All posts by Jenny

About Jenny

I am a public health nutrition counselor with fifteen years experience in the field of prenatal and early child health and lactation education (breast feeding support). Autoimmune disease, Autism Spectrum Disorders, and genetic defects that can cause nutrient deficiencies are also research interests.

Pre-eclampsia, oxidative stress, and Celiac sprue

Pre-eclampsia is a serious complication of pregnancy which can become life threatening to the mother and baby. High blood pressure and severe swelling of the lower legs and face are symptoms of pre-eclampsia. If the condition worsens it is called eclampsia and seizures may be the life threatening risk. The swelling can become severe enough that toxin removal by the kidneys is reduced.

What causes pre-eclampsia is not yet well understood. Providing IV solutions of magnesium sulfate just prior to delivery helps reduce risk of seizures and usually delivery of the baby causes the rest of the symptoms to resolve. However people who’ve experienced IVs of magnesium sulfate shared with me that it feels like fire running through their veins. Background information — magnesium is an electrically active mineral that during normal health is kept in a very narrow range within the blood and is largely found within the interior of cells and within the bones. Calcium is also electrically active and it is in higher concentration within the blood than within the interior of cells.

Skipping ahead, oxidative stress prenatally has been shown to be involved in pre-eclampsia and it causes an increase in calcium flow in the placenta. [1]

While looking for more information about pre-eclampsia I found a Celiac Sprue forum [2] that included questions and comments about whether anyone else with celiac gluten intolerance had also experienced pre-eclampsia or HELLP complications of pregnancy and if so any ideas why they might co-occur. HELLP is a blood coagulation problem which I didn’t look into but Celiac sprue and pre-eclampsia may be likely to co-occur because both involve oxidative stress:

Hi, I’m a dietitian with an autoimmune condition and previous work experience with prenatal health. I’ve been researching why the advice I gave when I was working helped so many women at the time worked – but isn’t in the mainstream medical treatment yet. Increasing magnesium rich foods such as beans, nuts, and seeds helped women that had a history of preeclampsia or high blood pressure to have a normal pregnancy.

In a nut shell – oxidative stress causes the placenta to increase flow of calcium. Too much calcium can cause other cellular reactions and fluid changes. And oxidative stress can be caused by gluten exposure when there is an underlying celiac autoimmune condition or probably other autoimmune conditions.

Re oxidative stress, and calcium channels in the placenta: Reactive Oxygen Species Inhibit Polycystin-2 (TRPP2) Cation Channel Activity In Term Human Syncytiotrophoblast [1]

Re Celiac Sprue and oxidative stress, “long chain omega 3 fatty acids, plant flavonoids and carotenoids” were suggested as antioxidants that may help reduce the “oxidative stress, gene expression & production of inflammatory mediators”:  Celiac disease, inflammation and oxidative damage: a nutrigenetic approach.   Carotenoids include beta-carotene from carrots. Orange, red and dark green fruits and vegetables are generally good sources of carotenoids and plant flavonoids are also found in a variety of colorful fruits and vegetables. Omega 3 fatty acids are found in fish oil supplements or salmon, tuna, sardines – limit as a mercury source however during pregnancy or child bearing years. Vegetarian sources of a precursor omega 3 fat include flax seed meal (ground is digestible, whole flax seeds aren’t really), walnuts, and hemp seed kernels.

Sesame seeds, or tahini, sesame paste, has been shown in sports research to help reduce oxidative stress. The trial subjects ate 2 tablespoons per day of the seeds. Effects of Sesame (Sesamum indicum L.) Supplementation on Creatine Kinase, Lactate Dehydrogenase, Oxidative Stress Markers, and Aerobic Capacity in Semi-Professional Soccer Players.

Dark chocolate has also been shown to be beneficial antioxidant source.

Best wishes to any Celiac sufferers – I avoid gluten due to intolerance, initially for fibromyalgia like symptoms, and later autoimmune thyroid  antibodies were found but not antibodies for Celiac Sprue.

A dietitian can help work out more balanced diets when major food items have to be excluded for health purposes. A professional organization offers a search feature for helping to find a Registered Dietitian eatright.org/find-an-expert

~~

One more link that didn’t make it into the comment, magnesium deficiency in combination with elevated calcium levels may be involved in increasing oxidative stress: Magnesium deficiency and oxidative stress: an update, 2016,  [3]

Who am I? What is my purpose? I am a sick person, with professional health experience, who reads and writes about sickness for my own health and for other sick people — they are the ones who realize just how valuable health is and who may appreciate information whether it has a large price tag & an expensive office — or is shared freely out of love and concern. Pain hurts.

One more link because they’re so informative, the inflammatory system seems to be connected to both pain receptors and other nerve receptors so inflammation, (which leads to oxidative stress) activates pain receptors (nociceptors) – /speculation/ which could be part of the reason fibromyalgia and other inflammatory conditions cause pain – they may simply be causing pain receptors to be over-active due to inflammation: Neurogenic Inflammation – The Peripheral Nervous System’s Role in Host Defense and Immunopathology [4]

The inflammatory process causes oxidative stress: Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. [5]

Adequate oxygen intake and flow to all the cells throughout the body is also necessary to prevent oxidative stress. Obesity can make it more difficult for oxygenated blood to reach all cells. [6]

Moderate exercise and deep breathing relaxation exercises may be helpful for improving oxygen intake and blood flow.

A previous article I wrote regarding magnesium and pre-eclampsia also includes information from a research hypothesis suggesting that intrauterine pressure itself may also be a trigger for worsening pre-eclampsia symptoms. [7] Not included in the hypothesis was why — which is likely to be due to the fact that physical (osmotic) pressure can cause TRP ion channels to open. TRP channels are a large group of specialized proteins which control flow of minerals such as calcium into the interior of cells. TRP channels include the ones that were shown to be dysregulated by oxidative stess in the placenta which allowed an increase of calcium to enter, which is described in the research article: Reactive Oxygen Species Inhibit Polycystin-2 (TRPP2) Cation Channel Activity In Term Human Syncytiotrophoblast [1]

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

  1.  https://www.researchgate.net/publication/5435874_Reactive_Oxygen_Species_Inhibit_Polycystin-2_TRPP2_Cation_Channel_Activity_In_Term_Human_Syncytiotrophoblast
  2. https://www.celiac.com/gluten-free/topic/55927-pre-eclampsia-celiac/
  3. A.A. Zheltova, et al., Magnesium deficiency and oxidative stress: an update, Biomedicine (Taipei). 2016 Dec; 6(4): 20.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112180/
  4. Isaac M. Chiu, et al., Neurogenic Inflammation – The Peripheral Nervous System’s Role in Host Defense and Immunopathology,  Nat Neurosci. 2012 Jul 26; 15(8): 1063–1067.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520068/
  5. Khansari N, Shakiba Y, Mahmoudi M., Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. Recent Pat Inflamm Allergy Drug Discov. 2009 Jan;3(1):73-80. https://www.ncbi.nlm.nih.gov/pubmed/19149749
  6. N. Netzer, Hypoxia, Oxidative Stress and Fat., Biomolecules. 2015 Jun; 5(2): 1143–1150.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496714/
  7. http://transcendingsquare.com/2011/02/19/preeclampsia-magnesium-deficiency-or-grass-staggers/

GPI anchors are cell membrane glycoproteins

Glycosylphosphatidylinositol (GPI)-anchored proteins are long and firmly embed within the membrane and leave an extension out over the surface of the membrane. One end of the protein stays embedded firmly within the cell membrane and the other end can attach to a variety of important molecules such as enzymes and antigens. The enzyme or antigen is held above the cell membrane in a position that makes it available to be activated on the cell surface.

The phosphatidylinositol end is lipid (oil or fat) based and dissolves well in the fatty acid rich environment found within the membrane. The glyco- or sugar part of the molecule is able to dissolve in water or form bonds with other proteins or carbohydrates and is found on the end of the molecule that sticks out over the surface of the membrane.

GPI anchor proteins are essential for life. Mice that were experimentally made to lack the gene thought to encode for GPI anchor proteins did not survive. Experimental “knockout” mice are usually observed to see what types of function the knocked out gene might have performed. The experiment showed that GPI anchors were necessary for basic survival of baby mice. (Ref. 1, Brooks, Dwek, Schumacher, 2002, p 225) When a protein is found to be so essential that a “knockout” mouse doesn’t survive than more minor differences are attempted to be made in order to try to find out what types of functions are changed or are missing from the more slightly modified “knockout” mice.

Background information: GPI anchors are found in some types of G-protein couple receptors and may have importance within the cannabinoid receptor system which has been found to play early and essential roles in implantation of the newly fertilized egg within the mother’s uterus.

/Disclosure: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes./

  1. Brooks SA, Dwek MV, Schumacher U., Functional and Molecular Glycobiology, (Bios, 2002, Oxford, UK)
  2. Landry Y, Niederhoffer N, Sick E, Gies JP., Heptahelical and other G-protein-coupled receptors (GPCRs) signaling., Curr Med Chem. 2006;13(1):51-63. [ncbi.nlm.nih.gov/pubmed/16457639]
  3. Maccarrone M, Bernardi G, […], and Centonze D., Cannabinoid receptor signalling in neurodegenerative diseases: a potential role for membrane fluidity disturbance., Br J Pharmacol. 2011 August; 163(7): 1379-1390 [ncbi.nlm.nih.gov/pmc/articles/PMC3165948/]

Additional note on GPI anchors:

  1. Fujita M, Kinoshita T. “GPI-anchor remodeling: potential functions of GPI-anchors in intracellular trafficking and membrane dynamics.” Biochim Biophys Acta. 2012 Aug;1821(8):1050-8. doi: 10.1016/j.bbalip.2012.01.004. Epub 2012 Jan 11.  Abstract: [http://www.ncbi.nlm.nih.gov/pubmed/22265715] “and discuss how GPI-anchors regulate protein sorting, trafficking, and dynamics.”

/Disclosure: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes./

Sugars give energy and structure to life

Carbohydrates are molecules of various size and shape which are formed from atoms of carbon (chemical symbol “C”) and water molecules (chemical symbol “H2O”).  An atom is the single smallest chemical unit of an element. A molecule is the single smallest unnit of a more complex chemical made up of atoms of other elemental chemicals or small groups of atoms that typically stay together in chemical reactions. The name carbohydrate means ‘hydrate of carbon.’

As single molecules carbohydrates are commonly known as sugars and  the single molecules  of  a sugar may be found in nature in a ring form or in a straight chain of carbon atoms that have hydrogen (H) and hydroxyl groups (OH) from the water molecules connected to the string of carbon atoms. As a visual, imagine a diamond ring where the gold band is made up of five to nine atoms of carbon and the diamond is an OH group that kind of points outward.

Individual carbohydrate molecules are called simple sugars or monosaccharides. They are commonly found in the diet as disaccharides, pairs of two monosaccharides, and as long chain polysaccharides in the form of the energy rich starches and the indigestible fiber found in cell walls of plants.

In a fluid environment such as a glass of fruit juice, the individual monosaccharides may be found as a straight chain of linked carbon atoms or as closed rings. The ring form is more stable chemically. A glass of sugar water made with pure glucose would only have ~0.0026% of the glucose molecules in the straight chain formation, the rest would be in some variation of the the ring form.

The juice of the sugar cane gives us sucrose or table sugar, which is made up of two 6 carbon monosaccharides, one molecule of glucose and one of fructose. The disaccharide lactose is better known as milk sugar and is made up of one molecule of galactose and one of glucose.

Mannose and fucose are monosaccharides that are less common in unprocessed foods but are very useful as food additives in mixtures such as ice cream or pudding.

  • Fucose is commonly found in brown seaweeds. About forty percent of the dry weight of brown seaweeds is the commercially useful alginate polysaccharides. Alginates are used as food additives to help stabilize mixtures and act as emulsifiers which help keep the mixture well mixed even while the food mixture remains still when sitting for weeks or months in a package on the grocery shelf or kitchen cupboard.
  • Mannans are the polysaccharide of mannose. Mannans are found in red algae which is useful for its agar and carrageenan content. They are used as food additives for their gelatinous properties and as thickeners.
  •  Carrageenan may be a health risk and has been shown to cause inflammation, impaired glucose tolerance and increased insulin resistance in lab animals at levels that might be found in comparable amounts in an average day’s food for a person. An update suggests that in larger quantities or more daily use that carrageenan may be linked to gastrointestinal symptoms or glucose intolerance. [12]
  • Mannans are also the main type of energy storage starch in the seeds of the oil palm trees.
  • One variety of the tree species, the ivory nut tree, is also known as ‘vegetable ivory.’ The mannan within the ivory like seeds resembles the overlapping long polysaccharide chains of cellulose, which is the type of fiber more commonly found in plant cell walls.

Other uses of the oil palm:  There are two types of oil produced from the seed of oil palm trees. Palm kernel oil is paler in color than the reddish color, beta-carotene rich, palm oil. Palm kernel oil contains a higher percentage of saturated fat than palm oil. It may increase the risk of high blood cholesterol but is an inexpensive cooking oil. Palm kernel oil is also frequently used in the production of soap because some of the saturated fatty acids produce good lather, even in salty sea water. Fibrous seed pulp that is left after oil production is used as animal feed.

  • The monosaccharide mannose may be the active factor that gives cranberries a reputation for helping prevent urinary tract infections (UTIs). The monsaccharide mannose is thought to help make the lining of the bladder more resistant to infectious bacteria. More research is needed though to prove health benefits from cranberries or from more concentrated supplemental doses of D-Mannose.
  • Update – clinical research with patients with UTI symptoms were found to benefit from the use of D-mannose supplements. Two grams of D-mannose in powder form was given dissolved in a glass of water each day as a preventative. Patients in the D-mannose group were found to have fewer Urinary Tract Infections than the group who received daily low dose antibiotics. The control group of patients who recieved neither D-mannose or antibiotics had the most UTIs during the study (six months). The role mannose has to play in helping protect against UTI causing bacteria is discussed in further detail in the following article: D-Mannose for UTI Prevention Validated in Clinical Trial. [10] Capsules of cranberry concentrate or extract were found effective for preventing UTIs compared to drinking cranberry juice. [11]

Glyconutrients are essential for helping protect cell surfaces from infectious agents – so fans of cranberries are probably onto a good thing for more than one reason. Cranberries provide other healthy nutrients such as vitamin C so enjoying them provides the body a variety of helpful nutrients. [11]

The complex branching that is possible when monosaccharides and disaccharides join together in long chains is an essential part of our immune system defense. The surface of cells and bacteria and other microbes all have identifying molecules of complex sugar containing molecules which are used to tell friend from foe – like having a Welcome mat out on the front door or a Please Don’t Disturb sign hanging on the doorknob.

These longer types of molecules and the types of structures they form are discussed in more detail in the post: To Termites, Trees are like giant Sugar Cubes .

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

First posted (July 16, 2013), revised 4/18/2017.

References:

  1. S.A. Brooks, M. V. Dwek, U. Schumacher, Functional and Molecular Glycobiology, (BIOS Scientific Publishers, Ltd., 2002), Amazon.
  2. Out of One Many, or How to Use Agar Agar,” (Dec. 17, 2008) by chocolatecoveredKatie.com.
  3. Palm Kernel,” Wikipedia (Warning: this Wikipedia entry contains an old war propaganda poster about harvesting palm seeds which may offend some people and for that very reason should never be forgotten.)
  4. Palm Kernel Oil,” Wikipedia.
  5. Palm Oil,” Wikipedia.
  6. D-Mannose Offers Great Protection Against Urinary Tract Infections,”  SmartPublications.com.
  7. Scientific Opinion on the substantiation of a health claim related to a Uroval® and urinary tract infection pursuant to Article 14 of Regulation,” (EC) No 1924/20061, EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), European Food Safety Authority (EFSA), Parma, Italy
    pdf: efsa.europa.eu.
  8. L. Johnston, “Natural Urinary Tract Health: The D-Mannose Solution,” healingtherapies.info.
  9. A Weil, “Is Carrageenan Safe?” (Oct. 1, 2012), drweil.com.
  10. D-Mannose for UTI Prevention Validated in Clinical Trialhttp://articles.mercola.com/sites/articles/archive/2014/04/28/d-mannose-uti-prevention.aspx
  11. Cranberries, Health Benefits, Facts, Researchhttp://www.medicalnewstoday.com/articles/269142.php
  12. What is Carrageenan? https://wellnessmama.com/2925/what-is-carrageenan/

To termites, trees are like giant sugar cubes

Sugar cubes contain the disaccharide known as sucrose which is made up of one molecule of the monosaccharide most common in fruit called fructose in addition to one molecule of the monosaccharide called glucose which is essential for energy production within the body and brain.

The cellulose portion of trees is made of long fairly straight chains of glucose with no fructose, so trees and sugar cubes aren’t really alike. The bonds between table sugar and tree fiber are at slightly different angles which means a hungry person or animal would require different enzymes in order to be able to break them down during digestion into smaller molecules and atoms for further use as an energy source.

The straighter angle between the simple sugars of plant fiber allow the linked chains of glucose to line up with each other.  When lined up the fibers then can form layers, which might seem a little like sheets of paper stacked on top of each other in a book, except it would be a round cylinder doughnut shaped book. Cellulose is one type of plant fiber, it and other types of plant fiber are found in the cell walls throughout the plant in the leaves, stems and roots.

Chitin is similar strong chain of the simple sugar N-acetylglucosamine. The simple sugars in chitin and cellulose both have the slightly straighter beta angle than the bonds found in energy storage starches or polysaccharides. Termites [3] and the bacteria found in the stomach of grazing animals are able to digest the stronger beta bonds of cellulose.

Humans and most other animals can’t digest the strong beta bonds of cellulose because a specific enzyme is needed. The termites and bacteria in the stomach of grazing animals can make the enzyme from other chemicals but humans and the grazing animals themselves can’t make it.

Energy rich plant starches have alpha type bonds between the simple sugars. Alpha bonds connect at an angle that might twist into a spiral chain similar to the double helix spiral of DNA.

The angled alpha bonds are also found in branching shapes of storage starches like glycogen or amylose. The sugar molecule at the end of each ‘branch’ is available for rapid digestion. Glycogen is the energy storage polysaccharide of glucose in animals and humans and amylose is the form of glucose storage used in plants. Glycogen is slightly more branched than amylose.

Tree bark and tree sap both contain glucose but the bark contains cellulose and the sap would have amylose or a similar alpha bonded energy storage starch. A shiny insect shell or seashells also are a type of sugar but not glucose. Shells contain N-acetyl-glucosamine in the form of chitin.

Supplements of glucosamine may be helpful for reducing joint pain. Clinical research studies with patients have found 1500 mg/day may be beneficial. [2]

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

References:

  1. S.A. Brooks, M. V. Dwek, U. Schumacher, Functional and Molecular Glycobiology, (BIOS Scientific Publishers, Ltd., 2002), Amazon.
  2. “Questions and Answers: NIH Glucosamine/Chondroitin Arthritis Intervention Trial Primary Study,” National Institutes of Health, National Center for Complementary and Alternative Medicine [nccam.nih.gov]
  3. Nakashima K, Watanabe H, Saitoh H, Tokuda G, Azuma JI.,”Dual cellulose-digesting system of the wood-feeding termite, Coptotermes formosanus Shiraki.” Insect Biochem Mol Biol. 2002 Jul;32(7):777-84. [ncbi.nlm.nih.gov]

Spring cleaning, pardon the dust

I’ve been working on updating some of my older posts and have closed a lot of things in the mean time. I plan to work towards publishing in more typical peer reviewed formats.

Cheerful springtime blooms brighten up a sunny day, snow crocus minus the snow.

Cheerful springtime blooms                             brighten up a sunny day,
snow crocus minus the snow.

 

Increase in electromagnetic radiation may be associated with increased autism

A graph showing a similar rate of increase in electromagnetic radiation exposure and increased rates of autism can be seen around 42 minutes in the following video, Dr. Erica Mallery-Blythe – Electromagnetic Radiation, Health and Children 2014:

This type of radiation can be from wireless cell phones or laptops or from living very close, within a few miles, of high powered electric lines or power stations.

And even wirelessly connected toys might be harmful to children. [1, 2, 3] A computer or telephone that is not wireless, but is on an old-fashioned landline would not have the same level of electromagnetic radiation.

Tinfoil hats would only act as an antennae and possibly increase radiation absorption, however grounded metal foil might absorb the radiation rather than deflecting it and causing it simply to bounce around more. Water also absorbs this type of radiation which may be part of the reason electromagnetic radiation is dangerous to humans and other life forms – we are water based. [4]

A nonprofit organization of physicians who would like to increase awareness of electromagnetic hypersensitity has more information available on their website and an opportunity to join their group: http://phiremedical.org/tag/pdfs-for-electromagnetic-hypersensitivity/

I’ve filed this under calcium on this site because EMF radiation can cause an increased flow of calcium into the interior of cells which can lead to overexcitement of the cell and may lead to cell death. People with hypersensitivity to electromagnetic radiation have measurable differences in their skin in response to exposure to EMF radiation compared to non hypersensitive people. An increase in mast cells may be part of the difference between the two groups.

See this video for more information, and/or a research article by the speaker regarding electrohypersensitivity, https://www.ncbi.nlm.nih.gov/pubmed/17178584:

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Chronic itch, ion channels, magnesium and calcium

Genetic differences in more than 70 genes have been associated with increased itchiness. [1] Calcium and serotonin levels may be involved in increased itch or arthritis pain signals being sent/perceived. [2] See the excerpts below:

Summary: Too much or too little calcium and magnesium can affect pain, itching, and mood. The minerals are both electrically active, and provide energy for ion channels which control the transport of messenger chemicals like serotonin across cell membranes – such as nerve cell membranes.

“For neurons to become excited, you need a receptor to communicate with an ion channel,” said Dr. Bautista. “We tried a variety of experiments and found that HTR7 communicates with the TRPA1 ion channel. Both receptors seem to be working together to mediate chronic itch.” “The researchers found more than 70 genes whose expression was higher in the more itch-sensitive mice. Of these, the gene for the HTR7 receptor was the most closely linked to itch. In fact, the HTR7 gene was twice as active in the itchiest mice compared to the least sensitive mice. ”  [1]

  1. An Itch You Just Can’t Scratch; NIH-funded study identifies proteins that may cause chronic itch (Oct. 27, 2015) http://www.ninds.nih.gov/news_and_events/news_articles/pressrelease_chronic_itch_10272015.htm
  2. Adam Horvath, et al., Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: in vivo study using TRPA1-deficient mice, Arthritis Res Ther. 2016; 18: 6http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718022/          

    Excerpt: “TRPA1 is also directly stimulated by intracellular calcium [24] and a broad range of noxious endogenous oxidative products, such as 4-hydroxy-2-nonenal, hydrogen peroxide, hypochloride, hydrogen sulphide, 15-delta prostaglandin J2 [2528]. Furthermore, there are several exogenous irritants like mustard oil (allyl isothiocyanate: AITC) [29], cinnamaldehyde [30, 31], allicin [32, 33] and formalin [34] that are known to be potent agonists of TRPA1. Inflammatory mediators, such as bradykinin and serotonin, can sensitize this receptor and increase the responsiveness of the nerve endings [19, 35]. These findings suggest that TRPA1 may be involved in the development and maintenance of arthritic pain, but the precise mechanisms are still unknown.”

  3. Rs6295: The “Single” and “Self-Transcendent” Gene (5-HT1A Receptor) https://selfhacked.com/2015/07/23/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/Magnesium and Calcium increase the binding of serotonin to the 5HT1A receptors in the cortex (purkinje cells). (R)

  4. Bujalska M., et. al., Magnesium ions and opioid agonist activity in streptozotocin-induced hyperalgesia. Pharmacology. 2008;82(3):180-6.http://www.ncbi.nlm.nih.gov/pubmed/18701828

  5. That Really Does Make It Worse

    Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

World Autism Awareness Day; “Please teacher” video

It is World Autism Awareness Day and this video of children with autism addressing their teachers is heart breaking – and hopeful.

 

Recently I was reading a poem by someone with autism and it reminded me of me. It was describing a feeling of not fitting in with the normal types of people but not wanting to be lumped in with the type of people who couldn’t communicate at all:

High functioning people with autism might understand and listen and be interested but not be comfortable or able to speak their thoughts well. They might enjoy going to a party and just listening and smiling on the outskirts rather than chatting much but they could still be enjoying themselves in their own ways. I liked to water plants during social gatherings at a church where I was a member. I was part of the group and enjoyed saying hi’s briefly to people and it helped the plants and gave me something to do so it wouldn’t seem odd to not get into longer chats with people. I’m much better at talking about nutrition then about social chit-chat.

Some families have found that smartphones allow instant texting as a modern solution to conversation. The family talks and the person with autism listens and texts back to them in response. It can also be common for people with autism to communicate in snippets of quoted lyrics or other phrases – using other’s words to say what’s also on their mind.

The Legoland article reminded me of my favorite “amusement” museum. The City Museum in St. Louis, Missouri is full of decorations made from recycled materials built into mosaics and patterned walls. The museum is built within and on the grounds of a large multi-storied building that was a shoelace factory. Shoelaces are still made there and can be purchased. There are numerous imaginative landscapes that can be physically explored and played on and in and under and above – the place is a jungle and cavern and a maze and amazing – truly. If I could live anywhere on the planet that I wanted to, then it might be here: http://www.citymuseum.org/

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

A U.S. Congressman is concerned about safety of glyphosate

“New questions about the safety of Monsanto weed killer Roundup are deeply troubling. I worked on the glyphosate issue last term and I believe consumers should immediately stop using Roundup, whose core ingredient glyphosate has been labeled a likely carcinogen and has been linked to non-Hodgkin’s lymphoma by the International Agency for Research on Cancer. We need to find out if Monsanto or the Environmental Protection Agency misled the public.”

-U.S. Congressman Ted Lieu,  “US Congressman Calls for DOJ Investigation into EPA-Monsanto Glyphosate Collusion” Mar 17 2017 – by Sustainable Pulse,

http://sustainablepulse.com/2017/03/17/us-congressman-calls-for-doj-investigation-into-epa-monsanto-glyphosate-collusion/#.WMv1yjvytPb

An employee of the EPA may have colluded with Monsanto to suppress investigation of the safety of glyphosate and the herbicide Roundup.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.