to using a couple spoonfuls in my bean soup instead of the lime juice or apple cider vinegar that I had been adding as a digestive aid. I’ve also tried it on salads in place of lime juice.

As a beverage I occasionally have the original blend of approximately 3 ounces of the pomegranate extract/soup stock with about 3 ounces of water and 1 ounce of cherry juice with four pinches of Baking Soda (sodium bicarbonate) to make it less acidic. Sugar is inflammatory in itself so I’v stopped using much of it. After the review of the blueberry/rhubarb jam recipe I bought some blueberries and will try a combination of the pomegranate extract with the less acidic fruit. Cherry juice is also acidic. Blueberry juice concentrate is available in specialty stores but I wasn’t at one.  The Baking Soda may be too much sodium or something in the pomegranate extract or the level of acidity it adds to the diet may have a diuretic effect like coffee – so like many things in life – it’s not perfect. But being sick isn’t either.

When you start thinking about food as fuel and as your body’s natural medicine cabinet then taste is something that can be acquired and adapted to suit the needs of health – but first the mind has to overpower the habit of “I always eat what my family ate, or what I got used to at college, or whatever my friends are eating.” Social settings and food are very strongly linked and it can be viewed as rude to refuse an offer of food that is being offered – sometimes life isn’t perfect either.

Good luck and best wishes all you Master Chefs out in virtual reader land – I know you can take on whatever culinary challenges you choose.

If at the beginning of 2017 someone predicted that I would successfully be using pomegranate peel, baker’s cocoa, cardamom, and leafy green herbs and vegetables instead of medical marijuana for my autoimmune health condition I might have thought they were imagining things – but Carl Menger was right we have to know the causal connection between a good and a problem it might solve before we go to the effort to purchase, prepare, and use the good for solving that problem/need (health care improvement in my case). pages 51-58, (Principles of Economics, by Carl Menger, a translation in English).

A tastes better than it looks salad – Blueberry Pomegranate Avocado Quinoa Salad.

Bring two and a half cups of water to a boil and add one cup quinoa (or amaranth or cracked wheat for a more traditional tabouli like salad). Cook for twenty minutes at a simmer. Stir occasionally to keep it from sticking to the saucepan. Once the water is fully absorbed remove the pan from the heat and add about (all of the following ingredients are estimates except for the avocado- this is a first try) one tablespoon coconut oil and stir into the hot cooked cereal. Add about one cup of frozen or fresh blueberries, 1/2 cup frozen or fresh pomegranate seeds, 1/4 cup pomegranate peel extract, one chopped ripe avocado, one tablespoon dried tarragon and one tablespoon dried basil (or more if fresh is available), and 1/4 cup chopped walnuts. Stir the mixture thoroughly. The cereal will turn purplish color from the blueberries. Serve a cup or so of the mixture over a plate of chopped salad greens and top with a pretty 1/8th cup of fresh or frozen pomegranate seeds.

I always add salt to taste at the table. We taste only the salt on the surface of food, not what has been cooked into a food or stirred into a mixture as much.

The flavors and textures work well together, sweet and tanginess from the fruit, creaminess from the avocado, quinoa and coconut oil. Tarragon adds flavor, the basil is milder and wasn’t noticeable in the amount I added here. Tarragon has a slightly minty flavor. The walnut is a stronger flavor and the crunch and flavor balance with the flavor of the blueberries and crunch of the pomegranate seeds. This was a success flavor and texture-wise no matter what it looks like and it would be nutritionally balanced with protein, essential fats and carbohydrates and plenty of fiber and trace nutrients and antioxidants. Walnuts and blueberries have both been found effective for cardiovascular health and male health issues.

Blueberry Pomegranate Avocado Quinoa Salad
Blueberry Pomegranate Avocado Quinoa Salad.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Why care about health? It’s about statistics.

The rate of cancer incidence has increased greatly in many countries and is expected to continue to increase, particularly in association with the aging of the population. Cancer is more often a diagnosis after age 65.  The rate of thyroid cancer in particular has increased greatly in women. The rate of developing some type of cancer during one’s lifetime is expected to reach 1 in 2 men and 1 in 3 women by the yea 2050, (MedScape) – or a more general 1 in 2 people, (medicalnewstoday) – those are not good odds.

It is common during youth to feel secure about health but our bodies tend to run out of stored nutrients as we age and metabolic pathways that we depend on to rebuild muscle and remove toxins or defective cells can become less effective. A healthy immune system also protects us from our own body’s normal rebuilding/regrowth of new cells. Defective ones are typically removed from growth areas in bone marrow before they enter circulation. Cancer cells are also removed on a regular basis when our immune systems are healthy.

Magnesium deficiency is a topic I keep stressing because the immune cells require magnesium in order to perform the apoptosis, killing, of defective or precancerous cells. The body’s defense systems are well developed but need fuel on a daily basis in order to be able to function as nature designed. While immune cells need magnesium in order to purposefully kill defective cells by apoptosis ( an enzyme is inserted into the cell which causes it to die and then the immune cell engulfs the debris and removes it for detoxification and excretion from the body), a cell that is deficient in magnesium or calcium may also undergo apoptosis due to the deficiency. (magnesium and apoptosis)

Too little Nrf2 may reduce immune system and antioxidant health but too much can be a problem in cancer cells that grow too rapidly. (Nrf2 overproduction and cancer)

Another person writing about the recent research in the area of Nrf2 shares more information about foods that help promote Nrf2 and how nature may have built in a mechanism within some foods that help prevent an over production of the important protein (Nrf2). See: “Activate Nrf2, then optimize: Brussel Sprouts.” – Bill Lagokos (patreon) /Spoiler, if not a fan of Brussel Sprouts the healthy phytonutrient that is discussed is also found in cruciferous vegetables including cabbage, cauliflower, broccoli, kohlrabi, and kale.

I personally am more sensitive to the group, especially if served raw or in larger quantities, but find steamed kale everyday tolerable to my digestive system. The bloating effect may be due to our good guy bacteria enjoying the fiber rich vegetables so much they produce the excess gas – but it can be a sign of healthy bacteria in our digestive tract. Irritable Bowel Syndrome can be affected by any food that causes bloating effects possibly due to TRP channel’s being activated by increased pressure. People with a history of IBS and other chronic pain syndromes may be suffereing from an underlying issue with overactive TRP ion channels. IBS and TRP channels are discussed on this site in a previous post. TRP channels are discussed in more detail with links on another website: Chronic Itch, migraines, IBS and stress; – that is one part frm a longer series: Relaxation and Stress, which is continued in:  Preeclampsia & TRP Channels.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.